Annotations: 6K7V

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth J]	CARD	e6k7vJ1	A: alpha arrays	X: DEATH domain	H: DEATH domain (From Topology)	T: DEATH domain	F: CARD	ECOD (1.6)
B [auth A]	CARD	e6k7vA1	A: alpha arrays	X: DEATH domain	H: DEATH domain (From Topology)	T: DEATH domain	F: CARD	ECOD (1.6)
C [auth B]	CARD	e6k7vB1	A: alpha arrays	X: DEATH domain	H: DEATH domain (From Topology)	T: DEATH domain	F: CARD	ECOD (1.6)
D [auth C]	CARD	e6k7vC1	A: alpha arrays	X: DEATH domain	H: DEATH domain (From Topology)	T: DEATH domain	F: CARD	ECOD (1.6)
E [auth D]	CARD	e6k7vD1	A: alpha arrays	X: DEATH domain	H: DEATH domain (From Topology)	T: DEATH domain	F: CARD	ECOD (1.6)
F [auth E]	CARD	e6k7vE1	A: alpha arrays	X: DEATH domain	H: DEATH domain (From Topology)	T: DEATH domain	F: CARD	ECOD (1.6)
G [auth F]	CARD	e6k7vF1	A: alpha arrays	X: DEATH domain	H: DEATH domain (From Topology)	T: DEATH domain	F: CARD	ECOD (1.6)
H [auth G]	CARD	e6k7vG1	A: alpha arrays	X: DEATH domain	H: DEATH domain (From Topology)	T: DEATH domain	F: CARD	ECOD (1.6)
I [auth H]	CARD	e6k7vH1	A: alpha arrays	X: DEATH domain	H: DEATH domain (From Topology)	T: DEATH domain	F: CARD	ECOD (1.6)
J [auth I]	CARD	e6k7vI1	A: alpha arrays	X: DEATH domain	H: DEATH domain (From Topology)	T: DEATH domain	F: CARD	ECOD (1.6)
K	CARD	e6k7vK1	A: alpha arrays	X: DEATH domain	H: DEATH domain (From Topology)	T: DEATH domain	F: CARD	ECOD (1.6)
L	CARD	e6k7vL1	A: alpha arrays	X: DEATH domain	H: DEATH domain (From Topology)	T: DEATH domain	F: CARD	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth J], B [auth A], C [auth B], D [auth C], E [auth D], A [auth J], B [auth A], C [auth B], D [auth C], E [auth D], F [auth E], G [auth F], H [auth G], I [auth H], J [auth I], K, L	PF00619	Caspase recruitment domain (CARD)	Caspase recruitment domain	Motif contained in proteins involved in apoptotic signaling. Predicted to possess a DEATH (Pfam:PF00531) domain-like fold .	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth J], B [auth A], C [auth B], D [auth C], E [auth D], A [auth J], B [auth A], C [auth B], D [auth C], E [auth D], F [auth E], G [auth F], H [auth G], I [auth H], J [auth I], K, L	NACHT, LRR and PYD domains-containing protein 1	RNA binding double-stranded RNA binding binding nucleic acid binding cysteine-type endopeptidase activator activity enzyme regulator activity peptidase activity peptidase regulator activity catalytic activity, acting on a protein molecular function activator activity hydrolase activity peptidase activator activity endopeptidase regulator activity cysteine-type peptidase activity RNA binding double-stranded RNA binding binding nucleic acid binding cysteine-type endopeptidase activator activity enzyme regulator activity peptidase activity peptidase regulator activity catalytic activity, acting on a protein molecular function activator activity hydrolase activity peptidase activator activity endopeptidase regulator activity cysteine-type peptidase activity endopeptidase activator activity enzyme activator activity molecular function regulator activity cysteine-type endopeptidase activity catalytic activity endopeptidase activity adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding cysteine-type endopeptidase activator activity involved in apoptotic process cysteine-type endopeptidase regulator activity involved in apoptotic process peptidase activator activity involved in apoptotic process protein binding protein domain specific binding protein-macromolecule adaptor activity molecular adaptor activity signaling adaptor activity molecular condensate scaffold activity molecular transducer activity pattern recognition receptor activity signaling receptor activity DNA binding double-stranded DNA binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity, acting on acid anhydrides ATP-dependent activity enzyme binding	cellular response to stimulus positive regulation of response to biotic stimulus regulation of cellular process pattern recognition receptor signaling pathway response to stimulus response to biotic stimulus intracellular signal transduction cell communication cellular component biogenesis immune response-activating signaling pathway cellular component assembly inflammasome-mediated signaling pathway positive regulation of immune response canonical inflammasome complex assembly cellular response to stimulus positive regulation of response to biotic stimulus regulation of cellular process pattern recognition receptor signaling pathway response to stimulus response to biotic stimulus intracellular signal transduction cell communication cellular component biogenesis immune response-activating signaling pathway cellular component assembly inflammasome-mediated signaling pathway positive regulation of immune response canonical inflammasome complex assembly regulation of immune system process signal transduction positive regulation of immune system process innate immune response-activating signaling pathway regulation of biological process immune response response to other organism regulation of innate immune response response to external stimulus regulation of response to stimulus defense response to other organism positive regulation of defense response activation of innate immune response regulation of immune response NLRP1 inflammasome complex assembly inflammatory response activation of immune response cytoplasmic pattern recognition receptor signaling pathway regulation of defense response regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms regulation of response to external stimulus intracellular receptor signaling pathway signaling positive regulation of biological process positive regulation of response to stimulus cellular component organization positive regulation of response to external stimulus immune response-regulating signaling pathway regulation of response to stress response to stress innate immune response protein-containing complex assembly response to external biotic stimulus cellular component organization or biogenesis positive regulation of innate immune response defense response protein-containing complex organization biological regulation defense response to symbiont immune system process cellular process regulation of inflammatory response positive regulation of inflammatory response apoptotic process cell death programmed cell death regulation of apoptotic process regulation of programmed cell death defense response to bacterium response to bacterium multicellular organismal process interleukin-1 production regulation of interleukin-1 beta production positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of interleukin-1 beta production positive regulation of biosynthetic process regulation of cytokine production cytokine production regulation of multicellular organismal process positive regulation of interleukin-1 production positive regulation of macromolecule metabolic process positive regulation of cellular process regulation of biosynthetic process regulation of interleukin-1 production regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of gene expression biosynthetic process interleukin-1 beta production positive regulation of gene expression positive regulation of multicellular organismal process regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process positive regulation of cytokine production regulation of metabolic process response to light stimulus cellular response to radiation response to UV response to UV-B cellular response to environmental stimulus cellular response to UV-B cellular response to light stimulus response to radiation response to abiotic stimulus cellular response to abiotic stimulus cellular response to UV defense response to virus response to virus proteolysis self proteolysis primary metabolic process protein metabolic process apoptotic signaling pathway intrinsic apoptotic signaling pathway antiviral innate immune response neuron apoptotic process response to chemical response to oxygen-containing compound response to muramyl dipeptide response to nitrogen compound protein complex oligomerization protein homooligomerization pyroptotic inflammatory response	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle membraneless organelle nuclear lumen nucleoplasm canonical inflammasome complex protein-containing complex NLRP3 inflammasome complex NLRP1 inflammasome complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth J], B [auth A], C [auth B], D [auth C], E [auth D], A [auth J], B [auth A], C [auth B], D [auth C], E [auth D], F [auth E], G [auth F], H [auth G], I [auth H], J [auth I], K, L	IPR051249	NLRP Inflammasome	Family
A [auth J], B [auth A], C [auth B], D [auth C], E [auth D], A [auth J], B [auth A], C [auth B], D [auth C], E [auth D], F [auth E], G [auth F], H [auth G], I [auth H], J [auth I], K, L	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A [auth J], B [auth A], C [auth B], D [auth C], E [auth D], A [auth J], B [auth A], C [auth B], D [auth C], E [auth D], F [auth E], G [auth F], H [auth G], I [auth H], J [auth I], K, L	IPR001611	Leucine-rich repeat	Repeat
A [auth J], B [auth A], C [auth B], D [auth C], E [auth D], A [auth J], B [auth A], C [auth B], D [auth C], E [auth D], F [auth E], G [auth F], H [auth G], I [auth H], J [auth I], K, L	IPR004020	DAPIN domain	Domain
A [auth J], B [auth A], C [auth B], D [auth C], E [auth D], A [auth J], B [auth A], C [auth B], D [auth C], E [auth D], F [auth E], G [auth F], H [auth G], I [auth H], J [auth I], K, L	IPR025307	FIIND domain	Domain
A [auth J], B [auth A], C [auth B], D [auth C], E [auth D], A [auth J], B [auth A], C [auth B], D [auth C], E [auth D], F [auth E], G [auth F], H [auth G], I [auth H], J [auth I], K, L	IPR007111	NACHT nucleoside triphosphatase	Domain
A [auth J], B [auth A], C [auth B], D [auth C], E [auth D], A [auth J], B [auth A], C [auth B], D [auth C], E [auth D], F [auth E], G [auth F], H [auth G], I [auth H], J [auth I], K, L	IPR011029	Death-like domain superfamily	Homologous Superfamily
A [auth J], B [auth A], C [auth B], D [auth C], E [auth D], A [auth J], B [auth A], C [auth B], D [auth C], E [auth D], F [auth E], G [auth F], H [auth G], I [auth H], J [auth I], K, L	IPR033516	CARD8/ASC/NALP1, CARD domain	Domain
A [auth J], B [auth A], C [auth B], D [auth C], E [auth D], A [auth J], B [auth A], C [auth B], D [auth C], E [auth D], F [auth E], G [auth F], H [auth G], I [auth H], J [auth I], K, L	IPR041267	NACHT, LRR and PYD domains-containing protein, helical domain HD2	Domain
A [auth J], B [auth A], C [auth B], D [auth C], E [auth D], A [auth J], B [auth A], C [auth B], D [auth C], E [auth D], F [auth E], G [auth F], H [auth G], I [auth H], J [auth I], K, L	IPR041075	NOD1/2, winged helix domain	Domain
A [auth J], B [auth A], C [auth B], D [auth C], E [auth D], A [auth J], B [auth A], C [auth B], D [auth C], E [auth D], F [auth E], G [auth F], H [auth G], I [auth H], J [auth I], K, L	IPR032675	Leucine-rich repeat domain superfamily	Homologous Superfamily
A [auth J], B [auth A], C [auth B], D [auth C], E [auth D], A [auth J], B [auth A], C [auth B], D [auth C], E [auth D], F [auth E], G [auth F], H [auth G], I [auth H], J [auth I], K, L	IPR001315	CARD domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth J], B [auth A], C [auth B], D [auth C], E [auth D], A [auth J], B [auth A], C [auth B], D [auth C], E [auth D], F [auth E], G [auth F], H [auth G], I [auth H], J [auth I], K, L	Pharos: Q9C000	vitiligo-associated multiple autoimmune disease susceptibility 1 corneal intraepithelial dyskeratosis-palmoplantar hyperkeratosis-laryngeal dyskeratosis syndrome autoinflammation with arthritis and dyskeratosis atypical teratoid rhabdoid tumor large cell medulloblastoma malignant glioma non-small cell lung carcinoma PALMOPLANTAR CARCINOMA, MULTIPLE SELF-HEALING subependymal giant cell astrocytoma cystic fibrosis lung cancer malignant mesothelioma osteosarcoma pancreatic intraductal papillary-mucinous carcinoma vitiligo vitiligo-associated multiple autoimmune disease susceptibility 1 corneal intraepithelial dyskeratosis-palmoplantar hyperkeratosis-laryngeal dyskeratosis syndrome autoinflammation with arthritis and dyskeratosis atypical teratoid rhabdoid tumor large cell medulloblastoma malignant glioma non-small cell lung carcinoma PALMOPLANTAR CARCINOMA, MULTIPLE SELF-HEALING subependymal giant cell astrocytoma cystic fibrosis lung cancer malignant mesothelioma osteosarcoma pancreatic intraductal papillary-mucinous carcinoma vitiligo breast cancer glioblastoma lung carcinoma medulloblastoma ovarian cancer psoriasis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.