Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
A [auth B]Pkinase_Tyre6vn8B1 A: a+b complex topologyX: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)H: Protein kinase/SAICAR synthase/ATP-graspT: Protein kinaseF: Pkinase_TyrECOD (1.6)
B [auth A]Pkinase_Tyre6vn8A1 A: a+b complex topologyX: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)H: Protein kinase/SAICAR synthase/ATP-graspT: Protein kinaseF: Pkinase_TyrECOD (1.6)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A [auth B],
B [auth A]
PF07714Protein tyrosine and serine/threonine kinase (PK_Tyr_Ser-Thr)Protein tyrosine and serine/threonine kinaseProtein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosph ...Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A [auth B],
B [auth A]
Tyrosine-protein kinase JAK2

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A [auth B],
B [auth A]
IPR020635Tyrosine-protein kinase, catalytic domainDomain
A [auth B],
B [auth A]
IPR000719Protein kinase domainDomain
A [auth B],
B [auth A]
IPR041381JAK1-3/TYK2, pleckstrin homology-like domainDomain
A [auth B],
B [auth A]
IPR017441Protein kinase, ATP binding siteBinding Site
A [auth B],
B [auth A]
IPR036860SH2 domain superfamilyHomologous Superfamily
A [auth B],
B [auth A]
IPR001245Serine-threonine/tyrosine-protein kinase, catalytic domainDomain
A [auth B],
B [auth A]
IPR051286Janus Kinase (JAK)Family
A [auth B],
B [auth A]
IPR041046JAK, FERM F2 lobe domainDomain
A [auth B],
B [auth A]
IPR019749Band 4.1 domainDomain
A [auth B],
B [auth A]
IPR020693Tyrosine-protein kinase, non-receptor Jak2Family
A [auth B],
B [auth A]
IPR035860Tyrosine-protein kinase JAK2, SH2 domainDomain
A [auth B],
B [auth A]
IPR037838JAK2, FERM domain C-lobeDomain
A [auth B],
B [auth A]
IPR000299FERM domainDomain
A [auth B],
B [auth A]
IPR016251Tyrosine-protein kinase, non-receptor Jak/Tyk2Family
A [auth B],
B [auth A]
IPR008266Tyrosine-protein kinase, active siteActive Site
A [auth B],
B [auth A]
IPR019748FERM central domainDomain
A [auth B],
B [auth A]
IPR035963FERM superfamily, second domainHomologous Superfamily
A [auth B],
B [auth A]
IPR000980SH2 domainDomain
A [auth B],
B [auth A]
IPR011993PH-like domain superfamilyHomologous Superfamily
A [auth B],
B [auth A]
IPR035588Janus kinase 2, pseudokinase domainDomain
A [auth B],
B [auth A]
IPR035589Janus kinase 2, catalytic domainDomain
A [auth B],
B [auth A]
IPR011009Protein kinase-like domain superfamilyHomologous Superfamily
A [auth B],
B [auth A]
IPR041155FERM F1 lobe ubiquitin-like domainDomain

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
A [auth B],
B [auth A]
PharosO60674

Protein Modification Annotation

Modified Residue(s)
ChainResidue(s)Description
A [auth B],
B [auth A]
PTR Parent Component: TYR

RESIDAA0039

PSI-MOD :  O4'-phospho-L-tyrosine MOD:00048