6VQB | pdb_00006vqb

Mammalian V-ATPase from rat brain soluble V1 region rotational state 2 with SidK and ADP (from focused refinement)

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C	ATP-synt_ab_N	e6vqbC2	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: ATP-synt_ab_N	ECOD (1.6)
C	ATP-synt_ab_C	e6vqbC4	A: alpha superhelices	X: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	H: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	T: C-terminal domain of alpha and beta subunits of F1 ATP synthase	F: ATP-synt_ab_C	ECOD (1.6)
C	ATP-synt_ab_Xtn	e6vqbC3	A: a+b complex topology	X: alpha/beta-Hammerhead/Barrel-sandwich hybrid	H: alpha/beta-Hammerhead/Barrel-sandwich hybrid	T: Single hybrid motif	F: ATP-synt_ab_Xtn	ECOD (1.6)
C	ATP-synt_ab	e6vqbC1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: ATP-synt_ab	ECOD (1.6)
A	ATP-synt_ab_N	e6vqbA2	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: ATP-synt_ab_N	ECOD (1.6)
A	ATP-synt_ab_C	e6vqbA3	A: alpha superhelices	X: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	H: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	T: C-terminal domain of alpha and beta subunits of F1 ATP synthase	F: ATP-synt_ab_C	ECOD (1.6)
A	ATP-synt_ab_Xtn	e6vqbA4	A: a+b complex topology	X: alpha/beta-Hammerhead/Barrel-sandwich hybrid	H: alpha/beta-Hammerhead/Barrel-sandwich hybrid	T: Single hybrid motif	F: ATP-synt_ab_Xtn	ECOD (1.6)
A	ATP-synt_ab	e6vqbA1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: ATP-synt_ab	ECOD (1.6)
B	ATP-synt_ab_N	e6vqbB3	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: ATP-synt_ab_N	ECOD (1.6)
B	ATP-synt_ab_C	e6vqbB4	A: alpha superhelices	X: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	H: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	T: C-terminal domain of alpha and beta subunits of F1 ATP synthase	F: ATP-synt_ab_C	ECOD (1.6)
B	ATP-synt_ab_Xtn	e6vqbB1	A: a+b complex topology	X: alpha/beta-Hammerhead/Barrel-sandwich hybrid	H: alpha/beta-Hammerhead/Barrel-sandwich hybrid	T: Single hybrid motif	F: ATP-synt_ab_Xtn	ECOD (1.6)
B	ATP-synt_ab	e6vqbB2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: ATP-synt_ab	ECOD (1.6)
D	ATP-synt_ab_N	e6vqbD1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: ATP-synt_ab_N	ECOD (1.6)
D	ATP-synt_ab_C	e6vqbD2	A: alpha superhelices	X: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	H: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	T: C-terminal domain of alpha and beta subunits of F1 ATP synthase	F: ATP-synt_ab_C	ECOD (1.6)
D	ATP-synt_ab	e6vqbD3	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: ATP-synt_ab	ECOD (1.6)
E	ATP-synt_ab_N	e6vqbE3	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: ATP-synt_ab_N	ECOD (1.6)
E	ATP-synt_ab_C	e6vqbE2	A: alpha superhelices	X: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	H: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	T: C-terminal domain of alpha and beta subunits of F1 ATP synthase	F: ATP-synt_ab_C	ECOD (1.6)
E	ATP-synt_ab	e6vqbE1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: ATP-synt_ab	ECOD (1.6)
F	ATP-synt_ab_N	e6vqbF2	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: ATP-synt_ab_N	ECOD (1.6)
F	ATP-synt_ab_C	e6vqbF1	A: alpha superhelices	X: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	H: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	T: C-terminal domain of alpha and beta subunits of F1 ATP synthase	F: ATP-synt_ab_C	ECOD (1.6)
F	ATP-synt_ab	e6vqbF3	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: ATP-synt_ab	ECOD (1.6)
G [auth H]	ATP-synt_D	e6vqbH1	A: alpha bundles	X: V-type proton ATPase subunit D (From Topology)	H: V-type proton ATPase subunit D (From Topology)	T: V-type proton ATPase subunit D	F: ATP-synt_D	ECOD (1.6)
I [auth J]	vATP-synt_E_C	e6vqbJ1	A: a+b two layers	X: FwdE/GAPDH domain-like	H: V-type ATPase subunit E (From Topology)	T: V-type ATPase subunit E	F: vATP-synt_E_C	ECOD (1.6)
I [auth J]	vATP-synt_E_N	e6vqbJ2	A: extended segments	X: Helical region in V-type proton ATPase subunit E (From Topology)	H: Helical region in V-type proton ATPase subunit E (From Topology)	T: Helical region in V-type proton ATPase subunit E	F: vATP-synt_E_N	ECOD (1.6)
J [auth K]	vATP-synt_E_C	e6vqbK1	A: a+b two layers	X: FwdE/GAPDH domain-like	H: V-type ATPase subunit E (From Topology)	T: V-type ATPase subunit E	F: vATP-synt_E_C	ECOD (1.6)
J [auth K]	vATP-synt_E_N	e6vqbK2	A: extended segments	X: Helical region in V-type proton ATPase subunit E (From Topology)	H: Helical region in V-type proton ATPase subunit E (From Topology)	T: Helical region in V-type proton ATPase subunit E	F: vATP-synt_E_N	ECOD (1.6)
H [auth I]	vATP-synt_E_C	e6vqbI1	A: a+b two layers	X: FwdE/GAPDH domain-like	H: V-type ATPase subunit E (From Topology)	T: V-type ATPase subunit E	F: vATP-synt_E_C	ECOD (1.6)
H [auth I]	vATP-synt_E_N	e6vqbI2	A: extended segments	X: Helical region in V-type proton ATPase subunit E (From Topology)	H: Helical region in V-type proton ATPase subunit E (From Topology)	T: Helical region in V-type proton ATPase subunit E	F: vATP-synt_E_N	ECOD (1.6)
N [auth Q]	UNK_F_TYPE	e6vqbQ1	A: alpha superhelices	X: Effector protein SidK (From Topology)	H: Effector protein SidK (From Topology)	T: Effector protein SidK	F: UNK_F_TYPE	ECOD (1.6)
O [auth R]	UNK_F_TYPE	e6vqbR1	A: alpha superhelices	X: Effector protein SidK (From Topology)	H: Effector protein SidK (From Topology)	T: Effector protein SidK	F: UNK_F_TYPE	ECOD (1.6)
P [auth S]	UNK_F_TYPE	e6vqbS1	A: alpha superhelices	X: Effector protein SidK (From Topology)	H: Effector protein SidK (From Topology)	T: Effector protein SidK	F: UNK_F_TYPE	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (utative)
C	2.40.50.100	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)	RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain	CATH (utative)
A	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (utative)
A	2.40.50.100	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)	RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain	CATH (utative)
B	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (utative)
B	2.40.50.100	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)	RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain	CATH (utative)
D	3.40.50.12240	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (utative)
E	3.40.50.12240	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (utative)
F	3.40.50.12240	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF00006	ATP synthase alpha/beta family, nucleotide-binding domain (ATP-synt_ab)	ATP synthase alpha/beta family, nucleotide-binding domain	This entry includes the ATP synthase alpha and beta subunits, the ATP synthase associated with flagella and the termination factor Rho.	Domain
A, B, C	PF22919	C-terminal domain of V and A type ATP synthase (ATP-synt_VA_C)	C-terminal domain of V and A type ATP synthase	This entry represents a small alpha helical domain found at the C-terminus of a variety of ATP synthases.	Domain
A, B, C	PF16886	ATPsynthase alpha/beta subunit barrel-sandwich domain (ATP-synt_ab_Xtn)	ATPsynthase alpha/beta subunit barrel-sandwich domain	This barrel-sandwich domain is found in the alpha-beta catalytic subunit of VATA or V-type proton ATPase catalytic subunit at the N-terminal end. This domain has a circularly permuted topology compared to other barrel-sandwich domains. In VATA barrel ...	This barrel-sandwich domain is found in the alpha-beta catalytic subunit of VATA or V-type proton ATPase catalytic subunit at the N-terminal end. This domain has a circularly permuted topology compared to other barrel-sandwich domains. In VATA barrel-sandwich domain the C-terminal strand is circularly permuted and occupies the spatial position of the N-terminal strand in other hybrid domains.	Domain
A, B, C	PF02874	ATP synthase alpha/beta family, beta-barrel domain (ATP-synt_ab_N)	ATP synthase alpha/beta family, beta-barrel domain	This family includes the ATP synthase alpha and beta subunits the ATP synthase associated with flagella.	Domain
D, E, F	PF00006	ATP synthase alpha/beta family, nucleotide-binding domain (ATP-synt_ab)	ATP synthase alpha/beta family, nucleotide-binding domain	This entry includes the ATP synthase alpha and beta subunits, the ATP synthase associated with flagella and the termination factor Rho.	Domain
D, E, F	PF22919	C-terminal domain of V and A type ATP synthase (ATP-synt_VA_C)	C-terminal domain of V and A type ATP synthase	This entry represents a small alpha helical domain found at the C-terminus of a variety of ATP synthases.	Domain
D, E, F	PF02874	ATP synthase alpha/beta family, beta-barrel domain (ATP-synt_ab_N)	ATP synthase alpha/beta family, beta-barrel domain	This family includes the ATP synthase alpha and beta subunits the ATP synthase associated with flagella.	Domain
G [auth H]	PF01813	ATP synthase subunit D (ATP-synt_D)	ATP synthase subunit D	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	ATPase H+-transporting V1 subunit A	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity monoatomic ion channel activity proton channel activity proton-transporting ATP synthase activity, rotational mechanism monoatomic cation channel activity passive transmembrane transporter activity channel activity catalytic activity ligase activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides	intracellular iron ion homeostasis inorganic ion homeostasis cellular homeostasis chemical homeostasis homeostatic process intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport intracellular iron ion homeostasis inorganic ion homeostasis cellular homeostasis chemical homeostasis homeostatic process intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport cellular response to stimulus cellular response to chemical stimulus response to stimulus cellular response to oxygen levels response to chemical response to oxygen levels response to abiotic stimulus cellular response to increased oxygen levels response to increased oxygen levels synaptic vesicle maturation cellular localization synaptic vesicle cycle vesicle-mediated transport vesicle-mediated transport in synapse vesicle organization cellular component organization establishment of localization in cell cellular component organization or biogenesis synaptic vesicle lumen acidification developmental process developmental maturation organelle organization neuron cellular homeostasis	ATPase dependent transmembrane transport complex protein-containing complex ATPase complex catalytic complex membrane membrane protein complex proton-transporting V-type ATPase, V1 domain proton-transporting V-type ATPase complex transporter complex cation-transporting ATPase complex cellular anatomical structure proton-transporting two-sector ATPase complex proton-transporting two-sector ATPase complex, catalytic domain transmembrane transporter complex ATPase dependent transmembrane transport complex protein-containing complex ATPase complex catalytic complex membrane membrane protein complex proton-transporting V-type ATPase, V1 domain proton-transporting V-type ATPase complex transporter complex cation-transporting ATPase complex cellular anatomical structure proton-transporting two-sector ATPase complex proton-transporting two-sector ATPase complex, catalytic domain transmembrane transporter complex membrane-bounded organelle intracellular anatomical structure vacuolar proton-transporting V-type ATPase, V1 domain intracellular organelle bounding membrane of organelle vacuolar membrane vacuole intracellular membrane-bounded organelle vacuolar proton-transporting V-type ATPase complex organelle cytoplasm organelle membrane cell periphery apical part of cell plasma membrane plasma membrane region apical plasma membrane cytosol intracellular vesicle endomembrane system cytoplasmic vesicle secretory granule secretory vesicle vesicle extrinsic component of synaptic vesicle membrane synapse transport vesicle membrane extrinsic component of organelle membrane presynapse vesicle membrane synaptic vesicle synaptic vesicle membrane cell junction transport vesicle exocytic vesicle membrane cytoplasmic vesicle membrane extrinsic component of membrane exocytic vesicle nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen coated vesicle membrane clathrin-coated vesicle coated vesicle clathrin-coated vesicle membrane cell projection actin-based cell projection microvillus plasma membrane bounded cell projection
D, E, F	V-type proton ATPase subunit B, brain isoform	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity	nucleoside phosphate metabolic process ribose phosphate metabolic process purine nucleoside triphosphate metabolic process ATP metabolic process carbohydrate derivative metabolic process primary metabolic process nucleotide metabolic process purine-containing compound metabolic process nucleobase-containing compound metabolic process purine nucleotide metabolic process ribonucleotide metabolic process organophosphate metabolic process nucleobase-containing small molecule metabolic process purine ribonucleoside triphosphate metabolic process phosphate-containing compound metabolic process nucleoside phosphate metabolic process ribose phosphate metabolic process purine nucleoside triphosphate metabolic process ATP metabolic process carbohydrate derivative metabolic process primary metabolic process nucleotide metabolic process purine-containing compound metabolic process nucleobase-containing compound metabolic process purine nucleotide metabolic process ribonucleotide metabolic process organophosphate metabolic process nucleobase-containing small molecule metabolic process purine ribonucleoside triphosphate metabolic process phosphate-containing compound metabolic process metabolic process cellular process small molecule metabolic process nucleoside triphosphate metabolic process purine ribonucleotide metabolic process phosphorus metabolic process ribonucleoside triphosphate metabolic process homeostatic process biological regulation cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis regulation of pH monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis regulation of cellular pH intracellular monoatomic ion homeostasis synaptic vesicle maturation cellular localization transport monoatomic ion transmembrane transport synaptic vesicle cycle vesicle-mediated transport vesicle-mediated transport in synapse monoatomic cation transmembrane transport vesicle organization cellular component organization localization establishment of localization in cell monoatomic ion transport cellular component organization or biogenesis synaptic vesicle lumen acidification monoatomic cation transport developmental process proton transmembrane transport inorganic ion transmembrane transport developmental maturation establishment of localization inorganic cation transmembrane transport transmembrane transport organelle organization neuron cellular homeostasis intracellular pH reduction regulation of intracellular pH vacuolar acidification regulation of biological quality	ATPase dependent transmembrane transport complex membrane-bounded organelle protein-containing complex ATPase complex intracellular anatomical structure membrane protein complex proton-transporting V-type ATPase complex proton-transporting V-type ATPase, V1 domain transporter complex vacuolar proton-transporting V-type ATPase, V1 domain intracellular organelle cellular anatomical structure bounding membrane of organelle proton-transporting two-sector ATPase complex ATPase dependent transmembrane transport complex membrane-bounded organelle protein-containing complex ATPase complex intracellular anatomical structure membrane protein complex proton-transporting V-type ATPase complex proton-transporting V-type ATPase, V1 domain transporter complex vacuolar proton-transporting V-type ATPase, V1 domain intracellular organelle cellular anatomical structure bounding membrane of organelle proton-transporting two-sector ATPase complex proton-transporting two-sector ATPase complex, catalytic domain vacuolar membrane catalytic complex membrane vacuole intracellular membrane-bounded organelle vacuolar proton-transporting V-type ATPase complex cation-transporting ATPase complex transmembrane transporter complex organelle cytoplasm organelle membrane pigment granule intracellular vesicle melanosome cytoplasmic vesicle vesicle cell periphery apical part of cell plasma membrane plasma membrane region apical plasma membrane ruffle cell projection cell leading edge plasma membrane bounded cell projection cytosol actin-based cell projection microvillus extrinsic component of synaptic vesicle membrane synapse transport vesicle membrane extrinsic component of organelle membrane endomembrane system presynapse vesicle membrane synaptic vesicle synaptic vesicle membrane cell junction transport vesicle exocytic vesicle membrane cytoplasmic vesicle membrane secretory vesicle extrinsic component of membrane exocytic vesicle coated vesicle membrane clathrin-coated vesicle coated vesicle clathrin-coated vesicle membrane
G [auth H]	ATPase H+-transporting V1 subunit D	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity	protein localization localization cellular localization protein localization to cilium protein localization to organelle cellular macromolecule localization macromolecule localization cellular process synaptic vesicle maturation homeostatic process transport monoatomic ion transmembrane transport synaptic vesicle cycle vesicle-mediated transport protein localization localization cellular localization protein localization to cilium protein localization to organelle cellular macromolecule localization macromolecule localization cellular process synaptic vesicle maturation homeostatic process transport monoatomic ion transmembrane transport synaptic vesicle cycle vesicle-mediated transport vesicle-mediated transport in synapse monoatomic cation transmembrane transport vesicle organization cellular component organization establishment of localization in cell monoatomic ion transport cellular component organization or biogenesis synaptic vesicle lumen acidification monoatomic cation transport developmental process proton transmembrane transport inorganic ion transmembrane transport developmental maturation establishment of localization inorganic cation transmembrane transport transmembrane transport organelle organization cellular homeostasis neuron cellular homeostasis organelle assembly plasma membrane bounded cell projection organization cell projection organization plasma membrane bounded cell projection assembly cellular component biogenesis cellular component assembly cilium assembly cilium organization cell projection assembly	membrane-bounded organelle cell projection cellular anatomical structure organelle cilium plasma membrane bounded cell projection membrane ATPase dependent transmembrane transport complex protein-containing complex ATPase complex catalytic complex membrane protein complex proton-transporting V-type ATPase complex transporter complex membrane-bounded organelle cell projection cellular anatomical structure organelle cilium plasma membrane bounded cell projection membrane ATPase dependent transmembrane transport complex protein-containing complex ATPase complex catalytic complex membrane protein complex proton-transporting V-type ATPase complex transporter complex cation-transporting ATPase complex proton-transporting two-sector ATPase complex transmembrane transporter complex intracellular organelle centrosome microtubule organizing center intracellular anatomical structure cytoskeleton membraneless organelle intracellular membraneless organelle microtubule cytoskeleton cell periphery plasma membrane extrinsic component of synaptic vesicle membrane synapse intracellular vesicle transport vesicle membrane extrinsic component of organelle membrane endomembrane system presynapse bounding membrane of organelle cytoplasmic vesicle vesicle membrane synaptic vesicle synaptic vesicle membrane cell junction vesicle transport vesicle exocytic vesicle membrane intracellular membrane-bounded organelle cytoplasmic vesicle membrane secretory vesicle cytoplasm organelle membrane extrinsic component of membrane exocytic vesicle nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen coated vesicle membrane clathrin-coated vesicle coated vesicle clathrin-coated vesicle membrane
H [auth I], I [auth J], J [auth K]	V-type proton ATPase subunit E 1	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity ATPase binding protein binding binding enzyme binding	transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport synaptic vesicle maturation cellular localization transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport synaptic vesicle maturation cellular localization homeostatic process synaptic vesicle cycle vesicle-mediated transport vesicle-mediated transport in synapse vesicle organization cellular component organization establishment of localization in cell cellular component organization or biogenesis synaptic vesicle lumen acidification developmental process developmental maturation organelle organization cellular homeostasis neuron cellular homeostasis	ATPase dependent transmembrane transport complex membrane-bounded organelle protein-containing complex ATPase complex intracellular anatomical structure membrane protein complex proton-transporting V-type ATPase complex proton-transporting V-type ATPase, V1 domain transporter complex vacuolar proton-transporting V-type ATPase, V1 domain intracellular organelle cellular anatomical structure bounding membrane of organelle proton-transporting two-sector ATPase complex ATPase dependent transmembrane transport complex membrane-bounded organelle protein-containing complex ATPase complex intracellular anatomical structure membrane protein complex proton-transporting V-type ATPase complex proton-transporting V-type ATPase, V1 domain transporter complex vacuolar proton-transporting V-type ATPase, V1 domain intracellular organelle cellular anatomical structure bounding membrane of organelle proton-transporting two-sector ATPase complex proton-transporting two-sector ATPase complex, catalytic domain vacuolar membrane catalytic complex membrane vacuole intracellular membrane-bounded organelle vacuolar proton-transporting V-type ATPase complex cation-transporting ATPase complex transmembrane transporter complex organelle cytoplasm organelle membrane cell periphery apical part of cell plasma membrane plasma membrane region apical plasma membrane endosome intracellular vesicle endomembrane system cytoplasmic vesicle vesicle cytosol cell projection actin-based cell projection microvillus plasma membrane bounded cell projection extrinsic component of synaptic vesicle membrane synapse transport vesicle membrane extrinsic component of organelle membrane presynapse vesicle membrane synaptic vesicle synaptic vesicle membrane cell junction transport vesicle exocytic vesicle membrane cytoplasmic vesicle membrane secretory vesicle extrinsic component of membrane exocytic vesicle coated vesicle membrane clathrin-coated vesicle coated vesicle clathrin-coated vesicle membrane
K [auth M], L [auth N], M [auth O]	V-type proton ATPase subunit G	monoatomic cation transmembrane transporter activity P-type transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity ATPase-coupled monoatomic cation transmembrane transporter activity P-type proton-exporting transporter activity ATP-dependent activity P-type ion transporter activity active monoatomic ion transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity monoatomic cation transmembrane transporter activity P-type transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity ATPase-coupled monoatomic cation transmembrane transporter activity P-type proton-exporting transporter activity ATP-dependent activity P-type ion transporter activity active monoatomic ion transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled ion transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism	transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport synaptic vesicle maturation cellular localization transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport synaptic vesicle maturation cellular localization homeostatic process synaptic vesicle cycle vesicle-mediated transport vesicle-mediated transport in synapse vesicle organization cellular component organization establishment of localization in cell cellular component organization or biogenesis synaptic vesicle lumen acidification developmental process developmental maturation organelle organization cellular homeostasis neuron cellular homeostasis	ATPase dependent transmembrane transport complex membrane-bounded organelle protein-containing complex ATPase complex intracellular anatomical structure membrane protein complex proton-transporting V-type ATPase complex transporter complex intracellular organelle cellular anatomical structure bounding membrane of organelle proton-transporting two-sector ATPase complex vacuolar membrane catalytic complex ATPase dependent transmembrane transport complex membrane-bounded organelle protein-containing complex ATPase complex intracellular anatomical structure membrane protein complex proton-transporting V-type ATPase complex transporter complex intracellular organelle cellular anatomical structure bounding membrane of organelle proton-transporting two-sector ATPase complex vacuolar membrane catalytic complex membrane vacuole intracellular membrane-bounded organelle vacuolar proton-transporting V-type ATPase complex cation-transporting ATPase complex transmembrane transporter complex organelle cytoplasm organelle membrane synapse intracellular vesicle transport vesicle membrane endomembrane system presynapse cytoplasmic vesicle vesicle membrane synaptic vesicle synaptic vesicle membrane cell junction vesicle transport vesicle exocytic vesicle membrane cytoplasmic vesicle membrane secretory vesicle exocytic vesicle proton-transporting V-type ATPase, V1 domain vacuolar proton-transporting V-type ATPase, V1 domain proton-transporting two-sector ATPase complex, catalytic domain extrinsic component of synaptic vesicle membrane extrinsic component of organelle membrane extrinsic component of membrane
N [auth Q], O [auth R], P [auth S]	Uncharacterized protein	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR022878	V-type ATP synthase catalytic alpha chain	Family
A, B, C	IPR024034	ATPase, F1/V1 complex, beta/alpha subunit, C-terminal	Homologous Superfamily
A, B, C	IPR036121	ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain superfamily	Homologous Superfamily
A, B, C	IPR031686	ATPsynthase alpha/beta subunit, barrel-sandwich domain	Domain
A, B, C	IPR000194	ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain	Domain
A, B, C	IPR005725	ATPase, V1 complex, subunit A	Family
A, B, C	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A, B, C	IPR004100	ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain	Domain
A, B, C	IPR023366	ATP synthase subunit alpha, N-terminal domain-like superfamily	Homologous Superfamily
A, B, C	IPR020003	ATPase, alpha/beta subunit, nucleotide-binding domain, active site	Active Site
A, B, C	IPR055190	ATP synthase A/B type, C-terminal domain	Domain
D, E, F	IPR004100	ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain	Domain
D, E, F	IPR005723	ATPase, V1 complex, subunit B	Family
D, E, F	IPR022879	V-type ATP synthase regulatory subunit B/beta	Family
D, E, F	IPR020003	ATPase, alpha/beta subunit, nucleotide-binding domain, active site	Active Site
D, E, F	IPR000194	ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain	Domain
D, E, F	IPR055190	ATP synthase A/B type, C-terminal domain	Domain
D, E, F	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
G [auth H]	IPR002699	ATPase, V1 complex, subunit D	Family
H [auth I], I [auth J], J [auth K]	IPR038495	V-type ATPase subunit E, C-terminal domain superfamily	Homologous Superfamily
H [auth I], I [auth J], J [auth K]	IPR002842	V-type ATPase subunit E	Family
K [auth M], L [auth N], M [auth O]	IPR005124	Vacuolar (H+)-ATPase G subunit	Family