6XUH

Crystal structure of human phosphoglucose isomerase in complex with inhibitor

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d6xuha_	Alpha and beta proteins (a/b)	SIS domain	SIS domain	Phosphoglucose isomerase, PGI	Phosphoglucose isomerase, PGI	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d6xuhd_	Alpha and beta proteins (a/b)	SIS domain	SIS domain	Phosphoglucose isomerase, PGI	Phosphoglucose isomerase, PGI	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d6xuhb_	Alpha and beta proteins (a/b)	SIS domain	SIS domain	Phosphoglucose isomerase, PGI	Phosphoglucose isomerase, PGI	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d6xuhc_	Alpha and beta proteins (a/b)	SIS domain	SIS domain	Phosphoglucose isomerase, PGI	Phosphoglucose isomerase, PGI	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	SIS domain/Ribosomal protein S2-like	8052806	3001397	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	SIS domain/Ribosomal protein S2-like	8033816	3001397	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	SIS domain/Ribosomal protein S2-like	8052806	3001397	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	SIS domain/Ribosomal protein S2-like	8033816	3001397	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	SIS domain/Ribosomal protein S2-like	8033816	3001397	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	SIS domain/Ribosomal protein S2-like	8052806	3001397	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	SIS domain/Ribosomal protein S2-like	8033816	3001397	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	SIS domain/Ribosomal protein S2-like	8052806	3001397	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PGI_N	e6xuhA1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Ribosomal protein S2/SIS domain (From Topology)	T: Ribosomal protein S2/SIS domain	F: PGI_N	ECOD (1.6)
A	PGI_C	e6xuhA2	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Ribosomal protein S2/SIS domain (From Topology)	T: Ribosomal protein S2/SIS domain	F: PGI_C	ECOD (1.6)
D	PGI_N	e6xuhD1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Ribosomal protein S2/SIS domain (From Topology)	T: Ribosomal protein S2/SIS domain	F: PGI_N	ECOD (1.6)
D	PGI_C	e6xuhD2	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Ribosomal protein S2/SIS domain (From Topology)	T: Ribosomal protein S2/SIS domain	F: PGI_C	ECOD (1.6)
B	PGI_N	e6xuhB2	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Ribosomal protein S2/SIS domain (From Topology)	T: Ribosomal protein S2/SIS domain	F: PGI_N	ECOD (1.6)
B	PGI_C	e6xuhB1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Ribosomal protein S2/SIS domain (From Topology)	T: Ribosomal protein S2/SIS domain	F: PGI_C	ECOD (1.6)
C	PGI_N	e6xuhC2	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Ribosomal protein S2/SIS domain (From Topology)	T: Ribosomal protein S2/SIS domain	F: PGI_N	ECOD (1.6)
C	PGI_C	e6xuhC1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Ribosomal protein S2/SIS domain (From Topology)	T: Ribosomal protein S2/SIS domain	F: PGI_C	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF00342	Phosphoglucose isomerase (PGI)	Phosphoglucose isomerase	Phosphoglucose isomerase catalyses the interconversion of glucose-6-phosphate and fructose-6-phosphate.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Glucose-6-phosphate isomerase	protein binding binding molecular function activator activity signaling receptor binding molecular function regulator activity signaling receptor regulator activity growth factor activity receptor ligand activity signaling receptor activator activity isomerase activity intramolecular oxidoreductase activity, interconverting aldoses and ketoses intramolecular oxidoreductase activity glucose-6-phosphate isomerase activity catalytic activity protein binding binding molecular function activator activity signaling receptor binding molecular function regulator activity signaling receptor regulator activity growth factor activity receptor ligand activity signaling receptor activator activity isomerase activity intramolecular oxidoreductase activity, interconverting aldoses and ketoses intramolecular oxidoreductase activity glucose-6-phosphate isomerase activity catalytic activity monosaccharide binding carbohydrate binding small molecule binding cytokine activity ubiquitin protein ligase binding ubiquitin-like protein ligase binding enzyme binding carbohydrate derivative binding	monosaccharide metabolic process carbohydrate derivative metabolic process nucleobase-containing compound metabolic process nucleobase-containing small molecule metabolic process phosphate-containing compound metabolic process GDP-mannose biosynthetic process small molecule metabolic process nucleotide-sugar biosynthetic process phosphorus metabolic process GDP-mannose metabolic process nucleoside phosphate metabolic process carbohydrate derivative biosynthetic process carbohydrate metabolic process nucleotide-sugar metabolic process monosaccharide metabolic process carbohydrate derivative metabolic process nucleobase-containing compound metabolic process nucleobase-containing small molecule metabolic process phosphate-containing compound metabolic process GDP-mannose biosynthetic process small molecule metabolic process nucleotide-sugar biosynthetic process phosphorus metabolic process GDP-mannose metabolic process nucleoside phosphate metabolic process carbohydrate derivative biosynthetic process carbohydrate metabolic process nucleotide-sugar metabolic process primary metabolic process hexose metabolic process nucleobase-containing compound biosynthetic process GDP-mannose biosynthetic process from glucose biosynthetic process organophosphate metabolic process organophosphate biosynthetic process nucleoside phosphate biosynthetic process metabolic process cellular process glucose metabolic process fructose 6-phosphate metabolic process regulation of body fluid levels hemostasis biological regulation regulation of biological quality positive regulation of locomotion regulation of biological process regulation of cell motility regulation of cellular process endothelial cell migration positive regulation of biological process positive regulation of cell migration regulation of locomotion positive regulation of endothelial cell migration positive regulation of cell motility regulation of cell migration regulation of endothelial cell migration cell migration cell motility locomotion positive regulation of cellular process humoral immune response response to stimulus immune response immune system process response to ketone response to lipid response to hormone response to steroid hormone response to chemical response to endogenous stimulus response to progesterone response to oxygen-containing compound response to organic cyclic compound response to testosterone glucose 6-phosphate metabolic process multicellular organismal process multicellular organismal-level homeostasis homeostatic process homeostasis of number of cells myeloid cell homeostasis erythrocyte homeostasis neuron apoptotic process negative regulation of neuron apoptotic process negative regulation of programmed cell death regulation of apoptotic process negative regulation of biological process regulation of programmed cell death cell death negative regulation of apoptotic process negative regulation of cellular process apoptotic process programmed cell death regulation of neuron apoptotic process developmental process multicellular organism development embryo development ending in birth or egg hatching chordate embryonic development anatomical structure development embryo development in utero embryonic development ribonucleotide catabolic process pyridine nucleotide catabolic process oxoacid metabolic process carbohydrate catabolic process organophosphate catabolic process nucleoside phosphate catabolic process organic acid metabolic process glycolytic process pyridine-containing compound metabolic process purine ribonucleotide catabolic process pyridine nucleotide metabolic process nicotinamide nucleotide metabolic process pyruvate metabolic process purine nucleoside diphosphate metabolic process purine-containing compound catabolic process nucleotide metabolic process nucleobase-containing compound catabolic process nucleoside diphosphate metabolic process purine nucleoside diphosphate catabolic process nucleoside diphosphate catabolic process nucleoside triphosphate metabolic process monocarboxylic acid metabolic process purine ribonucleotide metabolic process pyridine-containing compound catabolic process ribose phosphate metabolic process catabolic process ATP metabolic process purine nucleotide metabolic process ribonucleotide metabolic process purine ribonucleoside triphosphate metabolic process ribonucleoside diphosphate metabolic process ribonucleoside diphosphate catabolic process nucleotide catabolic process ribonucleoside triphosphate metabolic process purine nucleoside triphosphate metabolic process purine nucleotide catabolic process carbohydrate derivative catabolic process ADP catabolic process carboxylic acid metabolic process generation of precursor metabolites and energy purine-containing compound metabolic process ADP metabolic process purine ribonucleoside diphosphate metabolic process purine ribonucleoside diphosphate catabolic process regulation of immune effector process immunoglobulin production positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process positive regulation of immune effector process regulation of immune system process positive regulation of macromolecule metabolic process positive regulation of immune system process positive regulation of immunoglobulin production regulation of biosynthetic process production of molecular mediator of immune response regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process immune effector process regulation of gene expression regulation of immunoglobulin production positive regulation of gene expression positive regulation of production of molecular mediator of immune response regulation of macromolecule biosynthetic process regulation of production of molecular mediator of immune response macromolecule metabolic process regulation of metabolic process response to immobilization stress response to stress small molecule biosynthetic process carbohydrate biosynthetic process monosaccharide biosynthetic process gluconeogenesis hexose biosynthetic process behavior system process learning or memory nervous system process cognition response to metal ion response to cadmium ion chemical homeostasis glucose homeostasis carbohydrate homeostasis response to estradiol formation of primary germ layer mesoderm morphogenesis embryonic morphogenesis tissue development gastrulation tissue morphogenesis anatomical structure morphogenesis anatomical structure formation involved in morphogenesis mesoderm formation mesoderm development response to mechanical stimulus response to abiotic stimulus response to external stimulus response to muscle stretch	cellular anatomical structure membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol cellular anatomical structure membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol membrane-enclosed lumen intracellular vesicle ficolin-1-rich granule intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen intracellular organelle organelle lumen cytoplasmic vesicle ficolin-1-rich granule lumen secretory granule secretory vesicle plasma membrane cilium ciliary membrane plasma membrane bounded cell projection cell periphery cell projection bounding membrane of organelle plasma membrane region organelle membrane cell projection membrane vesicle lumen cytoplasmic vesicle lumen secretory granule lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR035476	Phosphoglucose isomerase, SIS domain 1	Domain
A, B, C, D	IPR018189	Phosphoglucose isomerase, conserved site	Conserved Site
A, B, C, D	IPR046348	SIS domain superfamily	Homologous Superfamily
A, B, C, D	IPR035482	Phosphoglucose isomerase, SIS domain 2	Domain
A, B, C, D	IPR001672	Phosphoglucose isomerase (PGI)	Family
A, B, C, D	IPR023096	Phosphoglucose isomerase, C-terminal	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: P06744	hemolytic anemia hemolytic anemia due to glucophosphate isomerase deficiency familial hemolytic anemia breast cancer breast carcinoma oligodendroglioma plasma cell myeloma Anemia, Hemolytic astrocytic tumor congenital anemia lung adenocarcinoma ovarian cancer congenital nonspherocytic hemolytic anemia lung cancer non-small cell lung carcinoma hemolytic anemia hemolytic anemia due to glucophosphate isomerase deficiency familial hemolytic anemia breast cancer breast carcinoma oligodendroglioma plasma cell myeloma Anemia, Hemolytic astrocytic tumor congenital anemia lung adenocarcinoma ovarian cancer congenital nonspherocytic hemolytic anemia lung cancer non-small cell lung carcinoma Pick disease lymphoplasmacytic lymphoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.