6YYE | pdb_00006yye

TREM2 extracellular domain (19-131) in complex with single-chain variable fragment (scFv-2)

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8068378	3000071	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8068378	3000071	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	V-set_14	e6yyeA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_14	ECOD (1.6)
B	V-set_14	e6yyeB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_14	ECOD (1.6)
D	V-set	e6yyeD2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set	ECOD (1.6)
D	V-set_12	e6yyeD1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_12	ECOD (1.6)
C	V-set	e6yyeC2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set	ECOD (1.6)
C	V-set_12	e6yyeC1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_12	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
D	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (utative)
C	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF07686	Immunoglobulin V-set domain (V-set)	Immunoglobulin V-set domain	This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Triggering receptor expressed on myeloid cells 2	amide binding amyloid-beta binding binding peptide binding phospholipid binding lipid binding phosphatidylethanolamine binding lipoprotein particle binding protein-containing complex binding protein binding protein-lipid complex binding very-low-density lipoprotein particle binding semaphorin receptor binding signaling receptor binding amide binding amyloid-beta binding binding peptide binding phospholipid binding lipid binding phosphatidylethanolamine binding lipoprotein particle binding protein-containing complex binding protein binding protein-lipid complex binding very-low-density lipoprotein particle binding semaphorin receptor binding signaling receptor binding high-density lipoprotein particle binding protein tyrosine kinase binding kinase binding enzyme binding protein kinase binding molecular transducer activity transmembrane signaling receptor activity signaling receptor activity lipopolysaccharide binding carbohydrate derivative binding scaffold protein binding low-density lipoprotein particle binding lipoteichoic acid binding beta-catenin binding sulfatide binding glycolipid binding apolipoprotein binding apolipoprotein A-I binding enzyme regulator activity kinase activator activity enzyme activator activity molecular function activator activity kinase activity molecular function regulator activity transferase activity catalytic activity kinase regulator activity transferase activity, transferring phosphorus-containing groups modified amino acid binding phosphatidylserine binding glycosaminoglycan binding peptidoglycan binding semaphorin receptor activity	positive regulation of cholesterol efflux regulation of localization transport positive regulation of sterol transport positive regulation of biological process regulation of lipid transport organic hydroxy compound transport localization regulation of cholesterol efflux sterol transport regulation of cholesterol transport positive regulation of cholesterol transport regulation of sterol transport regulation of biological process positive regulation of cholesterol efflux regulation of localization transport positive regulation of sterol transport positive regulation of biological process regulation of lipid transport organic hydroxy compound transport localization regulation of cholesterol efflux sterol transport regulation of cholesterol transport positive regulation of cholesterol transport regulation of sterol transport regulation of biological process regulation of transport biological regulation lipid localization lipid transport positive regulation of lipid localization establishment of localization positive regulation of lipid transport positive regulation of transport regulation of lipid localization macromolecule localization cholesterol transport cholesterol efflux cellular component disassembly regulation of synapse pruning positive regulation of cellular component organization regulation of cellular process regulation of cellular component organization cell junction disassembly synapse pruning positive regulation of synapse pruning cellular component organization regulation of synapse organization cell junction organization cellular process regulation of synapse structure or activity synapse organization cellular component organization or biogenesis regulation of biological quality positive regulation of cellular process cellular response to stimulus positive regulation of cell communication positive regulation of signal transduction response to stimulus signaling regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette regulation of calcium-mediated signaling positive regulation of calcium-mediated signaling signal transduction regulation of signaling positive regulation of intracellular signal transduction regulation of response to stimulus calcium-mediated signaling regulation of cell communication positive regulation of signaling multicellular organismal process regulation of tumor necrosis factor production negative regulation of biological process negative regulation of tumor necrosis factor production cytokine production regulation of cytokine production negative regulation of cellular process regulation of multicellular organismal process negative regulation of macromolecule metabolic process regulation of biosynthetic process negative regulation of metabolic process tumor necrosis factor superfamily cytokine production negative regulation of cytokine production regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process tumor necrosis factor production regulation of gene expression negative regulation of gene expression regulation of tumor necrosis factor superfamily cytokine production biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of tumor necrosis factor superfamily cytokine production metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process negative regulation of multicellular organismal process regulation of metabolic process excitatory synapse pruning catabolic process amyloid-beta metabolic process amyloid-beta clearance by cellular catabolic process amide metabolic process amyloid-beta clearance positive regulation of locomotion regulation of cell motility cellular developmental process regulation of microglial cell migration glial cell migration macrophage migration regulation of glial cell migration positive regulation of cell migration neurogenesis multicellular organism development regulation of macrophage migration gliogenesis cell differentiation positive regulation of cell motility regulation of cell migration myeloid leukocyte migration positive regulation of mononuclear cell migration anatomical structure development positive regulation of microglial cell migration cell migration regulation of immune system process regulation of mononuclear cell migration cell motility positive regulation of immune system process locomotion system development developmental process positive regulation of macrophage migration regulation of leukocyte migration microglial cell migration positive regulation of leukocyte migration nervous system development leukocyte migration positive regulation of glial cell migration immune system process regulation of locomotion mononuclear cell migration cellular response to low-density lipoprotein particle stimulus cellular response to oxidised low-density lipoprotein particle stimulus response to endogenous stimulus response to chemical response to lipoprotein particle response to nitrogen compound cellular response to lipoprotein particle stimulus positive regulation of response to biotic stimulus pattern recognition receptor signaling pathway regulation of NLRP3 inflammasome complex assembly response to biotic stimulus cellular component biogenesis immune response-activating signaling pathway cellular component assembly inflammasome-mediated signaling pathway positive regulation of immune response canonical inflammasome complex assembly negative regulation of NLRP3 inflammasome complex assembly innate immune response-activating signaling pathway negative regulation of cellular component organization immune response response to other organism regulation of innate immune response response to external stimulus regulation of inflammasome-mediated signaling pathway negative regulation of protein-containing complex assembly defense response to other organism regulation of pattern recognition receptor signaling pathway NLRP3 inflammasome complex assembly positive regulation of defense response activation of innate immune response regulation of immune response inflammatory response activation of immune response cytoplasmic pattern recognition receptor signaling pathway regulation of defense response regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms regulation of response to external stimulus intracellular receptor signaling pathway negative regulation of signaling negative regulation of cytoplasmic pattern recognition receptor signaling pathway negative regulation of intracellular signal transduction regulation of cytoplasmic pattern recognition receptor signaling pathway negative regulation of cell communication regulation of protein-containing complex assembly positive regulation of response to external stimulus immune response-regulating signaling pathway regulation of response to stress response to stress innate immune response protein-containing complex assembly response to external biotic stimulus positive regulation of innate immune response defense response negative regulation of response to stimulus protein-containing complex organization defense response to symbiont regulation of cellular component biogenesis negative regulation of signal transduction negative regulation of immune system process negative regulation of inflammasome-mediated signaling pathway positive regulation of protein localization to plasma membrane protein localization cellular localization regulation of protein localization cellular macromolecule localization regulation of protein localization to membrane positive regulation of protein localization to cell periphery protein localization to cell periphery protein localization to plasma membrane positive regulation of protein localization to membrane regulation of protein localization to cell periphery localization within membrane protein localization to membrane regulation of cellular localization positive regulation of protein localization regulation of protein localization to plasma membrane response to ischemia chemotaxis regulation of chemotaxis positive regulation of chemotaxis taxis detection of external biotic stimulus response to oxygen-containing compound response to lipoteichoic acid detection of molecule of bacterial origin detection of biotic stimulus detection of stimulus response to bacterium detection of lipoteichoic acid detection of chemical stimulus response to molecule of bacterial origin behavior system process learning or memory nervous system process cognition memory import into cell vesicle-mediated transport positive regulation of endocytosis phagocytosis regulation of endocytosis regulation of phagocytosis regulation of vesicle-mediated transport positive regulation of phagocytosis endocytosis immune response-regulating cell surface receptor signaling pathway negative regulation of toll-like receptor 2 signaling pathway cell surface toll-like receptor signaling pathway immune response-activating cell surface receptor signaling pathway regulation of toll-like receptor 2 signaling pathway innate immune response activating cell surface receptor signaling pathway toll-like receptor 2 signaling pathway cell surface pattern recognition receptor signaling pathway cell surface receptor signaling pathway astrocyte differentiation cell development astrocyte activation glial cell development astrocyte development cell activation central nervous system development glial cell differentiation glial cell activation neuroinflammatory response cellular response to lipoteichoic acid cellular response to molecule of bacterial origin cellular response to oxygen-containing compound cellular response to biotic stimulus cellular response to chemical stimulus interleukin-10 production positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of interleukin-10 production positive regulation of interleukin-10 production positive regulation of gene expression positive regulation of multicellular organismal process positive regulation of cytokine production negative regulation of catabolic process autophagy regulation of catabolic process regulation of autophagy negative regulation of autophagy process utilizing autophagic mechanism negative regulation of inflammatory response inflammatory response to antigenic stimulus negative regulation of inflammatory response to antigenic stimulus negative regulation of immune response regulation of inflammatory response to antigenic stimulus regulation of inflammatory response negative regulation of response to external stimulus negative regulation of defense response defense response to Gram-negative bacterium defense response to bacterium regulation of glial cell apoptotic process negative regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death negative regulation of glial cell apoptotic process cell death glial cell apoptotic process negative regulation of apoptotic process apoptotic process programmed cell death interleukin-6 production regulation of interleukin-6 production positive regulation of membrane invagination positive regulation of apoptotic cell clearance engulfment of apoptotic cell positive regulation of engulfment of apoptotic cell regulation of phagocytosis, engulfment membrane invagination apoptotic cell clearance plasma membrane invagination membrane organization regulation of engulfment of apoptotic cell phagocytosis, engulfment positive regulation of phagocytosis, engulfment regulation of membrane invagination regulation of apoptotic cell clearance myeloid leukocyte activation leukocyte activation macrophage activation leukocyte activation involved in inflammatory response microglial cell activation phagocytosis, recognition cell recognition macrophage inflammatory protein-1 alpha production regulation of macrophage inflammatory protein 1 alpha production regulation of chemokine production chemokine production negative regulation of astrocyte activation regulation of cell activation regulation of neurogenesis regulation of cell differentiation regulation of astrocyte differentiation regulation of cell development negative regulation of gliogenesis negative regulation of glial cell differentiation regulation of developmental process regulation of gliogenesis regulation of nervous system development negative regulation of neurogenesis regulation of neuroinflammatory response negative regulation of nervous system development negative regulation of cell differentiation regulation of multicellular organismal development negative regulation of developmental process regulation of glial cell differentiation negative regulation of astrocyte differentiation negative regulation of cell activation negative regulation of cell development regulation of astrocyte activation negative regulation of neuroinflammatory response CD40 signaling pathway positive regulation of CD40 signaling pathway regulation of CD40 signaling pathway regulation of lipid metabolic process primary metabolic process lipid metabolic process regulation of primary metabolic process positive regulation of ERK1 and ERK2 cascade positive regulation of MAPK cascade regulation of MAPK cascade MAPK cascade ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade neuron apoptotic process hippocampal neuron apoptotic process regulation of hippocampal neuron apoptotic process regulation of neuron apoptotic process positive regulation of C-C chemokine receptor CCR7 signaling pathway regulation of chemokine-mediated signaling pathway response to cytokine response to chemokine positive regulation of response to cytokine stimulus cytokine-mediated signaling pathway cellular response to chemokine chemokine-mediated signaling pathway regulation of C-C chemokine receptor CCR7 signaling pathway cellular response to cytokine stimulus positive regulation of chemokine-mediated signaling pathway regulation of G protein-coupled receptor signaling pathway C-C chemokine receptor CCR7 signaling pathway regulation of cytokine-mediated signaling pathway positive regulation of G protein-coupled receptor signaling pathway response to peptide regulation of response to cytokine stimulus G protein-coupled receptor signaling pathway positive regulation of cytokine-mediated signaling pathway complement-mediated synapse pruning macrophage activation involved in immune response cell activation involved in immune response myeloid cell activation involved in immune response immune effector process microglial cell activation involved in immune response leukocyte activation involved in immune response homeostatic process cellular response to glucose stimulus intracellular glucose homeostasis response to hexose cellular response to carbohydrate stimulus cellular homeostasis response to monosaccharide response to carbohydrate chemical homeostasis response to glucose glucose homeostasis carbohydrate homeostasis cellular response to hexose stimulus intracellular chemical homeostasis cellular response to monosaccharide stimulus lipid homeostasis negative regulation of cell population proliferation cell population proliferation fat cell proliferation regulation of cell population proliferation regulation of fat cell proliferation negative regulation of fat cell proliferation dendritic spine maintenance dendritic spine organization postsynapse organization plasma membrane bounded cell projection organization cell projection organization cellular component maintenance neuron projection organization regulation of cytokine production involved in inflammatory response production of molecular mediator involved in inflammatory response cytokine production involved in inflammatory response biological process involved in intraspecies interaction between organisms social behavior regulation of non-canonical NF-kappaB signal transduction non-canonical NF-kappaB signal transduction positive regulation of non-canonical NF-kappaB signal transduction microglial cell proliferation leukocyte proliferation macrophage proliferation glial cell proliferation myeloid leukocyte differentiation hemopoiesis myeloid cell differentiation osteoclast differentiation leukocyte differentiation regulation of humoral immune response adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains regulation of immune effector process lymphocyte mediated immunity humoral immune response positive regulation of leukocyte mediated immunity regulation of humoral immune response mediated by circulating immunoglobulin positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of lymphocyte mediated immunity positive regulation of B cell mediated immunity complement activation humoral immune response mediated by circulating immunoglobulin positive regulation of humoral immune response regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains regulation of immunoglobulin mediated immune response positive regulation of complement activation leukocyte mediated immunity positive regulation of immune effector process positive regulation of adaptive immune response complement activation, classical pathway positive regulation of immunoglobulin mediated immune response positive regulation of humoral immune response mediated by circulating immunoglobulin regulation of adaptive immune response positive regulation of complement activation, classical pathway immunoglobulin mediated immune response adaptive immune response regulation of B cell mediated immunity regulation of leukocyte mediated immunity regulation of lymphocyte mediated immunity B cell mediated immunity regulation of complement activation, classical pathway regulation of complement activation macrophage fusion regulation of syncytium formation by plasma membrane fusion cell-cell fusion positive regulation of developmental process syncytium formation positive regulation of macrophage fusion positive regulation of syncytium formation by plasma membrane fusion syncytium formation by plasma membrane fusion anatomical structure morphogenesis regulation of macrophage fusion anatomical structure formation involved in morphogenesis TOR signaling regulation of TOR signaling cellular response to nitrogen compound cellular response to amyloid-beta response to amyloid-beta regulation of protein modification process positive regulation of phosphorylation regulation of protein phosphorylation positive regulation of protein metabolic process peptidyl-tyrosine modification positive regulation of phosphate metabolic process positive regulation of peptidyl-tyrosine phosphorylation positive regulation of protein modification process regulation of phosphate metabolic process peptidyl-amino acid modification phosphate-containing compound metabolic process protein metabolic process protein modification process phosphorus metabolic process positive regulation of protein phosphorylation protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process regulation of peptidyl-tyrosine phosphorylation macromolecule modification regulation of phosphorylation regulation of phosphorus metabolic process peptidyl-tyrosine phosphorylation regulation of toll-like receptor 4 signaling pathway negative regulation of toll-like receptor 4 signaling pathway toll-like receptor 4 signaling pathway response to wounding response to axon injury positive regulation of proteasomal protein catabolic process proteolysis involved in protein catabolic process macromolecule catabolic process regulation of proteolysis regulation of proteolysis involved in protein catabolic process proteolysis proteasomal protein catabolic process protein catabolic process positive regulation of protein catabolic process positive regulation of proteolysis involved in protein catabolic process positive regulation of catabolic process positive regulation of proteolysis regulation of proteasomal protein catabolic process regulation of protein catabolic process regulation of resting membrane potential regulation of membrane potential response to decreased oxygen levels cellular response to oxygen levels cellular response to hypoxia cellular response to decreased oxygen levels cellular response to stress response to hypoxia response to oxygen levels response to abiotic stimulus positive regulation of TOR signaling detection of peptidoglycan response to peptidoglycan regulation of catalytic activity regulation of transferase activity positive regulation of molecular function positive regulation of transferase activity positive regulation of catalytic activity regulation of molecular function positive regulation of kinase activity regulation of kinase activity positive regulation of low-density lipoprotein particle clearance regulation of plasma lipoprotein particle levels regulation of low-density lipoprotein particle clearance positive regulation of lipoprotein particle clearance plasma lipoprotein particle clearance regulation of lipoprotein particle clearance low-density lipoprotein particle clearance regulation of macrophage activation positive regulation of macrophage activation regulation of leukocyte activation positive regulation of microglial cell activation positive regulation of neuroinflammatory response positive regulation of cell activation positive regulation of inflammatory response positive regulation of leukocyte activation regulation of microglial cell activation intrinsic apoptotic signaling pathway in response to oxidative stress regulation of oxidative stress-induced intrinsic apoptotic signaling pathway regulation of intrinsic apoptotic signaling pathway intrinsic apoptotic signaling pathway regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway neuron intrinsic apoptotic signaling pathway in response to oxidative stress apoptotic signaling pathway regulation of apoptotic signaling pathway respiratory burst respiratory burst involved in defense response respiratory burst after phagocytosis regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction phosphatidylinositol 3-kinase/protein kinase B signal transduction dendritic cell differentiation mononuclear cell differentiation nucleotide biosynthetic process carbohydrate derivative metabolic process purine ribonucleotide biosynthetic process purine ribonucleoside triphosphate biosynthetic process positive regulation of nucleotide biosynthetic process regulation of nucleotide biosynthetic process regulation of ATP metabolic process nucleobase-containing compound metabolic process ribonucleotide biosynthetic process purine nucleoside triphosphate biosynthetic process regulation of small molecule metabolic process positive regulation of purine nucleotide biosynthetic process regulation of nucleotide metabolic process small molecule metabolic process regulation of nucleobase-containing compound metabolic process ribose phosphate biosynthetic process nucleoside phosphate metabolic process positive regulation of nucleobase-containing compound metabolic process nucleotide metabolic process regulation of purine nucleotide metabolic process ribonucleoside triphosphate biosynthetic process positive regulation of ATP metabolic process organophosphate biosynthetic process nucleoside phosphate biosynthetic process nucleoside triphosphate metabolic process purine ribonucleotide metabolic process purine nucleotide biosynthetic process ribose phosphate metabolic process ATP metabolic process ATP biosynthetic process positive regulation of nucleotide metabolic process purine nucleotide metabolic process ribonucleotide metabolic process nucleobase-containing small molecule metabolic process purine ribonucleoside triphosphate metabolic process purine-containing compound biosynthetic process ribonucleoside triphosphate metabolic process purine nucleoside triphosphate metabolic process carbohydrate derivative biosynthetic process regulation of purine nucleotide biosynthetic process nucleoside triphosphate biosynthetic process nucleobase-containing compound biosynthetic process purine-containing compound metabolic process positive regulation of purine nucleotide metabolic process positive regulation of ATP biosynthetic process regulation of ATP biosynthetic process organophosphate metabolic process positive regulation of small molecule metabolic process positive regulation of CAMKK-AMPK signaling cascade regulation of CAMKK-AMPK signaling cascade CAMKK-AMPK signaling cascade regulation of cell projection organization regulation of plasma membrane bounded cell projection organization response to lipid detection of lipopolysaccharide response to lipopolysaccharide autophagic cell death regulation of autophagic cell death negative regulation of autophagic cell death positive regulation of cation transmembrane transport positive regulation of monoatomic ion transport positive regulation of monoatomic ion transmembrane transport monoatomic cation transport regulation of potassium ion transmembrane transporter activity regulation of monoatomic ion transport inorganic ion transmembrane transport regulation of potassium ion transmembrane transport positive regulation of cation channel activity regulation of cation channel activity inorganic cation transmembrane transport transmembrane transport regulation of transmembrane transport potassium ion transport regulation of potassium ion transport monoatomic ion transmembrane transport regulation of transmembrane transporter activity potassium ion transmembrane transport regulation of monoatomic ion transmembrane transport positive regulation of inward rectifier potassium channel activity regulation of inward rectifier potassium channel activity metal ion transport regulation of transporter activity monoatomic cation transmembrane transport positive regulation of transmembrane transport monoatomic ion transport regulation of metal ion transport regulation of monoatomic ion transmembrane transporter activity positive regulation of potassium ion transport positive regulation of transporter activity positive regulation of potassium ion transmembrane transport positive regulation of ion transmembrane transporter activity positive regulation of voltage-gated potassium channel activity regulation of monoatomic cation transmembrane transport positive regulation of potassium ion transmembrane transporter activity toll-like receptor 6 signaling pathway regulation of toll-like receptor 6 signaling pathway cellular response to peptidoglycan cholesterol storage negative regulation of cholesterol storage lipid storage negative regulation of lipid localization regulation of lipid storage negative regulation of lipid storage nutrient storage regulation of cholesterol storage negative regulation of p38MAPK cascade p38MAPK cascade regulation of p38MAPK cascade negative regulation of MAPK cascade negative regulation of canonical NF-kappaB signal transduction canonical NF-kappaB signal transduction regulation of canonical NF-kappaB signal transduction chemokine (C-X-C motif) ligand 12 signaling pathway CXCL12-activated CXCR4 signaling pathway C-X-C chemokine receptor CXCR4 signaling pathway positive regulation of amyloid-beta clearance regulation of amyloid-beta clearance interleukin-1 production regulation of interleukin-1 beta production negative regulation of interleukin-1 beta production negative regulation of interleukin-1 production regulation of interleukin-1 production interleukin-1 beta production establishment of protein localization regulation of establishment of protein localization positive regulation of establishment of protein localization positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction regulation of high-density lipoprotein particle clearance high-density lipoprotein particle clearance positive regulation of high-density lipoprotein particle clearance negative regulation of triglyceride storage regulation of triglyceride storage triglyceride storage nitrogen compound transport positive regulation of secretion by cell protein localization to extracellular region positive regulation of protein transport regulation of secretion by cell secretion by cell positive regulation of secretion secretion establishment of protein localization to extracellular region export from cell regulation of protein transport protein secretion positive regulation of protein secretion regulation of protein secretion regulation of secretion protein transport positive regulation of antigen processing and presentation of peptide antigen positive regulation of antigen processing and presentation of peptide antigen via MHC class II positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II positive regulation of antigen processing and presentation antigen processing and presentation regulation of antigen processing and presentation antigen processing and presentation of peptide or polysaccharide antigen via MHC class II regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II regulation of antigen processing and presentation of peptide antigen regulation of antigen processing and presentation of peptide antigen via MHC class II antigen processing and presentation of peptide antigen via MHC class II antigen processing and presentation of peptide antigen lymphocyte activation T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell T cell activation involved in immune response T cell activation lymphocyte activation involved in immune response pyroptotic inflammatory response negative regulation of amyloid fibril formation regulation of amyloid fibril formation amyloid fibril formation negative regulation of supramolecular fiber organization negative regulation of protein metabolic process regulation of supramolecular fiber organization supramolecular fiber organization regulation of macrophage colony-stimulating factor signaling pathway regulation of response to macrophage colony-stimulating factor regulation of cellular response to macrophage colony-stimulating factor stimulus negative regulation of macrophage colony-stimulating factor signaling pathway macrophage colony-stimulating factor signaling pathway response to macrophage colony-stimulating factor cellular response to macrophage colony-stimulating factor stimulus negative regulation of response to cytokine stimulus negative regulation of cytokine-mediated signaling pathway cellular response to lipid negative regulation of cytokine production involved in inflammatory response regulation of leukocyte differentiation positive regulation of osteoclast differentiation regulation of osteoclast differentiation positive regulation of cell differentiation positive regulation of hemopoiesis regulation of myeloid cell differentiation positive regulation of cell development regulation of myeloid leukocyte differentiation positive regulation of myeloid leukocyte differentiation positive regulation of myeloid cell differentiation regulation of hemopoiesis positive regulation of leukocyte differentiation	cell periphery cellular anatomical structure plasma membrane membrane extracellular region protein-containing complex semaphorin receptor complex receptor complex membrane microdomain membrane raft plasma membrane raft plasma membrane region
C, D	TREM2 Single chain variable 2	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
A, B	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A, B	IPR052314	Immune receptor domain-containing protein	Family
A, B	IPR013106	Immunoglobulin V-set domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q9NZC2	Alzheimer disease dementia polycystic lipomembranous osteodysplasia with sclerosing leukoencephaly amyotrophic lateral sclerosis behavioral variant of frontotemporal dementia polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 1 osteosarcoma progressive non-fluent aphasia Senile Paranoid Dementia astrocytic tumor lung carcinoma neurodegenerative disease pilocytic astrocytoma psoriasis subependymal giant cell astrocytoma Alzheimer disease dementia polycystic lipomembranous osteodysplasia with sclerosing leukoencephaly amyotrophic lateral sclerosis behavioral variant of frontotemporal dementia polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 1 osteosarcoma progressive non-fluent aphasia Senile Paranoid Dementia astrocytic tumor lung carcinoma neurodegenerative disease pilocytic astrocytoma psoriasis subependymal giant cell astrocytoma ductal breast carcinoma in situ glioblastoma malignant glioma osteogenesis imperfecta semantic dementia cutaneous lupus erythematosus invasive ductal breast carcinoma medulloblastoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.