6ZT0 | pdb_00006zt0

Crystal structure of the Eiger TNF domain/Grindelwald extracellular domain complex

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	TNF	e6zt0A1	A: beta sandwiches	X: jelly-roll	H: TNF-like (From Topology)	T: TNF-like	F: TNF	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00229	TNF(Tumour Necrosis Factor) family (TNF)	TNF(Tumour Necrosis Factor) family		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Protein eiger	protein binding binding signaling receptor binding molecular transducer activity molecular function activator activity signaling receptor activity molecular function regulator activity signaling receptor regulator activity receptor ligand activity signaling receptor activator activity cytokine activity cytokine receptor binding tumor necrosis factor receptor superfamily binding tumor necrosis factor receptor binding	protein localization localization cellular localization apical protein localization cellular macromolecule localization macromolecule localization cellular process multicellular organismal process regulation of biological process system process nervous system process regulation of system process biological regulation positive regulation of biological process protein localization localization cellular localization apical protein localization cellular macromolecule localization macromolecule localization cellular process multicellular organismal process regulation of biological process system process nervous system process regulation of system process biological regulation positive regulation of biological process sensory perception of pain regulation of nervous system process sensory perception positive regulation of nervous system process positive regulation of multicellular organismal process regulation of sensory perception regulation of multicellular organismal process regulation of sensory perception of pain positive regulation of sensory perception of pain response to stimulus immune response immune system process negative regulation of neuromuscular synaptic transmission regulation of cellular process signaling modulation of chemical synaptic transmission negative regulation of signaling negative regulation of biological process negative regulation of synaptic transmission negative regulation of cell communication cell communication synaptic signaling regulation of neuromuscular synaptic transmission negative regulation of cellular process trans-synaptic signaling regulation of signaling cell-cell signaling chemical synaptic transmission regulation of trans-synaptic signaling anterograde trans-synaptic signaling neuromuscular synaptic transmission regulation of cell communication reactive oxygen species biosynthetic process regulation of biosynthetic process negative regulation of metabolic process reactive oxygen species metabolic process regulation of reactive oxygen species biosynthetic process negative regulation of reactive oxygen species metabolic process biosynthetic process negative regulation of reactive oxygen species biosynthetic process negative regulation of biosynthetic process metabolic process regulation of metabolic process regulation of reactive oxygen species metabolic process apoptotic process cell death programmed cell death positive regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death positive regulation of apoptotic process positive regulation of cellular process biological process involved in interspecies interaction between organisms response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus defense response to other organism response to stress innate immune response response to external biotic stimulus developmental process cellular developmental process cell fate determination asymmetric protein localization involved in cell fate determination cell differentiation cell fate commitment pigment metabolic process melanization defense response melanin metabolic process secondary metabolic process phenol-containing compound metabolic process regulation of multicellular organism growth regulation of growth regulation of developmental growth negative regulation of multicellular organism growth regulation of developmental process developmental growth negative regulation of developmental process growth multicellular organism growth negative regulation of developmental growth negative regulation of growth negative regulation of multicellular organismal process positive regulation of reactive oxygen species metabolic process positive regulation of metabolic process cellular response to stimulus positive regulation of cell communication positive regulation of signal transduction regulation of signal transduction intracellular signal transduction positive regulation of response to stimulus positive regulation of JNK cascade regulation of intracellular signal transduction JNK cascade intracellular signaling cassette signal transduction positive regulation of MAPK cascade regulation of JNK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade regulation of response to stimulus MAPK cascade positive regulation of signaling response to tumor cell positive regulation of locomotion regulation of cell motility positive regulation of cell migration regulation of locomotion positive regulation of cell motility regulation of cell migration cell migration cell motility locomotion wound healing response to wounding cell surface receptor signaling pathway response to cytokine cytokine-mediated signaling pathway response to peptide cellular response to tumor necrosis factor response to chemical tumor necrosis factor-mediated signaling pathway cellular response to cytokine stimulus response to tumor necrosis factor defense response to Gram-negative bacterium defense response to bacterium response to bacterium response to nutrient levels cellular response to amino acid starvation cellular response to starvation cellular response to nutrient levels cellular response to stress response to amino acid starvation response to starvation membrane organization import into cell transport establishment of localization vesicle-mediated transport engulfment of apoptotic cell cellular component organization phagocytosis, engulfment membrane invagination phagocytosis cellular component organization or biogenesis apoptotic cell clearance endocytosis plasma membrane invagination cellular homeostasis neuron cellular homeostasis homeostatic process cell population proliferation nervous system development neurogenesis multicellular organism development gliogenesis anatomical structure development glial cell proliferation system development	cell periphery cellular anatomical structure plasma membrane membrane extracellular region extracellular space
B [auth AAAA]	Protein grindelwald	molecular transducer activity transmembrane signaling receptor activity signaling receptor activity tumor necrosis factor receptor activity death receptor activity	cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus positive regulation of JNK cascade regulation of intracellular signal transduction JNK cascade intracellular signaling cassette cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus positive regulation of JNK cascade regulation of intracellular signal transduction JNK cascade intracellular signaling cassette signal transduction positive regulation of cellular process regulation of biological process regulation of signaling positive regulation of MAPK cascade biological regulation regulation of JNK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade regulation of response to stimulus MAPK cascade regulation of cell communication cellular process positive regulation of signaling positive regulation of programmed cell death regulation of programmed cell death cell death programmed cell death cell surface receptor signaling pathway response to cytokine cytokine-mediated signaling pathway response to peptide cellular response to tumor necrosis factor response to chemical tumor necrosis factor-mediated signaling pathway cellular response to cytokine stimulus response to tumor necrosis factor reactive oxygen species biosynthetic process regulation of biosynthetic process negative regulation of metabolic process reactive oxygen species metabolic process negative regulation of biological process regulation of reactive oxygen species biosynthetic process negative regulation of reactive oxygen species metabolic process biosynthetic process negative regulation of reactive oxygen species biosynthetic process negative regulation of biosynthetic process negative regulation of cellular process metabolic process regulation of metabolic process regulation of reactive oxygen species metabolic process	cell periphery cellular anatomical structure plasma membrane membrane apical part of cell plasma membrane region apical plasma membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR008983	Tumour necrosis factor-like domain superfamily	Homologous Superfamily
A	IPR051748	Tumor Necrosis Factor Ligand Superfamily	Family
A	IPR006052	Tumour necrosis factor domain	Domain
A	IPR021184	Tumour necrosis factor, conserved site	Conserved Site

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.