6AHY | pdb_00006ahy

Wnt signaling complex

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Protein Modification Annotation

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d6ahya_	All alpha proteins	Frizzled cysteine-rich domain	Frizzled cysteine-rich domain	Frizzled cysteine-rich domain	Frizzled 8 (FZ8)	Mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
C	d6ahyc_	All alpha proteins	Frizzled cysteine-rich domain	Frizzled cysteine-rich domain	Frizzled cysteine-rich domain	Frizzled 8 (FZ8)	Mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
E	d6ahye_	All alpha proteins	Frizzled cysteine-rich domain	Frizzled cysteine-rich domain	Frizzled cysteine-rich domain	Frizzled 8 (FZ8)	Mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Frizzled domain-like	8034042	3001950	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Frizzled domain-like	8034042	3001950	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Frizzled domain-like	8034042	3001950	SCOP2B (2022-06-29)
B	SCOP2 Family	Proto-oncogene Wnt3, N-terminal domain-like	8093176	4005649	SCOP2 (2022-06-29)
B	SCOP2 Family	Proto-oncogene Wnt3, C-terminal domain-like	8093190	4007801	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	Serum amyloid A (SAA)-like	8093179	3002198	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	Proto-oncogene Wnt3, C-terminal domain-like	8093182	3002689	SCOP2 (2022-06-29)
D	SCOP2B Superfamily	Proto-oncogene Wnt3, C-terminal domain-like	8093182	3002689	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Serum amyloid A (SAA)-like	8093179	3002198	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Serum amyloid A (SAA)-like	8093179	3002198	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Fz	e6ahyA1	A: few secondary structure elements	X: Frizzled cysteine-rich domain-related (From Topology)	H: Frizzled cysteine-rich domain-related (From Topology)	T: Frizzled cysteine-rich domain-related	F: Fz	ECOD (1.6)
C	Fz	e6ahyC1	A: few secondary structure elements	X: Frizzled cysteine-rich domain-related (From Topology)	H: Frizzled cysteine-rich domain-related (From Topology)	T: Frizzled cysteine-rich domain-related	F: Fz	ECOD (1.6)
E	Fz	e6ahyE1	A: few secondary structure elements	X: Frizzled cysteine-rich domain-related (From Topology)	H: Frizzled cysteine-rich domain-related (From Topology)	T: Frizzled cysteine-rich domain-related	F: Fz	ECOD (1.6)
B	wnt	e6ahyB1	A: alpha arrays	X: Protein Wnt-8 (From Topology)	H: Protein Wnt-8 (From Topology)	T: Protein Wnt-8	F: wnt	ECOD (1.6)
D	wnt	e6ahyD1	A: alpha arrays	X: Protein Wnt-8 (From Topology)	H: Protein Wnt-8 (From Topology)	T: Protein Wnt-8	F: wnt	ECOD (1.6)
F	wnt	e6ahyF1	A: alpha arrays	X: Protein Wnt-8 (From Topology)	H: Protein Wnt-8 (From Topology)	T: Protein Wnt-8	F: wnt	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.2000.10	Mainly Alpha	Orthogonal Bundle	Frizzled cysteine-rich domain	Frizzled cysteine-rich domain	CATH (utative)
C	1.10.2000.10	Mainly Alpha	Orthogonal Bundle	Frizzled cysteine-rich domain	Frizzled cysteine-rich domain	CATH (utative)
E	1.10.2000.10	Mainly Alpha	Orthogonal Bundle	Frizzled cysteine-rich domain	Frizzled cysteine-rich domain	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C, E	PF01392	Fz domain (Fz)	Fz domain	Also known as the CRD (cysteine rich domain), the C6 box in MuSK receptor. This domain of unknown function has been independently identified by several groups [1,2,3,4]. The domain contains 10 conserved cysteines.	Domain
B, D, F	PF00110	wnt family (wnt)	wnt family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C, E	Frizzled-8	protein binding binding signaling receptor binding molecular transducer activity transmembrane signaling receptor activity signaling receptor activity Wnt receptor activity G protein-coupled receptor activity PDZ domain binding protein domain specific binding ubiquitin protein ligase binding ubiquitin-like protein ligase binding enzyme binding Wnt-protein binding	developmental process multicellular organismal process blood vessel morphogenesis tube development angiogenesis vasculature development circulatory system development anatomical structure morphogenesis multicellular organism development tube morphogenesis anatomical structure formation involved in morphogenesis anatomical structure development blood vessel development system development developmental process multicellular organismal process blood vessel morphogenesis tube development angiogenesis vasculature development circulatory system development anatomical structure morphogenesis multicellular organism development tube morphogenesis anatomical structure formation involved in morphogenesis anatomical structure development blood vessel development system development cellular response to stimulus regulation of biological process regulation of cellular process cell surface receptor signaling pathway response to stimulus signaling canonical Wnt signaling pathway biological regulation cell communication cellular process signal transduction Wnt signaling pathway cellular developmental process hemopoiesis cell activation cell development mononuclear cell differentiation lymphocyte activation lymphocyte differentiation leukocyte activation T cell differentiation in thymus T cell activation immune system process cell differentiation T cell differentiation leukocyte differentiation	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure Golgi apparatus organelle cytoplasm intracellular membrane-bounded organelle endomembrane system dense core granule intracellular vesicle cytoplasmic vesicle secretory granule secretory vesicle membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure Golgi apparatus organelle cytoplasm intracellular membrane-bounded organelle endomembrane system dense core granule intracellular vesicle cytoplasmic vesicle secretory granule secretory vesicle vesicle neuronal dense core vesicle extracellular region cell periphery plasma membrane membrane protein-containing complex Wnt-Frizzled-LRP5/6 complex plasma membrane protein complex membrane protein complex
B, D, F	Proto-oncogene Wnt-3	protein binding binding protein domain specific binding molecular transducer activity molecular function activator activity signaling receptor binding signaling receptor activity molecular function regulator activity signaling receptor regulator activity receptor ligand activity signaling receptor activator activity G protein-coupled receptor binding frizzled binding cytokine activity	developmental process multicellular organism development multicellular organismal process dorsal/ventral pattern formation dorsal/ventral axis specification anatomical structure development pattern specification process axis specification regionalization regulation of multicellular organismal development regulation of biological process regulation of cellular process regulation of developmental process cellular developmental process developmental process multicellular organism development multicellular organismal process dorsal/ventral pattern formation dorsal/ventral axis specification anatomical structure development pattern specification process axis specification regionalization regulation of multicellular organismal development regulation of biological process regulation of cellular process regulation of developmental process cellular developmental process biological regulation cell development regulation of neurogenesis regulation of cell differentiation nervous system development regulation of cell development regulation of nervous system development neurogenesis cell differentiation regulation of multicellular organismal process cellular process system development limb development appendage development limb bud formation anatomical structure morphogenesis appendage morphogenesis anatomical structure formation involved in morphogenesis limb morphogenesis embryonic forelimb morphogenesis embryonic limb morphogenesis embryonic morphogenesis embryonic appendage morphogenesis embryo development forelimb morphogenesis sexual reproduction reproductive process multicellular organismal reproductive process gamete generation Spemann organizer formation developmental induction Spemann organizer formation at the anterior end of the primitive streak cellular response to stimulus cell surface receptor signaling pathway response to stimulus signaling canonical Wnt signaling pathway cell communication signal transduction Wnt signaling pathway regulation of biosynthetic process positive regulation of biological process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process positive regulation of macromolecule biosynthetic process regulation of gene expression positive regulation of metabolic process biosynthetic process positive regulation of gene expression positive regulation of biosynthetic process regulation of macromolecule biosynthetic process metabolic process positive regulation of macromolecule metabolic process macromolecule metabolic process regulation of metabolic process positive regulation of cellular process head development head morphogenesis body morphogenesis epithelium development mammary gland epithelium development mammary gland development gland development animal organ development tissue development negative regulation of locomotion developmental growth cell projection organization negative regulation of chemotaxis neuron projection development cell projection morphogenesis neuron differentiation regulation of biological quality chemotaxis regulation of cell projection organization response to external stimulus generation of neurons negative regulation of axonogenesis negative regulation of developmental growth regulation of response to stimulus negative regulation of multicellular organismal process regulation of neuron projection development regulation of cellular component organization regulation of response to external stimulus plasma membrane bounded cell projection morphogenesis cell growth negative regulation of neurogenesis regulation of axon extension involved in axon guidance regulation of extent of cell growth negative regulation of nervous system development negative regulation of cell differentiation regulation of anatomical structure morphogenesis locomotion neuron projection extension regulation of developmental growth developmental cell growth negative regulation of developmental process growth axon development negative regulation of axon extension regulation of chemotaxis regulation of cell growth cell morphogenesis involved in neuron differentiation negative regulation of cell development neuron projection guidance neuron development axon extension regulation of growth axonogenesis regulation of cellular component size negative regulation of biological process negative regulation of growth neuron projection morphogenesis taxis neuron projection extension involved in neuron projection guidance negative regulation of cellular component organization negative regulation of axon extension involved in axon guidance negative regulation of cell growth developmental growth involved in morphogenesis response to chemical regulation of locomotion negative regulation of response to external stimulus cell morphogenesis regulation of axon extension cellular component organization regulation of axonogenesis negative regulation of cellular process cellular component organization or biogenesis axon extension involved in axon guidance negative regulation of cell projection organization regulation of cell size plasma membrane bounded cell projection organization negative regulation of response to stimulus axon guidance negative regulation of neuron projection development regulation of plasma membrane bounded cell projection organization regulation of anatomical structure size response to lipid response to oxygen-containing compound cellular response to oxygen-containing compound response to retinoic acid cellular response to chemical stimulus cellular response to retinoic acid cellular response to lipid embryonic hindlimb morphogenesis hindlimb morphogenesis anterior/posterior axis specification anterior/posterior pattern specification positive regulation of cell communication positive regulation of signal transduction regulation of signal transduction positive regulation of response to stimulus positive regulation of Wnt signaling pathway regulation of signaling regulation of Wnt signaling pathway regulation of cell communication positive regulation of signaling stem cell proliferation cell population proliferation regulation of osteoblast differentiation osteoblast differentiation positive regulation of developmental process positive regulation of osteoblast differentiation ossification positive regulation of cell differentiation cell fate commitment dopaminergic neuron differentiation brain development central nervous system neuron differentiation central nervous system development midbrain development midbrain dopaminergic neuron differentiation stem cell differentiation regulation of stem cell differentiation mesenchymal stem cell differentiation regulation of mesenchymal stem cell differentiation positive regulation of nervous system development collateral sprouting in absence of injury positive regulation of cell projection organization positive regulation of developmental growth regulation of collateral sprouting in absence of injury positive regulation of collateral sprouting positive regulation of cell development positive regulation of multicellular organismal process regulation of collateral sprouting positive regulation of cellular component organization positive regulation of neurogenesis positive regulation of axonogenesis collateral sprouting positive regulation of cell growth positive regulation of collateral sprouting in absence of injury positive regulation of growth formation of primary germ layer mesoderm morphogenesis gastrulation tissue morphogenesis mesoderm formation mesoderm development	extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle cell periphery plasma membrane membrane extracellular matrix extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle cell periphery plasma membrane membrane extracellular matrix external encapsulating structure protein-containing complex Wnt signalosome intracellular anatomical structure Golgi apparatus membrane-enclosed lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen Golgi lumen intracellular organelle organelle lumen cytoplasm intracellular vesicle cytoplasmic vesicle membrane bounding membrane of organelle cytoplasmic vesicle vesicle membrane endocytic vesicle membrane organelle membrane endocytic vesicle endoplasmic reticulum lumen endoplasmic reticulum

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C, E	IPR036790	Frizzled cysteine-rich domain superfamily	Homologous Superfamily
A, C, E	IPR015526	Frizzled/secreted frizzled-related protein	Family
A, C, E	IPR000539	Frizzled/Smoothened, 7TM	Domain
A, C, E	IPR041776	Frizzled 8, cysteine-rich domain	Domain
A, C, E	IPR020067	Frizzled domain	Domain
A, C, E	IPR017981	GPCR, family 2-like, 7TM	Domain
B, D, F	IPR005817	Wnt	Family
B, D, F	IPR043158	Wnt, C-terminal domain	Homologous Superfamily
B, D, F	IPR018161	Wnt protein, conserved site	Conserved Site
B, D, F	IPR009141	Wnt-3 protein	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B, D, F	Pharos: P56703	atrial fibrillation malignant mesothelioma mantle cell lymphoma Tetra-amelia autosomal recessive tetraamelia-multiple malformations syndrome B-cell chronic lymphocytic leukemia cleft lip hydrocephalus ovarian carcinoma attention deficit hyperactivity disorder, inattentive type breast carcinoma endogenous depression intellectual disability malignant ependymoma tetra-amelia atrial fibrillation malignant mesothelioma mantle cell lymphoma Tetra-amelia autosomal recessive tetraamelia-multiple malformations syndrome B-cell chronic lymphocytic leukemia cleft lip hydrocephalus ovarian carcinoma attention deficit hyperactivity disorder, inattentive type breast carcinoma endogenous depression intellectual disability malignant ependymoma tetra-amelia tetraamelia syndrome 1 autism spectrum disorder cancer facioscapulohumeral muscular dystrophy lung adenocarcinoma medulloblastoma

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
A, C, E	MLY	Parent Component: LYS RESID: AA0075 PSI-MOD : N6,N6-dimethyl-L-lysine MOD:00084
B, D, F	MLY	Parent Component: LYS RESID: AA0075 , AA0075 PSI-MOD : N6,N6-dimethyl-L-lysine MOD:00084 , N6,N6-dimethyl-L-lysine MOD:00084

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.