Annotations: 7B1C

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth C]	LRR_8_1	e7b1cC1	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: LRR_8_1	ECOD (1.6)
B [auth A]	LRR_8_3	e7b1cA1	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: LRR_8_3	ECOD (1.6)
E [auth B]	LRR_8_3	e7b1cB1	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: LRR_8_3	ECOD (1.6)
C [auth D]	Spaetzle	e7b1cD1	A: few secondary structure elements	X: Cystine-knot cytokines (From Topology)	H: Cystine-knot cytokines (From Topology)	T: Cystine-knot cytokines	F: Spaetzle	ECOD (1.6)
D [auth P]	Spaetzle	e7b1cP1	A: few secondary structure elements	X: Cystine-knot cytokines (From Topology)	H: Cystine-knot cytokines (From Topology)	T: Cystine-knot cytokines	F: Spaetzle	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C [auth D]	2.10.90.10	Mainly Beta	Ribbon	Cystine Knot Cytokines, subunit B	Cystine-knot cytokines	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth C], B [auth A], E [auth B]	PF13855	Leucine rich repeat (LRR_8)	Leucine rich repeat	-	Repeat
C [auth D], D [auth P]	PF16077	Spaetzle (Spaetzle)	Spaetzle	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth C], B [auth A], E [auth B]	Toll-like receptor	molecular transducer activity signaling receptor activity	biological process involved in interspecies interaction between organisms response to stimulus immune response response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus immune system process defense response to other organism response to stress innate immune response response to external biotic stimulus cellular response to stimulus biological process involved in interspecies interaction between organisms response to stimulus immune response response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus immune system process defense response to other organism response to stress innate immune response response to external biotic stimulus cellular response to stimulus regulation of biological process regulation of cellular process signaling biological regulation cellular process signal transduction cell communication	cell periphery cellular anatomical structure plasma membrane membrane
C [auth D], D [auth P]	AAEL013433-PA	protein binding binding signaling receptor binding Toll binding molecular transducer activity molecular function activator activity signaling receptor activity growth factor activity signaling receptor activator activity molecular function regulator activity signaling receptor regulator activity receptor ligand activity	biological process involved in interspecies interaction between organisms response to stimulus immune response response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus immune system process defense response to other organism response to stress innate immune response response to external biotic stimulus developmental process biological process involved in interspecies interaction between organisms response to stimulus immune response response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus immune system process defense response to other organism response to stress innate immune response response to external biotic stimulus developmental process multicellular organismal process central nervous system formation nervous system development anatomical structure morphogenesis multicellular organism development central nervous system development anatomical structure formation involved in morphogenesis anatomical structure development central nervous system morphogenesis system development	cellular anatomical structure extracellular region extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth C], B [auth A], E [auth B]	IPR032675	Leucine-rich repeat domain superfamily	Homologous Superfamily
A [auth C], B [auth A], E [auth B]	IPR000157	Toll/interleukin-1 receptor homology (TIR) domain	Domain
A [auth C], B [auth A], E [auth B]	IPR035897	Toll/interleukin-1 receptor homology (TIR) domain superfamily	Homologous Superfamily
A [auth C], B [auth A], E [auth B]	IPR001611	Leucine-rich repeat	Repeat
A [auth C], B [auth A], E [auth B]	IPR003591	Leucine-rich repeat, typical subtype	Repeat
C [auth D], D [auth P]	IPR032104	Spaetzle	Domain
C [auth D], D [auth P]	IPR029034	Cystine-knot cytokine	Homologous Superfamily
C [auth D], D [auth P]	IPR052444	Spaetzle/Toll ligand-like	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.