7C6A

Crystal structure of AT2R-BRIL and SRP2070_Fab complex

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
IMGT Antibody Annotation
SAbDab Antibody Annotation
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD
Membrane Protein Annotation: mpstruc
Protein Modification Annotation

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C [auth A]	SCOP2B Superfamily	G protein-coupled receptor-like	8091222	3000473	SCOP2B (2022-06-29)
C [auth A]	SCOP2B Superfamily	Cytochromes	8057879	3001526	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth L]	C1-set_4	e7c6aL1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_4	ECOD (1.6)
A [auth L]	V-set	e7c6aL2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set	ECOD (1.6)
B [auth H]	V-set_8	e7c6aH2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_8	ECOD (1.6)
B [auth H]	C1-set_1	e7c6aH1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_1	ECOD (1.6)
C [auth A]	7tm_1_1,Cytochrom_B562_1	e7c6aA2	A: alpha bundles	X: Family A G protein-coupled receptor-like (From Topology)	H: Family A G protein-coupled receptor-like (From Topology)	T: Family A G protein-coupled receptor-like	F: 7tm_1_1,Cytochrom_B562_1	ECOD (1.6)
C [auth A]	7tm_1_1	e7c6aA1	A: alpha bundles	X: Four-helical up-and-down bundle	H: Cytochromes (From Topology)	T: Cytochromes	F: 7tm_1_1	ECOD (1.6)

IMGT Antibody Annotation IMGT Database Homepage

Chain	Protein Name	Description	Organism Name	Gene Allele Name(s)	Domain Name(s)	Receptor Type	Receptor Description	Provenance Source
A [auth L]	Fab SRP2070, anti- GPCRs	L-KAPPA	Mus musculus (house mouse)	IGKV5-4501, IGKJ501, IGKC01, IGKC02	V-DOMAIN V-KAPPA, C-DOMAIN C-KAPPA	IG	FAB-GAMMA-1_KAPPA	IMGT (202450-0)
B [auth H]	Fab SRP2070, anti- GPCRs	VH-CH1	Mus musculus (house mouse)	IGHV1-8401, IGHJ201, IGHG2A01, IGHG2A02	V-DOMAIN VH, C-DOMAIN CH1	IG	FAB-GAMMA-1_KAPPA	IMGT (202450-0)

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
A [auth L]	Light Chain	IGKV5	Kappa	type-2 angiotensin ii receptor,soluble cytochrome b562,type-2 angiotensin ii receptor	SAbDab (2024-12-20)
B [auth H]	Heavy Chain	IGHV1	-	type-2 angiotensin ii receptor,soluble cytochrome b562,type-2 angiotensin ii receptor	SAbDab (2024-12-20)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
C [auth A]	PF07361	Cytochrome b562 (Cytochrom_B562)	Cytochrome b562	-	Family
C [auth A]	PF00001	7 transmembrane receptor (rhodopsin family) (7tm_1)	7 transmembrane receptor (rhodopsin family)	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth L]	IgG Light Chain	-	-	-
B [auth H]	IgG heavy chain	-	-	-
C [auth A]	Type-2 angiotensin II receptor,Soluble cytochrome b562,Type-2 angiotensin II receptor	binding organic cyclic compound binding tetrapyrrole binding heme binding electron transfer activity cation binding transition metal ion binding iron ion binding ion binding metal ion binding small molecule binding angiotensin type II receptor activity peptide receptor activity molecular transducer activity binding organic cyclic compound binding tetrapyrrole binding heme binding electron transfer activity cation binding transition metal ion binding iron ion binding ion binding metal ion binding small molecule binding angiotensin type II receptor activity peptide receptor activity molecular transducer activity G protein-coupled receptor activity G protein-coupled peptide receptor activity transmembrane signaling receptor activity signaling receptor activity angiotensin receptor activity molecular function inhibitor activity protein binding signaling receptor binding molecular function regulator activity signaling receptor inhibitor activity receptor antagonist activity signaling receptor regulator activity	electron transport chain metabolic process cellular process generation of precursor metabolites and energy regulation of systemic arterial blood pressure by renin-angiotensin regulation of systemic arterial blood pressure by hormone multicellular organismal process regulation of blood volume by renin-angiotensin regulation of systemic arterial blood pressure mediated by a chemical signal system process nervous system process regulation of blood pressure biological regulation brain renin-angiotensin system electron transport chain metabolic process cellular process generation of precursor metabolites and energy regulation of systemic arterial blood pressure by renin-angiotensin regulation of systemic arterial blood pressure by hormone multicellular organismal process regulation of blood volume by renin-angiotensin regulation of systemic arterial blood pressure mediated by a chemical signal system process nervous system process regulation of blood pressure biological regulation brain renin-angiotensin system regulation of systemic arterial blood pressure circulatory system process endocrine process regulation of biological quality nervous system process involved in regulation of systemic arterial blood pressure blood circulation developmental process multicellular organism development head development central nervous system development anatomical structure development animal organ development brain development nervous system development system development regulation of systemic arterial blood pressure by circulatory renin-angiotensin behavior exploration behavior mesonephric epithelium development kidney epithelium development branching morphogenesis of an epithelial tube nephron tubule morphogenesis regulation of kidney development regulation of branching involved in ureteric bud morphogenesis positive regulation of developmental process tube morphogenesis animal organ morphogenesis nephron development regulation of morphogenesis of a branching structure epithelium development regulation of biological process regulation of animal organ morphogenesis tissue development positive regulation of multicellular organismal process mesonephric tubule development renal tubule morphogenesis regulation of developmental process nephron morphogenesis nephron epithelium morphogenesis positive regulation of biological process nephron tubule development renal system development ureteric bud morphogenesis positive regulation of morphogenesis of an epithelium branching involved in ureteric bud morphogenesis renal tubule development regulation of morphogenesis of an epithelium regulation of multicellular organismal process epithelial tube morphogenesis regulation of anatomical structure morphogenesis nephron epithelium development ureteric bud development tube development mesonephros development morphogenesis of an epithelium tissue morphogenesis anatomical structure morphogenesis kidney morphogenesis morphogenesis of a branching structure positive regulation of branching involved in ureteric bud morphogenesis mesonephric tubule morphogenesis kidney development morphogenesis of a branching epithelium negative regulation of blood pressure renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure negative regulation of systemic arterial blood pressure blood vessel diameter maintenance renal system process involved in regulation of systemic arterial blood pressure regulation of tube diameter maintenance of blood vessel diameter homeostasis by renin-angiotensin renal system process regulation of tube size vascular process in circulatory system vasodilation regulation of anatomical structure size positive regulation of metanephric glomerulus development metanephric glomerulus development metanephros development regulation of glomerulus development metanephric nephron development regulation of metanephric glomerulus development positive regulation of glomerulus development positive regulation of kidney development glomerulus development regulation of metanephros development positive regulation of metanephros development cellular response to stimulus cellular response to growth factor stimulus regulation of cellular process response to stimulus signaling negative regulation of signaling negative regulation of biological process regulation of signal transduction negative regulation of cellular response to growth factor stimulus cell surface receptor protein tyrosine kinase signaling pathway negative regulation of cell communication cell communication cellular response to endogenous stimulus neurotrophin signaling pathway negative regulation of cellular process signal transduction enzyme-linked receptor protein signaling pathway regulation of signaling cell surface receptor signaling pathway negative regulation of response to stimulus response to endogenous stimulus regulation of cellular response to growth factor stimulus neurotrophin TRK receptor signaling pathway negative regulation of signal transduction regulation of neurotrophin TRK receptor signaling pathway regulation of response to stimulus negative regulation of neurotrophin TRK receptor signaling pathway regulation of cell communication response to growth factor regulation of metanephros size regulation of kidney size metanephros morphogenesis regulation of growth regulation of cellular component organization growth negative regulation of cell growth regulation of cell growth cell growth cellular component organization negative regulation of growth cellular component organization or biogenesis positive regulation of cell communication positive regulation of signal transduction regulation of programmed cell death extrinsic apoptotic signaling pathway positive regulation of apoptotic signaling pathway positive regulation of response to stimulus positive regulation of cellular process positive regulation of programmed cell death regulation of apoptotic process positive regulation of extrinsic apoptotic signaling pathway cell death positive regulation of apoptotic process regulation of extrinsic apoptotic signaling pathway apoptotic signaling pathway apoptotic process programmed cell death regulation of apoptotic signaling pathway positive regulation of signaling negative regulation of locomotion regulation of cell motility regulation of blood vessel endothelial cell migration endothelial cell migration negative regulation of endothelial cell migration negative regulation of blood vessel endothelial cell migration regulation of locomotion regulation of cell migration blood vessel endothelial cell migration regulation of endothelial cell migration negative regulation of cell motility cell migration cell motility locomotion negative regulation of cell migration blood vessel remodeling tissue remodeling neuron apoptotic process positive regulation of DNA-templated transcription RNA metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process positive regulation of nucleobase-containing compound metabolic process primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process regulation of gene expression biosynthetic process positive regulation of RNA biosynthetic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process nitric oxide mediated signal transduction cGMP-mediated signaling intracellular signal transduction nitric oxide-cGMP-mediated signaling intracellular signaling cassette defense response response to stress inflammatory response G protein-coupled receptor signaling pathway heart process negative regulation of heart rate regulation of heart contraction regulation of system process negative regulation of blood circulation negative regulation of heart contraction regulation of blood circulation heart contraction negative regulation of multicellular organismal process regulation of heart rate G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	cellular anatomical structure periplasmic space cell periphery plasma membrane membrane
D [auth B]	SAR1, ILE8-ANGIOTENSIN II	protein binding binding molecular function activator activity signaling receptor binding molecular function regulator activity signaling receptor regulator activity growth factor activity receptor ligand activity signaling receptor activator activity angiotensin receptor binding type 1 angiotensin receptor binding G protein-coupled receptor binding type 2 angiotensin receptor binding enzyme regulator activity protein binding binding molecular function activator activity signaling receptor binding molecular function regulator activity signaling receptor regulator activity growth factor activity receptor ligand activity signaling receptor activator activity angiotensin receptor binding type 1 angiotensin receptor binding G protein-coupled receptor binding type 2 angiotensin receptor binding enzyme regulator activity molecular function inhibitor activity peptidase regulator activity serine-type endopeptidase inhibitor activity enzyme inhibitor activity peptidase inhibitor activity endopeptidase regulator activity endopeptidase inhibitor activity hormone activity	heart process multicellular organismal process system process regulation of biological process regulation of cardiac conduction regulation of heart contraction regulation of system process biological regulation circulatory system process regulation of blood circulation cardiac conduction regulation of multicellular organismal process heart contraction blood circulation heart process multicellular organismal process system process regulation of biological process regulation of cardiac conduction regulation of heart contraction regulation of system process biological regulation circulatory system process regulation of blood circulation cardiac conduction regulation of multicellular organismal process heart contraction blood circulation regulation of blood pressure regulation of biological quality regulation of defense response response to stimulus regulation of response to external stimulus defense response positive regulation of biological process response to external stimulus regulation of inflammatory response positive regulation of response to stimulus positive regulation of response to external stimulus positive regulation of inflammatory response regulation of response to stimulus regulation of response to stress response to stress positive regulation of defense response inflammatory response renal system process positive regulation of cellular component organization regulation of cellular process regulation of cellular component organization gap junction assembly cellular component organization cellular component biogenesis cellular component assembly positive regulation of gap junction assembly cell junction assembly cellular component organization or biogenesis positive regulation of cellular process cell-cell junction assembly cell-cell junction organization positive regulation of cellular component biogenesis regulation of gap junction assembly regulation of cellular component biogenesis regulation of cell junction assembly positive regulation of cell junction assembly cell junction organization cellular process regulation of systemic arterial blood pressure by renin-angiotensin regulation of systemic arterial blood pressure by hormone regulation of blood volume by renin-angiotensin regulation of systemic arterial blood pressure mediated by a chemical signal regulation of systemic arterial blood pressure endocrine process regulation of renal output by angiotensin cellular response to stimulus regulation of catalytic activity negative regulation of biological process negative regulation of catalytic activity regulation of signal transduction regulation of transferase activity regulation of MAP kinase activity intracellular signal transduction regulation of primary metabolic process cell communication negative regulation of kinase activity negative regulation of transferase activity regulation of phosphate metabolic process phosphate-containing compound metabolic process intracellular signaling cassette negative regulation of protein modification process signal transduction phosphorus metabolic process protein modification process negative regulation of protein metabolic process protein phosphorylation phosphorylation regulation of protein metabolic process negative regulation of metabolic process primary metabolic process regulation of MAPK cascade regulation of molecular function regulation of kinase activity negative regulation of protein phosphorylation regulation of protein serine/threonine kinase activity macromolecule modification regulation of phosphorus metabolic process metabolic process macromolecule metabolic process regulation of metabolic process regulation of protein modification process regulation of protein phosphorylation signaling negative regulation of signaling negative regulation of intracellular signal transduction negative regulation of phosphate metabolic process negative regulation of cell communication regulation of intracellular signal transduction negative regulation of protein serine/threonine kinase activity negative regulation of cellular process protein metabolic process negative regulation of macromolecule metabolic process regulation of signaling negative regulation of response to stimulus negative regulation of molecular function negative regulation of MAP kinase activity regulation of protein kinase activity regulation of macromolecule metabolic process negative regulation of protein kinase activity negative regulation of signal transduction negative regulation of phosphorus metabolic process MAPK cascade regulation of cell communication regulation of phosphorylation negative regulation of phosphorylation negative regulation of MAPK cascade regulation of CoA-transferase activity positive regulation of molecular function positive regulation of transferase activity positive regulation of CoA-transferase activity positive regulation of catalytic activity regulation of localization renal sodium excretion inorganic ion homeostasis regulation of renal system process transport homeostatic process localization monoatomic ion homeostasis monoatomic cation homeostasis excretion sodium ion homeostasis regulation of transport secretion renal tubular secretion establishment of localization regulation of secretion regulation of renal sodium excretion chemical homeostasis regulation of excretion regulation of tube diameter regulation of tube size vascular process in circulatory system blood vessel diameter maintenance vasoconstriction regulation of anatomical structure size cellular response to growth factor stimulus negative regulation of cellular response to growth factor stimulus cell surface receptor protein tyrosine kinase signaling pathway cellular response to endogenous stimulus neurotrophin signaling pathway enzyme-linked receptor protein signaling pathway cell surface receptor signaling pathway response to endogenous stimulus regulation of cellular response to growth factor stimulus neurotrophin TRK receptor signaling pathway regulation of neurotrophin TRK receptor signaling pathway negative regulation of neurotrophin TRK receptor signaling pathway response to growth factor regulation of growth growth regulation of cell growth cell growth response to angiotensin response to hormone response to chemical response to peptide hormone response to oxygen-containing compound response to nitrogen compound cell-cell signaling regulation of apoptotic process apoptotic process regulation of programmed cell death cell death programmed cell death regulation of vasoconstriction cellular response to nitrogen compound angiotensin-activated signaling pathway cellular response to angiotensin cellular response to hormone stimulus cellular response to peptide hormone stimulus cellular response to oxygen-containing compound cellular response to chemical stimulus G protein-coupled receptor signaling pathway positive regulation of cell communication positive regulation of signal transduction positive regulation of ERBB signaling pathway regulation of epidermal growth factor receptor signaling pathway epidermal growth factor receptor signaling pathway positive regulation of epidermal growth factor receptor signaling pathway regulation of ERBB signaling pathway ERBB signaling pathway positive regulation of signaling positive regulation of DNA-templated transcription RNA metabolic process positive regulation of miRNA transcription positive regulation of miRNA metabolic process positive regulation of macromolecule biosynthetic process nucleobase-containing compound metabolic process RNA biosynthetic process DNA-templated transcription nucleic acid biosynthetic process positive regulation of metabolic process regulation of RNA metabolic process miRNA transcription positive regulation of biosynthetic process regulation of miRNA metabolic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process miRNA metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process positive regulation of nucleobase-containing compound metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process regulation of gene expression biosynthetic process positive regulation of RNA biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of miRNA transcription regulation of aldosterone secretion regulation of steroid hormone secretion aldosterone secretion mineralocorticoid secretion regulation of hormone levels lipid transport regulation of corticosteroid hormone secretion endocrine hormone secretion lipid export from cell renin-angiotensin regulation of aldosterone production regulation of mineralocorticoid secretion regulation of endocrine process corticosteroid hormone secretion regulation of hormone secretion steroid hormone secretion regulation of lipid transport organic hydroxy compound transport hormone secretion secretion by cell regulation of secretion by cell signal release renal system process involved in regulation of systemic arterial blood pressure lipid localization export from cell regulation of lipid localization macromolecule localization hormone transport positive regulation of DNA-binding transcription factor activity positive regulation of NF-kappaB transcription factor activity regulation of DNA-binding transcription factor activity phospholipase C-activating G protein-coupled receptor signaling pathway muscle hypertrophy regulation of muscle adaptation positive regulation of cardiac muscle hypertrophy striated muscle hypertrophy regulation of muscle system process muscle system process regulation of cardiac muscle hypertrophy regulation of muscle hypertrophy muscle adaptation positive regulation of muscle hypertrophy cardiac muscle hypertrophy positive regulation of multicellular organismal process nitric oxide mediated signal transduction cGMP-mediated signaling nitric oxide-cGMP-mediated signaling developmental process multicellular organism development anatomical structure development animal organ development kidney development renal system development system development G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger positive regulation of protein metabolic process plasma lipoprotein particle organization low-density lipoprotein particle remodeling protein-containing complex organization protein-containing complex remodeling protein-lipid complex organization plasma lipoprotein particle remodeling regulation of plasma lipoprotein particle levels protein-lipid complex remodeling positive regulation of locomotion regulation of cell motility endothelial cell migration positive regulation of cell migration regulation of locomotion positive regulation of endothelial cell migration positive regulation of cell motility regulation of cell migration regulation of endothelial cell migration cell migration cell motility locomotion mesonephric epithelium development kidney epithelium development branching morphogenesis of an epithelial tube nephron tubule morphogenesis regulation of kidney development regulation of branching involved in ureteric bud morphogenesis positive regulation of developmental process tube morphogenesis animal organ morphogenesis nephron development regulation of morphogenesis of a branching structure epithelium development regulation of animal organ morphogenesis tissue development mesonephric tubule development renal tubule morphogenesis regulation of developmental process nephron morphogenesis nephron epithelium morphogenesis nephron tubule development ureteric bud morphogenesis positive regulation of morphogenesis of an epithelium branching involved in ureteric bud morphogenesis renal tubule development regulation of morphogenesis of an epithelium epithelial tube morphogenesis regulation of anatomical structure morphogenesis nephron epithelium development ureteric bud development tube development mesonephros development morphogenesis of an epithelium tissue morphogenesis anatomical structure morphogenesis kidney morphogenesis morphogenesis of a branching structure positive regulation of branching involved in ureteric bud morphogenesis mesonephric tubule morphogenesis morphogenesis of a branching epithelium response to muscle activity involved in regulation of muscle adaptation response to activity response to stimulus involved in regulation of muscle adaptation response to muscle activity regulation of epithelial to mesenchymal transition cellular developmental process positive regulation of epithelial to mesenchymal transition regulation of cell differentiation mesenchyme development positive regulation of cell differentiation cell differentiation epithelial to mesenchymal transition mesenchymal cell differentiation positive regulation of extracellular matrix organization extracellular matrix organization regulation of extracellular matrix assembly positive regulation of extracellular matrix assembly regulation of extracellular matrix organization extracellular matrix assembly extracellular structure organization external encapsulating structure organization fibroblast proliferation cell population proliferation positive regulation of cell population proliferation regulation of fibroblast proliferation regulation of cell population proliferation positive regulation of fibroblast proliferation extrinsic apoptotic signaling pathway positive regulation of apoptotic signaling pathway positive regulation of programmed cell death positive regulation of extrinsic apoptotic signaling pathway positive regulation of apoptotic process regulation of extrinsic apoptotic signaling pathway apoptotic signaling pathway regulation of apoptotic signaling pathway regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of intracellular signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction phosphatidylinositol 3-kinase/protein kinase B signal transduction macrophage derived foam cell differentiation foam cell differentiation regulation of macrophage derived foam cell differentiation positive regulation of macrophage derived foam cell differentiation reactive oxygen species metabolic process positive regulation of reactive oxygen species metabolic process regulation of reactive oxygen species metabolic process blood vessel remodeling tissue remodeling maintenance of blood vessel diameter homeostasis by renin-angiotensin renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure cytokine production regulation of cytokine production positive regulation of gene expression positive regulation of cytokine production	extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle cell periphery extracellular matrix external encapsulating structure collagen-containing extracellular matrix extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle cell periphery extracellular matrix external encapsulating structure collagen-containing extracellular matrix blood microparticle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
C [auth A]	IPR010980	Cytochrome c/b562	Homologous Superfamily
C [auth A]	IPR009155	Cytochrome b562	Family
C [auth A]	IPR000147	Angiotensin II receptor type 2	Family
C [auth A]	IPR000276	G protein-coupled receptor, rhodopsin-like	Family
C [auth A]	IPR017452	GPCR, rhodopsin-like, 7TM	Domain
C [auth A]	IPR050119	C-C chemokine receptor type 1-9-like	Family
C [auth A]	IPR000248	Angiotensin II receptor family	Family
D [auth B]	IPR000215	Serpin family	Family
D [auth B]	IPR042178	Serpin superfamily, domain 1	Homologous Superfamily
D [auth B]	IPR023795	Serpin, conserved site	Conserved Site
D [auth B]	IPR033834	Angiotensinogen, serpin domain	Domain
D [auth B]	IPR036186	Serpin superfamily	Homologous Superfamily
D [auth B]	IPR000227	Angiotensinogen	Family
D [auth B]	IPR023796	Serpin domain	Domain
D [auth B]	IPR042185	Serpin superfamily, domain 2	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
C [auth A]	Pharos: P50052	hypertensive disorder Mammary Neoplasms, Experimental invasive lobular breast carcinoma non-small cell lung carcinoma autism, susceptibility to, X-linked 2 cystic fibrosis gastric cancer lung carcinoma osteosarcoma gastric neoplasm intellectual disability lung adenocarcinoma lung disease ovarian cyst corpus luteum cyst hypertensive disorder Mammary Neoplasms, Experimental invasive lobular breast carcinoma non-small cell lung carcinoma autism, susceptibility to, X-linked 2 cystic fibrosis gastric cancer lung carcinoma osteosarcoma gastric neoplasm intellectual disability lung adenocarcinoma lung disease ovarian cyst corpus luteum cyst hereditary diffuse gastric adenocarcinoma lung cancer
D [auth B]	Pharos: P01019	hypertensive disorder endomyocardial fibrosis IgA glomerulonephritis abdominal aortic aneurysm aortic aneurysm retinopathy of prematurity essential hypertension kidney disease heart disease renal hypertension cardiomyopathy kidney failure glomerulonephritis diabetic retinopathy Myocardial Reperfusion Injury hypertensive disorder endomyocardial fibrosis IgA glomerulonephritis abdominal aortic aneurysm aortic aneurysm retinopathy of prematurity essential hypertension kidney disease heart disease renal hypertension cardiomyopathy kidney failure glomerulonephritis diabetic retinopathy Myocardial Reperfusion Injury preeclampsia glucose intolerance anemia visual epilepsy renal tubular dysgenesis of genetic origin myocardial infarction cardiovascular disease cirrhosis of liver focal segmental glomerulosclerosis alcoholic cardiomyopathy potassium deficiency disease ureteral obstruction nephrosis carotid artery disease cholestasis pneumonia congestive heart failure proteinuria anuria malignant hypertension pulmonary fibrosis atherosclerosis bipolar disorder esophageal adenocarcinoma large cell medulloblastoma pneumonitis ulcerative colitis lung cancer psoriasis malignant pancreatic neoplasm diabetic kidney disease arteriosclerosis disorder Down syndrome hypotensive disorder subependymal giant cell astrocytoma interstitial cystitis pancreatic ductal adenocarcinoma pituitary cancer congenital diaphragmatic hernia primitive neuroectodermal tumor lung carcinoma depressive disorder atypical teratoid rhabdoid tumor breast cancer myocardial ischemia essential hypertension, genetic idiopathic interstitial pneumonia fetal growth restriction intellectual disability ischemia reperfusion injury pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia thrombotic disease gastric carcinoma lung adenocarcinoma coronary artery disease heart failure medulloblastoma renal tubular dysgenesis

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
C [auth A], D [auth B]	OPM	Transmembrane	Alpha-helical polytopic	Rhodopsin-like receptors and pumps	G-protein coupled receptors, family A

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
C [auth A], D [auth B]	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
C [auth A], D [auth B]	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
C [auth A], D [auth B]	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	G Protein-Coupled Receptors: Class A	A_2A adenosine receptor with SRP2070_Fab complex

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
D [auth B]	SAR	Parent Component: GLY RESID: AA0063 PSI-MOD : N-methylglycine MOD:00072

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.