7EGA | pdb_00007ega

TFIID-based intermediate PIC on PUMA promoter

External Resource: Annotation


Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyRap30/74 heterodimerisation domain-like 8054050 3000142 SCOP2B (2022-06-29)
J [auth L]SCOP2B SuperfamilyCore histone-like 8042408 3001387 SCOP2B (2022-06-29)
Z [auth l]SCOP2B SuperfamilyCore histone-like 8042408 3001387 SCOP2B (2022-06-29)
K [auth O]SCOP2B SuperfamilyTranscription factor IIA (TFIIA), alpha-helical domain 8037005 3001887 SCOP2B (2022-06-29)
K [auth O]SCOP2B SuperfamilyTranscription factor IIA (TFIIA), beta-barrel domain 8037007 3001281 SCOP2B (2022-06-29)
L [auth P]SCOP2B SuperfamilyTATA-box binding protein-like 8036293 3000705 SCOP2B (2022-06-29)
L [auth P]SCOP2B SuperfamilyTATA-box binding protein-like 8036295 3000705 SCOP2B (2022-06-29)
M [auth Q]SCOP2B SuperfamilyTranscription factor IIA (TFIIA), alpha-helical domain 8037001 3001887 SCOP2B (2022-06-29)
M [auth Q]SCOP2B SuperfamilyTranscription factor IIA (TFIIA), beta-barrel domain 8037002 3001281 SCOP2B (2022-06-29)
N [auth R]SCOP2B SuperfamilyCyclin-like 8043880 3000768 SCOP2B (2022-06-29)
N [auth R]SCOP2B SuperfamilyCyclin-like 8043882 3000768 SCOP2B (2022-06-29)
P [auth T]SCOP2B SuperfamilyWinged helix DNA-binding domain 8003005 3000034 SCOP2B (2022-06-29)
P [auth T]SCOP2B SuperfamilyRap30/74 heterodimerisation domain-like 8003550 3000142 SCOP2B (2022-06-29)
Q [auth U]SCOP2B SuperfamilyZinc beta-ribbon 8043056 3001238 SCOP2B (2022-06-29)
R [auth V]SCOP2B SuperfamilyWinged helix DNA-binding domain 8003067 3000034 SCOP2B (2022-06-29)
S [auth c]SCOP2B SuperfamilyCore histone-like 8086844 3001387 SCOP2B (2022-06-29)
Y [auth k]SCOP2B SuperfamilyCore histone-like 8036824 3001387 SCOP2B (2022-06-29)
AA [auth m]SCOP2B SuperfamilyCore histone-like 8036818 3001387 SCOP2B (2022-06-29)
EA [auth r]SCOP2B SuperfamilyHRDC-like 8101241 3000132 SCOP2B (2022-06-29)
GA [auth t]SCOP2B SuperfamilyRPB6/omega subunit-like 8106082 3000189 SCOP2B (2022-06-29)
C [auth D]SCOP2B SuperfamilyCore histone-like 8042407 3001387 SCOP2B (2022-06-29)
T [auth d]SCOP2B SuperfamilyCore histone-like 8042407 3001387 SCOP2B (2022-06-29)
JA [auth x]SCOP2B SuperfamilyRNA polymerase subunit RPB10 8101287 3001213 SCOP2B (2022-06-29)
KA [auth y]SCOP2B SuperfamilyRBP11-like subunits of RNA polymerase 8080728 3001655 SCOP2B (2022-06-29)
LA [auth z]SCOP2B SuperfamilyRNA polymerase subunits 8103068 3001823 SCOP2B (2022-06-29)
D [auth E]SCOP2B SuperfamilyTaf5 N-terminal domain-like 8034920 3001495 SCOP2B (2022-06-29)
U [auth e]SCOP2B SuperfamilyTaf5 N-terminal domain-like 8034920 3001495 SCOP2B (2022-06-29)
E [auth F]SCOP2B SuperfamilyCore histone-like 8081687 3001387 SCOP2B (2022-06-29)
V [auth f]SCOP2B SuperfamilyCore histone-like 8081687 3001387 SCOP2B (2022-06-29)
F [auth G]SCOP2B SuperfamilyRap30/74 heterodimerisation domain-like 8054049 3000142 SCOP2B (2022-06-29)
G [auth H]SCOP2B SuperfamilyCore histone-like 8053232 3001387 SCOP2B (2022-06-29)
I [auth J]SCOP2B SuperfamilyCore histone-like 8053233 3001387 SCOP2B (2022-06-29)
X [auth j]SCOP2B SuperfamilyCore histone-like 8053233 3001387 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
J [auth L]TFIID_20kDae7egaL1 A: alpha arraysX: Histone-likeH: Histone-relatedT: HistoneF: TFIID_20kDaECOD (1.6)
K [auth O]TFIIA_gamma_Ce7egaO2 A: beta duplicates or obligate multimersX: Transcription factor IIA (TFIIA), beta-barrel domain (From Topology)H: Transcription factor IIA (TFIIA), beta-barrel domain (From Topology)T: Transcription factor IIA (TFIIA), beta-barrel domainF: TFIIA_gamma_CECOD (1.6)
K [auth O]TFIIA_gamma_Ne7egaO1 A: alpha duplicates or obligate multimersX: TFIIA, alpha-helical domain (From Topology)H: TFIIA, alpha-helical domain (From Topology)T: TFIIA, alpha-helical domainF: TFIIA_gamma_NECOD (1.6)
L [auth P]TBPe7egaP2 A: a+b two layersX: TBP-likeH: TATA-box binding protein-like (From Topology)T: TATA-box binding protein-likeF: TBPECOD (1.6)
M [auth Q]TFIIA_Ce7egaQ2 A: beta duplicates or obligate multimersX: Transcription factor IIA (TFIIA), beta-barrel domain (From Topology)H: Transcription factor IIA (TFIIA), beta-barrel domain (From Topology)T: Transcription factor IIA (TFIIA), beta-barrel domainF: TFIIA_CECOD (1.6)
M [auth Q]TFIIA_Ne7egaQ1 A: alpha duplicates or obligate multimersX: TFIIA, alpha-helical domain (From Topology)H: TFIIA, alpha-helical domain (From Topology)T: TFIIA, alpha-helical domainF: TFIIA_NECOD (1.6)
N [auth R]TFIIBe7egaR1 A: alpha arraysX: HTHH: HTHT: Cyclin-likeF: TFIIBECOD (1.6)
N [auth R]TF_Zn_Ribbone7egaR2 A: few secondary structure elementsX: Rubredoxin-likeH: Rubredoxin-relatedT: Rubredoxin-relatedF: TF_Zn_RibbonECOD (1.6)
O [auth S]TFIIF_alpha_Ne7egaS1 A: beta complex topologyX: triple barrel (From Homology)H: triple barrelT: Rap30/74 interaction domains-likeF: TFIIF_alpha_NECOD (1.6)
Q [auth U]TFIIE_alphae7egaU1 A: alpha arraysX: HTHH: HTHT: wingedF: TFIIE_alphaECOD (1.6)
Q [auth U]TF_Zn_Ribbone7egaU2 A: few secondary structure elementsX: Rubredoxin-likeH: Rubredoxin-relatedT: Rubredoxin-relatedF: TF_Zn_RibbonECOD (1.6)
R [auth V]TFIIE_betae7egaV1 A: alpha arraysX: HTHH: HTHT: wingedF: TFIIE_betaECOD (1.6)
R [auth V]KOG3095e7egaV2 A: alpha arraysX: HTHH: HTHT: wingedF: KOG3095ECOD (1.6)
R [auth V]EF-hand_11e7egaV3 A: alpha arraysX: HTHH: HTHT: wingedF: EF-hand_11ECOD (1.6)
BPeptidase_M1_2e7egaB2 A: beta sandwichesX: Baculovirus p35 protein-related (From Topology)H: Baculovirus p35 protein-related (From Topology)T: Baculovirus p35 protein-relatedF: Peptidase_M1_2ECOD (1.6)
BCLASP_N_2e7egaB3 A: alpha superhelicesX: Repetitive alpha hairpinsH: ARM repeat (From Topology)T: ARM repeatF: CLASP_N_2ECOD (1.6)
BPeptidase_M1e7egaB1 A: mixed a+b and a/bX: Zincin-likeH: Metalloproteases (zincins) catalytic domain (From Topology)T: Metalloproteases (zincins) catalytic domainF: Peptidase_M1ECOD (1.6)
Y [auth k]TAFII28e7egak1 A: alpha arraysX: Histone-likeH: Histone-relatedT: HistoneF: TAFII28ECOD (1.6)
BA [auth o]RNA_pol_Rpb1_2e7egao6 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: double psiF: RNA_pol_Rpb1_2ECOD (1.6)
BA [auth o]RNA_pol_Rpb1_2_1e7egao4 A: a+b two layersX: MoeA-I/Ornithine decarboxylase-C/Reverse ferredoxin-like domain in RNA-polymerase (From Topology)H: MoeA-I/Ornithine decarboxylase-C/Reverse ferredoxin-like domain in RNA-polymerase (From Topology)T: MoeA-I/Ornithine decarboxylase-C/Reverse ferredoxin-like domain in RNA-polymeraseF: RNA_pol_Rpb1_2_1ECOD (1.6)
BA [auth o]RNA_pol_Rpb1_7e7egao8 A: a+b two layersX: permuted ferredoxin-like domain in yeast RNA-polymerase beta-prime subunit (From Topology)H: permuted ferredoxin-like domain in yeast RNA-polymerase beta-prime subunit (From Topology)T: permuted ferredoxin-like domain in yeast RNA-polymerase beta-prime subunitF: RNA_pol_Rpb1_7ECOD (1.6)
BA [auth o]RNAP_II_Rpb1_Ce7egao2 A: a+b two layersX: ferredoxin-like domain in yeast RNA-polymerase beta-prime subunit (From Topology)H: ferredoxin-like domain in yeast RNA-polymerase beta-prime subunit (From Topology)T: ferredoxin-like domain in yeast RNA-polymerase beta-prime subunitF: RNAP_II_Rpb1_CECOD (1.6)
BA [auth o]RNA_pol_Rpb1_1e7egao1 A: a+b complex topologyX: N-terminal domain in RNA-polymerase beta-prime subunit (From Topology)H: N-terminal domain in RNA-polymerase beta-prime subunit (From Topology)T: N-terminal domain in RNA-polymerase beta-prime subunitF: RNA_pol_Rpb1_1ECOD (1.6)
BA [auth o]RNA_pol_Rpb1_5_3rde7egao3 A: a+b complex topologyX: central helical domain in RNA-polymerase beta-prime subunit (From Topology)H: central helical domain in RNA-polymerase beta-prime subunit (From Topology)T: central helical domain in RNA-polymerase beta-prime subunitF: RNA_pol_Rpb1_5_3rdECOD (1.6)
BA [auth o]RNA_pol_Rpb1_6e7egao7 A: a+b complex topologyX: helical domain in yeast RNA-polymerasesH: third helical domain in yeast RNA-polymerase II beta-prime subunit (From Topology)T: third helical domain in yeast RNA-polymerase II beta-prime subunitF: RNA_pol_Rpb1_6ECOD (1.6)
BA [auth o]RNA_pol_Rpb1_4e7egao9 A: a+b complex topologyX: second helical domain in RNA-polymerase beta-prime subunit (From Topology)H: second helical domain in RNA-polymerase beta-prime subunit (From Topology)T: second helical domain in RNA-polymerase beta-prime subunitF: RNA_pol_Rpb1_4ECOD (1.6)
BA [auth o]RNA_pol_Rpb1_3e7egao5 A: a+b complex topologyX: first helical domain in RNA-polymerase beta-prime subunit (From Topology)H: first helical domain in RNA-polymerase beta-prime subunit (From Topology)T: first helical domain in RNA-polymerase beta-prime subunitF: RNA_pol_Rpb1_3ECOD (1.6)
CA [auth p]RNA_pol_Rpb2_6_3rd_2e7egap4 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: double psiF: RNA_pol_Rpb2_6_3rd_2ECOD (1.6)
CA [auth p]RNA_pol_Rpb2_6_2nd_1e7egap7 A: a+b complex topologyX: alpha/beta-Hammerhead/Barrel-sandwich hybridH: alpha/beta-Hammerhead/Barrel-sandwich hybridT: Single hybrid motifF: RNA_pol_Rpb2_6_2nd_1ECOD (1.6)
CA [auth p]RNA_pol_Rpb2_3e7egap3 A: a+b complex topologyX: N-terminal domain in beta subunit of DNA dependent RNA-polymerase (From Topology)H: N-terminal domain in beta subunit of DNA dependent RNA-polymerase (From Topology)T: N-terminal domain in beta subunit of DNA dependent RNA-polymeraseF: RNA_pol_Rpb2_3ECOD (1.6)
CA [auth p]RNA_pol_Rpb2_1e7egap5 A: a+b complex topologyX: insertion domain in beta subunit of DNA dependent RNA-polymerase (From Topology)H: insertion domain in beta subunit of DNA dependent RNA-polymerase (From Topology)T: insertion domain in beta subunit of DNA dependent RNA-polymeraseF: RNA_pol_Rpb2_1ECOD (1.6)
CA [auth p]RNA_pol_Rpb2_45_1e7egap2 A: a+b complex topologyX: barrel domain in beta subunit of DNA dependent RNA-polymerase (From Topology)H: barrel domain in beta subunit of DNA dependent RNA-polymerase (From Topology)T: barrel domain in beta subunit of DNA dependent RNA-polymeraseF: RNA_pol_Rpb2_45_1ECOD (1.6)
CA [auth p]RNA_pol_Rpb2_7e7egap1 A: a+b complex topologyX: C-terminal domain in beta subunit of DNA dependent RNA-polymerase (From Topology)H: C-terminal domain in beta subunit of DNA dependent RNA-polymerase (From Topology)T: C-terminal domain in beta subunit of DNA dependent RNA-polymeraseF: RNA_pol_Rpb2_7ECOD (1.6)
CA [auth p]RNA_pol_Rpb2_4e7egap6 A: a+b complex topologyX: inserted a+b domain in yeast RNA polymerase beta subunit (From Topology)H: inserted a+b domain in yeast RNA polymerase beta subunit (From Topology)T: inserted a+b domain in yeast RNA polymerase beta subunitF: RNA_pol_Rpb2_4ECOD (1.6)
DA [auth q]RNA_pol_L_1e7egaq1 A: a+b two layersX: DCoH-likeH: RBP11-like subunits of RNA polymerase (From Topology)T: RBP11-like subunits of RNA polymeraseF: RNA_pol_L_1ECOD (1.6)
DA [auth q]RNA_pol_A_bac_1e7egaq2 A: a+b complex topologyX: Ribosomal protein TL5/L25 C-terminal domain-likeH: Insert subdomain of RNA polymerase alpha subunit (From Topology)T: Insert subdomain of RNA polymerase alpha subunitF: RNA_pol_A_bac_1ECOD (1.6)
EA [auth r]RNA_pol_Rpb4e7egar1 A: alpha arraysX: HhH/H2THH: SAM/DNA-glycosylaseT: SAM domain-likeF: RNA_pol_Rpb4ECOD (1.6)
FA [auth s]RNA_pol_Rpb5_Ce7egas1 A: a+b two layersX: RPB5-like RNA polymerase subunit (From Topology)H: RPB5-like RNA polymerase subunit (From Topology)T: RPB5-like RNA polymerase subunitF: RNA_pol_Rpb5_CECOD (1.6)
FA [auth s]RNA_pol_Rpb5_Ne7egas2 A: a/b three-layered sandwichesX: Restriction endonuclease-likeH: Eukaryotic RPB5 N-terminal domain (From Topology)T: Eukaryotic RPB5 N-terminal domainF: RNA_pol_Rpb5_NECOD (1.6)
GA [auth t]RNA_pol_Rpb6_1e7egat1 A: alpha arraysX: RPB6/omega subunit-like (From Homology)H: RPB6/omega subunit-likeT: RPB6F: RNA_pol_Rpb6_1ECOD (1.6)
HA [auth v]RNA_pol_Rpb8e7egav1 A: beta barrelsX: OB-foldH: Nucleic acid-binding proteins (From Topology)T: Nucleic acid-binding proteinsF: RNA_pol_Rpb8ECOD (1.6)
IA [auth w]RNA_POL_M_15KDe7egaw1 A: few secondary structure elementsX: Rubredoxin-likeH: Rubredoxin-relatedT: Rubredoxin-relatedF: RNA_POL_M_15KDECOD (1.6)
IA [auth w]TFIIS_Ce7egaw2 A: few secondary structure elementsX: Rubredoxin-likeH: Rubredoxin-relatedT: Rubredoxin-relatedF: TFIIS_CECOD (1.6)
JA [auth x]RNA_pol_Ne7egax1 A: alpha arraysX: HTHH: RPB10 (From Topology)T: RPB10F: RNA_pol_NECOD (1.6)
KA [auth y]RNA_pol_L_2e7egay1 A: a+b two layersX: DCoH-likeH: RBP11-like subunits of RNA polymerase (From Topology)T: RBP11-like subunits of RNA polymeraseF: RNA_pol_L_2ECOD (1.6)
LA [auth z]DNA_RNApol_7kDe7egaz1 A: few secondary structure elementsX: Rubredoxin-likeH: Rubredoxin-relatedT: Rubredoxin-relatedF: DNA_RNApol_7kDECOD (1.6)
OA [auth u]S1_1e7egau1 A: beta barrelsX: OB-foldH: Nucleic acid-binding proteins (From Topology)T: Nucleic acid-binding proteinsF: S1_1ECOD (1.6)
OA [auth u]SHS2_Rpb7-Ne7egau2 A: a+b two layersX: Dodecin subunit-likeH: Flavin-binding protein dodecin-like (From Topology)T: Flavin-binding protein dodecin-likeF: SHS2_Rpb7-NECOD (1.6)
D [auth E]ANAPC4_WD40_2e7egaE1 A: beta duplicates or obligate multimersX: beta-propeller-likeH: beta-propellerT: 8-bladedF: ANAPC4_WD40_2ECOD (1.6)
D [auth E]TFIID_NTD2e7egaE2 A: alpha superhelicesX: Taf5 N-terminal domain-like (From Topology)H: Taf5 N-terminal domain-like (From Topology)T: Taf5 N-terminal domain-likeF: TFIID_NTD2ECOD (1.6)
U [auth e]ANAPC4_WD40_10e7egae2 A: beta duplicates or obligate multimersX: beta-propeller-likeH: beta-propellerT: 8-bladedF: ANAPC4_WD40_10ECOD (1.6)
U [auth e]TFIID_NTD2e7egae1 A: alpha superhelicesX: Taf5 N-terminal domain-like (From Topology)H: Taf5 N-terminal domain-like (From Topology)T: Taf5 N-terminal domain-likeF: TFIID_NTD2ECOD (1.6)
I [auth J]TFIID_30kDae7egaJ1 A: alpha arraysX: Histone-likeH: Histone-relatedT: HistoneF: TFIID_30kDaECOD (1.6)
X [auth j]TFIID_30kDae7egaj1 A: alpha arraysX: Histone-likeH: Histone-relatedT: HistoneF: TFIID_30kDaECOD (1.6)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF12157Protein of unknown function (DUF3591) (DUF3591)Protein of unknown function (DUF3591)- Family
J [auth L],
Z [auth l]		PF03847Transcription initiation factor TFIID subunit A (TFIID_20kDa)Transcription initiation factor TFIID subunit ADomain
K [auth O]PF02751Transcription initiation factor IIA, gamma subunit (TFIIA_gamma_C)Transcription initiation factor IIA, gamma subunitAccurate transcription in vivo requires at least six general transcription initiation factors, in addition to RNA polymerase II. Transcription initiation factor IIA (TFIIA) is a multimeric protein which facilitates the binding of TFIID to the TATA b ...Domain
K [auth O]PF04997RNA polymerase Rpb1, domain 1 (RNA_pol_Rpb1_1)RNA polymerase Rpb1, domain 1RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain, domain 1, represents the clamp dom ...Domain
L [auth P]PF04561RNA polymerase Rpb2, domain 2 (RNA_pol_Rpb2_2)RNA polymerase Rpb2, domain 2RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Rpb2 is the second largest subunit of the RNA po ...Domain
L [auth P]PF00352Transcription factor TFIID (or TATA-binding protein, TBP) (TBP)Transcription factor TFIID (or TATA-binding protein, TBP)Domain
L [auth P]PF04563RNA polymerase beta subunit (RNA_pol_Rpb2_1)RNA polymerase beta subunit- Family
M [auth Q]PF03153Transcription factor IIA, alpha/beta subunit (TFIIA)Transcription factor IIA, alpha/beta subunit- Family
M [auth Q]PF01193RNA polymerase Rpb3/Rpb11 dimerisation domain (RNA_pol_L)RNA polymerase Rpb3/Rpb11 dimerisation domainThe two eukaryotic subunits Rpb3 and Rpb11 dimerise to from a platform onto which the other subunits of the RNA polymerase assemble (D/L in archaea). The prokaryotic equivalent of the Rpb3/Rpb11 platform is the alpha-alpha dimer. The dimerisation do ...Domain
M [auth Q]PF01000RNA polymerase Rpb3/RpoA insert domain (RNA_pol_A_bac)RNA polymerase Rpb3/RpoA insert domainMembers of this family include: alpha subunit from eubacteria alpha subunits from chloroplasts Rpb3 subunits from eukaryotes RpoD subunits from archaeal Domain
N [auth R]PF00382Transcription factor TFIIB repeat (TFIIB)Transcription factor TFIIB repeatDomain
N [auth R]PF08271TFIIB zinc-binding (Zn_Ribbon_TF)TFIIB zinc-bindingThe transcription factor TFIIB contains a zinc-binding motif near the N-terminus. This domain is involved in the interaction with RNA pol II and TFIIF and plays a crucial role in selecting the transcription initiation site. The domain adopts a zinc ...Domain
N [auth R]PF03874RNA polymerase Rpb4 (RNA_pol_Rpb4)RNA polymerase Rpb4- Family
O [auth S]PF01191RNA polymerase Rpb5, C-terminal domain (RNA_pol_Rpb5_C)RNA polymerase Rpb5, C-terminal domainThe assembly domain of Rpb5 [1]. The archaeal equivalent to this domain is subunit H. Subunit H lacks the N-terminal domain. Domain
O [auth S]PF03871RNA polymerase Rpb5, N-terminal domain (RNA_pol_Rpb5_N)RNA polymerase Rpb5, N-terminal domainRpb5 has a bipartite structure which includes a eukaryote-specific N-terminal domain and a C-terminal domain resembling the archaeal RNAP subunit H [1,2]. The N-terminal domain is involved in DNA binding and is part of the jaw module in the RNA p ...Domain
P [auth T]PF02270TFIIF, beta subunit HTH domain (TFIIF_beta)TFIIF, beta subunit HTH domainAccurate transcription in vivo requires at least six general transcription initiation factors, in addition to RNA polymerase II. Transcription initiation factor IIF (TFIIF) is a tetramer of two beta subunits associate with two alpha subunits which ...Domain
P [auth T]PF01192RNA polymerase Rpb6 (RNA_pol_Rpb6)RNA polymerase Rpb6- Family
P [auth T]PF17683TFIIF, beta subunit N-terminus (TFIIF_beta_N)TFIIF, beta subunit N-terminus- Family
Q [auth U]PF08271TFIIB zinc-binding (Zn_Ribbon_TF)TFIIB zinc-bindingThe transcription factor TFIIB contains a zinc-binding motif near the N-terminus. This domain is involved in the interaction with RNA pol II and TFIIF and plays a crucial role in selecting the transcription initiation site. The domain adopts a zinc ...Domain
Q [auth U]PF02002TFIIE alpha subunit (TFIIE_alpha)TFIIE alpha subunit- Family
Q [auth U]PF03876SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 (SHS2_Rpb7-N)SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397Rpb7 bind to Rpb4 to form a heterodimer. This complex is thought to interact with the nascent RNA strand during RNA polymerase II elongation[1]. This family includes the homologs from RNA polymerase I and III. In RNA polymerase I, Rpa43 is at leas ...Domain
Q [auth U]PF00575S1 RNA binding domain (S1)S1 RNA binding domainThe S1 domain occurs in a wide range of RNA associated proteins. It is structurally similar to cold shock protein which binds nucleic acids. The S1 domain has an OB-fold structure. Domain
R [auth V]PF18121TFA2 Winged helix domain 2 (TFA2_Winged_2)TFA2 Winged helix domain 2This is the second winged helix domain can be found in TFA2 proteins present in Saccharomyces cerevisiae. In form 2, the domain interacts directly with Rad3, a DNA helicase [1]. Domain
R [auth V]PF02186TFIIE beta subunit core domain (TFIIE_beta)TFIIE beta subunit core domainGeneral transcription factor TFIIE consists of two subunits, TFIIE alpha Pfam:PF02002 and TFIIE beta. TFIIE beta has been found to bind to the region where the promoter starts to open to be single-stranded upon transcription initiation by RNA polymer ...Domain
R [auth V]PF03870RNA polymerase Rpb8 (RNA_pol_Rpb8)RNA polymerase Rpb8- Family
MA [auth X]PF01194RNA polymerases N / 8 kDa subunit (RNA_pol_N)RNA polymerases N / 8 kDa subunitDomain
NA [auth Y]PF13656RNA polymerase Rpb3/Rpb11 dimerisation domain (RNA_pol_L_2)RNA polymerase Rpb3/Rpb11 dimerisation domainThe two eukaryotic subunits Rpb3 and Rpb11 dimerise to from a platform onto which the other subunits of the RNA polymerase assemble (D/L in archaea). The prokaryotic equivalent of the Rpb3/Rpb11 platform is the alpha-alpha dimer. The dimerisation do ...Domain
D [auth E],
U [auth e]		PF04494WD40 associated region in TFIID subunit, NTD2 domain (TFIID_NTD2)WD40 associated region in TFIID subunit, NTD2 domain- Family
D [auth E],
U [auth e]		PF00400WD domain, G-beta repeat (WD40)WD domain, G-beta repeat- Repeat
E [auth F],
V [auth f]		PF07571TAF6 C-terminal HEAT repeat domain (TAF6_C)TAF6 C-terminal HEAT repeat domain- Repeat
E [auth F],
V [auth f]		PF02969TATA box binding protein associated factor (TAF) (TAF)TATA box binding protein associated factor (TAF)TAF proteins adopt a histone-like fold. Domain
F [auth G]PF04658TAFII55 protein conserved region (TAFII55_N)TAFII55 protein conserved region- Family
G [auth H]PF07524Bromodomain associated (Bromo_TP)Bromodomain associatedThis domain is predicted to bind DNA [1] and is often found associated with Pfam:PF00439 and in transcription factors. It has a histone-like fold. Domain
G [auth H]PF10406Transcription factor TFIID complex subunit 8 C-term (TAF8_C)Transcription factor TFIID complex subunit 8 C-termThis is the C-terminal, Delta, part of the TAF8 protein [1]. The N-terminal is generally the histone fold domain, Bromo_TP (Pfam:PF07524). TAF8 is one of the key subunits of the transcription factor for pol II, TFIID. TAF8 is one of the several gener ...Domain
I [auth J],
X [auth j]		PF03540Transcription initiation factor TFIID 23-30kDa subunit (TAF10)Transcription initiation factor TFIID 23-30kDa subunit- Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
Transcription initiation factor TFIID subunit 1
J [auth L],
Z [auth l]		Transcription initiation factor TFIID subunit 12
K [auth O]Transcription initiation factor IIA subunit 2
L [auth P]TATA-box-binding protein
M [auth Q]Transcription initiation factor IIA subunit 1
N [auth R]Transcription initiation factor IIB
O [auth S]General transcription factor IIF subunit 1
P [auth T]General transcription factor IIF subunit 2
Q [auth U]General transcription factor IIE subunit 1
R [auth V]Transcription initiation factor IIE subunit beta
S [auth c]Transcription initiation factor TFIID subunit 3
Transcription initiation factor TFIID subunit 2
Y [auth k]Transcription initiation factor TFIID subunit 11
AA [auth m]Transcription initiation factor TFIID subunit 13
BA [auth o]DNA-directed RNA polymerase subunit -
CA [auth p]DNA-directed RNA polymerase subunit beta -
DA [auth q]DNA-directed RNA polymerase II subunit RPB3
EA [auth r]DNA-directed RNA polymerase II subunit RPB4
FA [auth s]DNA-directed RNA polymerase II subunit E
GA [auth t]DNA-directed RNA polymerase II subunit F
HA [auth v]DNA-directed RNA polymerases I, II, and III subunit RPABC3
IA [auth w]DNA-directed RNA polymerase II subunit RPB9
C [auth D],
T [auth d]		Transcription initiation factor TFIID subunit 4
JA [auth x]RPB10
KA [auth y]RNA_pol_L_2 domain-containing protein -
LA [auth z]RPB12
MA [auth X]DNA (85-MER)---
NA [auth Y]DNA (85-MER)---
OA [auth u]DNA-directed RNA polymerase II subunit RPB7
D [auth E],
U [auth e]		Transcription initiation factor TFIID subunit 5
E [auth F],
V [auth f]		Transcription initiation factor TFIID subunit 6
F [auth G]Transcription initiation factor TFIID subunit 7
G [auth H]Transcription initiation factor TFIID subunit 8
H [auth I],
W [auth i]		Transcription initiation factor TFIID subunit 9
I [auth J],
X [auth j]		Transcription initiation factor TFIID subunit 10

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
IPR018359Bromodomain, conserved siteConserved Site
IPR009067TAFII-230 TBP-bindingDomain
IPR040240Transcription initiation factor TFIID subunit 1Family
IPR011177Transcription initiation factor TFIID subunit 1, animalFamily
IPR022591Transcription initiation factor TFIID subunit 1, histone acetyltransferase domainDomain
IPR036427Bromodomain-like superfamilyHomologous Superfamily
IPR001487BromodomainDomain
IPR041670Zinc knuckleDomain
IPR036741TAFII-230 TBP-binding domain superfamilyHomologous Superfamily
J [auth L],
Z [auth l]		IPR009072Histone-foldHomologous Superfamily
J [auth L],
Z [auth l]		IPR037794Transcription initiation factor TFIID subunit 12Family
J [auth L],
Z [auth l]		IPR003228Transcription initiation factor TFIID subunit 12 domainDomain
K [auth O]IPR015871Transcription initiation factor IIA, gamma subunit, C-terminalDomain
K [auth O]IPR015872Transcription initiation factor IIA, gamma subunit, N-terminalDomain
K [auth O]IPR009083Transcription factor IIA, alpha-helical domainHomologous Superfamily
K [auth O]IPR009088Transcription factor IIA, beta-barrelHomologous Superfamily
K [auth O]IPR003194Transcription initiation factor IIA, gamma subunitFamily
L [auth P]IPR030491TATA-box binding protein, conserved siteConserved Site
L [auth P]IPR000814TATA-box binding proteinFamily
L [auth P]IPR012295TBP domain superfamilyHomologous Superfamily
L [auth P]IPR033710TATA-box binding protein, eukaryoticFamily
M [auth Q]IPR004855Transcription factor IIA, alpha/beta subunitFamily
M [auth Q]IPR009088Transcription factor IIA, beta-barrelHomologous Superfamily
N [auth R]IPR000812Transcription factor TFIIBFamily
N [auth R]IPR013137Zinc finger, TFIIB-typeDomain
N [auth R]IPR023486Transcription factor TFIIB, conserved siteConserved Site
N [auth R]IPR013150Transcription factor TFIIB, cyclin-like domainDomain
N [auth R]IPR036915Cyclin-like superfamilyHomologous Superfamily
N [auth R]IPR013763Cyclin-like domainDomain
O [auth S]IPR008851Transcription initiation factor IIF, alpha subunitFamily
O [auth S]IPR036388Winged helix-like DNA-binding domain superfamilyHomologous Superfamily
O [auth S]IPR036390Winged helix DNA-binding domain superfamilyHomologous Superfamily
O [auth S]IPR011039Transcription Factor IIF, Rap30/Rap74, interactionHomologous Superfamily
P [auth T]IPR003196Transcription initiation factor IIF, beta subunitFamily
P [auth T]IPR036388Winged helix-like DNA-binding domain superfamilyHomologous Superfamily
P [auth T]IPR036390Winged helix DNA-binding domain superfamilyHomologous Superfamily
P [auth T]IPR040450TFIIF beta subunit, HTH domainDomain
P [auth T]IPR040504TFIIF, beta subunit, N-terminalDomain
P [auth T]IPR011039Transcription Factor IIF, Rap30/Rap74, interactionHomologous Superfamily
Q [auth U]IPR021600Transcription factor TFIIE alpha subunit, C-terminalDomain
Q [auth U]IPR024550TFIIEalpha/SarR/Rpc3 HTH domainDomain
Q [auth U]IPR013083Zinc finger, RING/FYVE/PHD-typeHomologous Superfamily
Q [auth U]IPR013137Zinc finger, TFIIB-typeDomain
Q [auth U]IPR039997Transcription factor EFamily
Q [auth U]IPR017919Transcription factor TFE/TFIIEalpha HTH domainDomain
Q [auth U]IPR002853Transcription initiation factor IIE subunit alpha, N-terminalDomain
R [auth V]IPR036388Winged helix-like DNA-binding domain superfamilyHomologous Superfamily
R [auth V]IPR003166Transcription factor TFIIE beta subunit, DNA-binding domainDomain
R [auth V]IPR036390Winged helix DNA-binding domain superfamilyHomologous Superfamily
R [auth V]IPR040501TFA2, Winged helix domain 2Domain
R [auth V]IPR016656Transcription initiation factor TFIIE, beta subunitFamily
S [auth c]IPR009072Histone-foldHomologous Superfamily
S [auth c]IPR001965Zinc finger, PHD-typeDomain
S [auth c]IPR006565Bromodomain associated domainDomain
S [auth c]IPR013083Zinc finger, RING/FYVE/PHD-typeHomologous Superfamily
S [auth c]IPR019787Zinc finger, PHD-fingerDomain
S [auth c]IPR011011Zinc finger, FYVE/PHD-typeHomologous Superfamily
S [auth c]IPR019786Zinc finger, PHD-type, conserved siteConserved Site
IPR016024Armadillo-type foldHomologous Superfamily
IPR027268Peptidase M4/M1, CTD superfamilyHomologous Superfamily
IPR037813Transcription initiation factor TFIID subunit 2Family
IPR042097Aminopeptidase N-like , N-terminal domain superfamliyHomologous Superfamily
Y [auth k]IPR009072Histone-foldHomologous Superfamily
Y [auth k]IPR045127Transcription initiation factor TFIID subunit 11-likeFamily
Y [auth k]IPR006809TAFII28-like protein domainDomain
AA [auth m]IPR009072Histone-foldHomologous Superfamily
AA [auth m]IPR003195Transcription initiation factor IID, subunit 13Family
BA [auth o]IPR007081RNA polymerase Rpb1, domain 5Domain
BA [auth o]IPR045867DNA-directed RNA polymerase, subunit beta-primeFamily
BA [auth o]IPR007075RNA polymerase Rpb1, domain 6Domain
BA [auth o]IPR000684RNA polymerase II, heptapeptide repeat, eukaryoticRepeat
BA [auth o]IPR007083RNA polymerase Rpb1, domain 4Domain
BA [auth o]IPR044893RNA polymerase Rpb1, clamp domain superfamilyHomologous Superfamily
BA [auth o]IPR006592RNA polymerase, N-terminalDomain
BA [auth o]IPR007066RNA polymerase Rpb1, domain 3Domain
BA [auth o]IPR007073RNA polymerase Rpb1, domain 7Domain
BA [auth o]IPR042102RNA polymerase Rpb1, domain 3 superfamilyHomologous Superfamily
BA [auth o]IPR038593RNA polymerase Rpb1, domain 7 superfamilyHomologous Superfamily
BA [auth o]IPR000722RNA polymerase, alpha subunitDomain
BA [auth o]IPR038120RNA polymerase Rpb1, funnel domain superfamilyHomologous Superfamily
BA [auth o]IPR007080RNA polymerase Rpb1, domain 1Domain
CA [auth p]IPR007120DNA-directed RNA polymerase, subunit 2, hybrid-binding domainDomain
CA [auth p]IPR007121RNA polymerase, beta subunit, conserved siteConserved Site
CA [auth p]IPR007646RNA polymerase Rpb2, domain 4Domain
CA [auth p]IPR007647RNA polymerase Rpb2, domain 5Domain
CA [auth p]IPR014724RNA polymerase Rpb2, OB-foldHomologous Superfamily
CA [auth p]IPR007642RNA polymerase Rpb2, domain 2Domain
CA [auth p]IPR015712DNA-directed RNA polymerase, subunit 2Family
CA [auth p]IPR037033DNA-directed RNA polymerase, subunit 2, hybrid-binding domain superfamilyHomologous Superfamily
CA [auth p]IPR037034RNA polymerase Rpb2, domain 2 superfamilyHomologous Superfamily
CA [auth p]IPR007645RNA polymerase Rpb2, domain 3Domain
CA [auth p]IPR007644RNA polymerase, beta subunit, protrusionDomain
CA [auth p]IPR007641RNA polymerase Rpb2, domain 7Domain
DA [auth q]IPR011262DNA-directed RNA polymerase, insert domainDomain
DA [auth q]IPR011263DNA-directed RNA polymerase, RpoA/D/Rpb3-typeDomain
DA [auth q]IPR050518Archaeal Rpo3/Eukaryotic RPB3 RNA Polymerase SubunitFamily
DA [auth q]IPR022842DNA-directed RNA polymerase subunit Rpo3/Rpb3/RPAC1Family
DA [auth q]IPR036643DNA-directed RNA polymerase, insert domain superfamilyHomologous Superfamily
DA [auth q]IPR001514DNA-directed RNA polymerase, 30-40kDa subunit, conserved siteConserved Site
DA [auth q]IPR036603RNA polymerase, RBP11-like subunitHomologous Superfamily
EA [auth r]IPR005574RNA polymerase subunit Rpb4/RPC9Family
EA [auth r]IPR010997HRDC-like superfamilyHomologous Superfamily
EA [auth r]IPR006590RNA polymerase Rpb4/RPC9, coreDomain
EA [auth r]IPR038324Rpb4/RPC9 superfamilyHomologous Superfamily
EA [auth r]IPR045222DNA-directed RNA polymerase II subunit Rpb4-likeFamily
FA [auth s]IPR014381DNA-directed RNA polymerase subunit Rpo5/Rpb5Family
FA [auth s]IPR036710RNA polymerase Rpb5, N-terminal domain superfamilyHomologous Superfamily
FA [auth s]IPR035913RPB5-like RNA polymerase subunit superfamilyHomologous Superfamily
FA [auth s]IPR000783RNA polymerase, subunit H/Rpb5 C-terminalDomain
FA [auth s]IPR020608RNA polymerase, subunit H/Rpb5, conserved siteConserved Site
FA [auth s]IPR005571RNA polymerase, Rpb5, N-terminalDomain
GA [auth t]IPR020708DNA-directed RNA polymerase, 14-18kDa subunit, conserved siteConserved Site
GA [auth t]IPR036161RPB6/omega subunit-like superfamilyHomologous Superfamily
GA [auth t]IPR028363DNA-directed RNA polymerase, subunit RPB6Family
GA [auth t]IPR006110RNA polymerase, subunit omega/Rpo6/RPB6Family
GA [auth t]IPR006111Archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunitFamily
HA [auth v]IPR012340Nucleic acid-binding, OB-foldHomologous Superfamily
HA [auth v]IPR005570DNA-directed RNA polymerases I, II, and III subunit RPABC3Family
IA [auth w]IPR001529DNA-directed RNA polymerase II subunit RPB9-like, zinc ribbonDomain
IA [auth w]IPR012164DNA-directed RNA polymerase subunit/transcription factor SFamily
IA [auth w]IPR001222Zinc finger, TFIIS-typeDomain
IA [auth w]IPR034012Pol II subunit B9, C-terminal zinc ribbonDomain
IA [auth w]IPR019761DNA-directed RNA polymerase M, 15kDa subunit, conserved siteConserved Site
C [auth D],
T [auth d]		IPR003894TAFH/NHR1Domain
C [auth D],
T [auth d]		IPR007900Transcription initiation factor TFIID component TAF4, C-terminalDomain
C [auth D],
T [auth d]		IPR009072Histone-foldHomologous Superfamily
C [auth D],
T [auth d]		IPR045144Transcription initiation factor TFIID component TAF4Family
C [auth D],
T [auth d]		IPR037249TAFH/NHR1 domain superfamilyHomologous Superfamily
JA [auth x]IPR023580RNA polymerase subunit RPB10Homologous Superfamily
JA [auth x]IPR020789RNA polymerases, subunit N, zinc binding siteBinding Site
JA [auth x]IPR000268DNA-directed RNA polymerase subunit RPABC5/Rpb10Family
KA [auth y]IPR022905DNA-directed RNA polymerase subunit Rpo11-likeFamily
KA [auth y]IPR009025DNA-directed RNA polymerase, RBP11-like dimerisation domainDomain
KA [auth y]IPR036603RNA polymerase, RBP11-like subunitHomologous Superfamily
KA [auth y]IPR008193DNA-directed RNA polymerase Rpb11, 13-16kDa subunit, conserved siteConserved Site
KA [auth y]IPR037685RNA polymerase RBP11Family
LA [auth z]IPR006591RNA polymerase archaeal subunit P/eukaryotic subunit RPABC4Family
LA [auth z]IPR029040RNA polymerase subunit RPABC4/transcription elongation factor Spt4Homologous Superfamily
LA [auth z]IPR039747DNA-directed RNA polymerases I, II, and III subunit RPABC4Family
OA [auth u]IPR036898RNA polymerase Rpb7-like, N-terminal domain superfamilyHomologous Superfamily
OA [auth u]IPR003029S1 domainDomain
OA [auth u]IPR012340Nucleic acid-binding, OB-foldHomologous Superfamily
OA [auth u]IPR045113RNA polymerase subunit Rpb7-likeFamily
OA [auth u]IPR005576RNA polymerase Rpb7-like , N-terminalDomain
D [auth E],
U [auth e]		IPR007582TFIID subunit TAF5, NTD2 domainDomain
D [auth E],
U [auth e]		IPR019775WD40 repeat, conserved siteConserved Site
D [auth E],
U [auth e]		IPR006594LIS1 homology motifConserved Site
D [auth E],
U [auth e]		IPR015943WD40/YVTN repeat-like-containing domain superfamilyHomologous Superfamily
D [auth E],
U [auth e]		IPR037264TFIID subunit TAF5, NTD2 domain superfamilyHomologous Superfamily
D [auth E],
U [auth e]		IPR036322WD40-repeat-containing domain superfamilyHomologous Superfamily
D [auth E],
U [auth e]		IPR001680WD40 repeatRepeat
D [auth E],
U [auth e]		IPR020472G-protein beta WD-40 repeatRepeat
E [auth F],
V [auth f]		IPR011442TAF6, C-terminal HEAT repeat domainDomain
E [auth F],
V [auth f]		IPR016024Armadillo-type foldHomologous Superfamily
E [auth F],
V [auth f]		IPR009072Histone-foldHomologous Superfamily
E [auth F],
V [auth f]		IPR037796Transcription initiation factor TFIID subunit 6Family
E [auth F],
V [auth f]		IPR046344TAF6, C-terminal HEAT repeat domain superfamilyHomologous Superfamily
E [auth F],
V [auth f]		IPR004823TATA box binding protein associated factor (TAF), histone-like fold domainDomain
F [auth G]IPR006751TAFII55 protein, conserved regionDomain
F [auth G]IPR037817Transcription initiation factor TFIID subunit 7Family
G [auth H]IPR009072Histone-foldHomologous Superfamily
G [auth H]IPR037818Transcription initiation factor TFIID subunit 8Family
G [auth H]IPR006565Bromodomain associated domainDomain
G [auth H]IPR019473Transcription factor TFIID, subunit 8, C-terminalDomain
H [auth I],
W [auth i]		IPR051431Transcription initiation factor TFIID subunit 9Family
H [auth I],
W [auth i]		IPR009072Histone-foldHomologous Superfamily
H [auth I],
W [auth i]		IPR003162Transcription initiation factor TAFII31Family
I [auth J],
X [auth j]		IPR003923Transcription initiation factor TFIID, subunit 10Family

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
Pharos:  P21675
J [auth L],
Z [auth l]		Pharos:  Q16514
K [auth O]Pharos:  P52657
L [auth P]Pharos:  P20226
M [auth Q]Pharos:  P52655
N [auth R]Pharos:  Q00403
P [auth T]Pharos:  P13984
Q [auth U]Pharos:  P29083
R [auth V]Pharos:  P29084
S [auth c]Pharos:  Q5VWG9
Pharos:  Q6P1X5
Y [auth k]Pharos:  Q15544
AA [auth m]Pharos:  Q15543
C [auth D],
T [auth d]		Pharos:  O00268
D [auth E],
U [auth e]		Pharos:  Q15542
E [auth F],
V [auth f]		Pharos:  P49848
F [auth G]Pharos:  Q15545
G [auth H]Pharos:  Q7Z7C8
H [auth I],
W [auth i]		Pharos:  Q16594
I [auth J],
X [auth j]		Pharos:  Q12962