Annotations: 7EGH

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Rap30/74 heterodimerisation domain-like	8054050	3000142	SCOP2B (2022-06-29)
D [auth G]	SCOP2B Superfamily	Rap30/74 heterodimerisation domain-like	8054049	3000142	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	Peptidase_M1_2	e7eghB3	A: beta sandwiches	X: Baculovirus p35 protein-related (From Topology)	H: Baculovirus p35 protein-related (From Topology)	T: Baculovirus p35 protein-related	F: Peptidase_M1_2	ECOD (1.6)
B	CLASP_N_2	e7eghB1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: CLASP_N_2	ECOD (1.6)
B	Peptidase_M1	e7eghB2	A: mixed a+b and a/b	X: Zincin-like	H: Metalloproteases (zincins) catalytic domain (From Topology)	T: Metalloproteases (zincins) catalytic domain	F: Peptidase_M1	ECOD (1.6)
H [auth f]	TAF6_C	e7eghf1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: TAF6_C	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF12157	Protein of unknown function (DUF3591) (DUF3591)	Protein of unknown function (DUF3591)	-	Family
C [auth F], H [auth f]	PF07571	TAF6 C-terminal HEAT repeat domain (TAF6_C)	TAF6 C-terminal HEAT repeat domain	-	Repeat
D [auth G]	PF04658	TAFII55 protein conserved region (TAFII55_N)	TAFII55 protein conserved region	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B	Transcription initiation factor TFIID subunit 2	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding binding double-stranded DNA binding nucleic acid binding transcription regulatory region nucleic acid binding chromatin binding general transcription initiation factor activity RNA polymerase II general transcription initiation factor activity	regulation of cellular process positive regulation of DNA-templated transcription positive regulation of biological process RNA metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription positive regulation of metabolic process regulation of DNA-templated transcription initiation regulation of RNA metabolic process transcription by RNA polymerase II positive regulation of biosynthetic process regulation of cellular process positive regulation of DNA-templated transcription positive regulation of biological process RNA metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription positive regulation of metabolic process regulation of DNA-templated transcription initiation regulation of RNA metabolic process transcription by RNA polymerase II positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process transcription initiation at RNA polymerase II promoter positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of transcription by RNA polymerase II regulation of biological process positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription initiation by RNA polymerase II biological regulation primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression positive regulation of transcription by RNA polymerase II macromolecule biosynthetic process nucleic acid metabolic process DNA-templated transcription initiation positive regulation of DNA-templated transcription initiation positive regulation of RNA metabolic process regulation of gene expression biosynthetic process positive regulation of RNA biosynthetic process regulation of transcription initiation by RNA polymerase II cellular process metabolic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription macromolecule metabolic process regulation of metabolic process transcription preinitiation complex assembly cellular component organization cellular component biogenesis protein-DNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis protein-containing complex organization protein-DNA complex assembly RNA polymerase II preinitiation complex assembly mRNA transcription by RNA polymerase II mRNA transcription mRNA metabolic process cell cycle G2/M phase transition mitotic cell cycle process G2/M transition of mitotic cell cycle cell cycle phase transition cell cycle mitotic cell cycle cell cycle process mitotic cell cycle phase transition cellular response to stimulus response to stimulus regulation of cellular response to stress cellular response to stress response to stress regulation of response to stress DNA repair DNA metabolic process regulation of DNA repair DNA damage response regulation of response to stimulus regulation of DNA metabolic process	RNA polymerase II transcription regulator complex membrane-bounded organelle transcription factor TFTC complex RNA polymerase II, holoenzyme protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex transcription regulator complex chromosome transferase complex histone acetyltransferase complex intracellular organelle lumen RNA polymerase II transcription regulator complex membrane-bounded organelle transcription factor TFTC complex RNA polymerase II, holoenzyme protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex transcription regulator complex chromosome transferase complex histone acetyltransferase complex intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm membraneless organelle SAGA-type complex catalytic complex intracellular membraneless organelle chromatin intracellular membrane-bounded organelle acetyltransferase complex transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex organelle lumen organelle RNA polymerase complex protein acetyltransferase complex DNA-directed RNA polymerase complex intracellular protein-containing complex nuclear lumen transcription factor TFIID complex
E [auth H]	Transcription initiation factor TFIID subunit 8	protein heterodimerization activity protein binding binding protein dimerization activity general transcription initiation factor activity RNA polymerase II general transcription initiation factor activity	regulation of cellular process positive regulation of DNA-templated transcription positive regulation of biological process RNA metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription positive regulation of metabolic process regulation of DNA-templated transcription initiation regulation of RNA metabolic process transcription by RNA polymerase II positive regulation of biosynthetic process regulation of cellular process positive regulation of DNA-templated transcription positive regulation of biological process RNA metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription positive regulation of metabolic process regulation of DNA-templated transcription initiation regulation of RNA metabolic process transcription by RNA polymerase II positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process transcription initiation at RNA polymerase II promoter positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of transcription by RNA polymerase II regulation of biological process positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription initiation by RNA polymerase II biological regulation primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression positive regulation of transcription by RNA polymerase II macromolecule biosynthetic process nucleic acid metabolic process DNA-templated transcription initiation positive regulation of DNA-templated transcription initiation positive regulation of RNA metabolic process regulation of gene expression biosynthetic process positive regulation of RNA biosynthetic process regulation of transcription initiation by RNA polymerase II cellular process metabolic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription macromolecule metabolic process regulation of metabolic process developmental process cellular developmental process cell differentiation transcription preinitiation complex assembly cellular component organization cellular component biogenesis protein-DNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis protein-containing complex organization protein-DNA complex assembly RNA polymerase II preinitiation complex assembly maintenance of protein location protein localization cellular localization maintenance of protein location in nucleus protein localization to nucleus maintenance of location maintenance of location in cell localization maintenance of protein location in cell cellular macromolecule localization macromolecule localization protein localization to organelle maintenance of protein localization in organelle fat cell differentiation regulation of developmental process regulation of cell differentiation regulation of fat cell differentiation mRNA transcription by RNA polymerase II mRNA transcription mRNA metabolic process multicellular organismal process inner cell mass cell proliferation cell population proliferation developmental growth chordate embryonic development growth embryo development in utero embryonic development multicellular organism development embryo development ending in birth or egg hatching anatomical structure development blastocyst growth blastocyst development protein-DNA complex remodeling DNA-templated transcription open complex formation protein-containing complex remodeling	cellular anatomical structure intracellular anatomical structure perinuclear region of cytoplasm cytoplasm RNA polymerase II transcription regulator complex membrane-bounded organelle RNA polymerase II, holoenzyme protein-containing complex nucleus membrane-enclosed lumen nuclear protein-containing complex transcription regulator complex transferase complex intracellular organelle lumen cellular anatomical structure intracellular anatomical structure perinuclear region of cytoplasm cytoplasm RNA polymerase II transcription regulator complex membrane-bounded organelle RNA polymerase II, holoenzyme protein-containing complex nucleus membrane-enclosed lumen nuclear protein-containing complex transcription regulator complex transferase complex intracellular organelle lumen intracellular organelle nucleoplasm catalytic complex intracellular membrane-bounded organelle transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex organelle lumen organelle RNA polymerase complex transcription factor TFIID complex DNA-directed RNA polymerase complex intracellular protein-containing complex nuclear lumen
G [auth Y]	DNA (45-MER)	-	-	-
A	Transcription initiation factor TFIID subunit 1	protein serine/threonine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity DNA-dependent protein kinase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups sequence-specific DNA binding DNA binding binding nucleic acid binding adenyl ribonucleotide binding protein serine/threonine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity DNA-dependent protein kinase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups sequence-specific DNA binding DNA binding binding nucleic acid binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding histone H3T6 kinase activity histone H3 kinase activity histone modifying activity histone kinase activity double-stranded DNA binding core promoter sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding transcription regulatory region nucleic acid binding histone H3S57 kinase activity protein-lysine-acetyltransferase activity protein N-acetyltransferase activity N-acetyltransferase activity acyltransferase activity histone acetyltransferase activity acetyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups N-acyltransferase activity histone H4 acetyltransferase activity histone H4K8 acetyltransferase activity histone H3 acetyltransferase activity histone H3K14 acetyltransferase activity transcription factor binding basal transcription machinery binding protein binding basal RNA polymerase II transcription machinery binding general transcription initiation factor binding RNA polymerase II general transcription initiation factor binding histone H4S1 kinase activity histone H4 kinase activity histone H2B acetyltransferase activity histone H2BK12 acetyltransferase activity histone H2A acetyltransferase activity histone H2AK5 acetyltransferase activity histone H4K5 acetyltransferase activity histone H3T11 kinase activity histone H3S28 kinase activity histone H2B kinase activity histone H2BS36 kinase activity RNA polymerase II-specific DNA-binding transcription factor binding nuclear receptor binding DNA-binding transcription factor binding ribosomal protein S6 kinase activity histone H3K36 acetyltransferase activity histone H3S10 kinase activity histone H3K23 acetyltransferase activity histone H2AS121 kinase activity histone H2A kinase activity histone H3K56 acetyltransferase activity histone H3K122 acetyltransferase activity ubiquitin conjugating enzyme activity aminoacyltransferase activity ubiquitin-like protein transferase activity ubiquitin-like protein conjugating enzyme activity ubiquitin-protein transferase activity molecular function inhibitor activity transcription regulator activity molecular function regulator activity transcription regulator inhibitor activity AMP-activated protein kinase activity histone H3K9 acetyltransferase activity histone H3T45 kinase activity eukaryotic translation initiation factor 2alpha kinase activity TBP-class protein binding general transcription initiation factor activity RNA polymerase I general transcription initiation factor activity RNA polymerase II general transcription initiation factor activity histone H3K27 acetyltransferase activity histone H3T3 kinase activity histone H2BS14 kinase activity p53 binding histone H4K12 acetyltransferase activity modification-dependent protein binding lysine-acetylated histone binding histone binding acetylation-dependent protein binding Rho-dependent protein serine/threonine kinase activity histone H2AT120 kinase activity protein heterodimerization activity protein dimerization activity histone H3K4 acetyltransferase activity histone H2AXS139 kinase activity histone H2AX kinase activity protein serine kinase activity histone H3K18 acetyltransferase activity histone H2AK9 acetyltransferase activity histone H2BK5 acetyltransferase activity 3-phosphoinositide-dependent protein kinase activity histone H4K16 acetyltransferase activity histone H2AS1 kinase activity	regulation of protein stability biological regulation regulation of biological quality protein stabilization transcription preinitiation complex assembly RNA metabolic process cellular component organization cellular component biogenesis protein-DNA complex organization RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process cellular component assembly regulation of protein stability biological regulation regulation of biological quality protein stabilization transcription preinitiation complex assembly RNA metabolic process cellular component organization cellular component biogenesis protein-DNA complex organization RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process cellular component assembly transcription by RNA polymerase II protein-containing complex assembly cellular component organization or biogenesis transcription initiation at RNA polymerase II promoter protein-containing complex organization protein-DNA complex assembly primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process DNA-templated transcription initiation nucleic acid metabolic process biosynthetic process RNA polymerase II preinitiation complex assembly cellular process metabolic process macromolecule metabolic process positive regulation of proteasomal protein catabolic process regulation of cellular process catabolic process positive regulation of protein metabolic process proteolysis involved in protein catabolic process positive regulation of biological process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process regulation of ubiquitin-dependent protein catabolic process regulation of primary metabolic process positive regulation of metabolic process positive regulation of ubiquitin-dependent protein catabolic process regulation of proteolysis regulation of proteolysis involved in protein catabolic process modification-dependent macromolecule catabolic process proteolysis positive regulation of macromolecule metabolic process protein metabolic process positive regulation of cellular process regulation of biological process regulation of protein metabolic process proteasomal protein catabolic process regulation of macromolecule metabolic process protein catabolic process regulation of catabolic process positive regulation of protein catabolic process positive regulation of proteolysis involved in protein catabolic process positive regulation of catabolic process regulation of proteasomal ubiquitin-dependent protein catabolic process modification-dependent protein catabolic process positive regulation of proteolysis regulation of proteasomal protein catabolic process positive regulation of proteasomal ubiquitin-dependent protein catabolic process ubiquitin-dependent protein catabolic process regulation of metabolic process regulation of protein catabolic process regulation of cell cycle phase transition regulation of cell cycle process cell cycle phase transition regulation of cell cycle G1/S phase transition cell cycle G1/S phase transition cell cycle regulation of cell cycle cell cycle process negative regulation of post-translational protein modification regulation of protein modification process negative regulation of biological process regulation of protein autoubiquitination regulation of protein ubiquitination protein ubiquitination negative regulation of protein modification process negative regulation of cellular process regulation of protein modification by small protein conjugation or removal protein modification process negative regulation of protein ubiquitination negative regulation of protein metabolic process negative regulation of macromolecule metabolic process negative regulation of protein autoubiquitination negative regulation of protein modification by small protein conjugation or removal regulation of post-translational protein modification protein autoubiquitination negative regulation of metabolic process macromolecule modification post-translational protein modification protein modification by small protein conjugation protein modification by small protein conjugation or removal protein phosphorylation phosphorylation phosphate-containing compound metabolic process phosphorus metabolic process mRNA transcription by RNA polymerase II mRNA transcription mRNA metabolic process negative regulation of RNA biosynthetic process regulation of RNA metabolic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription negative regulation of RNA metabolic process regulation of protein binding positive regulation of molecular function regulation of molecular function positive regulation of protein binding regulation of binding positive regulation of binding positive regulation of DNA-templated transcription positive regulation of macromolecule biosynthetic process regulation of DNA-templated transcription initiation positive regulation of biosynthetic process positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription initiation by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of DNA-templated transcription initiation positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process regulation of transcription initiation by RNA polymerase II cellular response to stimulus positive regulation of DNA-binding transcription factor activity response to stimulus signaling regulation of signaling receptor activity regulation of signal transduction cell communication signal transduction regulation of signaling positive regulation of signaling receptor activity regulation of response to stimulus regulation of DNA-binding transcription factor activity regulation of cell communication positive regulation of androgen receptor activity signal transduction by p53 class mediator intracellular signal transduction regulation of intracellular signal transduction regulation of signal transduction by p53 class mediator negative regulation of gene expression cellular response to stress DNA damage response response to stress negative regulation of proteolysis negative regulation of proteolysis involved in protein catabolic process negative regulation of ubiquitin-dependent protein catabolic process negative regulation of catabolic process peptidyl-amino acid modification peptidyl-threonine modification peptidyl-threonine phosphorylation protein autophosphorylation protein polyubiquitination peptidyl-serine modification peptidyl-serine phosphorylation cellular response to nitrogen compound cellular response to ATP response to organophosphorus response to oxygen-containing compound response to nitrogen compound response to ATP response to purine-containing compound cellular response to oxygen-containing compound cellular response to chemical stimulus response to chemical transcription initiation at RNA polymerase I promoter transcription by RNA polymerase I developmental process multicellular organismal process head development animal organ development brain development nervous system development multicellular organism development central nervous system development midbrain development anatomical structure development system development response to light stimulus cellular response to radiation response to UV cellular response to environmental stimulus cellular response to light stimulus response to radiation response to abiotic stimulus cellular response to abiotic stimulus cellular response to UV	RNA polymerase II transcription regulator complex membrane-bounded organelle RNA polymerase II, holoenzyme protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex transcription regulator complex transferase complex intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm RNA polymerase II transcription regulator complex membrane-bounded organelle RNA polymerase II, holoenzyme protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex transcription regulator complex transferase complex intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm catalytic complex intracellular membrane-bounded organelle transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex organelle lumen organelle RNA polymerase complex transcription factor TFIID complex DNA-directed RNA polymerase complex intracellular protein-containing complex nuclear lumen histone methyltransferase complex MLL1/2 complex MLL1 complex methyltransferase complex membraneless organelle intracellular membraneless organelle chromatin chromosome
C [auth F], H [auth f]	Transcription initiation factor TFIID subunit 6	protein heterodimerization activity protein binding binding protein dimerization activity transcription coactivator activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity DNA binding nucleic acid binding general transcription initiation factor activity RNA polymerase II general transcription initiation factor activity transcription factor binding protein heterodimerization activity protein binding binding protein dimerization activity transcription coactivator activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity DNA binding nucleic acid binding general transcription initiation factor activity RNA polymerase II general transcription initiation factor activity transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding signaling receptor binding DNA-binding transcription factor binding aryl hydrocarbon receptor binding	transcription preinitiation complex assembly RNA metabolic process cellular component organization cellular component biogenesis protein-DNA complex organization RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process cellular component assembly transcription by RNA polymerase II protein-containing complex assembly cellular component organization or biogenesis transcription initiation at RNA polymerase II promoter transcription preinitiation complex assembly RNA metabolic process cellular component organization cellular component biogenesis protein-DNA complex organization RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process cellular component assembly transcription by RNA polymerase II protein-containing complex assembly cellular component organization or biogenesis transcription initiation at RNA polymerase II promoter protein-containing complex organization protein-DNA complex assembly primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process DNA-templated transcription initiation nucleic acid metabolic process biosynthetic process RNA polymerase II preinitiation complex assembly cellular process metabolic process macromolecule metabolic process apoptotic process cell death programmed cell death regulation of biological process regulation of cellular process negative regulation of cellular process biological regulation negative regulation of biological process negative regulation of cell cycle cell cycle regulation of cell cycle positive regulation of programmed cell death regulation of apoptotic process positive regulation of biological process regulation of programmed cell death positive regulation of apoptotic process positive regulation of cellular process positive regulation of DNA-templated transcription positive regulation of macromolecule biosynthetic process regulation of primary metabolic process positive regulation of metabolic process regulation of DNA-templated transcription initiation regulation of RNA metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription initiation by RNA polymerase II regulation of macromolecule metabolic process positive regulation of transcription by RNA polymerase II positive regulation of DNA-templated transcription initiation positive regulation of RNA metabolic process regulation of gene expression positive regulation of RNA biosynthetic process regulation of transcription initiation by RNA polymerase II regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of cell population proliferation cell population proliferation regulation of cell population proliferation mRNA transcription by RNA polymerase II mRNA transcription mRNA metabolic process cellular response to stimulus positive regulation of cell communication positive regulation of signal transduction response to stimulus signaling regulation of signal transduction regulation of intrinsic apoptotic signaling pathway intracellular signal transduction cell communication positive regulation of apoptotic signaling pathway positive regulation of response to stimulus regulation of intracellular signal transduction signal transduction intrinsic apoptotic signaling pathway regulation of signaling positive regulation of intracellular signal transduction apoptotic signaling pathway regulation of response to stimulus regulation of cell communication positive regulation of intrinsic apoptotic signaling pathway regulation of apoptotic signaling pathway positive regulation of signaling regulation of cellular response to stress cellular response to stress response to stress regulation of response to stress DNA repair DNA metabolic process regulation of DNA repair DNA damage response regulation of DNA metabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol RNA polymerase II transcription regulator complex membrane-bounded organelle RNA polymerase II, holoenzyme protein-containing complex nucleus membrane-enclosed lumen nuclear protein-containing complex transcription regulator complex transferase complex intracellular organelle lumen cellular anatomical structure intracellular anatomical structure cytoplasm cytosol RNA polymerase II transcription regulator complex membrane-bounded organelle RNA polymerase II, holoenzyme protein-containing complex nucleus membrane-enclosed lumen nuclear protein-containing complex transcription regulator complex transferase complex intracellular organelle lumen intracellular organelle nucleoplasm catalytic complex intracellular membrane-bounded organelle transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex organelle lumen organelle RNA polymerase complex transcription factor TFIID complex DNA-directed RNA polymerase complex intracellular protein-containing complex nuclear lumen intracellular membraneless organelle chromatin chromosome histone acetyltransferase complex acetyltransferase complex membraneless organelle protein acetyltransferase complex SAGA-type complex SLIK (SAGA-like) complex peptidase complex SAGA complex transcription factor TFTC complex histone methyltransferase complex MLL1/2 complex MLL1 complex methyltransferase complex
D [auth G]	Transcription initiation factor TFIID subunit 7	transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding nuclear receptor binding protein binding binding DNA-binding transcription factor binding nuclear vitamin D receptor binding DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding double-stranded DNA binding nucleic acid binding transcription regulatory region nucleic acid binding transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding nuclear receptor binding protein binding binding DNA-binding transcription factor binding nuclear vitamin D receptor binding DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding double-stranded DNA binding nucleic acid binding transcription regulatory region nucleic acid binding nuclear thyroid hormone receptor binding basal transcription machinery binding protein-containing complex binding basal RNA polymerase II transcription machinery binding TFIIH-class transcription factor complex binding general transcription initiation factor binding RNA polymerase II general transcription initiation factor binding protein heterodimerization activity protein dimerization activity histone acetyltransferase binding enzyme binding P-TEFb complex binding general transcription initiation factor activity RNA polymerase II general transcription initiation factor activity	regulation of cellular process negative regulation of biological process RNA metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of cellular process negative regulation of biological process RNA metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process negative regulation of DNA-templated transcription regulation of biological process negative regulation of metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process metabolic process cellular process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process transcription preinitiation complex assembly cellular component organization cellular component biogenesis protein-DNA complex organization cellular component assembly transcription by RNA polymerase II protein-containing complex assembly cellular component organization or biogenesis transcription initiation at RNA polymerase II promoter protein-containing complex organization protein-DNA complex assembly DNA-templated transcription initiation RNA polymerase II preinitiation complex assembly regulation of MHC class I biosynthetic process negative regulation of MHC class I biosynthetic process MHC class I biosynthetic process regulation of MHC class II biosynthetic process negative regulation of MHC class II biosynthetic process MHC class II biosynthetic process localization nitrogen compound transport transport spermine transport polyamine transport establishment of localization regulation of protein modification process regulation of catalytic activity regulation of protein phosphorylation negative regulation of phosphate metabolic process negative regulation of catalytic activity regulation of transferase activity negative regulation of kinase activity negative regulation of transferase activity regulation of phosphate metabolic process phosphate-containing compound metabolic process negative regulation of protein modification process protein metabolic process phosphorus metabolic process protein modification process negative regulation of protein metabolic process protein phosphorylation phosphorylation regulation of protein metabolic process negative regulation of molecular function negative regulation of protein kinase activity regulation of protein kinase activity regulation of molecular function regulation of kinase activity negative regulation of protein phosphorylation macromolecule modification negative regulation of phosphorus metabolic process regulation of phosphorylation regulation of phosphorus metabolic process negative regulation of phosphorylation positive regulation of DNA-templated transcription positive regulation of biological process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process regulation of DNA-templated transcription initiation positive regulation of biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription initiation by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of DNA-templated transcription initiation positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process regulation of transcription initiation by RNA polymerase II cellular response to stimulus intracellular receptor signaling pathway response to stimulus response to lipid signaling hormone-mediated signaling pathway intracellular signal transduction cell communication cellular response to endogenous stimulus response to hormone response to steroid hormone signal transduction nuclear receptor-mediated steroid hormone signaling pathway cellular response to steroid hormone stimulus steroid hormone receptor signaling pathway cellular response to hormone stimulus response to endogenous stimulus estrogen receptor signaling pathway cellular response to chemical stimulus response to chemical cellular response to lipid nuclear receptor-mediated signaling pathway mRNA transcription by RNA polymerase II mRNA transcription mRNA metabolic process negative regulation of transcription by RNA polymerase II regulation of cellular response to stress cellular response to stress response to stress regulation of response to stress DNA repair DNA metabolic process regulation of DNA repair DNA damage response regulation of response to stimulus regulation of DNA metabolic process	protein-containing complex transcription regulator complex RNA polymerase II transcription regulator complex membrane-bounded organelle RNA polymerase II, holoenzyme intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex transferase complex intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm protein-containing complex transcription regulator complex RNA polymerase II transcription regulator complex membrane-bounded organelle RNA polymerase II, holoenzyme intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex transferase complex intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm catalytic complex intracellular membrane-bounded organelle transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex organelle lumen organelle RNA polymerase complex transcription factor TFIID complex DNA-directed RNA polymerase complex intracellular protein-containing complex nuclear lumen cytoplasm transcription factor TFTC complex chromosome histone acetyltransferase complex membraneless organelle SAGA-type complex intracellular membraneless organelle chromatin acetyltransferase complex protein acetyltransferase complex male germ cell nucleus germ cell nucleus histone methyltransferase complex MLL1/2 complex MLL1 complex methyltransferase complex
F [auth X]	DNA (45-MER)	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B	IPR016024	Armadillo-type fold	Homologous Superfamily
B	IPR027268	Peptidase M4/M1, CTD superfamily	Homologous Superfamily
B	IPR037813	Transcription initiation factor TFIID subunit 2	Family
B	IPR042097	Aminopeptidase N-like , N-terminal domain superfamliy	Homologous Superfamily
E [auth H]	IPR009072	Histone-fold	Homologous Superfamily
E [auth H]	IPR037818	Transcription initiation factor TFIID subunit 8	Family
E [auth H]	IPR006565	Bromodomain associated domain	Domain
E [auth H]	IPR019473	Transcription factor TFIID, subunit 8, C-terminal	Domain
A	IPR018359	Bromodomain, conserved site	Conserved Site
A	IPR009067	TAFII-230 TBP-binding	Domain
A	IPR040240	Transcription initiation factor TFIID subunit 1	Family
A	IPR011177	Transcription initiation factor TFIID subunit 1, animal	Family
A	IPR022591	Transcription initiation factor TFIID subunit 1, histone acetyltransferase domain	Domain
A	IPR036427	Bromodomain-like superfamily	Homologous Superfamily
A	IPR001487	Bromodomain	Domain
A	IPR041670	Zinc knuckle	Domain
A	IPR036741	TAFII-230 TBP-binding domain superfamily	Homologous Superfamily
C [auth F], H [auth f]	IPR011442	TAF6, C-terminal HEAT repeat domain	Domain
C [auth F], H [auth f]	IPR016024	Armadillo-type fold	Homologous Superfamily
C [auth F], H [auth f]	IPR009072	Histone-fold	Homologous Superfamily
C [auth F], H [auth f]	IPR037796	Transcription initiation factor TFIID subunit 6	Family
C [auth F], H [auth f]	IPR046344	TAF6, C-terminal HEAT repeat domain superfamily	Homologous Superfamily
C [auth F], H [auth f]	IPR004823	TATA box binding protein associated factor (TAF), histone-like fold domain	Domain
D [auth G]	IPR006751	TAFII55 protein, conserved region	Domain
D [auth G]	IPR037817	Transcription initiation factor TFIID subunit 7	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B	Pharos: Q6P1X5	intellectual disability microcephaly-thin corpus callosum-intellectual disability syndrome autosomal recessive non-syndromic intellectual disability large cell medulloblastoma Mental Retardation, Psychosocial osteosarcoma idiopathic pulmonary fibrosis lung cancer microcephaly ovarian cancer primitive neuroectodermal tumor
E [auth H]	Pharos: Q7Z7C8	inflammatory bowel disease malignant ependymoma osteosarcoma
A	Pharos: P21675	X-linked dystonia-parkinsonism dystonic disorder intellectual disability, X-linked, syndromic 33 intellectual disability Parkinson disease colorectal adenocarcinoma medulloblastoma metastatic melanoma rheumatoid arthritis generalized dystonia juvenile dermatomyositis osteosarcoma
C [auth F], H [auth f]	Pharos: P49848	Alazami-Yuan syndrome intellectual disability idiopathic pulmonary fibrosis chronic obstructive pulmonary disease Cornelia de Lange syndrome 1 ovarian cancer
D [auth G]	Pharos: Q15545	lymphoplasmacytic lymphoma ovarian cancer plasma cell myeloma