Annotations: 7FDB

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
O	SCOP2B Superfamily	Vacuolar ATP synthase subunit C	8042806	3001744	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	ATP-synt_ab_N	e7fdbA3	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: ATP-synt_ab_N	ECOD (1.6)
A	ATP-synt_ab_C	e7fdbA4	A: alpha superhelices	X: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	H: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	T: C-terminal domain of alpha and beta subunits of F1 ATP synthase	F: ATP-synt_ab_C	ECOD (1.6)
A	ATP-synt_ab_Xtn	e7fdbA2	A: a+b complex topology	X: alpha/beta-Hammerhead/Barrel-sandwich hybrid	H: alpha/beta-Hammerhead/Barrel-sandwich hybrid	T: Single hybrid motif	F: ATP-synt_ab_Xtn	ECOD (1.6)
A	ATP-synt_ab	e7fdbA1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: ATP-synt_ab	ECOD (1.6)
C	ATP-synt_ab_N	e7fdbC4	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: ATP-synt_ab_N	ECOD (1.6)
C	ATP-synt_ab_C	e7fdbC2	A: alpha superhelices	X: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	H: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	T: C-terminal domain of alpha and beta subunits of F1 ATP synthase	F: ATP-synt_ab_C	ECOD (1.6)
C	ATP-synt_ab_Xtn	e7fdbC1	A: a+b complex topology	X: alpha/beta-Hammerhead/Barrel-sandwich hybrid	H: alpha/beta-Hammerhead/Barrel-sandwich hybrid	T: Single hybrid motif	F: ATP-synt_ab_Xtn	ECOD (1.6)
C	ATP-synt_ab	e7fdbC3	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: ATP-synt_ab	ECOD (1.6)
E	ATP-synt_ab_N	e7fdbE3	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: ATP-synt_ab_N	ECOD (1.6)
E	ATP-synt_ab_C	e7fdbE2	A: alpha superhelices	X: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	H: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	T: C-terminal domain of alpha and beta subunits of F1 ATP synthase	F: ATP-synt_ab_C	ECOD (1.6)
E	ATP-synt_ab_Xtn	e7fdbE1	A: a+b complex topology	X: alpha/beta-Hammerhead/Barrel-sandwich hybrid	H: alpha/beta-Hammerhead/Barrel-sandwich hybrid	T: Single hybrid motif	F: ATP-synt_ab_Xtn	ECOD (1.6)
E	ATP-synt_ab	e7fdbE4	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: ATP-synt_ab	ECOD (1.6)
R [auth S]	vATP-synt_AC39_3rd	e7fdbS2	A: alpha bundles	X: V-type ATP synthase subunit C	H: V-type ATP synthase subunit C (From Topology)	T: V-type ATP synthase subunit C	F: vATP-synt_AC39_3rd	ECOD (1.6)
R [auth S]	vATP-synt_AC39_1st	e7fdbS1	A: alpha bundles	X: V-type ATP synthase subunit C	H: V-type ATP synthase subunit C (From Topology)	T: V-type ATP synthase subunit C	F: vATP-synt_AC39_1st	ECOD (1.6)
T [auth U]	ATP-synt_C	e7fdbU1	A: extended segments	X: F1F0 ATP synthase subunit C (From Topology)	H: F1F0 ATP synthase subunit C (From Topology)	T: F1F0 ATP synthase subunit C	F: ATP-synt_C	ECOD (1.6)
AA [auth b]	ATP-synt_C	e7fdbb1	A: extended segments	X: F1F0 ATP synthase subunit C (From Topology)	H: F1F0 ATP synthase subunit C (From Topology)	T: F1F0 ATP synthase subunit C	F: ATP-synt_C	ECOD (1.6)
BA [auth c]	ATP-synt_C	e7fdbc1	A: extended segments	X: F1F0 ATP synthase subunit C (From Topology)	H: F1F0 ATP synthase subunit C (From Topology)	T: F1F0 ATP synthase subunit C	F: ATP-synt_C	ECOD (1.6)
U [auth V]	ATP-synt_C	e7fdbV1	A: extended segments	X: F1F0 ATP synthase subunit C (From Topology)	H: F1F0 ATP synthase subunit C (From Topology)	T: F1F0 ATP synthase subunit C	F: ATP-synt_C	ECOD (1.6)
V [auth W]	ATP-synt_C	e7fdbW1	A: extended segments	X: F1F0 ATP synthase subunit C (From Topology)	H: F1F0 ATP synthase subunit C (From Topology)	T: F1F0 ATP synthase subunit C	F: ATP-synt_C	ECOD (1.6)
W [auth X]	ATP-synt_C	e7fdbX1	A: extended segments	X: F1F0 ATP synthase subunit C (From Topology)	H: F1F0 ATP synthase subunit C (From Topology)	T: F1F0 ATP synthase subunit C	F: ATP-synt_C	ECOD (1.6)
X [auth Y]	ATP-synt_C	e7fdbY1	A: extended segments	X: F1F0 ATP synthase subunit C (From Topology)	H: F1F0 ATP synthase subunit C (From Topology)	T: F1F0 ATP synthase subunit C	F: ATP-synt_C	ECOD (1.6)
Y [auth Z]	ATP-synt_C	e7fdbZ1	A: extended segments	X: F1F0 ATP synthase subunit C (From Topology)	H: F1F0 ATP synthase subunit C (From Topology)	T: F1F0 ATP synthase subunit C	F: ATP-synt_C	ECOD (1.6)
Z [auth a]	ATP-synt_C	e7fdba1	A: extended segments	X: F1F0 ATP synthase subunit C (From Topology)	H: F1F0 ATP synthase subunit C (From Topology)	T: F1F0 ATP synthase subunit C	F: ATP-synt_C	ECOD (1.6)
B	ATP-synt_ab_N	e7fdbB3	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: ATP-synt_ab_N	ECOD (1.6)
B	ATP-synt_ab_C	e7fdbB2	A: alpha superhelices	X: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	H: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	T: C-terminal domain of alpha and beta subunits of F1 ATP synthase	F: ATP-synt_ab_C	ECOD (1.6)
B	ATP-synt_ab	e7fdbB1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: ATP-synt_ab	ECOD (1.6)
D	ATP-synt_ab_N	e7fdbD3	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: ATP-synt_ab_N	ECOD (1.6)
D	ATP-synt_ab_C	e7fdbD2	A: alpha superhelices	X: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	H: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	T: C-terminal domain of alpha and beta subunits of F1 ATP synthase	F: ATP-synt_ab_C	ECOD (1.6)
D	ATP-synt_ab	e7fdbD1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: ATP-synt_ab	ECOD (1.6)
F	ATP-synt_ab_N	e7fdbF3	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: ATP-synt_ab_N	ECOD (1.6)
F	ATP-synt_ab_C	e7fdbF2	A: alpha superhelices	X: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	H: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	T: C-terminal domain of alpha and beta subunits of F1 ATP synthase	F: ATP-synt_ab_C	ECOD (1.6)
F	ATP-synt_ab	e7fdbF1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: ATP-synt_ab	ECOD (1.6)
G	vATP-synt_E_C	e7fdbG1	A: a+b two layers	X: FwdE/GAPDH domain-like	H: V-type ATPase subunit E (From Topology)	T: V-type ATPase subunit E	F: vATP-synt_E_C	ECOD (1.6)
G	vATP-synt_E_N	e7fdbG2	A: extended segments	X: Helical region in V-type proton ATPase subunit E (From Topology)	H: Helical region in V-type proton ATPase subunit E (From Topology)	T: Helical region in V-type proton ATPase subunit E	F: vATP-synt_E_N	ECOD (1.6)
I	vATP-synt_E_C	e7fdbI1	A: a+b two layers	X: FwdE/GAPDH domain-like	H: V-type ATPase subunit E (From Topology)	T: V-type ATPase subunit E	F: vATP-synt_E_C	ECOD (1.6)
I	vATP-synt_E_N	e7fdbI2	A: extended segments	X: Helical region in V-type proton ATPase subunit E (From Topology)	H: Helical region in V-type proton ATPase subunit E (From Topology)	T: Helical region in V-type proton ATPase subunit E	F: vATP-synt_E_N	ECOD (1.6)
K	vATP-synt_E_C	e7fdbK1	A: a+b two layers	X: FwdE/GAPDH domain-like	H: V-type ATPase subunit E (From Topology)	T: V-type ATPase subunit E	F: vATP-synt_E_C	ECOD (1.6)
K	vATP-synt_E_N	e7fdbK2	A: extended segments	X: Helical region in V-type proton ATPase subunit E (From Topology)	H: Helical region in V-type proton ATPase subunit E (From Topology)	T: Helical region in V-type proton ATPase subunit E	F: vATP-synt_E_N	ECOD (1.6)
H	V-ATPase_G	e7fdbH1	A: extended segments	X: V-type proton ATPase subunit G (From Topology)	H: V-type proton ATPase subunit G (From Topology)	T: V-type proton ATPase subunit G	F: V-ATPase_G	ECOD (1.6)
J	V-ATPase_G	e7fdbJ1	A: extended segments	X: V-type proton ATPase subunit G (From Topology)	H: V-type proton ATPase subunit G (From Topology)	T: V-type proton ATPase subunit G	F: V-ATPase_G	ECOD (1.6)
L	V-ATPase_G	e7fdbL1	A: extended segments	X: V-type proton ATPase subunit G (From Topology)	H: V-type proton ATPase subunit G (From Topology)	T: V-type proton ATPase subunit G	F: V-ATPase_G	ECOD (1.6)
M	ATP-synt_D	e7fdbM1	A: alpha bundles	X: V-type proton ATPase subunit D (From Topology)	H: V-type proton ATPase subunit D (From Topology)	T: V-type proton ATPase subunit D	F: ATP-synt_D	ECOD (1.6)
N	ATP-synt_F	e7fdbN1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: AtpF-like (From Topology)	T: AtpF-like	F: ATP-synt_F	ECOD (1.6)
O	V-ATPase_C_1st	e7fdbO1	A: alpha bundles	X: helical bundle domain in vacuolar ATP synthase subunit C (From Topology)	H: helical bundle domain in vacuolar ATP synthase subunit C (From Topology)	T: helical bundle domain in vacuolar ATP synthase subunit C	F: V-ATPase_C_1st	ECOD (1.6)
O	V-ATPase_C_3rd	e7fdbO3	A: a+b two layers	X: Alpha-beta plaits	H: ferredoxin-like domain in vacuolar ATP synthase subunit C (From Topology)	T: ferredoxin-like domain in vacuolar ATP synthase subunit C	F: V-ATPase_C_3rd	ECOD (1.6)
O	V-ATPase_C_2nd	e7fdbO2	A: a+b two layers	X: Alpha-beta plaits	H: ferredoxin-like domain in vacuolar ATP synthase subunit C (From Topology)	T: ferredoxin-like domain in vacuolar ATP synthase subunit C	F: V-ATPase_C_2nd	ECOD (1.6)
P	V-ATPase_H_C	e7fdbP1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: V-ATPase_H_C	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C, E	PF00006	ATP synthase alpha/beta family, nucleotide-binding domain (ATP-synt_ab)	ATP synthase alpha/beta family, nucleotide-binding domain	This entry includes the ATP synthase alpha and beta subunits, the ATP synthase associated with flagella and the termination factor Rho.	Domain
A, C, E	PF20520	V0 complex accessory subunit Ac45/VOA1 transmembrane domain (Ac45-VOA1_TM)	V0 complex accessory subunit Ac45/VOA1 transmembrane domain	This entry represents the transmembrane domain from ER/Golgi membrane proteins including V0 complex accessory subunit Ac45 (ATP6AP1, also known as V-type proton ATPase subunit S1) from animals and the yeast homologue V0 assembly protein 1 (VOA1) whic ...	This entry represents the transmembrane domain from ER/Golgi membrane proteins including V0 complex accessory subunit Ac45 (ATP6AP1, also known as V-type proton ATPase subunit S1) from animals and the yeast homologue V0 assembly protein 1 (VOA1) which are essential for V0 ATPase assembly, stability and function [1,2]. In humans, mutations of ATP6AP1 cause immunodeficiency with hypogammaglobulinemia, hepatopathy and neurocognitive abnormalities [3]. This entry also includes ER membrane BIG1 proteins from yeast, involved in cell wall biogenesis.	Domain
A, C, E	PF22919	C-terminal domain of V and A type ATP synthase (ATP-synt_VA_C)	C-terminal domain of V and A type ATP synthase	This entry represents a small alpha helical domain found at the C-terminus of a variety of ATP synthases.	Domain
A, C, E	PF16886	ATPsynthase alpha/beta subunit barrel-sandwich domain (ATP-synt_ab_Xtn)	ATPsynthase alpha/beta subunit barrel-sandwich domain	This barrel-sandwich domain is found in the alpha-beta catalytic subunit of VATA or V-type proton ATPase catalytic subunit at the N-terminal end. This domain has a circularly permuted topology compared to other barrel-sandwich domains. In VATA barrel ...	This barrel-sandwich domain is found in the alpha-beta catalytic subunit of VATA or V-type proton ATPase catalytic subunit at the N-terminal end. This domain has a circularly permuted topology compared to other barrel-sandwich domains. In VATA barrel-sandwich domain the C-terminal strand is circularly permuted and occupies the spatial position of the N-terminal strand in other hybrid domains.	Domain
A, C, E	PF02874	ATP synthase alpha/beta family, beta-barrel domain (ATP-synt_ab_N)	ATP synthase alpha/beta family, beta-barrel domain	This family includes the ATP synthase alpha and beta subunits the ATP synthase associated with flagella.	Domain
A, C, E	PF00137	ATP synthase subunit C (ATP-synt_C)	ATP synthase subunit C	This domain is found in the subunit c of ATP synthases and similar sequences from all cellular organisms. It forms two alpha-helices [1-4].	Domain
R [auth S]	PF01992	ATP synthase (C/AC39) subunit (vATP-synt_AC39)	ATP synthase (C/AC39) subunit	-	Family
S [auth T]	PF00137	ATP synthase subunit C (ATP-synt_C)	ATP synthase subunit C	This domain is found in the subunit c of ATP synthases and similar sequences from all cellular organisms. It forms two alpha-helices [1-4].	Domain
T [auth U]	PF00137	ATP synthase subunit C (ATP-synt_C)	ATP synthase subunit C	This domain is found in the subunit c of ATP synthases and similar sequences from all cellular organisms. It forms two alpha-helices [1-4].	Domain
AA [auth b], BA [auth c], U [auth V], V [auth W], W [auth X], AA [auth b], BA [auth c], U [auth V], V [auth W], W [auth X], X [auth Y], Y [auth Z], Z [auth a]	PF00137	ATP synthase subunit C (ATP-synt_C)	ATP synthase subunit C	This domain is found in the subunit c of ATP synthases and similar sequences from all cellular organisms. It forms two alpha-helices [1-4].	Domain
B, D, F	PF00006	ATP synthase alpha/beta family, nucleotide-binding domain (ATP-synt_ab)	ATP synthase alpha/beta family, nucleotide-binding domain	This entry includes the ATP synthase alpha and beta subunits, the ATP synthase associated with flagella and the termination factor Rho.	Domain
B, D, F	PF05493	ATP synthase subunit H (ATP_synt_H)	ATP synthase subunit H	-	Family
B, D, F	PF22919	C-terminal domain of V and A type ATP synthase (ATP-synt_VA_C)	C-terminal domain of V and A type ATP synthase	This entry represents a small alpha helical domain found at the C-terminus of a variety of ATP synthases.	Domain
B, D, F	PF02874	ATP synthase alpha/beta family, beta-barrel domain (ATP-synt_ab_N)	ATP synthase alpha/beta family, beta-barrel domain	This family includes the ATP synthase alpha and beta subunits the ATP synthase associated with flagella.	Domain
B, D, F	PF00137	ATP synthase subunit C (ATP-synt_C)	ATP synthase subunit C	This domain is found in the subunit c of ATP synthases and similar sequences from all cellular organisms. It forms two alpha-helices [1-4].	Domain
G, I, K	PF01991	ATP synthase (E/31 kDa) subunit (vATP-synt_E)	ATP synthase (E/31 kDa) subunit	-	Family
H, J, L	PF03179	Vacuolar (H+)-ATPase G subunit (V-ATPase_G)	Vacuolar (H+)-ATPase G subunit	-	Coiled-coil
M	PF01813	ATP synthase subunit D (ATP-synt_D)	ATP synthase subunit D	-	Family
N	PF01990	ATP synthase (F/14-kDa) subunit (ATP-synt_F)	ATP synthase (F/14-kDa) subunit	-	Family
O	PF03223	V-ATPase subunit C (V-ATPase_C)	V-ATPase subunit C	-	Family
P	PF11698	V-ATPase subunit H (V-ATPase_H_C)	V-ATPase subunit H	-	Repeat
P	PF03224	V-ATPase subunit H (V-ATPase_H_N)	V-ATPase subunit H	-	Repeat
Q	PF01496	V-type ATPase 116kDa subunit family (V_ATPase_I)	V-type ATPase 116kDa subunit family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C, E	Yeast Vacuolar ATPase A subunit	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity monoatomic ion channel activity proton channel activity proton-transporting ATP synthase activity, rotational mechanism monoatomic cation channel activity passive transmembrane transporter activity channel activity catalytic activity ligase activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding DNA binding nucleic acid binding RNA binding mRNA binding endonuclease activity nuclease activity hydrolase activity, acting on ester bonds hydrolase activity	transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport nucleobase-containing compound metabolic process DNA recombination transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport nucleobase-containing compound metabolic process DNA recombination metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process intron homing homeostatic process biological regulation intracellular pH reduction regulation of intracellular pH vesicle organization cellular component organization organelle organization cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis regulation of pH monoatomic ion homeostasis endosome organization intracellular chemical homeostasis cellular component organization or biogenesis regulation of biological quality endosomal lumen acidification monoatomic cation homeostasis endomembrane system organization regulation of cellular pH intracellular monoatomic ion homeostasis intein-mediated protein splicing gene expression macromolecule biosynthetic process protein maturation biosynthetic process proteolysis protein processing protein metabolic process protein splicing Golgi lumen acidification vacuolar acidification	ATPase dependent transmembrane transport complex membrane-bounded organelle protein-containing complex ATPase complex intracellular anatomical structure membrane protein complex proton-transporting V-type ATPase complex proton-transporting V-type ATPase, V1 domain transporter complex vacuolar proton-transporting V-type ATPase, V1 domain intracellular organelle cellular anatomical structure bounding membrane of organelle proton-transporting two-sector ATPase complex ATPase dependent transmembrane transport complex membrane-bounded organelle protein-containing complex ATPase complex intracellular anatomical structure membrane protein complex proton-transporting V-type ATPase complex proton-transporting V-type ATPase, V1 domain transporter complex vacuolar proton-transporting V-type ATPase, V1 domain intracellular organelle cellular anatomical structure bounding membrane of organelle proton-transporting two-sector ATPase complex proton-transporting two-sector ATPase complex, catalytic domain vacuolar membrane catalytic complex membrane vacuole intracellular membrane-bounded organelle vacuolar proton-transporting V-type ATPase complex cation-transporting ATPase complex transmembrane transporter complex organelle cytoplasm organelle membrane storage vacuole lytic vacuole fungal-type vacuole lytic vacuole membrane fungal-type vacuole membrane Golgi membrane Golgi apparatus endomembrane system
R [auth S]	V-type proton ATPase subunit d	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity	transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport cellular localization establishment of localization in cell transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport cellular localization establishment of localization in cell vacuolar transport intracellular transport homeostatic process biological regulation intracellular pH reduction Golgi lumen acidification regulation of intracellular pH cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis regulation of pH monoatomic ion homeostasis intracellular chemical homeostasis regulation of biological quality monoatomic cation homeostasis regulation of cellular pH intracellular monoatomic ion homeostasis vesicle organization cellular component organization organelle organization endosome organization cellular component organization or biogenesis endosomal lumen acidification endomembrane system organization vacuolar acidification	vacuolar membrane membrane-bounded organelle storage vacuole intracellular anatomical structure membrane lytic vacuole vacuole intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle lytic vacuole membrane bounding membrane of organelle cellular anatomical structure organelle vacuolar membrane membrane-bounded organelle storage vacuole intracellular anatomical structure membrane lytic vacuole vacuole intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle lytic vacuole membrane bounding membrane of organelle cellular anatomical structure organelle cytoplasm organelle membrane fungal-type vacuole membrane ATPase dependent transmembrane transport complex protein-containing complex ATPase complex catalytic complex membrane protein complex proton-transporting V-type ATPase complex transporter complex cation-transporting ATPase complex proton-transporting two-sector ATPase complex transmembrane transporter complex Golgi membrane Golgi apparatus endomembrane system vacuolar proton-transporting V-type ATPase, V0 domain proton-transporting V-type ATPase, V0 domain proton-transporting two-sector ATPase complex, proton-transporting domain vacuolar proton-transporting V-type ATPase complex
S [auth T]	V-type proton ATPase subunit c''	monoatomic cation transmembrane transporter activity P-type transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity ATPase-coupled monoatomic cation transmembrane transporter activity P-type proton-exporting transporter activity ATP-dependent activity P-type ion transporter activity active monoatomic ion transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity monoatomic cation transmembrane transporter activity P-type transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity ATPase-coupled monoatomic cation transmembrane transporter activity P-type proton-exporting transporter activity ATP-dependent activity P-type ion transporter activity active monoatomic ion transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled ion transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism	transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport homeostatic process biological regulation transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport homeostatic process biological regulation intracellular pH reduction Golgi lumen acidification regulation of intracellular pH cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis regulation of pH monoatomic ion homeostasis intracellular chemical homeostasis regulation of biological quality monoatomic cation homeostasis regulation of cellular pH intracellular monoatomic ion homeostasis vesicle organization cellular component organization organelle organization endosome organization cellular component organization or biogenesis endosomal lumen acidification endomembrane system organization vacuolar acidification	vacuolar membrane membrane-bounded organelle storage vacuole intracellular anatomical structure membrane lytic vacuole vacuole intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle lytic vacuole membrane bounding membrane of organelle cellular anatomical structure organelle vacuolar membrane membrane-bounded organelle storage vacuole intracellular anatomical structure membrane lytic vacuole vacuole intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle lytic vacuole membrane bounding membrane of organelle cellular anatomical structure organelle cytoplasm organelle membrane fungal-type vacuole membrane ATPase dependent transmembrane transport complex protein-containing complex ATPase complex catalytic complex membrane protein complex proton-transporting V-type ATPase complex transporter complex cation-transporting ATPase complex proton-transporting two-sector ATPase complex transmembrane transporter complex Golgi membrane Golgi apparatus endomembrane system vacuolar proton-transporting V-type ATPase, V0 domain proton-transporting V-type ATPase, V0 domain proton-transporting two-sector ATPase complex, proton-transporting domain vacuolar proton-transporting V-type ATPase complex
T [auth U]	V-type proton ATPase subunit c'	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity	transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport homeostatic process biological regulation transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport homeostatic process biological regulation intracellular pH reduction Golgi lumen acidification regulation of intracellular pH cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis regulation of pH monoatomic ion homeostasis intracellular chemical homeostasis regulation of biological quality monoatomic cation homeostasis regulation of cellular pH intracellular monoatomic ion homeostasis vesicle organization cellular component organization organelle organization endosome organization cellular component organization or biogenesis endosomal lumen acidification endomembrane system organization vacuolar acidification	membrane-bounded organelle storage vacuole intracellular anatomical structure lytic vacuole vacuole intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle cellular anatomical structure organelle cytoplasm vacuolar membrane membrane lytic vacuole membrane membrane-bounded organelle storage vacuole intracellular anatomical structure lytic vacuole vacuole intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle cellular anatomical structure organelle cytoplasm vacuolar membrane membrane lytic vacuole membrane bounding membrane of organelle organelle membrane fungal-type vacuole membrane ATPase dependent transmembrane transport complex protein-containing complex ATPase complex catalytic complex membrane protein complex proton-transporting V-type ATPase complex transporter complex cation-transporting ATPase complex proton-transporting two-sector ATPase complex transmembrane transporter complex Golgi membrane Golgi apparatus endomembrane system vacuolar proton-transporting V-type ATPase, V0 domain proton-transporting V-type ATPase, V0 domain proton-transporting two-sector ATPase complex, proton-transporting domain vacuolar proton-transporting V-type ATPase complex cell periphery
AA [auth b], BA [auth c], U [auth V], V [auth W], W [auth X], AA [auth b], BA [auth c], U [auth V], V [auth W], W [auth X], X [auth Y], Y [auth Z], Z [auth a]	V-type proton ATPase subunit c	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity	intracellular iron ion homeostasis inorganic ion homeostasis cellular homeostasis chemical homeostasis homeostatic process intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport intracellular iron ion homeostasis inorganic ion homeostasis cellular homeostasis chemical homeostasis homeostatic process intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport protein localization establishment of protein localization cellular localization nitrogen compound transport protein targeting establishment of protein localization to vacuole intracellular transport protein localization to vacuole establishment of protein localization to organelle protein transport cellular macromolecule localization macromolecule localization establishment of localization in cell protein localization to organelle vacuolar transport protein targeting to vacuole intracellular protein transport intracellular copper ion homeostasis copper ion homeostasis import into cell endocytosis vesicle-mediated transport biological regulation intracellular pH reduction Golgi lumen acidification regulation of intracellular pH regulation of pH regulation of biological quality regulation of cellular pH vesicle organization cellular component organization organelle organization endosome organization cellular component organization or biogenesis endosomal lumen acidification endomembrane system organization vacuole organization vacuolar acidification	vacuolar membrane membrane-bounded organelle storage vacuole intracellular anatomical structure membrane lytic vacuole vacuole intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle lytic vacuole membrane bounding membrane of organelle cellular anatomical structure organelle vacuolar membrane membrane-bounded organelle storage vacuole intracellular anatomical structure membrane lytic vacuole vacuole intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle lytic vacuole membrane bounding membrane of organelle cellular anatomical structure organelle cytoplasm organelle membrane fungal-type vacuole membrane ATPase dependent transmembrane transport complex protein-containing complex ATPase complex catalytic complex membrane protein complex proton-transporting V-type ATPase complex transporter complex cation-transporting ATPase complex proton-transporting two-sector ATPase complex transmembrane transporter complex Golgi membrane Golgi apparatus endomembrane system vacuolar proton-transporting V-type ATPase, V0 domain proton-transporting V-type ATPase, V0 domain proton-transporting two-sector ATPase complex, proton-transporting domain vacuolar proton-transporting V-type ATPase complex
CA [auth d]	V-type proton ATPase subunit e	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity	transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport cellular component organization cellular component biogenesis transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular component organization or biogenesis homeostatic process biological regulation intracellular pH reduction Golgi lumen acidification regulation of intracellular pH cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis regulation of pH monoatomic ion homeostasis intracellular chemical homeostasis regulation of biological quality monoatomic cation homeostasis regulation of cellular pH intracellular monoatomic ion homeostasis carbohydrate derivative biosynthetic process mannoprotein biosynthetic process cell wall mannoprotein biosynthetic process cell wall organization or biogenesis glycoprotein biosynthetic process carbohydrate derivative metabolic process primary metabolic process glycoprotein metabolic process macromolecule biosynthetic process mannoprotein metabolic process biosynthetic process metabolic process protein metabolic process macromolecule metabolic process cell wall glycoprotein biosynthetic process cell wall macromolecule metabolic process vesicle organization organelle organization endosome organization endosomal lumen acidification endomembrane system organization vacuolar acidification	vacuolar membrane membrane-bounded organelle storage vacuole intracellular anatomical structure membrane lytic vacuole vacuole intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle lytic vacuole membrane bounding membrane of organelle cellular anatomical structure organelle vacuolar membrane membrane-bounded organelle storage vacuole intracellular anatomical structure membrane lytic vacuole vacuole intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle lytic vacuole membrane bounding membrane of organelle cellular anatomical structure organelle cytoplasm organelle membrane fungal-type vacuole membrane ATPase dependent transmembrane transport complex protein-containing complex ATPase complex catalytic complex membrane protein complex proton-transporting V-type ATPase complex transporter complex cation-transporting ATPase complex proton-transporting two-sector ATPase complex transmembrane transporter complex Golgi membrane Golgi apparatus endomembrane system vacuolar proton-transporting V-type ATPase, V0 domain proton-transporting V-type ATPase, V0 domain proton-transporting two-sector ATPase complex, proton-transporting domain vacuolar proton-transporting V-type ATPase complex
DA [auth e]	V0 assembly protein 1	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity	transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport cellular component organization cellular component biogenesis transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular component organization or biogenesis homeostatic process biological regulation intracellular pH reduction Golgi lumen acidification regulation of intracellular pH cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis regulation of pH monoatomic ion homeostasis intracellular chemical homeostasis regulation of biological quality monoatomic cation homeostasis regulation of cellular pH intracellular monoatomic ion homeostasis vesicle organization organelle organization endosome organization endosomal lumen acidification endomembrane system organization vacuolar acidification	vacuolar membrane membrane-bounded organelle storage vacuole intracellular anatomical structure membrane lytic vacuole vacuole intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle lytic vacuole membrane bounding membrane of organelle cellular anatomical structure organelle vacuolar membrane membrane-bounded organelle storage vacuole intracellular anatomical structure membrane lytic vacuole vacuole intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle lytic vacuole membrane bounding membrane of organelle cellular anatomical structure organelle cytoplasm organelle membrane fungal-type vacuole membrane ATPase dependent transmembrane transport complex protein-containing complex ATPase complex catalytic complex membrane protein complex proton-transporting V-type ATPase complex transporter complex cation-transporting ATPase complex proton-transporting two-sector ATPase complex transmembrane transporter complex Golgi membrane Golgi apparatus endomembrane system vacuolar proton-transporting V-type ATPase, V0 domain proton-transporting V-type ATPase, V0 domain proton-transporting two-sector ATPase complex, proton-transporting domain vacuolar proton-transporting V-type ATPase complex organelle subcompartment endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum endoplasmic reticulum membrane
EA [auth f]	Yeast Vacuolar ATPase f subunit	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity endonuclease activity nuclease activity hydrolase activity, acting on ester bonds catalytic activity, acting on RNA RNA endonuclease activity catalytic activity, acting on a nucleic acid RNA nuclease activity hydrolase activity catalytic activity	transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport homeostatic process biological regulation transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport homeostatic process biological regulation intracellular pH reduction Golgi lumen acidification regulation of intracellular pH cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis regulation of pH monoatomic ion homeostasis intracellular chemical homeostasis regulation of biological quality monoatomic cation homeostasis regulation of cellular pH intracellular monoatomic ion homeostasis vesicle organization cellular component organization organelle organization endosome organization cellular component organization or biogenesis endosomal lumen acidification endomembrane system organization vacuolar acidification	vacuolar membrane membrane-bounded organelle storage vacuole intracellular anatomical structure membrane lytic vacuole vacuole intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle lytic vacuole membrane bounding membrane of organelle cellular anatomical structure organelle vacuolar membrane membrane-bounded organelle storage vacuole intracellular anatomical structure membrane lytic vacuole vacuole intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle lytic vacuole membrane bounding membrane of organelle cellular anatomical structure organelle cytoplasm organelle membrane fungal-type vacuole membrane ATPase dependent transmembrane transport complex protein-containing complex ATPase complex catalytic complex membrane protein complex proton-transporting V-type ATPase complex transporter complex cation-transporting ATPase complex proton-transporting two-sector ATPase complex transmembrane transporter complex Golgi membrane Golgi apparatus endomembrane system vacuolar proton-transporting V-type ATPase, V0 domain proton-transporting V-type ATPase, V0 domain proton-transporting two-sector ATPase complex, proton-transporting domain vacuolar proton-transporting V-type ATPase complex organelle subcompartment endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum endoplasmic reticulum membrane
B, D, F	V-type proton ATPase subunit B	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding	transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport nucleoside phosphate metabolic process ribose phosphate metabolic process transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport nucleoside phosphate metabolic process ribose phosphate metabolic process purine nucleoside triphosphate metabolic process ATP metabolic process carbohydrate derivative metabolic process primary metabolic process nucleotide metabolic process purine-containing compound metabolic process nucleobase-containing compound metabolic process purine nucleotide metabolic process ribonucleotide metabolic process organophosphate metabolic process nucleobase-containing small molecule metabolic process purine ribonucleoside triphosphate metabolic process phosphate-containing compound metabolic process metabolic process small molecule metabolic process nucleoside triphosphate metabolic process purine ribonucleotide metabolic process phosphorus metabolic process ribonucleoside triphosphate metabolic process homeostatic process biological regulation intracellular pH reduction regulation of intracellular pH vesicle organization cellular component organization organelle organization cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis regulation of pH monoatomic ion homeostasis endosome organization intracellular chemical homeostasis cellular component organization or biogenesis regulation of biological quality endosomal lumen acidification monoatomic cation homeostasis endomembrane system organization regulation of cellular pH intracellular monoatomic ion homeostasis inorganic ion homeostasis intracellular calcium ion homeostasis calcium ion homeostasis autophagy of peroxisome catabolic process macroautophagy pexophagy autophagy process utilizing autophagic mechanism cellular component biogenesis cellular component assembly organelle assembly membraneless organelle assembly proteasome storage granule assembly Golgi lumen acidification vacuolar acidification	organelle membrane contact site vacuole-mitochondrion membrane contact site cellular anatomical structure organelle intracellular anatomical structure cytoplasmic ribonucleoprotein granule intracellular membraneless organelle ribonucleoprotein granule intracellular organelle membraneless organelle cytoplasm supramolecular complex cytoplasmic stress granule ATPase dependent transmembrane transport complex organelle membrane contact site vacuole-mitochondrion membrane contact site cellular anatomical structure organelle intracellular anatomical structure cytoplasmic ribonucleoprotein granule intracellular membraneless organelle ribonucleoprotein granule intracellular organelle membraneless organelle cytoplasm supramolecular complex cytoplasmic stress granule ATPase dependent transmembrane transport complex membrane-bounded organelle protein-containing complex ATPase complex membrane protein complex proton-transporting V-type ATPase complex proton-transporting V-type ATPase, V1 domain transporter complex vacuolar proton-transporting V-type ATPase, V1 domain bounding membrane of organelle proton-transporting two-sector ATPase complex proton-transporting two-sector ATPase complex, catalytic domain vacuolar membrane catalytic complex membrane vacuole intracellular membrane-bounded organelle vacuolar proton-transporting V-type ATPase complex cation-transporting ATPase complex transmembrane transporter complex organelle membrane membrane microdomain membrane raft storage vacuole lytic vacuole fungal-type vacuole lytic vacuole membrane fungal-type vacuole membrane Golgi membrane Golgi apparatus endomembrane system
G, I, K	V-type proton ATPase subunit E	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity	transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport homeostatic process biological regulation transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport homeostatic process biological regulation intracellular pH reduction Golgi lumen acidification regulation of intracellular pH cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis regulation of pH monoatomic ion homeostasis intracellular chemical homeostasis regulation of biological quality monoatomic cation homeostasis regulation of cellular pH intracellular monoatomic ion homeostasis vesicle organization cellular component organization organelle organization endosome organization cellular component organization or biogenesis endosomal lumen acidification endomembrane system organization vacuolar acidification	vacuolar membrane membrane-bounded organelle storage vacuole intracellular anatomical structure membrane lytic vacuole vacuole intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle lytic vacuole membrane bounding membrane of organelle cellular anatomical structure organelle vacuolar membrane membrane-bounded organelle storage vacuole intracellular anatomical structure membrane lytic vacuole vacuole intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle lytic vacuole membrane bounding membrane of organelle cellular anatomical structure organelle cytoplasm organelle membrane fungal-type vacuole membrane ATPase dependent transmembrane transport complex protein-containing complex ATPase complex membrane protein complex proton-transporting V-type ATPase complex proton-transporting V-type ATPase, V1 domain transporter complex vacuolar proton-transporting V-type ATPase, V1 domain proton-transporting two-sector ATPase complex proton-transporting two-sector ATPase complex, catalytic domain catalytic complex vacuolar proton-transporting V-type ATPase complex cation-transporting ATPase complex transmembrane transporter complex Golgi membrane Golgi apparatus endomembrane system membrane microdomain membrane raft
H, J, L	V-type proton ATPase subunit G	pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity	transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport homeostatic process biological regulation transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport homeostatic process biological regulation intracellular pH reduction regulation of intracellular pH vesicle organization cellular component organization organelle organization cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis regulation of pH monoatomic ion homeostasis endosome organization intracellular chemical homeostasis cellular component organization or biogenesis regulation of biological quality endosomal lumen acidification monoatomic cation homeostasis endomembrane system organization regulation of cellular pH intracellular monoatomic ion homeostasis Golgi lumen acidification vacuolar acidification	vacuolar membrane membrane-bounded organelle storage vacuole intracellular anatomical structure membrane lytic vacuole vacuole intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle lytic vacuole membrane bounding membrane of organelle cellular anatomical structure organelle vacuolar membrane membrane-bounded organelle storage vacuole intracellular anatomical structure membrane lytic vacuole vacuole intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle lytic vacuole membrane bounding membrane of organelle cellular anatomical structure organelle cytoplasm organelle membrane fungal-type vacuole membrane ATPase dependent transmembrane transport complex protein-containing complex ATPase complex membrane protein complex proton-transporting V-type ATPase complex transporter complex proton-transporting two-sector ATPase complex catalytic complex vacuolar proton-transporting V-type ATPase complex cation-transporting ATPase complex transmembrane transporter complex proton-transporting V-type ATPase, V1 domain vacuolar proton-transporting V-type ATPase, V1 domain proton-transporting two-sector ATPase complex, catalytic domain Golgi membrane Golgi apparatus endomembrane system
M	V-type proton ATPase subunit D	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity	transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport homeostatic process biological regulation transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport homeostatic process biological regulation intracellular pH reduction regulation of intracellular pH vesicle organization cellular component organization organelle organization cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis regulation of pH monoatomic ion homeostasis endosome organization intracellular chemical homeostasis cellular component organization or biogenesis regulation of biological quality endosomal lumen acidification monoatomic cation homeostasis endomembrane system organization regulation of cellular pH intracellular monoatomic ion homeostasis Golgi lumen acidification vacuolar acidification	vacuolar membrane membrane-bounded organelle storage vacuole intracellular anatomical structure membrane lytic vacuole vacuole intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle lytic vacuole membrane bounding membrane of organelle cellular anatomical structure organelle vacuolar membrane membrane-bounded organelle storage vacuole intracellular anatomical structure membrane lytic vacuole vacuole intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle lytic vacuole membrane bounding membrane of organelle cellular anatomical structure organelle cytoplasm organelle membrane fungal-type vacuole membrane ATPase dependent transmembrane transport complex protein-containing complex ATPase complex membrane protein complex proton-transporting V-type ATPase complex transporter complex proton-transporting two-sector ATPase complex catalytic complex vacuolar proton-transporting V-type ATPase complex cation-transporting ATPase complex transmembrane transporter complex membrane microdomain membrane raft proton-transporting V-type ATPase, V1 domain vacuolar proton-transporting V-type ATPase, V1 domain proton-transporting two-sector ATPase complex, catalytic domain Golgi membrane Golgi apparatus endomembrane system
N	V-type proton ATPase subunit F	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity	transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport homeostatic process biological regulation transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport homeostatic process biological regulation intracellular pH reduction Golgi lumen acidification regulation of intracellular pH cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis regulation of pH monoatomic ion homeostasis intracellular chemical homeostasis regulation of biological quality monoatomic cation homeostasis regulation of cellular pH intracellular monoatomic ion homeostasis vesicle organization cellular component organization organelle organization endosome organization cellular component organization or biogenesis endosomal lumen acidification endomembrane system organization vacuolar acidification	vacuolar membrane membrane-bounded organelle storage vacuole intracellular anatomical structure membrane lytic vacuole vacuole intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle lytic vacuole membrane bounding membrane of organelle cellular anatomical structure organelle vacuolar membrane membrane-bounded organelle storage vacuole intracellular anatomical structure membrane lytic vacuole vacuole intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle lytic vacuole membrane bounding membrane of organelle cellular anatomical structure organelle cytoplasm organelle membrane fungal-type vacuole membrane ATPase dependent transmembrane transport complex protein-containing complex ATPase complex membrane protein complex proton-transporting V-type ATPase complex proton-transporting V-type ATPase, V1 domain transporter complex vacuolar proton-transporting V-type ATPase, V1 domain proton-transporting two-sector ATPase complex proton-transporting two-sector ATPase complex, catalytic domain catalytic complex vacuolar proton-transporting V-type ATPase complex cation-transporting ATPase complex transmembrane transporter complex Golgi membrane Golgi apparatus endomembrane system
O	V-type proton ATPase subunit C	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity	transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport homeostatic process biological regulation transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport homeostatic process biological regulation intracellular pH reduction Golgi lumen acidification regulation of intracellular pH cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis regulation of pH monoatomic ion homeostasis intracellular chemical homeostasis regulation of biological quality monoatomic cation homeostasis regulation of cellular pH intracellular monoatomic ion homeostasis vesicle organization cellular component organization organelle organization endosome organization cellular component organization or biogenesis endosomal lumen acidification endomembrane system organization vacuolar acidification	vacuolar membrane membrane-bounded organelle storage vacuole intracellular anatomical structure membrane lytic vacuole vacuole intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle lytic vacuole membrane bounding membrane of organelle cellular anatomical structure organelle vacuolar membrane membrane-bounded organelle storage vacuole intracellular anatomical structure membrane lytic vacuole vacuole intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle lytic vacuole membrane bounding membrane of organelle cellular anatomical structure organelle cytoplasm organelle membrane fungal-type vacuole membrane ATPase dependent transmembrane transport complex protein-containing complex ATPase complex membrane protein complex proton-transporting V-type ATPase complex proton-transporting V-type ATPase, V1 domain transporter complex vacuolar proton-transporting V-type ATPase, V1 domain proton-transporting two-sector ATPase complex proton-transporting two-sector ATPase complex, catalytic domain catalytic complex vacuolar proton-transporting V-type ATPase complex cation-transporting ATPase complex transmembrane transporter complex Golgi membrane Golgi apparatus endomembrane system
P	Fusion of yeast V-type proton ATPase subunit H(NT) and human V-type proton ATPase subunit H(CT)	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity enzyme regulator activity molecular function regulator activity	transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport homeostatic process biological regulation transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport homeostatic process biological regulation intracellular pH reduction Golgi lumen acidification regulation of intracellular pH cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis regulation of pH monoatomic ion homeostasis intracellular chemical homeostasis regulation of biological quality monoatomic cation homeostasis regulation of cellular pH intracellular monoatomic ion homeostasis vesicle organization cellular component organization organelle organization endosome organization cellular component organization or biogenesis endosomal lumen acidification endomembrane system organization vacuolar acidification regulation of biological process catabolic process regulation of cellular process macroautophagy autophagy regulation of catabolic process regulation of autophagy regulation of macroautophagy metabolic process process utilizing autophagic mechanism regulation of metabolic process import into cell endocytosis vesicle-mediated transport lysosome organization lysosomal lumen acidification regulation of lysosomal lumen pH vacuole organization lytic vacuole organization synaptic vesicle maturation cellular localization synaptic vesicle cycle vesicle-mediated transport in synapse establishment of localization in cell synaptic vesicle lumen acidification developmental process developmental maturation neuron cellular homeostasis	vacuolar membrane membrane-bounded organelle storage vacuole intracellular anatomical structure membrane lytic vacuole vacuole intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle lytic vacuole membrane bounding membrane of organelle cellular anatomical structure organelle vacuolar membrane membrane-bounded organelle storage vacuole intracellular anatomical structure membrane lytic vacuole vacuole intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle lytic vacuole membrane bounding membrane of organelle cellular anatomical structure organelle cytoplasm organelle membrane fungal-type vacuole membrane ATPase dependent transmembrane transport complex protein-containing complex ATPase complex membrane protein complex proton-transporting V-type ATPase complex proton-transporting V-type ATPase, V1 domain transporter complex vacuolar proton-transporting V-type ATPase, V1 domain proton-transporting two-sector ATPase complex proton-transporting two-sector ATPase complex, catalytic domain catalytic complex vacuolar proton-transporting V-type ATPase complex cation-transporting ATPase complex transmembrane transporter complex Golgi membrane Golgi apparatus endomembrane system extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytosol cell periphery plasma membrane extrinsic component of synaptic vesicle membrane synapse intracellular vesicle transport vesicle membrane extrinsic component of organelle membrane presynapse cytoplasmic vesicle vesicle membrane synaptic vesicle synaptic vesicle membrane cell junction transport vesicle exocytic vesicle membrane cytoplasmic vesicle membrane secretory vesicle extrinsic component of membrane exocytic vesicle coated vesicle membrane clathrin-coated vesicle coated vesicle clathrin-coated vesicle membrane lysosomal membrane lysosome endosome membrane endosome
Q	Yeast Vacuolar ATPase a subunit	phosphatidylinositol-3,5-bisphosphate binding binding ion binding anion binding phosphatidylinositol bisphosphate binding phospholipid binding lipid binding phosphatidylinositol phosphate binding phosphatidylinositol binding small molecule binding monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity phosphatidylinositol-3,5-bisphosphate binding binding ion binding anion binding phosphatidylinositol bisphosphate binding phospholipid binding lipid binding phosphatidylinositol phosphate binding phosphatidylinositol binding small molecule binding monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity ATPase binding protein binding enzyme binding	transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport cellular component organization cellular component biogenesis transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular component organization or biogenesis protein localization to vacuolar membrane protein localization cellular localization protein localization to vacuole localization within membrane protein localization to membrane cellular macromolecule localization macromolecule localization protein localization to organelle cellular response to stimulus response to stimulus response to pH cellular response to pH response to alkaline pH response to abiotic stimulus cellular response to alkaline pH cellular response to abiotic stimulus cellular response to environmental stimulus response to osmotic stress cellular response to chemical stress cellular response to osmotic stress cellular response to chemical stimulus hyperosmotic response cellular hyperosmotic response cellular response to stress response to stress response to chemical oxoacid metabolic process metabolic process small molecule metabolic process organic acid metabolic process phosphorus metabolic process polyphosphate metabolic process homeostatic process biological regulation intracellular pH reduction regulation of intracellular pH vacuolar acidification cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis regulation of pH monoatomic ion homeostasis intracellular chemical homeostasis regulation of biological quality monoatomic cation homeostasis regulation of cellular pH intracellular monoatomic ion homeostasis	membrane-bounded organelle storage vacuole intracellular anatomical structure lytic vacuole vacuole intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle cellular anatomical structure organelle cytoplasm vacuolar membrane membrane lytic vacuole membrane membrane-bounded organelle storage vacuole intracellular anatomical structure lytic vacuole vacuole intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle cellular anatomical structure organelle cytoplasm vacuolar membrane membrane lytic vacuole membrane bounding membrane of organelle organelle membrane fungal-type vacuole membrane ATPase dependent transmembrane transport complex protein-containing complex ATPase complex vacuolar proton-transporting V-type ATPase, V0 domain membrane protein complex proton-transporting V-type ATPase complex transporter complex proton-transporting two-sector ATPase complex proton-transporting V-type ATPase, V0 domain catalytic complex proton-transporting two-sector ATPase complex, proton-transporting domain vacuolar proton-transporting V-type ATPase complex cation-transporting ATPase complex transmembrane transporter complex membrane microdomain membrane raft

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C, E	IPR036844	Hint domain superfamily	Homologous Superfamily
A, C, E	IPR022878	V-type ATP synthase catalytic alpha chain	Family
A, C, E	IPR006142	Intein	Domain
A, C, E	IPR007868	Hom-end-associated Hint	Domain
A, C, E	IPR004042	Intein DOD homing endonuclease, central region	Domain
A, C, E	IPR024034	ATPase, F1/V1 complex, beta/alpha subunit, C-terminal	Homologous Superfamily
A, C, E	IPR036121	ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain superfamily	Homologous Superfamily
A, C, E	IPR031686	ATPsynthase alpha/beta subunit, barrel-sandwich domain	Domain
A, C, E	IPR006141	Intein N-terminal splicing region	PTM
A, C, E	IPR000194	ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain	Domain
A, C, E	IPR003586	Hint domain C-terminal	Domain
A, C, E	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A, C, E	IPR004100	ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain	Domain
A, C, E	IPR030934	Intein C-terminal splicing region	Conserved Site
A, C, E	IPR027434	Homing endonuclease	Homologous Superfamily
A, C, E	IPR023366	ATP synthase subunit alpha, N-terminal domain-like superfamily	Homologous Superfamily
A, C, E	IPR020003	ATPase, alpha/beta subunit, nucleotide-binding domain, active site	Active Site
A, C, E	IPR055190	ATP synthase A/B type, C-terminal domain	Domain
A, C, E	IPR003587	Hint domain N-terminal	Domain
A, C, E	IPR007869	Homing endonuclease PI-Sce	Domain
R [auth S]	IPR036079	V-type ATP synthase subunit c/d subunit superfamily	Homologous Superfamily
R [auth S]	IPR035067	V-type ATPase subunit C/d	Homologous Superfamily
R [auth S]	IPR044911	V-type ATP synthase c/d subunit, domain 3 superfamily	Homologous Superfamily
R [auth S]	IPR016727	ATPase, V0 complex, subunit d	Family
R [auth S]	IPR002843	ATPase, V0 complex, c/d subunit	Family
S [auth T]	IPR035921	F/V-ATP synthase subunit C superfamily	Homologous Superfamily
S [auth T]	IPR002379	V-ATPase proteolipid subunit C-like domain	Domain
S [auth T]	IPR000245	V-ATPase proteolipid subunit	Family
T [auth U]	IPR035921	F/V-ATP synthase subunit C superfamily	Homologous Superfamily
T [auth U]	IPR002379	V-ATPase proteolipid subunit C-like domain	Domain
T [auth U]	IPR011555	V-ATPase proteolipid subunit C, eukaryotic	Family
T [auth U]	IPR000245	V-ATPase proteolipid subunit	Family
AA [auth b], BA [auth c], U [auth V], V [auth W], W [auth X], AA [auth b], BA [auth c], U [auth V], V [auth W], W [auth X], X [auth Y], Y [auth Z], Z [auth a]	IPR035921	F/V-ATP synthase subunit C superfamily	Homologous Superfamily
AA [auth b], BA [auth c], U [auth V], V [auth W], W [auth X], AA [auth b], BA [auth c], U [auth V], V [auth W], W [auth X], X [auth Y], Y [auth Z], Z [auth a]	IPR002379	V-ATPase proteolipid subunit C-like domain	Domain
AA [auth b], BA [auth c], U [auth V], V [auth W], W [auth X], AA [auth b], BA [auth c], U [auth V], V [auth W], W [auth X], X [auth Y], Y [auth Z], Z [auth a]	IPR011555	V-ATPase proteolipid subunit C, eukaryotic	Family
AA [auth b], BA [auth c], U [auth V], V [auth W], W [auth X], AA [auth b], BA [auth c], U [auth V], V [auth W], W [auth X], X [auth Y], Y [auth Z], Z [auth a]	IPR000245	V-ATPase proteolipid subunit	Family
CA [auth d]	IPR008389	ATPase, V0 complex, subunit e1/e2	Family
DA [auth e]	IPR046756	V-type proton ATPase subunit S1/VOA1, transmembrane domain	Domain
EA [auth f]	IPR026770	Ribonuclease kappa	Family
B, D, F	IPR000194	ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain	Domain
B, D, F	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
B, D, F	IPR004100	ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain	Domain
B, D, F	IPR005723	ATPase, V1 complex, subunit B	Family
B, D, F	IPR022879	V-type ATP synthase regulatory subunit B/beta	Family
B, D, F	IPR020003	ATPase, alpha/beta subunit, nucleotide-binding domain, active site	Active Site
B, D, F	IPR055190	ATP synthase A/B type, C-terminal domain	Domain
G, I, K	IPR038495	V-type ATPase subunit E, C-terminal domain superfamily	Homologous Superfamily
G, I, K	IPR002842	V-type ATPase subunit E	Family
H, J, L	IPR005124	Vacuolar (H+)-ATPase G subunit	Family
M	IPR002699	ATPase, V1 complex, subunit D	Family
N	IPR036906	ATPase, V1 complex, subunit F superfamily	Homologous Superfamily
N	IPR005772	ATPase, V1 complex, subunit F, eukaryotic	Family
N	IPR008218	ATPase, V1 complex, subunit F	Family
O	IPR036132	Vacuolar ATP synthase subunit C superfamily	Homologous Superfamily
O	IPR004907	ATPase, V1 complex, subunit C	Family
P	IPR004908	ATPase, V1 complex, subunit H	Family
P	IPR016024	Armadillo-type fold	Homologous Superfamily
P	IPR011989	Armadillo-like helical	Homologous Superfamily
P	IPR038497	ATPase, V1 complex, subunit H, C-terminal domain superfamily	Homologous Superfamily
P	IPR011987	ATPase, V1 complex, subunit H, C-terminal	Domain
P	IPR004908	ATPase, V1 complex, subunit H	Family
P	IPR016024	Armadillo-type fold	Homologous Superfamily
P	IPR011989	Armadillo-like helical	Homologous Superfamily
P	IPR038497	ATPase, V1 complex, subunit H, C-terminal domain superfamily	Homologous Superfamily
P	IPR011987	ATPase, V1 complex, subunit H, C-terminal	Domain
Q	IPR026028	ATPase, V0 complex, subunit 116kDa, eukaryotic	Family
Q	IPR002490	V-type ATPase, V0 complex, 116kDa subunit family	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
P	Pharos: Q9UI12	astrocytic tumor large cell medulloblastoma medulloblastoma Pick disease primitive neuroectodermal tumor atypical teratoid rhabdoid tumor malignant ependymoma oligodendroglioma pilocytic astrocytoma glioblastoma malignant glioma ovarian cancer plasma cell myeloma

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, AA [auth b], B, BA [auth c], C A, AA [auth b], B, BA [auth c], C, CA [auth d], D, DA [auth e], E, EA [auth f], F, G, H, I, J, K, L, M, N, O, P, Q, R [auth S], S [auth T], T [auth U], U [auth V], V [auth W], W [auth X], X [auth Y], Y [auth Z], Z [auth a]	OPM	Transmembrane	Alpha-helical polytopic	Proton or Sodium translocating F-type, V-type and A-type ATPases	V-type and F-type ATPases

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, AA [auth b], B, BA [auth c], C A, AA [auth b], B, BA [auth c], C, CA [auth d], D, DA [auth e], E, EA [auth f], F, G, H, I, J, K, L, M, N, O, P, Q, R [auth S], S [auth T], T [auth U], U [auth V], V [auth W], W [auth X], X [auth Y], Y [auth Z], Z [auth a]	PDBTM	Annotated as membrane protein by PDBTM