7K7H | pdb_00007k7h

Density-fitted Model Structure of Antibody Variable Domains of TyTx1 in Complex with PltB pentamer of Typhoid Toxin

External Resource: Annotation

Domain Annotation: ECOD Classification
IMGT Antibody Annotation
SAbDab Antibody Annotation
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Pertussis_S2S3	e7k7hA1	A: beta barrels	X: OB-fold	H: Bacterial enterotoxins (From Topology)	T: Bacterial enterotoxins	F: Pertussis_S2S3	ECOD (1.6)
C	Pertussis_S2S3	e7k7hC1	A: beta barrels	X: OB-fold	H: Bacterial enterotoxins (From Topology)	T: Bacterial enterotoxins	F: Pertussis_S2S3	ECOD (1.6)
B	Pertussis_S2S3	e7k7hB1	A: beta barrels	X: OB-fold	H: Bacterial enterotoxins (From Topology)	T: Bacterial enterotoxins	F: Pertussis_S2S3	ECOD (1.6)
D	Pertussis_S2S3	e7k7hD1	A: beta barrels	X: OB-fold	H: Bacterial enterotoxins (From Topology)	T: Bacterial enterotoxins	F: Pertussis_S2S3	ECOD (1.6)
E	Pertussis_S2S3	e7k7hE1	A: beta barrels	X: OB-fold	H: Bacterial enterotoxins (From Topology)	T: Bacterial enterotoxins	F: Pertussis_S2S3	ECOD (1.6)
F [auth L]	V-set	e7k7hL1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set	ECOD (1.6)
G [auth H]	V-set_8	e7k7hH1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_8	ECOD (1.6)

IMGT Antibody Annotation IMGT Database Homepage

Chain	Protein Name	Description	Organism Name	Gene Allele Name(s)	Domain Name(s)	Receptor Type	Receptor Description	Provenance Source
A, B, C, D, E	A2B5 toxin(Pertussis like toxin subunit B)(Pr1-114) A0A286LNT9	null	Salmonella enterica	-	-	TOX	Toxin	IMGT (202510-0)
F [auth L]	Antibody Fab fragment	V-KAPPA	Mus musculus (house mouse)	IGKV8-2101, IGKJ202, IGKJ3*01	V-DOMAIN V-KAPPA	IG	FV-HEAVY_KAPPA	IMGT (202510-0)
G [auth H]	Antibody Fab fragment	VH	Mus musculus (house mouse)	IGHV1S13501, IGHJ301	V-DOMAIN VH	IG	FV-HEAVY_KAPPA	IMGT (202510-0)
H [auth G]	A2B5 toxin(Pertussis like toxin subunit B)(Pr1-14) A0A286LNT9	Peptide	Salmonella enterica	-	-	TOX	Toxin	IMGT (202510-0)

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
F [auth L]	Light Chain	IGKV8	Kappa	pertussis like toxin subunit b \| pertussis like toxin subunit b \| pertussis toxin-like subunit arta	SAbDab (2025-03-21)
G [auth H]	Heavy Chain	IGHV1	-	pertussis like toxin subunit b \| pertussis like toxin subunit b \| pertussis toxin-like subunit arta	SAbDab (2025-03-21)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E	PF02918	Pertussis toxin, subunit 2 and 3, C-terminal domain (Pertussis_S2S3)	Pertussis toxin, subunit 2 and 3, C-terminal domain		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E	Pertussis like toxin subunit B	-	-	cellular anatomical structure extracellular region
F [auth L]	Fab Light Chain Variable Domain	-	-	-
G [auth H]	Fab Heavy Chain Variable Domain	-	-	-
H [auth G]	Pertussis toxin-like subunit ArtA	pentosyltransferase activity NAD+ poly-ADP-ribosyltransferase activity glycosyltransferase activity transferase activity catalytic activity	-	cellular anatomical structure extracellular region

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E	IPR008992	Enterotoxin	Homologous Superfamily
A, B, C, D, E	IPR020063	Bordetella pertussis toxin B, subunit 2/3, C-terminal	Domain
H [auth G]	IPR003898	Bordetella pertussis toxin A	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.