7NLC | pdb_00007nlc

Crystallographic structure of human Tsg101 UEV domain in complex with a HEV ORF3 peptide

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	UBC-like	8041226	3000570	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	UEV	e7nlcA1	A: a+b two layers	X: UBC-like	H: UBC-like (From Topology)	T: UBC-like	F: UEV	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF05743	UEV domain (UEV)	UEV domain	This family includes the eukaryotic tumour susceptibility gene 101 protein (TSG101). Altered transcripts of this gene have been detected in sporadic breast cancers and many other human malignancies. However, the involvement of this gene in neoplastic ...	This family includes the eukaryotic tumour susceptibility gene 101 protein (TSG101). Altered transcripts of this gene have been detected in sporadic breast cancers and many other human malignancies. However, the involvement of this gene in neoplastic transformation and tumorigenesis is still elusive. TSG101 is required for normal cell function of embryonic and adult tissues but that this gene is not a tumour suppressor for sporadic forms of breast cancer [1]. This family is related to the ubiquitin conjugating enzymes.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Tsg101 UEV domain	DNA binding binding nucleic acid binding protein-containing complex binding ubiquitin protein ligase binding protein binding ubiquitin-like protein ligase binding enzyme binding ubiquitin binding ubiquitin-like protein binding transcription corepressor activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity DNA binding binding nucleic acid binding protein-containing complex binding ubiquitin protein ligase binding protein binding ubiquitin-like protein ligase binding enzyme binding ubiquitin binding ubiquitin-like protein binding transcription corepressor activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity identical protein binding protein homodimerization activity protein dimerization activity calcium-dependent protein binding virion binding	localization transport extracellular transport establishment of localization macromolecule modification metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process protein modification process cellular component disassembly catabolic process protein-containing complex organization localization transport extracellular transport establishment of localization macromolecule modification metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process protein modification process cellular component disassembly catabolic process protein-containing complex organization macroautophagy autophagy protein-containing complex disassembly cellular component organization autophagosome maturation cellular component organization or biogenesis process utilizing autophagic mechanism regulation of biological process positive regulation of viral life cycle positive regulation of viral process biological regulation positive regulation of biological process viral budding viral budding via host ESCRT complex viral life cycle regulation of viral budding via host ESCRT complex virion assembly regulation of viral process regulation of viral life cycle viral process positive regulation of viral budding via host ESCRT complex cellular response to stimulus regulation of cellular process response to stimulus negative regulation of protein tyrosine kinase activity regulation of catalytic activity negative regulation of biological process negative regulation of catalytic activity regulation of signal transduction regulation of transferase activity cell surface receptor protein tyrosine kinase signaling pathway regulation of primary metabolic process cell communication negative regulation of kinase activity negative regulation of transferase activity regulation of phosphate metabolic process peptidyl-amino acid modification phosphate-containing compound metabolic process negative regulation of protein modification process epidermal growth factor receptor signaling pathway signal transduction phosphorus metabolic process negative regulation of protein metabolic process regulation of ERBB signaling pathway protein phosphorylation phosphorylation regulation of protein metabolic process negative regulation of metabolic process regulation of molecular function regulation of protein tyrosine kinase activity regulation of kinase activity regulation of response to stimulus negative regulation of protein phosphorylation negative regulation of epidermal growth factor receptor signaling pathway ERBB signaling pathway regulation of phosphorus metabolic process regulation of metabolic process regulation of protein modification process regulation of protein phosphorylation signaling negative regulation of signaling regulation of epidermal growth factor-activated receptor activity regulation of signaling receptor activity negative regulation of ERBB signaling pathway negative regulation of phosphate metabolic process peptidyl-tyrosine modification negative regulation of cell communication regulation of epidermal growth factor receptor signaling pathway negative regulation of cellular process enzyme-linked receptor protein signaling pathway negative regulation of macromolecule metabolic process negative regulation of peptidyl-tyrosine phosphorylation regulation of signaling cell surface receptor signaling pathway negative regulation of response to stimulus regulation of peptidyl-tyrosine phosphorylation negative regulation of molecular function regulation of macromolecule metabolic process regulation of protein kinase activity negative regulation of protein kinase activity negative regulation of epidermal growth factor-activated receptor activity negative regulation of signal transduction negative regulation of phosphorus metabolic process regulation of cell communication regulation of phosphorylation negative regulation of phosphorylation peptidyl-tyrosine phosphorylation negative regulation of signaling receptor activity cell division proteolysis involved in protein catabolic process protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway ubiquitin-dependent protein catabolic process regulation of growth regulation of cellular component organization growth regulation of cell growth cell growth protein localization import into cell regulation of localization ubiquitin-dependent endocytosis establishment of protein localization cellular localization nitrogen compound transport positive regulation of cellular component organization regulation of protein localization positive regulation of establishment of protein localization vesicle-mediated transport positive regulation of protein transport positive regulation of endocytosis cellular macromolecule localization regulation of ubiquitin-dependent endocytosis positive regulation of cellular process regulation of endocytosis regulation of transport regulation of establishment of protein localization regulation of protein transport regulation of vesicle-mediated transport establishment of protein localization to organelle positive regulation of transport protein transport regulation of cellular localization macromolecule localization protein localization to organelle positive regulation of ubiquitin-dependent endocytosis positive regulation of protein localization endocytosis regulation of MAP kinase activity regulation of protein serine/threonine kinase activity organelle assembly regulation of extracellular exosome assembly regulation of cellular component biogenesis extracellular exosome biogenesis regulation of organelle organization cellular component biogenesis vesicle organization organelle organization cellular component assembly extracellular vesicle biogenesis regulation of organelle assembly extracellular exosome assembly RNA metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process transcription by RNA polymerase II negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription negative regulation of RNA metabolic process developmental process epithelium development epidermal cell differentiation cellular developmental process epidermis development animal organ development tissue development epithelial cell differentiation skin development cell differentiation keratinocyte differentiation anatomical structure development endosome to lysosome transport intracellular transport lysosomal transport establishment of localization in cell vacuolar transport multivesicular body assembly multivesicular body organization endosome organization endomembrane system organization membrane organization membrane fission negative regulation of cell population proliferation cell population proliferation regulation of cell population proliferation exit from host cell biological process involved in interspecies interaction between organisms viral release from host cell biological process involved in interaction with host biological process involved in symbiotic interaction establishment of protein localization to vacuole late endosome to vacuole transport late endosome to vacuole transport via multivesicular body sorting pathway endosome transport via multivesicular body sorting pathway protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway protein localization to vacuole endosomal transport multivesicular body sorting pathway intracellular protein transport exosomal secretion establishment of organelle localization positive regulation of secretion by cell positive regulation of exosomal secretion positive regulation of exocytosis secretion by cell regulation of secretion by cell positive regulation of secretion organelle localization vesicle localization positive regulation of cellular component biogenesis secretion regulation of exosomal secretion establishment of vesicle localization export from cell regulation of secretion exocytosis regulation of exocytosis cell cycle regulation of cell cycle	extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol endosome membrane extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol endosome membrane protein-containing complex ESCRT complex endosome membrane intracellular vesicle membrane protein complex intracellular membrane-bounded organelle ESCRT I complex endomembrane system intracellular organelle cytoplasmic vesicle membrane bounding membrane of organelle cytoplasmic vesicle vesicle membrane organelle membrane late endosome membrane late endosome nucleus membrane-enclosed lumen intracellular membraneless organelle nucleolus intracellular organelle lumen organelle lumen membraneless organelle nuclear lumen centrosome microtubule organizing center cytoskeleton microtubule cytoskeleton cell periphery plasma membrane multivesicular body early endosome early endosome membrane Flemming body midbody
B	Protein ORF3	-	-	host cellular component host intracellular part host cytoskeleton cellular anatomical structure host cell part host intracellular region host intracellular organelle host intracellular membrane-bounded organelle host cell endoplasmic reticulum host cell membrane host cell cytoplasm part host cell cytoplasm host cell endomembrane system host cell endoplasmic reticulum membrane host cellular component host intracellular part host cytoskeleton cellular anatomical structure host cell part host intracellular region host intracellular organelle host intracellular membrane-bounded organelle host cell endoplasmic reticulum host cell membrane host cell cytoplasm part host cell cytoplasm host cell endomembrane system host cell endoplasmic reticulum membrane virion component membrane host cell plasma membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR052070	ESCRT-I complex UEV domain-containing protein	Family
A	IPR016135	Ubiquitin-conjugating enzyme/RWD-like	Homologous Superfamily
A	IPR037202	ESCRT assembly domain	Homologous Superfamily
A	IPR017916	Steadiness box (SB) domain	Domain
A	IPR008883	Ubiquitin E2 variant, N-terminal	Domain
B	IPR003384	Hepatitis E virus Orf2, capsid	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q99816	breast carcinoma Mammary Neoplasms plasma cell myeloma hereditary breast carcinoma ovarian cancer

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.