7QJ6 | pdb_00007qj6

Structure of recombinant human gamma-Tubulin Ring Complex 10-spoked assembly intermediate (spokes 3-12, substoichiometric spokes 13-14)

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
J [auth I]	SCOP2B Superfamily	GCP component repeat-like	8090499	3002440	SCOP2B (2022-06-29)
J [auth I]	SCOP2B Superfamily	GCP component repeat-like	8090497	3002440	SCOP2B (2022-06-29)
L [auth K]	SCOP2B Superfamily	GCP component repeat-like	8090499	3002440	SCOP2B (2022-06-29)
L [auth K]	SCOP2B Superfamily	GCP component repeat-like	8090497	3002440	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth e]	Actin_1st	e7qj6e2	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: Actin_1st	ECOD (1.6)
A [auth e]	Actin_2nd	e7qj6e1	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: Actin_2nd	ECOD (1.6)
J [auth I]	Spc97_Spc98	e7qj6I1	A: alpha complex topology	X: gamma-tubulin complex protein 4 (GCP4) (From Topology)	H: gamma-tubulin complex protein 4 (GCP4) (From Topology)	T: gamma-tubulin complex protein 4 (GCP4)	F: Spc97_Spc98	ECOD (1.6)
L [auth K]	Spc97_Spc98	e7qj6K1	A: alpha complex topology	X: gamma-tubulin complex protein 4 (GCP4) (From Topology)	H: gamma-tubulin complex protein 4 (GCP4) (From Topology)	T: gamma-tubulin complex protein 4 (GCP4)	F: Spc97_Spc98	ECOD (1.6)
Q	Tubulin_C	e7qj6Q2	A: a+b three layers	X: Bacillus chorismate mutase-like	H: Tubulin C-terminal domain-like (From Topology)	T: Tubulin C-terminal domain-like	F: Tubulin_C	ECOD (1.6)
Q	Tubulin	e7qj6Q1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: Tubulin nucleotide-binding domain-like	F: Tubulin	ECOD (1.6)
R	Tubulin_C	e7qj6R2	A: a+b three layers	X: Bacillus chorismate mutase-like	H: Tubulin C-terminal domain-like (From Topology)	T: Tubulin C-terminal domain-like	F: Tubulin_C	ECOD (1.6)
R	Tubulin	e7qj6R1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: Tubulin nucleotide-binding domain-like	F: Tubulin	ECOD (1.6)
S	Tubulin_C	e7qj6S2	A: a+b three layers	X: Bacillus chorismate mutase-like	H: Tubulin C-terminal domain-like (From Topology)	T: Tubulin C-terminal domain-like	F: Tubulin_C	ECOD (1.6)
S	Tubulin	e7qj6S1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: Tubulin nucleotide-binding domain-like	F: Tubulin	ECOD (1.6)
T	Tubulin_C	e7qj6T2	A: a+b three layers	X: Bacillus chorismate mutase-like	H: Tubulin C-terminal domain-like (From Topology)	T: Tubulin C-terminal domain-like	F: Tubulin_C	ECOD (1.6)
T	Tubulin	e7qj6T1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: Tubulin nucleotide-binding domain-like	F: Tubulin	ECOD (1.6)
U	Tubulin_C	e7qj6U2	A: a+b three layers	X: Bacillus chorismate mutase-like	H: Tubulin C-terminal domain-like (From Topology)	T: Tubulin C-terminal domain-like	F: Tubulin_C	ECOD (1.6)
U	Tubulin	e7qj6U1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: Tubulin nucleotide-binding domain-like	F: Tubulin	ECOD (1.6)
V	Tubulin_C	e7qj6V2	A: a+b three layers	X: Bacillus chorismate mutase-like	H: Tubulin C-terminal domain-like (From Topology)	T: Tubulin C-terminal domain-like	F: Tubulin_C	ECOD (1.6)
V	Tubulin	e7qj6V1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: Tubulin nucleotide-binding domain-like	F: Tubulin	ECOD (1.6)
W	Tubulin_C	e7qj6W2	A: a+b three layers	X: Bacillus chorismate mutase-like	H: Tubulin C-terminal domain-like (From Topology)	T: Tubulin C-terminal domain-like	F: Tubulin_C	ECOD (1.6)
W	Tubulin	e7qj6W1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: Tubulin nucleotide-binding domain-like	F: Tubulin	ECOD (1.6)
X	Tubulin_C	e7qj6X1	A: a+b three layers	X: Bacillus chorismate mutase-like	H: Tubulin C-terminal domain-like (From Topology)	T: Tubulin C-terminal domain-like	F: Tubulin_C	ECOD (1.6)
X	Tubulin	e7qj6X2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: Tubulin nucleotide-binding domain-like	F: Tubulin	ECOD (1.6)
Y	Tubulin_C	e7qj6Y1	A: a+b three layers	X: Bacillus chorismate mutase-like	H: Tubulin C-terminal domain-like (From Topology)	T: Tubulin C-terminal domain-like	F: Tubulin_C	ECOD (1.6)
Y	Tubulin	e7qj6Y2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: Tubulin nucleotide-binding domain-like	F: Tubulin	ECOD (1.6)
Z	Tubulin_C	e7qj6Z2	A: a+b three layers	X: Bacillus chorismate mutase-like	H: Tubulin C-terminal domain-like (From Topology)	T: Tubulin C-terminal domain-like	F: Tubulin_C	ECOD (1.6)
Z	Tubulin	e7qj6Z1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: Tubulin nucleotide-binding domain-like	F: Tubulin	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
C [auth a], CA [auth h], DA [auth j], E [auth D], G [auth F], C [auth a], CA [auth h], DA [auth j], E [auth D], G [auth F], I [auth H]	PF17681	Gamma tubulin complex component N-terminal (GCP_N_terminal)	Gamma tubulin complex component N-terminal	This is the N-terminal domain found in components of the gamma-tubulin complex proteins (GCPs). Family members include spindle pole body (SBP) components such as Spc97 and Spc98 which function as the microtubule-organizing center in yeast [1]. Furthe ...	This is the N-terminal domain found in components of the gamma-tubulin complex proteins (GCPs). Family members include spindle pole body (SBP) components such as Spc97 and Spc98 which function as the microtubule-organizing center in yeast [1]. Furthermore, family members such as human GCP4 (Gamma-tubulin complex component 4) have been structurally elucidated Swiss:Q9UGJ1 [2]. Functional studies have shown that the N-terminal domain defines the functional identity of GCPs, suggesting that all GCPs are incorporated into the helix of gamma-tubulin small complexes (gTURCs) via lateral interactions between their N-terminal domains. Thereby, they define the direct neighbors and position the GCPs within the helical wall of gTuRC [3]. Sequence alignment of human GCPs based on the GCP4 structure helped delineate conserved regions in the N- and C-terminal domains [2]. In addition to the conserved sequences, the N-terminal domains carry specific insertions of various sizes depending on the GCP, i.e. internal insertions or N-terminal extensions. These insertions may equally contribute to the function of individual GCPs as they have been implied in specific interactions with regulatory or structural proteins. For instance, GCP6 carries a large internal insertion phosphorylated by Plk4 and containing a domain of interaction with keratins, whereas the N-terminal extension of GCP3 interacts with the recruitment protein MOZART1[3].	Domain
C [auth a], CA [auth h], DA [auth j], E [auth D], G [auth F], C [auth a], CA [auth h], DA [auth j], E [auth D], G [auth F], I [auth H]	PF12554	Mitotic-spindle organizing gamma-tubulin ring associated (MOZART1)	Mitotic-spindle organizing gamma-tubulin ring associated	-	Family
C [auth a], CA [auth h], DA [auth j], E [auth D], G [auth F], C [auth a], CA [auth h], DA [auth j], E [auth D], G [auth F], I [auth H]	PF04130	Gamma tubulin complex component C-terminal (GCP_C_terminal)	Gamma tubulin complex component C-terminal	This is the C-terminal domain found in components of the gamma-tubulin complex proteins (GCPs). Family members include spindle pole body (SBP) components such as Spc97 and Spc98 which function as the microtubule-organizing center in yeast [1]. Furthe ...	This is the C-terminal domain found in components of the gamma-tubulin complex proteins (GCPs). Family members include spindle pole body (SBP) components such as Spc97 and Spc98 which function as the microtubule-organizing center in yeast [1]. Furthermore, family members such as human GCP4 (Gamma-tubulin complex component 4) have been structurally elucidated Swiss:Q9UGJ1 . Structure-based sequence analysis revealed the existence of an exposed surface area conserved in all human GCPs and in GCP4 orthologs. This area is located in the C-terminal domain of GCP4, which was confirmed in vitro to bind directly to gamma-tubulin. Sequence alignment of human GCPs based on the GCP4 structure helped delineate conserved regions in the N- and C-terminal domains [2].	Domain
D [auth C], F [auth E], H [auth G]	PF17681	Gamma tubulin complex component N-terminal (GCP_N_terminal)	Gamma tubulin complex component N-terminal	This is the N-terminal domain found in components of the gamma-tubulin complex proteins (GCPs). Family members include spindle pole body (SBP) components such as Spc97 and Spc98 which function as the microtubule-organizing center in yeast [1]. Furthe ...	This is the N-terminal domain found in components of the gamma-tubulin complex proteins (GCPs). Family members include spindle pole body (SBP) components such as Spc97 and Spc98 which function as the microtubule-organizing center in yeast [1]. Furthermore, family members such as human GCP4 (Gamma-tubulin complex component 4) have been structurally elucidated Swiss:Q9UGJ1 [2]. Functional studies have shown that the N-terminal domain defines the functional identity of GCPs, suggesting that all GCPs are incorporated into the helix of gamma-tubulin small complexes (gTURCs) via lateral interactions between their N-terminal domains. Thereby, they define the direct neighbors and position the GCPs within the helical wall of gTuRC [3]. Sequence alignment of human GCPs based on the GCP4 structure helped delineate conserved regions in the N- and C-terminal domains [2]. In addition to the conserved sequences, the N-terminal domains carry specific insertions of various sizes depending on the GCP, i.e. internal insertions or N-terminal extensions. These insertions may equally contribute to the function of individual GCPs as they have been implied in specific interactions with regulatory or structural proteins. For instance, GCP6 carries a large internal insertion phosphorylated by Plk4 and containing a domain of interaction with keratins, whereas the N-terminal extension of GCP3 interacts with the recruitment protein MOZART1[3].	Domain
D [auth C], F [auth E], H [auth G]	PF04130	Gamma tubulin complex component C-terminal (GCP_C_terminal)	Gamma tubulin complex component C-terminal	This is the C-terminal domain found in components of the gamma-tubulin complex proteins (GCPs). Family members include spindle pole body (SBP) components such as Spc97 and Spc98 which function as the microtubule-organizing center in yeast [1]. Furthe ...	This is the C-terminal domain found in components of the gamma-tubulin complex proteins (GCPs). Family members include spindle pole body (SBP) components such as Spc97 and Spc98 which function as the microtubule-organizing center in yeast [1]. Furthermore, family members such as human GCP4 (Gamma-tubulin complex component 4) have been structurally elucidated Swiss:Q9UGJ1 . Structure-based sequence analysis revealed the existence of an exposed surface area conserved in all human GCPs and in GCP4 orthologs. This area is located in the C-terminal domain of GCP4, which was confirmed in vitro to bind directly to gamma-tubulin. Sequence alignment of human GCPs based on the GCP4 structure helped delineate conserved regions in the N- and C-terminal domains [2].	Domain
D [auth C], F [auth E], H [auth G]	PF00022	Actin (Actin)	Actin	-	Family
J [auth I], L [auth K]	PF17681	Gamma tubulin complex component N-terminal (GCP_N_terminal)	Gamma tubulin complex component N-terminal	This is the N-terminal domain found in components of the gamma-tubulin complex proteins (GCPs). Family members include spindle pole body (SBP) components such as Spc97 and Spc98 which function as the microtubule-organizing center in yeast [1]. Furthe ...	This is the N-terminal domain found in components of the gamma-tubulin complex proteins (GCPs). Family members include spindle pole body (SBP) components such as Spc97 and Spc98 which function as the microtubule-organizing center in yeast [1]. Furthermore, family members such as human GCP4 (Gamma-tubulin complex component 4) have been structurally elucidated Swiss:Q9UGJ1 [2]. Functional studies have shown that the N-terminal domain defines the functional identity of GCPs, suggesting that all GCPs are incorporated into the helix of gamma-tubulin small complexes (gTURCs) via lateral interactions between their N-terminal domains. Thereby, they define the direct neighbors and position the GCPs within the helical wall of gTuRC [3]. Sequence alignment of human GCPs based on the GCP4 structure helped delineate conserved regions in the N- and C-terminal domains [2]. In addition to the conserved sequences, the N-terminal domains carry specific insertions of various sizes depending on the GCP, i.e. internal insertions or N-terminal extensions. These insertions may equally contribute to the function of individual GCPs as they have been implied in specific interactions with regulatory or structural proteins. For instance, GCP6 carries a large internal insertion phosphorylated by Plk4 and containing a domain of interaction with keratins, whereas the N-terminal extension of GCP3 interacts with the recruitment protein MOZART1[3].	Domain
J [auth I], L [auth K]	PF12554	Mitotic-spindle organizing gamma-tubulin ring associated (MOZART1)	Mitotic-spindle organizing gamma-tubulin ring associated	-	Family
J [auth I], L [auth K]	PF04130	Gamma tubulin complex component C-terminal (GCP_C_terminal)	Gamma tubulin complex component C-terminal	This is the C-terminal domain found in components of the gamma-tubulin complex proteins (GCPs). Family members include spindle pole body (SBP) components such as Spc97 and Spc98 which function as the microtubule-organizing center in yeast [1]. Furthe ...	This is the C-terminal domain found in components of the gamma-tubulin complex proteins (GCPs). Family members include spindle pole body (SBP) components such as Spc97 and Spc98 which function as the microtubule-organizing center in yeast [1]. Furthermore, family members such as human GCP4 (Gamma-tubulin complex component 4) have been structurally elucidated Swiss:Q9UGJ1 . Structure-based sequence analysis revealed the existence of an exposed surface area conserved in all human GCPs and in GCP4 orthologs. This area is located in the C-terminal domain of GCP4, which was confirmed in vitro to bind directly to gamma-tubulin. Sequence alignment of human GCPs based on the GCP4 structure helped delineate conserved regions in the N- and C-terminal domains [2].	Domain
EA [auth l], K [auth J]	PF17681	Gamma tubulin complex component N-terminal (GCP_N_terminal)	Gamma tubulin complex component N-terminal	This is the N-terminal domain found in components of the gamma-tubulin complex proteins (GCPs). Family members include spindle pole body (SBP) components such as Spc97 and Spc98 which function as the microtubule-organizing center in yeast [1]. Furthe ...	This is the N-terminal domain found in components of the gamma-tubulin complex proteins (GCPs). Family members include spindle pole body (SBP) components such as Spc97 and Spc98 which function as the microtubule-organizing center in yeast [1]. Furthermore, family members such as human GCP4 (Gamma-tubulin complex component 4) have been structurally elucidated Swiss:Q9UGJ1 [2]. Functional studies have shown that the N-terminal domain defines the functional identity of GCPs, suggesting that all GCPs are incorporated into the helix of gamma-tubulin small complexes (gTURCs) via lateral interactions between their N-terminal domains. Thereby, they define the direct neighbors and position the GCPs within the helical wall of gTuRC [3]. Sequence alignment of human GCPs based on the GCP4 structure helped delineate conserved regions in the N- and C-terminal domains [2]. In addition to the conserved sequences, the N-terminal domains carry specific insertions of various sizes depending on the GCP, i.e. internal insertions or N-terminal extensions. These insertions may equally contribute to the function of individual GCPs as they have been implied in specific interactions with regulatory or structural proteins. For instance, GCP6 carries a large internal insertion phosphorylated by Plk4 and containing a domain of interaction with keratins, whereas the N-terminal extension of GCP3 interacts with the recruitment protein MOZART1[3].	Domain
EA [auth l], K [auth J]	PF04130	Gamma tubulin complex component C-terminal (GCP_C_terminal)	Gamma tubulin complex component C-terminal	This is the C-terminal domain found in components of the gamma-tubulin complex proteins (GCPs). Family members include spindle pole body (SBP) components such as Spc97 and Spc98 which function as the microtubule-organizing center in yeast [1]. Furthe ...	This is the C-terminal domain found in components of the gamma-tubulin complex proteins (GCPs). Family members include spindle pole body (SBP) components such as Spc97 and Spc98 which function as the microtubule-organizing center in yeast [1]. Furthermore, family members such as human GCP4 (Gamma-tubulin complex component 4) have been structurally elucidated Swiss:Q9UGJ1 . Structure-based sequence analysis revealed the existence of an exposed surface area conserved in all human GCPs and in GCP4 orthologs. This area is located in the C-terminal domain of GCP4, which was confirmed in vitro to bind directly to gamma-tubulin. Sequence alignment of human GCPs based on the GCP4 structure helped delineate conserved regions in the N- and C-terminal domains [2].	Domain
BA [auth c], M [auth L]	PF17681	Gamma tubulin complex component N-terminal (GCP_N_terminal)	Gamma tubulin complex component N-terminal	This is the N-terminal domain found in components of the gamma-tubulin complex proteins (GCPs). Family members include spindle pole body (SBP) components such as Spc97 and Spc98 which function as the microtubule-organizing center in yeast [1]. Furthe ...	This is the N-terminal domain found in components of the gamma-tubulin complex proteins (GCPs). Family members include spindle pole body (SBP) components such as Spc97 and Spc98 which function as the microtubule-organizing center in yeast [1]. Furthermore, family members such as human GCP4 (Gamma-tubulin complex component 4) have been structurally elucidated Swiss:Q9UGJ1 [2]. Functional studies have shown that the N-terminal domain defines the functional identity of GCPs, suggesting that all GCPs are incorporated into the helix of gamma-tubulin small complexes (gTURCs) via lateral interactions between their N-terminal domains. Thereby, they define the direct neighbors and position the GCPs within the helical wall of gTuRC [3]. Sequence alignment of human GCPs based on the GCP4 structure helped delineate conserved regions in the N- and C-terminal domains [2]. In addition to the conserved sequences, the N-terminal domains carry specific insertions of various sizes depending on the GCP, i.e. internal insertions or N-terminal extensions. These insertions may equally contribute to the function of individual GCPs as they have been implied in specific interactions with regulatory or structural proteins. For instance, GCP6 carries a large internal insertion phosphorylated by Plk4 and containing a domain of interaction with keratins, whereas the N-terminal extension of GCP3 interacts with the recruitment protein MOZART1[3].	Domain
BA [auth c], M [auth L]	PF04130	Gamma tubulin complex component C-terminal (GCP_C_terminal)	Gamma tubulin complex component C-terminal	This is the C-terminal domain found in components of the gamma-tubulin complex proteins (GCPs). Family members include spindle pole body (SBP) components such as Spc97 and Spc98 which function as the microtubule-organizing center in yeast [1]. Furthe ...	This is the C-terminal domain found in components of the gamma-tubulin complex proteins (GCPs). Family members include spindle pole body (SBP) components such as Spc97 and Spc98 which function as the microtubule-organizing center in yeast [1]. Furthermore, family members such as human GCP4 (Gamma-tubulin complex component 4) have been structurally elucidated Swiss:Q9UGJ1 . Structure-based sequence analysis revealed the existence of an exposed surface area conserved in all human GCPs and in GCP4 orthologs. This area is located in the C-terminal domain of GCP4, which was confirmed in vitro to bind directly to gamma-tubulin. Sequence alignment of human GCPs based on the GCP4 structure helped delineate conserved regions in the N- and C-terminal domains [2].	Domain
Q, R, S, T, U Q, R, S, T, U, V, W, X, Y, Z	PF00091	Tubulin/FtsZ family, GTPase domain (Tubulin)	Tubulin/FtsZ family, GTPase domain	This family includes the tubulin alpha, beta and gamma chains, as well as the bacterial FtsZ family of proteins. Members of this family are involved in polymer formation. FtsZ is the polymer-forming protein of bacterial cell division. It is part of a ...	This family includes the tubulin alpha, beta and gamma chains, as well as the bacterial FtsZ family of proteins. Members of this family are involved in polymer formation. FtsZ is the polymer-forming protein of bacterial cell division. It is part of a ring in the middle of the dividing cell that is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ and tubulin are GTPases. FtsZ can polymerise into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria and archaea. Tubulin is the major component of microtubules.	Domain
Q, R, S, T, U Q, R, S, T, U, V, W, X, Y, Z	PF03953	Tubulin C-terminal domain (Tubulin_C)	Tubulin C-terminal domain	This family includes the tubulin alpha, beta and gamma chains. Members of this family are involved in polymer formation. Tubulins are GTPases. FtsZ can polymerise into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria and archaea. Tub ...	This family includes the tubulin alpha, beta and gamma chains. Members of this family are involved in polymer formation. Tubulins are GTPases. FtsZ can polymerise into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria and archaea. Tubulin is the major component of microtubules. (The FtsZ GTPases have been split into their won family).	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth e]	actin, cytoplasmic 1	structural constituent of postsynapse structural constituent of cytoskeleton structural molecule activity structural constituent of synapse structural constituent of postsynaptic actin cytoskeleton binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding structural constituent of postsynapse structural constituent of cytoskeleton structural molecule activity structural constituent of synapse structural constituent of postsynaptic actin cytoskeleton binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding cytoskeletal protein binding protein binding tau protein binding nitric-oxide synthase binding enzyme binding identical protein binding kinesin binding transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding DNA-binding transcription factor binding Tat protein binding kinase binding protein kinase binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity	regulation of chromosome segregation regulation of cell cycle phase transition regulation of cellular process regulation of metaphase/anaphase transition of cell cycle regulation of cellular component organization cell cycle phase transition regulation of mitotic metaphase/anaphase transition mitotic cell cycle cellular component organization regulation of mitotic cell cycle cell cycle cellular component organization or biogenesis regulation of cell cycle chromosome segregation regulation of chromosome segregation regulation of cell cycle phase transition regulation of cellular process regulation of metaphase/anaphase transition of cell cycle regulation of cellular component organization cell cycle phase transition regulation of mitotic metaphase/anaphase transition mitotic cell cycle cellular component organization regulation of mitotic cell cycle cell cycle cellular component organization or biogenesis regulation of cell cycle chromosome segregation cell cycle process regulation of biological process regulation of cell cycle process biological regulation chromosome organization sister chromatid segregation regulation of chromosome organization regulation of organelle organization regulation of mitotic cell cycle phase transition organelle organization mitotic cell cycle process regulation of sister chromatid segregation nuclear chromosome segregation metaphase/anaphase transition of mitotic cell cycle cellular process metaphase/anaphase transition of cell cycle mitotic cell cycle phase transition developmental process regulation of developmental process cellular developmental process positive regulation of biological process regulation of cell differentiation positive regulation of myoblast differentiation muscle structure development positive regulation of developmental process positive regulation of cell differentiation cell differentiation anatomical structure development regulation of myoblast differentiation myoblast differentiation positive regulation of cellular process multicellular organismal process regulation of body fluid levels wound healing response to stimulus homotypic cell-cell adhesion cell activation hemostasis platelet aggregation blood coagulation cell adhesion cell-cell adhesion response to stress coagulation regulation of biological quality response to wounding platelet activation regulation of apoptotic process apoptotic process regulation of programmed cell death cell death programmed cell death cellular response to nitrogen compound cellular response to stimulus response to cytochalasin B response to oxygen-containing compound response to nitrogen compound cellular response to oxygen-containing compound cellular response to cytochalasin B cellular response to chemical stimulus response to chemical regulation of localization import into cell cellular localization transport synaptic vesicle cycle regulation of synaptic vesicle recycling vesicle-mediated transport presynaptic endocytosis vesicle-mediated transport in synapse localization synaptic vesicle recycling regulation of synaptic vesicle endocytosis establishment of localization in cell regulation of endocytosis synaptic vesicle endocytosis regulation of transport regulation of vesicle-mediated transport establishment of localization endocytosis axonogenesis cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis neurogenesis multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis system development plasma membrane bounded cell projection organization nervous system development axon development cell morphogenesis involved in neuron differentiation generation of neurons anatomical structure morphogenesis neuron development tissue morphogenesis epithelium development morphogenesis of a polarized epithelium morphogenesis of an epithelium tissue development regulation of DNA recombination regulation of double-strand break repair regulation of cellular response to stress positive regulation of double-strand break repair via homologous recombination regulation of primary metabolic process nucleobase-containing compound metabolic process positive regulation of response to stimulus positive regulation of metabolic process positive regulation of DNA repair cellular response to stress regulation of response to stress recombinational repair positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process double-strand break repair via homologous recombination DNA repair positive regulation of DNA recombination double-strand break repair positive regulation of nucleobase-containing compound metabolic process DNA recombination primary metabolic process DNA metabolic process regulation of macromolecule metabolic process nucleic acid metabolic process positive regulation of double-strand break repair regulation of DNA repair regulation of double-strand break repair via homologous recombination positive regulation of DNA metabolic process DNA damage response regulation of response to stimulus metabolic process macromolecule metabolic process regulation of metabolic process regulation of DNA metabolic process monoamine transport norepinephrine transport nitrogen compound transport organic hydroxy compound transport organic cation transport catecholamine uptake catecholamine transport regulation of norepinephrine uptake norepinephrine uptake establishment or maintenance of cell polarity protein localization protein localization to cell periphery regulation of protein localization protein localization to plasma membrane regulation of protein localization to cell periphery localization within membrane protein localization to membrane regulation of cellular localization cellular macromolecule localization macromolecule localization regulation of protein localization to plasma membrane regulation of protein localization to membrane negative regulation of developmental process negative regulation of biological process negative regulation of cellular process negative regulation of cell differentiation cell motility regulation of protein modification process regulation of catalytic activity regulation of protein phosphorylation regulation of transferase activity regulation of cyclin-dependent protein serine/threonine kinase activity regulation of phosphate metabolic process phosphate-containing compound metabolic process protein metabolic process phosphorus metabolic process protein modification process protein phosphorylation phosphorylation regulation of protein metabolic process regulation of protein kinase activity regulation of molecular function regulation of kinase activity regulation of protein serine/threonine kinase activity macromolecule modification regulation of phosphorylation regulation of phosphorus metabolic process adherens junction organization adherens junction assembly cellular component biogenesis cell junction organization cellular component assembly cell junction assembly cell-cell junction assembly cell-cell junction organization transepithelial transport regulation of transepithelial transport apical protein localization positive regulation of norepinephrine uptake positive regulation of transport regulation of transmembrane transporter activity regulation of transporter activity transmembrane transport regulation of transmembrane transport regulation of stem cell population maintenance stem cell population maintenance positive regulation of stem cell population maintenance positive regulation of multicellular organismal process regulation of multicellular organismal process maintenance of cell number cell population proliferation positive regulation of cell population proliferation regulation of cell population proliferation head development animal organ development brain development substantia nigra development central nervous system development midbrain development neural nucleus development nucleotide-excision repair regulation of nucleotide-excision repair positive regulation of DNA-templated transcription RNA metabolic process positive regulation of macromolecule biosynthetic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process positive regulation of biosynthetic process regulation of RNA biosynthetic process regulation of biosynthetic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process positive regulation of RNA metabolic process regulation of gene expression biosynthetic process positive regulation of RNA biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of G0 to G1 transition G0 to G1 transition maintenance of blood-brain barrier multicellular organismal-level homeostasis homeostatic process anatomical structure homeostasis tissue homeostasis protein localization to cell junction protein localization to adherens junction protein localization to cell-cell junction transcription by RNA polymerase II regulation of transcription by RNA polymerase II regulation of cell cycle G1/S phase transition cell cycle G1/S phase transition regulation of G1/S transition of mitotic cell cycle G1/S transition of mitotic cell cycle regulation of leukocyte differentiation regulation of leukocyte activation regulation of cell activation mononuclear cell differentiation lymphocyte differentiation positive regulation of T cell differentiation regulation of cell development positive regulation of cell activation T cell activation positive regulation of leukocyte activation T cell differentiation regulation of immune system process positive regulation of immune system process positive regulation of T cell activation positive regulation of cell development regulation of leukocyte cell-cell adhesion leukocyte differentiation positive regulation of leukocyte cell-cell adhesion lymphocyte activation leukocyte cell-cell adhesion leukocyte activation positive regulation of cell-cell adhesion regulation of T cell differentiation positive regulation of lymphocyte activation positive regulation of hemopoiesis regulation of cell-cell adhesion regulation of lymphocyte differentiation regulation of multicellular organismal development hemopoiesis positive regulation of cell adhesion regulation of cell adhesion regulation of T cell activation immune system process regulation of hemopoiesis positive regulation of leukocyte differentiation positive regulation of lymphocyte differentiation regulation of lymphocyte activation chromatin organization chromatin remodeling	cell projection cellular anatomical structure cell leading edge plasma membrane bounded cell projection lamellipodium membrane cell-cell junction anchoring junction cell junction membrane-bounded organelle ATPase complex protein-containing complex intracellular anatomical structure catalytic complex cell projection cellular anatomical structure cell leading edge plasma membrane bounded cell projection lamellipodium membrane cell-cell junction anchoring junction cell junction membrane-bounded organelle ATPase complex protein-containing complex intracellular anatomical structure catalytic complex nucleus nuclear protein-containing complex intracellular membraneless organelle chromatin chromosome intracellular membrane-bounded organelle intracellular organelle organelle membraneless organelle SWI/SNF superfamily-type complex brahma complex GBAF complex extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytoskeleton actin cytoskeleton cytoplasm cytosol SWI/SNF complex cluster of actin-based cell projections brush border synapse glutamatergic synapse apical junction complex adherens junction nBAF complex axon neuron projection axon terminus presynapse distal axon calyx of Held neuron projection terminus npBAF complex polymeric cytoskeletal fiber actin filament supramolecular fiber supramolecular polymer supramolecular complex cell cortex cortical cytoskeleton cell periphery membrane-enclosed lumen intracellular organelle lumen organelle lumen nuclear lumen nuclear matrix focal adhesion cell-substrate junction postsynapse postsynaptic cytoskeleton postsynaptic actin cytoskeleton NuA4 histone acetyltransferase complex transferase complex H4/H2A histone acetyltransferase complex histone acetyltransferase complex acetyltransferase complex H4 histone acetyltransferase complex protein acetyltransferase complex intracellular protein-containing complex RSC-type complex dense body plasma membrane protein-DNA complex nucleosome nucleoplasm bBAF complex cytoplasmic ribonucleoprotein granule ribonucleoprotein granule blood microparticle chromosomal region kinetochore chromosome, centromeric region condensed chromosome, centromeric region condensed chromosome Schaffer collateral - CA1 synapse tight junction ribonucleoprotein complex
AA [auth d], B [auth b], N [auth k], O [auth m], P [auth i]	Mitotic-spindle organizing protein 1	-	microtubule cytoskeleton organization membraneless organelle assembly mitotic cell cycle cellular component organization cellular component biogenesis cellular component assembly mitotic sister chromatid segregation cell cycle cellular component organization or biogenesis chromosome segregation microtubule cytoskeleton organization involved in mitosis spindle organization cell cycle process mitotic nuclear division microtubule cytoskeleton organization membraneless organelle assembly mitotic cell cycle cellular component organization cellular component biogenesis cellular component assembly mitotic sister chromatid segregation cell cycle cellular component organization or biogenesis chromosome segregation microtubule cytoskeleton organization involved in mitosis spindle organization cell cycle process mitotic nuclear division organelle assembly organelle fission chromosome organization sister chromatid segregation spindle assembly mitotic spindle organization mitotic spindle assembly organelle organization nuclear division mitotic cell cycle process nuclear chromosome segregation cellular process microtubule-based process cytoskeleton organization protein polymerization protein-containing complex organization microtubule nucleation by microtubule organizing center microtubule polymerization microtubule polymerization or depolymerization microtubule nucleation microtubule nucleation by interphase microtubule organizing center protein-containing complex assembly supramolecular fiber organization gamma-tubulin complex localization localization protein-containing complex localization	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol protein-containing complex gamma-tubulin ring complex intracellular membraneless organelle gamma-tubulin complex intracellular organelle microtubule organizing center cytoskeleton organelle membraneless organelle microtubule cytoskeleton cellular anatomical structure intracellular anatomical structure cytoplasm cytosol protein-containing complex gamma-tubulin ring complex intracellular membraneless organelle gamma-tubulin complex intracellular organelle microtubule organizing center cytoskeleton organelle membraneless organelle microtubule cytoskeleton interphase microtubule organizing center spindle centrosome
C [auth a], CA [auth h], DA [auth j], E [auth D], G [auth F], C [auth a], CA [auth h], DA [auth j], E [auth D], G [auth F], I [auth H]	Gamma-tubulin complex component 3	cytoskeletal protein binding protein binding binding gamma-tubulin binding tubulin binding structural constituent of cytoskeleton structural molecule activity	cellular process cell cycle mitotic cell cycle cellular component organization organelle organization microtubule cytoskeleton organization microtubule-based process cytoplasmic microtubule organization cellular component organization or biogenesis supramolecular fiber organization cytoskeleton organization sexual reproduction reproductive process fertilization cellular process cell cycle mitotic cell cycle cellular component organization organelle organization microtubule cytoskeleton organization microtubule-based process cytoplasmic microtubule organization cellular component organization or biogenesis supramolecular fiber organization cytoskeleton organization sexual reproduction reproductive process fertilization single fertilization meiotic cell cycle organelle assembly membraneless organelle assembly spindle assembly cellular component biogenesis cellular component assembly chromosome segregation spindle organization cell cycle process protein polymerization protein-containing complex organization microtubule polymerization microtubule polymerization or depolymerization microtubule nucleation protein-containing complex assembly	cellular anatomical structure membrane intracellular organelle centrosome microtubule organizing center intracellular anatomical structure cytoskeleton organelle membraneless organelle intracellular membraneless organelle microtubule cytoskeleton polymeric cytoskeletal fiber spindle spindle microtubule cellular anatomical structure membrane intracellular organelle centrosome microtubule organizing center intracellular anatomical structure cytoskeleton organelle membraneless organelle intracellular membraneless organelle microtubule cytoskeleton polymeric cytoskeletal fiber spindle spindle microtubule polar microtubule spindle pole supramolecular fiber microtubule supramolecular polymer supramolecular complex centriole cytoplasm cytosol protein-containing complex gamma-tubulin complex
D [auth C], F [auth E], H [auth G]	Gamma-tubulin complex component 2	cytoskeletal protein binding protein binding binding gamma-tubulin binding tubulin binding	cellular process cell cycle mitotic cell cycle developmental process multicellular organism development multicellular organismal process head development central nervous system development anatomical structure development animal organ development brain development nervous system development system development cellular component organization cellular process cell cycle mitotic cell cycle developmental process multicellular organism development multicellular organismal process head development central nervous system development anatomical structure development animal organ development brain development nervous system development system development cellular component organization organelle organization microtubule cytoskeleton organization microtubule-based process cytoplasmic microtubule organization cellular component organization or biogenesis supramolecular fiber organization cytoskeleton organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly neuron migration cellular developmental process generation of neurons neurogenesis cell differentiation cell migration cell motility sexual reproduction reproductive process meiotic cell cycle organelle assembly membraneless organelle assembly spindle assembly chromosome segregation spindle organization cell cycle process protein polymerization microtubule polymerization microtubule polymerization or depolymerization microtubule nucleation	intracellular organelle cellular anatomical structure intracellular anatomical structure cytoskeleton spindle organelle membraneless organelle intracellular membraneless organelle spindle pole microtubule cytoskeleton membrane centrosome microtubule organizing center cytoplasm intracellular organelle cellular anatomical structure intracellular anatomical structure cytoskeleton spindle organelle membraneless organelle intracellular membraneless organelle spindle pole microtubule cytoskeleton membrane centrosome microtubule organizing center cytoplasm cytosol polymeric cytoskeletal fiber cytoplasmic microtubule supramolecular fiber microtubule supramolecular polymer supramolecular complex membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen protein-containing complex gamma-tubulin complex
J [auth I], L [auth K]	Gamma-tubulin complex component 4	cytoskeletal protein binding protein binding binding gamma-tubulin binding tubulin binding structural constituent of cytoskeleton structural molecule activity	cellular process cell cycle mitotic cell cycle cellular component organization organelle organization microtubule cytoskeleton organization microtubule-based process cytoplasmic microtubule organization cellular component organization or biogenesis supramolecular fiber organization cytoskeleton organization cellular component biogenesis cellular component assembly protein-containing complex organization cellular process cell cycle mitotic cell cycle cellular component organization organelle organization microtubule cytoskeleton organization microtubule-based process cytoplasmic microtubule organization cellular component organization or biogenesis supramolecular fiber organization cytoskeleton organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly sexual reproduction reproductive process meiotic cell cycle organelle assembly membraneless organelle assembly spindle assembly chromosome segregation spindle organization cell cycle process protein polymerization microtubule polymerization microtubule polymerization or depolymerization microtubule nucleation	intracellular organelle cellular anatomical structure intracellular anatomical structure cytoskeleton spindle organelle membraneless organelle intracellular membraneless organelle spindle pole microtubule cytoskeleton membrane membrane-bounded organelle endosome intracellular vesicle intracellular organelle cellular anatomical structure intracellular anatomical structure cytoskeleton spindle organelle membraneless organelle intracellular membraneless organelle spindle pole microtubule cytoskeleton membrane membrane-bounded organelle endosome intracellular vesicle intracellular membrane-bounded organelle recycling endosome endomembrane system cytoplasmic vesicle cytoplasm vesicle centrosome microtubule organizing center cytosol protein-containing complex gamma-tubulin ring complex gamma-tubulin complex polymeric cytoskeletal fiber supramolecular fiber microtubule supramolecular polymer supramolecular complex
EA [auth l], K [auth J]	Gamma-tubulin complex component 5	cytoskeletal protein binding protein binding binding gamma-tubulin binding tubulin binding microtubule binding	cellular process cell cycle mitotic cell cycle cellular component organization organelle organization microtubule cytoskeleton organization microtubule-based process cytoplasmic microtubule organization cellular component organization or biogenesis supramolecular fiber organization cytoskeleton organization sexual reproduction reproductive process meiotic cell cycle cellular process cell cycle mitotic cell cycle cellular component organization organelle organization microtubule cytoskeleton organization microtubule-based process cytoplasmic microtubule organization cellular component organization or biogenesis supramolecular fiber organization cytoskeleton organization sexual reproduction reproductive process meiotic cell cycle organelle assembly membraneless organelle assembly spindle assembly cellular component biogenesis cellular component assembly chromosome segregation spindle organization cell cycle process protein polymerization protein-containing complex organization microtubule polymerization microtubule polymerization or depolymerization microtubule nucleation protein-containing complex assembly	intracellular organelle cellular anatomical structure intracellular anatomical structure cytoskeleton spindle organelle membraneless organelle intracellular membraneless organelle spindle pole microtubule cytoskeleton centrosome microtubule organizing center cytoplasm cytosol intracellular organelle cellular anatomical structure intracellular anatomical structure cytoskeleton spindle organelle membraneless organelle intracellular membraneless organelle spindle pole microtubule cytoskeleton centrosome microtubule organizing center cytoplasm cytosol protein-containing complex gamma-tubulin ring complex gamma-tubulin complex polymeric cytoskeletal fiber supramolecular fiber microtubule supramolecular polymer supramolecular complex
BA [auth c], M [auth L]	Gamma-tubulin complex component 6	cytoskeletal protein binding protein binding binding gamma-tubulin binding tubulin binding microtubule binding	cellular process cell cycle mitotic cell cycle cellular component organization organelle organization microtubule cytoskeleton organization microtubule-based process cytoplasmic microtubule organization cellular component organization or biogenesis supramolecular fiber organization cytoskeleton organization sexual reproduction reproductive process meiotic cell cycle cellular process cell cycle mitotic cell cycle cellular component organization organelle organization microtubule cytoskeleton organization microtubule-based process cytoplasmic microtubule organization cellular component organization or biogenesis supramolecular fiber organization cytoskeleton organization sexual reproduction reproductive process meiotic cell cycle organelle assembly membraneless organelle assembly spindle assembly cellular component biogenesis cellular component assembly chromosome segregation spindle organization cell cycle process protein polymerization protein-containing complex organization microtubule polymerization microtubule polymerization or depolymerization microtubule nucleation protein-containing complex assembly	intracellular organelle cellular anatomical structure intracellular anatomical structure cytoskeleton spindle organelle membraneless organelle intracellular membraneless organelle spindle pole microtubule cytoskeleton membrane centrosome microtubule organizing center cytoplasm intracellular organelle cellular anatomical structure intracellular anatomical structure cytoskeleton spindle organelle membraneless organelle intracellular membraneless organelle spindle pole microtubule cytoskeleton membrane centrosome microtubule organizing center cytoplasm cytosol protein-containing complex gamma-tubulin ring complex gamma-tubulin complex polymeric cytoskeletal fiber supramolecular fiber microtubule supramolecular polymer supramolecular complex
Q, R, S, T, U Q, R, S, T, U, V, W, X, Y, Z	Tubulin gamma-1 chain	binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding structural constituent of cytoskeleton structural molecule activity identical protein binding protein binding	cellular process cell cycle mitotic cell cycle mitotic nuclear division organelle fission chromosome organization sister chromatid segregation cellular component organization organelle organization nuclear division mitotic cell cycle process mitotic sister chromatid segregation nuclear chromosome segregation cellular component organization or biogenesis cellular process cell cycle mitotic cell cycle mitotic nuclear division organelle fission chromosome organization sister chromatid segregation cellular component organization organelle organization nuclear division mitotic cell cycle process mitotic sister chromatid segregation nuclear chromosome segregation cellular component organization or biogenesis chromosome segregation cell cycle process microtubule cytoskeleton organization microtubule-based process cytoplasmic microtubule organization supramolecular fiber organization cytoskeleton organization sexual reproduction reproductive process meiotic cell cycle meiotic spindle organization meiotic cell cycle process spindle organization mitotic spindle organization microtubule cytoskeleton organization involved in mitosis protein polymerization protein-containing complex organization microtubule polymerization cellular component biogenesis microtubule polymerization or depolymerization cellular component assembly microtubule nucleation protein-containing complex assembly	cellular anatomical structure apical part of cell membrane-bounded organelle condensed nuclear chromosome intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle nuclear chromosome chromosome intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle organelle lumen cellular anatomical structure apical part of cell membrane-bounded organelle condensed nuclear chromosome intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle nuclear chromosome chromosome intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle organelle lumen organelle membraneless organelle condensed chromosome nuclear lumen centrosome microtubule organizing center cytoskeleton microtubule cytoskeleton polymeric cytoskeletal fiber spindle spindle microtubule polar microtubule spindle pole supramolecular fiber microtubule supramolecular polymer supramolecular complex centriole cytoplasm cytosol cell leading edge non-motile cilium cell projection cilium plasma membrane bounded cell projection protein-containing complex gamma-tubulin complex neuron projection endosome intracellular vesicle recycling endosome endomembrane system cytoplasmic vesicle vesicle pericentriolar material cytoplasmic microtubule ciliary basal body mitotic spindle mitotic spindle microtubule

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth e]	IPR020902	Actin/actin-like conserved site	Conserved Site
A [auth e]	IPR004001	Actin, conserved site	Conserved Site
A [auth e]	IPR043129	ATPase, nucleotide binding domain	Homologous Superfamily
A [auth e]	IPR004000	Actin family	Family
AA [auth d], B [auth b], N [auth k], O [auth m], P [auth i]	IPR022214	Mitotic-spindle organizing protein 1	Family
C [auth a], CA [auth h], DA [auth j], E [auth D], G [auth F], C [auth a], CA [auth h], DA [auth j], E [auth D], G [auth F], I [auth H]	IPR040457	Gamma tubulin complex component, C-terminal	Domain
C [auth a], CA [auth h], DA [auth j], E [auth D], G [auth F], C [auth a], CA [auth h], DA [auth j], E [auth D], G [auth F], I [auth H]	IPR042241	Gamma-tubulin complex component, C-terminal domain superfamily	Homologous Superfamily
C [auth a], CA [auth h], DA [auth j], E [auth D], G [auth F], C [auth a], CA [auth h], DA [auth j], E [auth D], G [auth F], I [auth H]	IPR007259	Gamma-tubulin complex component protein	Family
C [auth a], CA [auth h], DA [auth j], E [auth D], G [auth F], C [auth a], CA [auth h], DA [auth j], E [auth D], G [auth F], I [auth H]	IPR041470	Gamma tubulin complex component protein, N-terminal	Domain
D [auth C], F [auth E], H [auth G]	IPR040457	Gamma tubulin complex component, C-terminal	Domain
D [auth C], F [auth E], H [auth G]	IPR042241	Gamma-tubulin complex component, C-terminal domain superfamily	Homologous Superfamily
D [auth C], F [auth E], H [auth G]	IPR007259	Gamma-tubulin complex component protein	Family
D [auth C], F [auth E], H [auth G]	IPR041470	Gamma tubulin complex component protein, N-terminal	Domain
J [auth I], L [auth K]	IPR040457	Gamma tubulin complex component, C-terminal	Domain
J [auth I], L [auth K]	IPR042241	Gamma-tubulin complex component, C-terminal domain superfamily	Homologous Superfamily
J [auth I], L [auth K]	IPR007259	Gamma-tubulin complex component protein	Family
J [auth I], L [auth K]	IPR041470	Gamma tubulin complex component protein, N-terminal	Domain
EA [auth l], K [auth J]	IPR040457	Gamma tubulin complex component, C-terminal	Domain
EA [auth l], K [auth J]	IPR042241	Gamma-tubulin complex component, C-terminal domain superfamily	Homologous Superfamily
EA [auth l], K [auth J]	IPR007259	Gamma-tubulin complex component protein	Family
EA [auth l], K [auth J]	IPR041470	Gamma tubulin complex component protein, N-terminal	Domain
BA [auth c], M [auth L]	IPR040457	Gamma tubulin complex component, C-terminal	Domain
BA [auth c], M [auth L]	IPR045818	Gamma-tubulin complex component 6, N-terminal	Domain
BA [auth c], M [auth L]	IPR042241	Gamma-tubulin complex component, C-terminal domain superfamily	Homologous Superfamily
BA [auth c], M [auth L]	IPR007259	Gamma-tubulin complex component protein	Family
BA [auth c], M [auth L]	IPR041470	Gamma tubulin complex component protein, N-terminal	Domain
Q, R, S, T, U Q, R, S, T, U, V, W, X, Y, Z	IPR008280	Tubulin/FtsZ, C-terminal	Homologous Superfamily
Q, R, S, T, U Q, R, S, T, U, V, W, X, Y, Z	IPR002454	Gamma tubulin	Family
Q, R, S, T, U Q, R, S, T, U, V, W, X, Y, Z	IPR017975	Tubulin, conserved site	Conserved Site
Q, R, S, T, U Q, R, S, T, U, V, W, X, Y, Z	IPR023123	Tubulin, C-terminal	Homologous Superfamily
Q, R, S, T, U Q, R, S, T, U, V, W, X, Y, Z	IPR018316	Tubulin/FtsZ, 2-layer sandwich domain	Domain
Q, R, S, T, U Q, R, S, T, U, V, W, X, Y, Z	IPR003008	Tubulin/FtsZ, GTPase domain	Domain
Q, R, S, T, U Q, R, S, T, U, V, W, X, Y, Z	IPR037103	Tubulin/FtsZ-like, C-terminal domain	Homologous Superfamily
Q, R, S, T, U Q, R, S, T, U, V, W, X, Y, Z	IPR000217	Tubulin	Family
Q, R, S, T, U Q, R, S, T, U, V, W, X, Y, Z	IPR036525	Tubulin/FtsZ, GTPase domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth e]	Pharos: P60709	developmental malformations-deafness-dystonia syndrome coloboma dystonic disorder Baraitser-Winter cerebrofrontofacial syndrome intellectual disability Neoplasm Invasiveness Baraitser-Winter syndrome 1 carcinoma dysostosis esophageal cancer sarcomatoid carcinoma ovarian cancer central nervous system malformation large cell medulloblastoma pancreatic intraductal papillary-mucinous neoplasm developmental malformations-deafness-dystonia syndrome coloboma dystonic disorder Baraitser-Winter cerebrofrontofacial syndrome intellectual disability Neoplasm Invasiveness Baraitser-Winter syndrome 1 carcinoma dysostosis esophageal cancer sarcomatoid carcinoma ovarian cancer central nervous system malformation large cell medulloblastoma pancreatic intraductal papillary-mucinous neoplasm liver disease plasma cell myeloma lung disease prostate disease schizophrenia drug-induced liver injury mammary neoplasms, animal arthritic joint disease stomach disease multiple endocrine neoplasia type 2A atypical teratoid rhabdoid tumor uterine disease glioblastoma hepatocellular carcinoma obesity disorder Borst-Jadassohn intraepidermal carcinoma ovarian disease cerebrovascular disorder linear and whorled nevoid hypermelanosis pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia colonic disease lung adenocarcinoma primary cutaneous amyloidosis coronary artery disease rheumatoid arthritis craniosynostosis malignant ependymoma seborrheic keratosis malignant pancreatic neoplasm skin basal cell carcinoma astrocytic tumor type 2 diabetes mellitus mycosis fungoides autoimmune disease vertebral column disease head and neck cancer neoplasm of esophagus Becker nevus syndrome hyperglycemia osteoarthritis breast disease osteosarcoma kidney disease pancreatic ductal adenocarcinoma chronic obstructive pulmonary disease pilocytic astrocytoma lung benign neoplasm primitive neuroectodermal tumor lymphatic system disease dermatomyositis malignant glioma Down syndrome skin disease medulloblastoma atherosclerosis undifferentiated carcinoma eye disease myocardial ischemia X-linked mixed deafness with perilymphatic gusher hematologic disease neurodegenerative disease bipolar disorder hypertensive disorder osteoarthritis susceptibility 1 cancer
AA [auth d], B [auth b], N [auth k], O [auth m], P [auth i]	Pharos: Q08AG7	astrocytic tumor malignant ependymoma pancreatic intraductal papillary-mucinous neoplasm atypical teratoid rhabdoid tumor malignant glioma pilocytic astrocytoma glioblastoma oligodendroglioma subependymal giant cell astrocytoma
C [auth a], CA [auth h], DA [auth j], E [auth D], G [auth F], C [auth a], CA [auth h], DA [auth j], E [auth D], G [auth F], I [auth H]	Pharos: Q96CW5	adenoma large cell medulloblastoma oligodendroglioma Primary microcephaly amyotrophic lateral sclerosis malignant mesothelioma osteosarcoma psoriasis atypical teratoid rhabdoid tumor medulloblastoma ovarian cancer tuberculosis
D [auth C], F [auth E], H [auth G]	Pharos: Q9BSJ2	epilepsy ovarian cancer Gaucher disease lissencephaly spectrum disorders
J [auth I], L [auth K]	Pharos: Q9UGJ1	intellectual disability microcephaly and chorioretinopathy 3 microcephaly Microcephaly with Chorioretinopathy, Autosomal Recessive subependymal giant cell astrocytoma microcephaly and chorioretinopathy 1
EA [auth l], K [auth J]	Pharos: Q96RT8	malignant mesothelioma tuberculosis osteosarcoma psoriasis
BA [auth c], M [auth L]	Pharos: Q96RT7	microcephaly and chorioretinopathy 1 Microcephaly with Chorioretinopathy, Autosomal Recessive atopic eczema cutaneous melanoma hypertensive disorder microcephaly osteosarcoma progressive supranuclear palsy atypical teratoid rhabdoid tumor endogenous depression intellectual disability Pick disease bipolar disorder glioblastoma large cell medulloblastoma
Q, R, S, T, U Q, R, S, T, U, V, W, X, Y, Z	Pharos: P23258	complex cortical dysplasia with other brain malformations 4 microcephaly breast cancer Epileptic encephalopathy microlissencephaly ovarian cancer cerebral cortical dysplasia lissencephaly spectrum disorders metabolic syndrome X non-small cell lung carcinoma psoriasis cerebrovascular disorder dermatomyositis lung adenocarcinoma osteosarcoma