7SA9 | pdb_00007sa9

Human MUC16 SEA5 Domain

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	SEA	e7sa9A1	A: a+b two layers	X: Alpha-beta plaits	H: SEA domain (From Topology)	T: SEA domain	F: SEA	ECOD (1.6)
B	SEA	e7sa9B1	A: a+b two layers	X: Alpha-beta plaits	H: SEA domain (From Topology)	T: SEA domain	F: SEA	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF01390	SEA domain (SEA)	SEA domain	Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed function of regulating or binding carbohydrate side chains. Recently a proteolytic activity has been shown for a SEA domain [4].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Mucin-16	-	cell adhesion cellular process	membrane-bounded organelle intracellular anatomical structure Golgi apparatus membrane-enclosed lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen Golgi lumen intracellular organelle cellular anatomical structure organelle lumen organelle cytoplasm cell periphery membrane-bounded organelle intracellular anatomical structure Golgi apparatus membrane-enclosed lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen Golgi lumen intracellular organelle cellular anatomical structure organelle lumen organelle cytoplasm cell periphery plasma membrane membrane cell surface external side of plasma membrane side of membrane vesicle extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space extracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR036364	SEA domain superfamily	Homologous Superfamily
A, B	IPR028850	Mucin-16	Family
A, B	IPR000082	SEA domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q8WXI7	ovarian cancer proteinuria cystic fibrosis malignant pancreatic neoplasm ovarian disease psoriasis lung adenocarcinoma nasopharyngeal carcinoma ovarian neoplasm Malignant neoplasm of ovary

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.