7ZV9 | pdb_00007zv9

Crystal structure of FLT3 in complex with a monomeric FLT3 Ligand variant

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	4-helical cytokines	8037098	3001717	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	4-helical cytokines	8037098	3001717	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	4-helical cytokines	8037098	3001717	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	4-helical cytokines	8037098	3001717	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	4-helical cytokines	8037098	3001717	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	4-helical cytokines	8037098	3001717	SCOP2B (2022-06-29)
M	SCOP2B Superfamily	4-helical cytokines	8037098	3001717	SCOP2B (2022-06-29)
O	SCOP2B Superfamily	4-helical cytokines	8037098	3001717	SCOP2B (2022-06-29)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C, E, G, I A, C, E, G, I, K, M, O	PF02947	flt3 ligand (Flt3_lig)	flt3 ligand	The flt3 ligand is a short chain cytokine with a 4 helical bundle fold.	Domain
B, D, F, H, J B, D, F, H, J, L, N, P	PF00047	Immunoglobulin domain (ig)	Immunoglobulin domain	Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-prote ...	Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C, E, G, I A, C, E, G, I, K, M, O	Fms-related tyrosine kinase 3 ligand	protein binding binding signaling receptor binding molecular transducer activity molecular function activator activity signaling receptor activity signaling receptor activator activity molecular function regulator activity cytokine activity signaling receptor regulator activity receptor ligand activity protein tyrosine kinase binding kinase binding receptor tyrosine kinase binding protein binding binding signaling receptor binding molecular transducer activity molecular function activator activity signaling receptor activity signaling receptor activator activity molecular function regulator activity cytokine activity signaling receptor regulator activity receptor ligand activity protein tyrosine kinase binding kinase binding receptor tyrosine kinase binding enzyme binding protein kinase binding	regulation of biological process cell population proliferation regulation of cellular process positive regulation of cell population proliferation regulation of cell population proliferation biological regulation positive regulation of biological process cellular process positive regulation of cellular process developmental process multicellular organismal process cellular developmental process hemopoiesis animal organ development regulation of biological process cell population proliferation regulation of cellular process positive regulation of cell population proliferation regulation of cell population proliferation biological regulation positive regulation of biological process cellular process positive regulation of cellular process developmental process multicellular organismal process cellular developmental process hemopoiesis animal organ development cell development embryo development multicellular organism development embryonic hemopoiesis cell differentiation anatomical structure development embryonic organ development B cell activation cell activation mononuclear cell differentiation lymphocyte differentiation lymphocyte activation leukocyte activation B cell differentiation immune system process leukocyte differentiation dendritic cell differentiation cellular response to stimulus response to stimulus signaling signal transduction cell communication	cellular anatomical structure membrane extracellular region cell surface intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane extracellular space
B, D, F, H, J B, D, F, H, J, L, N, P	Receptor-type tyrosine-protein kinase FLT3	transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding nuclear receptor binding protein binding binding nuclear glucocorticoid receptor binding DNA-binding transcription factor binding molecular transducer activity catalytic activity, acting on a protein ephrin receptor activity kinase activity protein kinase activity signaling receptor activity transferase activity transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding nuclear receptor binding protein binding binding nuclear glucocorticoid receptor binding DNA-binding transcription factor binding molecular transducer activity catalytic activity, acting on a protein ephrin receptor activity kinase activity protein kinase activity signaling receptor activity transferase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups transmembrane-ephrin receptor activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity transmembrane receptor protein kinase activity transmembrane signaling receptor activity catalytic activity collagen receptor activity protein tyrosine kinase collagen receptor activity GPI-linked ephrin receptor activity protein-hormone receptor activity insulin receptor activity histone H3Y41 kinase activity histone H3 kinase activity histone modifying activity histone kinase activity placental growth factor receptor activity adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding platelet-derived growth factor beta-receptor activity platelet-derived growth factor receptor activity stem cell factor receptor activity protein-containing complex binding brain-derived neurotrophic factor receptor activity neurotrophin receptor activity phosphatidylinositol 3-kinase activator activity enzyme regulator activity molecular function regulator activity phosphatidylinositol 3-kinase regulator activity kinase regulator activity insulin-like growth factor receptor activity hepatocyte growth factor receptor activity boss receptor activity epidermal growth factor receptor activity macrophage colony-stimulating factor receptor activity platelet-derived growth factor alpha-receptor activity cytokine receptor activity immune receptor activity growth factor binding fibroblast growth factor receptor activity vascular endothelial growth factor receptor activity histone H2AXY142 kinase activity histone H2AX kinase activity	cellular response to stimulus regulation of biological process regulation of cellular process cell surface receptor signaling pathway response to stimulus signaling biological regulation response to cytokine cytokine-mediated signaling pathway cell communication response to peptide response to chemical cellular process cellular response to cytokine stimulus cellular response to stimulus regulation of biological process regulation of cellular process cell surface receptor signaling pathway response to stimulus signaling biological regulation response to cytokine cytokine-mediated signaling pathway cell communication response to peptide response to chemical cellular process cellular response to cytokine stimulus signal transduction multicellular organismal process multicellular organismal-level homeostasis leukocyte homeostasis homeostatic process immune system process homeostasis of number of cells regulation of apoptotic process apoptotic process regulation of programmed cell death cell death programmed cell death developmental process cellular developmental process hemopoiesis cell differentiation anatomical structure development cell development cell population proliferation mononuclear cell proliferation lymphocyte proliferation cell activation lymphocyte activation leukocyte proliferation leukocyte activation protein phosphorylation protein autophosphorylation phosphorylation primary metabolic process macromolecule modification phosphate-containing compound metabolic process metabolic process protein metabolic process macromolecule metabolic process protein modification process phosphorus metabolic process dendritic cell differentiation mononuclear cell differentiation leukocyte differentiation common myeloid progenitor cell proliferation pro-B cell differentiation lymphoid progenitor cell differentiation hematopoietic progenitor cell differentiation B cell activation lymphocyte differentiation B cell differentiation positive regulation of cell communication regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of signal transduction positive regulation of biological process regulation of signal transduction intracellular signal transduction positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette positive regulation of cellular process regulation of signaling positive regulation of intracellular signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction regulation of response to stimulus regulation of cell communication phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of signaling myeloid progenitor cell differentiation positive regulation of cell population proliferation regulation of cell population proliferation peptidyl-tyrosine modification peptidyl-amino acid modification peptidyl-tyrosine phosphorylation positive regulation of phosphorylation regulation of catalytic activity regulation of transferase activity positive regulation of phosphate metabolic process regulation of MAP kinase activity regulation of primary metabolic process positive regulation of protein serine/threonine kinase activity positive regulation of metabolic process regulation of phosphate metabolic process positive regulation of macromolecule metabolic process positive regulation of protein phosphorylation positive regulation of MAP kinase activity positive regulation of phosphorus metabolic process positive regulation of MAPK cascade regulation of protein metabolic process regulation of MAPK cascade regulation of molecular function positive regulation of kinase activity regulation of kinase activity regulation of protein serine/threonine kinase activity regulation of phosphorus metabolic process regulation of metabolic process regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of molecular function positive regulation of protein modification process positive regulation of protein kinase activity positive regulation of transferase activity positive regulation of catalytic activity regulation of protein kinase activity regulation of macromolecule metabolic process MAPK cascade regulation of phosphorylation tyrosine phosphorylation of STAT protein cell surface receptor signaling pathway via STAT positive regulation of peptidyl-tyrosine phosphorylation regulation of tyrosine phosphorylation of STAT protein regulation of peptidyl-tyrosine phosphorylation positive regulation of tyrosine phosphorylation of STAT protein cell surface receptor signaling pathway via JAK-STAT cell surface receptor protein tyrosine kinase signaling pathway enzyme-linked receptor protein signaling pathway animal organ regeneration animal organ development regeneration response to lipid response to endogenous stimulus response to glucocorticoid cellular response to glucocorticoid stimulus cellular response to corticosteroid stimulus cellular response to endogenous stimulus response to corticosteroid cellular response to chemical stimulus response to hormone response to steroid hormone cellular response to lipid cellular response to steroid hormone stimulus cellular response to hormone stimulus	protein-containing complex receptor complex membrane-bounded organelle intracellular anatomical structure membrane-enclosed lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen endoplasmic reticulum lumen intracellular organelle cellular anatomical structure organelle lumen organelle endoplasmic reticulum protein-containing complex receptor complex membrane-bounded organelle intracellular anatomical structure membrane-enclosed lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen endoplasmic reticulum lumen intracellular organelle cellular anatomical structure organelle lumen organelle endoplasmic reticulum cytoplasm endosome membrane membrane endosome intracellular vesicle cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane cytoplasmic vesicle vesicle organelle membrane cell periphery plasma membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C, E, G, I A, C, E, G, I, K, M, O	IPR004213	Flt3 ligand	Family
A, C, E, G, I A, C, E, G, I, K, M, O	IPR009079	Four-helical cytokine-like, core	Homologous Superfamily
B, D, F, H, J B, D, F, H, J, L, N, P	IPR001824	Tyrosine-protein kinase, receptor class III, conserved site	Conserved Site
B, D, F, H, J B, D, F, H, J, L, N, P	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
B, D, F, H, J B, D, F, H, J, L, N, P	IPR008266	Tyrosine-protein kinase, active site	Active Site
B, D, F, H, J B, D, F, H, J, L, N, P	IPR020635	Tyrosine-protein kinase, catalytic domain	Domain
B, D, F, H, J B, D, F, H, J, L, N, P	IPR000719	Protein kinase domain	Domain
B, D, F, H, J B, D, F, H, J, L, N, P	IPR013151	Immunoglobulin-like beta-sandwich domain	Domain
B, D, F, H, J B, D, F, H, J, L, N, P	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
B, D, F, H, J B, D, F, H, J, L, N, P	IPR007110	Immunoglobulin-like domain	Domain
B, D, F, H, J B, D, F, H, J, L, N, P	IPR017441	Protein kinase, ATP binding site	Binding Site
B, D, F, H, J B, D, F, H, J, L, N, P	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain	Domain
B, D, F, H, J B, D, F, H, J, L, N, P	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
B, D, F, H, J B, D, F, H, J, L, N, P	IPR050122	Receptor Tyrosine Kinase	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B, D, F, H, J B, D, F, H, J, L, N, P	Pharos: P36888	acute myeloid leukemia acute promyelocytic leukemia acute biphenotypic leukemia Leukocytosis cancer gastrointestinal stromal tumor hepatocellular carcinoma malignant mesothelioma medullary thyroid gland carcinoma osteosarcoma acute T cell leukemia Burkitt lymphoma childhood acute lymphoblastic leukemia renal cell carcinoma Hashimoto thyroiditis acute myeloid leukemia acute promyelocytic leukemia acute biphenotypic leukemia Leukocytosis cancer gastrointestinal stromal tumor hepatocellular carcinoma malignant mesothelioma medullary thyroid gland carcinoma osteosarcoma acute T cell leukemia Burkitt lymphoma childhood acute lymphoblastic leukemia renal cell carcinoma Hashimoto thyroiditis tuberculosis hypothyroidism MALT lymphoma acute lymphoblastic leukemia medulloblastoma pancreatic intraductal papillary-mucinous carcinoma acute myelomonocytic leukemia M4 aggressive systemic mastocytosis congenital anemia exocrine pancreatic carcinoma thrombotic disease hematologic disease leukemia, acute lymphocytic, susceptibility to, 1 lymphatic system disease mast cell leukemia acute myeloid leukemia with minimal differentiation pancreatic intraductal papillary-mucinous neoplasm primary myelofibrosis tenosynovial giant cell tumor

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.