7A8Y | pdb_00007a8y

X-ray crystal structure of Aspartate alpha-decarboxylase in complex with D-Serine

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Protein Modification Annotation

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth AAA]	Asp_decarbox	e7a8yAAA1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: double psi	F: Asp_decarbox	ECOD (1.6)
C [auth DDD]	Asp_decarbox	e7a8yDDD1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: double psi	F: Asp_decarbox	ECOD (1.6)
B [auth BBB]	Asp_decarbox	e7a8yBBB1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: double psi	F: Asp_decarbox	ECOD (1.6)
D [auth EaE]	Asp_decarbox	e7a8yEaE1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: double psi	F: Asp_decarbox	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B [auth BBB], D [auth EaE]	PF02261	Aspartate decarboxylase (Asp_decarbox)	Aspartate decarboxylase	Decarboxylation of aspartate is the major route of beta-alanine production in bacteria, and is catalysed by the enzyme aspartate decarboxylase EC:4.1.1.11 which requires a pyruvoyl group for its activity. It is synthesised initially as a proenzyme wh ...	Decarboxylation of aspartate is the major route of beta-alanine production in bacteria, and is catalysed by the enzyme aspartate decarboxylase EC:4.1.1.11 which requires a pyruvoyl group for its activity. It is synthesised initially as a proenzyme which is then proteolytically cleaved to an alpha (C-terminal) and beta (N-terminal) subunit and a pyruvoyl group. This family contains both chains of aspartate decarboxylase.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth AAA], C [auth DDD]	Aspartate 1-decarboxylase	aspartate 1-decarboxylase activity carboxy-lyase activity lyase activity catalytic activity carbon-carbon lyase activity	pantothenate metabolic process water-soluble vitamin biosynthetic process monocarboxylic acid biosynthetic process small molecule biosynthetic process oxoacid metabolic process modified amino acid biosynthetic process carboxylic acid metabolic process modified amino acid metabolic process vitamin biosynthetic process amide biosynthetic process organic acid biosynthetic process organic acid metabolic process carboxylic acid biosynthetic process vitamin metabolic process biosynthetic process pantothenate metabolic process water-soluble vitamin biosynthetic process monocarboxylic acid biosynthetic process small molecule biosynthetic process oxoacid metabolic process modified amino acid biosynthetic process carboxylic acid metabolic process modified amino acid metabolic process vitamin biosynthetic process amide biosynthetic process organic acid biosynthetic process organic acid metabolic process carboxylic acid biosynthetic process vitamin metabolic process biosynthetic process pantothenate biosynthetic process metabolic process cellular process small molecule metabolic process amide metabolic process monocarboxylic acid metabolic process water-soluble vitamin metabolic process amino acid metabolic process primary metabolic process alpha-amino acid metabolic process amino acid biosynthetic process alanine biosynthetic process alanine metabolic process alpha-amino acid biosynthetic process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol
B [auth BBB], D [auth EaE]	Aspartate 1-decarboxylase	aspartate 1-decarboxylase activity carboxy-lyase activity lyase activity catalytic activity carbon-carbon lyase activity	pantothenate metabolic process water-soluble vitamin biosynthetic process monocarboxylic acid biosynthetic process small molecule biosynthetic process oxoacid metabolic process modified amino acid biosynthetic process carboxylic acid metabolic process modified amino acid metabolic process vitamin biosynthetic process amide biosynthetic process organic acid biosynthetic process organic acid metabolic process carboxylic acid biosynthetic process vitamin metabolic process biosynthetic process pantothenate metabolic process water-soluble vitamin biosynthetic process monocarboxylic acid biosynthetic process small molecule biosynthetic process oxoacid metabolic process modified amino acid biosynthetic process carboxylic acid metabolic process modified amino acid metabolic process vitamin biosynthetic process amide biosynthetic process organic acid biosynthetic process organic acid metabolic process carboxylic acid biosynthetic process vitamin metabolic process biosynthetic process pantothenate biosynthetic process metabolic process cellular process small molecule metabolic process amide metabolic process monocarboxylic acid metabolic process water-soluble vitamin metabolic process amino acid metabolic process primary metabolic process alpha-amino acid metabolic process amino acid biosynthetic process alanine biosynthetic process alanine metabolic process alpha-amino acid biosynthetic process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth AAA], C [auth DDD]	IPR003190	Aspartate decarboxylase	Family
A [auth AAA], C [auth DDD]	IPR009010	Aspartate decarboxylase-like domain superfamily	Homologous Superfamily
B [auth BBB], D [auth EaE]	IPR003190	Aspartate decarboxylase	Family
B [auth BBB], D [auth EaE]	IPR009010	Aspartate decarboxylase-like domain superfamily	Homologous Superfamily

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
B [auth BBB], D [auth EaE]	PYR	RESID: AA0127 PSI-MOD : pyruvic acid (Cys) MOD:00136 , pyruvic acid (Ser) MOD:00807 , pyruvic acid MOD:01154 , pyruvic acid (Tyr) MOD:01661

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.