8JPS | pdb_00008jps

Structure of Duffy Antigen Receptor for Chemokines (DARC)/ACKR1 in complex with the chemokine, CCL7 (Composite map)

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Membrane Protein Annotation: PDBTM

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B [auth D]	SCOP2B Superfamily	Interleukin 8-like chemokines	8034323	3001955	SCOP2B (2022-06-29)
D [auth C]	SCOP2B Superfamily	Interleukin 8-like chemokines	8034323	3001955	SCOP2B (2022-06-29)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B [auth D], D [auth C]	PF00048	Small cytokines (intecrine/chemokine), interleukin-8 like (IL8)	Small cytokines (intecrine/chemokine), interleukin-8 like	Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B], C [auth A]	Atypical chemokine receptor 1	C-C chemokine binding protein binding binding chemokine binding cytokine binding molecular transducer activity signaling receptor activity G protein-coupled receptor activity transmembrane signaling receptor activity	response to stimulus defense response response to stress inflammatory response cellular response to stimulus regulation of biological process regulation of cellular process cell surface receptor signaling pathway signaling biological regulation response to cytokine response to chemokine cytokine-mediated signaling pathway cellular response to chemokine response to stimulus defense response response to stress inflammatory response cellular response to stimulus regulation of biological process regulation of cellular process cell surface receptor signaling pathway signaling biological regulation response to cytokine response to chemokine cytokine-mediated signaling pathway cellular response to chemokine chemokine-mediated signaling pathway cell communication response to peptide response to chemical G protein-coupled receptor signaling pathway cellular process cellular response to cytokine stimulus signal transduction regulation of biosynthetic process multicellular organismal process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of chemokine production regulation of gene expression biosynthetic process regulation of cytokine production cytokine production chemokine production regulation of macromolecule biosynthetic process metabolic process regulation of multicellular organismal process macromolecule metabolic process regulation of metabolic process	membrane-bounded organelle intracellular anatomical structure early endosome endosome intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cellular anatomical structure cytoplasmic vesicle organelle cytoplasm vesicle cell periphery membrane-bounded organelle intracellular anatomical structure early endosome endosome intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cellular anatomical structure cytoplasmic vesicle organelle cytoplasm vesicle cell periphery plasma membrane membrane recycling endosome
B [auth D], D [auth C]	C-C motif chemokine 7	molecular transducer activity binding molecular function activator activity signaling receptor binding signaling receptor activity G protein-coupled receptor binding signaling receptor activator activity protein binding cytokine receptor binding chemokine activity molecular function regulator activity cytokine activity signaling receptor regulator activity chemokine receptor binding molecular transducer activity binding molecular function activator activity signaling receptor binding signaling receptor activity G protein-coupled receptor binding signaling receptor activator activity protein binding cytokine receptor binding chemokine activity molecular function regulator activity cytokine activity signaling receptor regulator activity chemokine receptor binding receptor ligand activity CCR chemokine receptor binding CCR1 chemokine receptor binding CCR2 chemokine receptor binding heparin binding glycosaminoglycan binding carbohydrate derivative binding sulfur compound binding	cellular response to stimulus positive regulation of locomotion regulation of cell motility regulation of cellular process response to stimulus positive regulation of chemotaxis positive regulation of cell migration regulation of lymphocyte chemotaxis natural killer cell chemotaxis taxis positive regulation of natural killer cell chemotaxis cell migration regulation of immune system process regulation of mononuclear cell migration cellular response to stimulus positive regulation of locomotion regulation of cell motility regulation of cellular process response to stimulus positive regulation of chemotaxis positive regulation of cell migration regulation of lymphocyte chemotaxis natural killer cell chemotaxis taxis positive regulation of natural killer cell chemotaxis cell migration regulation of immune system process regulation of mononuclear cell migration positive regulation of immune system process chemotaxis regulation of biological process regulation of leukocyte chemotaxis positive regulation of lymphocyte migration regulation of leukocyte migration lymphocyte migration response to external stimulus positive regulation of leukocyte chemotaxis leukocyte migration regulation of response to stimulus response to chemical regulation of locomotion regulation of natural killer cell chemotaxis regulation of response to external stimulus positive regulation of biological process lymphocyte chemotaxis regulation of lymphocyte migration positive regulation of lymphocyte chemotaxis positive regulation of response to stimulus positive regulation of response to external stimulus positive regulation of cell motility regulation of cell migration positive regulation of mononuclear cell migration cell motility locomotion positive regulation of cellular process cell chemotaxis biological regulation positive regulation of leukocyte migration regulation of chemotaxis cellular response to chemical stimulus immune system process mononuclear cell migration cellular process leukocyte chemotaxis cell surface receptor signaling pathway signaling response to cytokine response to chemokine cytokine-mediated signaling pathway cellular response to chemokine chemokine-mediated signaling pathway cell communication response to peptide G protein-coupled receptor signaling pathway cellular response to cytokine stimulus signal transduction cell-cell signaling inorganic ion homeostasis intracellular calcium ion homeostasis homeostatic process calcium ion homeostasis cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis developmental process regulation of developmental process regulation of cell shape cell morphogenesis regulation of cell morphogenesis anatomical structure morphogenesis anatomical structure development regulation of biological quality regulation of anatomical structure morphogenesis cellular component organization organelle organization cellular component organization or biogenesis cytoskeleton organization monocyte chemotaxis myeloid leukocyte migration response to alcohol response to oxygen-containing compound cellular response to oxygen-containing compound cellular response to alcohol cellular response to ethanol response to ethanol humoral immune response biological process involved in interspecies interaction between organisms response to other organism defense response immune response defense response to symbiont antimicrobial humoral response response to biotic stimulus antimicrobial humoral immune response mediated by antimicrobial peptide defense response to other organism response to stress response to external biotic stimulus response to ionizing radiation response to radiation response to abiotic stimulus response to gamma radiation eosinophil chemotaxis granulocyte migration eosinophil migration granulocyte chemotaxis inflammatory response	cellular anatomical structure extracellular region extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth B], C [auth A]	IPR005384	Duffy antigen/chemokine receptor	Family
B [auth D], D [auth C]	IPR001811	Chemokine interleukin-8-like domain	Domain
B [auth D], D [auth C]	IPR000827	CC chemokine, conserved site	Conserved Site
B [auth D], D [auth C]	IPR036048	Chemokine interleukin-8-like superfamily	Homologous Superfamily
B [auth D], D [auth C]	IPR039809	Chemokine beta/gamma/delta	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth B], C [auth A]	Pharos: Q16570	malaria psoriasis subependymal giant cell astrocytoma atypical teratoid rhabdoid tumor cystic fibrosis Emery-Dreifuss muscular dystrophy invasive ductal breast carcinoma myopathy pancreatic intraductal papillary-mucinous carcinoma pilocytic astrocytoma pterygium ulcerative colitis breast cancer Duchenne muscular dystrophy glioblastoma malaria psoriasis subependymal giant cell astrocytoma atypical teratoid rhabdoid tumor cystic fibrosis Emery-Dreifuss muscular dystrophy invasive ductal breast carcinoma myopathy pancreatic intraductal papillary-mucinous carcinoma pilocytic astrocytoma pterygium ulcerative colitis breast cancer Duchenne muscular dystrophy glioblastoma lung adenocarcinoma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous neoplasm pituitary cancer Sjogren syndrome breast carcinoma ductal breast carcinoma in situ interstitial cystitis osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia
B [auth D], D [auth C]	Pharos: P80098	glomerulonephritis allergic disease interstitial nephritis malignant mesothelioma pneumonia cholestasis middle cerebral artery infarction psoriasis tuberculosis Crohn disease Middle Cerebral Artery Occlusion pneumonitis inflammatory bowel disease

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A [auth B], B [auth D], C [auth A], D [auth C]	PDBTM	Annotated as membrane protein by PDBTM

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.