8OUW | pdb_00008ouw

Cryo-EM structure of CMG helicase bound to TIM-1/TIPN-1 and homodimeric DNSN-1 on fork DNA (Caenorhabditis elegans)

External Resource: Annotation

Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
C [auth 4]	PF14551	MCM N-terminal domain (MCM_N)	MCM N-terminal domain	This family contains the N-terminal domain of MCM proteins.	Domain
C [auth 4]	PF00493	MCM P-loop domain (MCM)	MCM P-loop domain		Domain
C [auth 4]	PF17855	MCM AAA-lid domain (MCM_lid)	MCM AAA-lid domain	This entry represents the AAA-lid domain found in MCM proteins.	Domain
C [auth 4]	PF17207	MCM OB domain (MCM_OB)	MCM OB domain	This family contains an OB-fold found within MCM proteins. This domain contains an insertion at the zinc binding motif [2].	Domain
F [auth 7]	PF14551	MCM N-terminal domain (MCM_N)	MCM N-terminal domain	This family contains the N-terminal domain of MCM proteins.	Domain
F [auth 7]	PF00493	MCM P-loop domain (MCM)	MCM P-loop domain		Domain
F [auth 7]	PF17855	MCM AAA-lid domain (MCM_lid)	MCM AAA-lid domain	This entry represents the AAA-lid domain found in MCM proteins.	Domain
F [auth 7]	PF17207	MCM OB domain (MCM_OB)	MCM OB domain	This family contains an OB-fold found within MCM proteins. This domain contains an insertion at the zinc binding motif [2].	Domain
R [auth L]	PF07962	Replication Fork Protection Component Swi3 (Swi3)	Replication Fork Protection Component Swi3	-	Family
A [auth 2]	PF14551	MCM N-terminal domain (MCM_N)	MCM N-terminal domain	This family contains the N-terminal domain of MCM proteins.	Domain
A [auth 2]	PF00493	MCM P-loop domain (MCM)	MCM P-loop domain		Domain
A [auth 2]	PF17855	MCM AAA-lid domain (MCM_lid)	MCM AAA-lid domain	This entry represents the AAA-lid domain found in MCM proteins.	Domain
A [auth 2]	PF17207	MCM OB domain (MCM_OB)	MCM OB domain	This family contains an OB-fold found within MCM proteins. This domain contains an insertion at the zinc binding motif [2].	Domain
J [auth D]	PF05916	GINS complex protein helical bundle domain (Sld5)	GINS complex protein helical bundle domain	This entry represents the C-terminal alpha helical bundle domain. The eukaryotic GINS complex is essential for the initiation and elongation phases of DNA replication [1-3]. It consists of four paralogous protein subunits (Sld5, Psf1, Psf2 and Psf3) ...	This entry represents the C-terminal alpha helical bundle domain. The eukaryotic GINS complex is essential for the initiation and elongation phases of DNA replication [1-3]. It consists of four paralogous protein subunits (Sld5, Psf1, Psf2 and Psf3), all of which are included in this family. The GINS complex is conserved from yeast to humans, and has been shown in human to bind directly to DNA primase [4].	Domain
J [auth D]	PF16922	DNA replication complex GINS protein SLD5 C-terminus (SLD5_C)	DNA replication complex GINS protein SLD5 C-terminus	The C-terminal domain of DNA replication complex GINS protein SLD5 is important in the assembly of the GINS complex, a complex which is involved in initiation of DNA replication and progression of DNA replication forks [1].	Domain
K [auth E]	PF02724	CDC45 (CDC45)	CDC45	-	Family
Q [auth K]	PF04821	Timeless protein (TIMELESS)	Timeless protein	-	Family
B [auth 3]	PF14551	MCM N-terminal domain (MCM_N)	MCM N-terminal domain	This family contains the N-terminal domain of MCM proteins.	Domain
B [auth 3]	PF00493	MCM P-loop domain (MCM)	MCM P-loop domain		Domain
B [auth 3]	PF17855	MCM AAA-lid domain (MCM_lid)	MCM AAA-lid domain	This entry represents the AAA-lid domain found in MCM proteins.	Domain
B [auth 3]	PF17207	MCM OB domain (MCM_OB)	MCM OB domain	This family contains an OB-fold found within MCM proteins. This domain contains an insertion at the zinc binding motif [2].	Domain
D [auth 5]	PF14551	MCM N-terminal domain (MCM_N)	MCM N-terminal domain	This family contains the N-terminal domain of MCM proteins.	Domain
D [auth 5]	PF00493	MCM P-loop domain (MCM)	MCM P-loop domain		Domain
D [auth 5]	PF17855	MCM AAA-lid domain (MCM_lid)	MCM AAA-lid domain	This entry represents the AAA-lid domain found in MCM proteins.	Domain
D [auth 5]	PF17207	MCM OB domain (MCM_OB)	MCM OB domain	This family contains an OB-fold found within MCM proteins. This domain contains an insertion at the zinc binding motif [2].	Domain
E [auth 6]	PF14551	MCM N-terminal domain (MCM_N)	MCM N-terminal domain	This family contains the N-terminal domain of MCM proteins.	Domain
E [auth 6]	PF00493	MCM P-loop domain (MCM)	MCM P-loop domain		Domain
E [auth 6]	PF17855	MCM AAA-lid domain (MCM_lid)	MCM AAA-lid domain	This entry represents the AAA-lid domain found in MCM proteins.	Domain
E [auth 6]	PF17207	MCM OB domain (MCM_OB)	MCM OB domain	This family contains an OB-fold found within MCM proteins. This domain contains an insertion at the zinc binding motif [2].	Domain
G [auth A]	PF05916	GINS complex protein helical bundle domain (Sld5)	GINS complex protein helical bundle domain	This entry represents the C-terminal alpha helical bundle domain. The eukaryotic GINS complex is essential for the initiation and elongation phases of DNA replication [1-3]. It consists of four paralogous protein subunits (Sld5, Psf1, Psf2 and Psf3) ...	This entry represents the C-terminal alpha helical bundle domain. The eukaryotic GINS complex is essential for the initiation and elongation phases of DNA replication [1-3]. It consists of four paralogous protein subunits (Sld5, Psf1, Psf2 and Psf3), all of which are included in this family. The GINS complex is conserved from yeast to humans, and has been shown in human to bind directly to DNA primase [4].	Domain
H [auth B]	PF05916	GINS complex protein helical bundle domain (Sld5)	GINS complex protein helical bundle domain	This entry represents the C-terminal alpha helical bundle domain. The eukaryotic GINS complex is essential for the initiation and elongation phases of DNA replication [1-3]. It consists of four paralogous protein subunits (Sld5, Psf1, Psf2 and Psf3) ...	This entry represents the C-terminal alpha helical bundle domain. The eukaryotic GINS complex is essential for the initiation and elongation phases of DNA replication [1-3]. It consists of four paralogous protein subunits (Sld5, Psf1, Psf2 and Psf3), all of which are included in this family. The GINS complex is conserved from yeast to humans, and has been shown in human to bind directly to DNA primase [4].	Domain
I [auth C]	PF05916	GINS complex protein helical bundle domain (Sld5)	GINS complex protein helical bundle domain	This entry represents the C-terminal alpha helical bundle domain. The eukaryotic GINS complex is essential for the initiation and elongation phases of DNA replication [1-3]. It consists of four paralogous protein subunits (Sld5, Psf1, Psf2 and Psf3) ...	This entry represents the C-terminal alpha helical bundle domain. The eukaryotic GINS complex is essential for the initiation and elongation phases of DNA replication [1-3]. It consists of four paralogous protein subunits (Sld5, Psf1, Psf2 and Psf3), all of which are included in this family. The GINS complex is conserved from yeast to humans, and has been shown in human to bind directly to DNA primase [4].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
C [auth 4]	DNA replication licensing factor mcm-4	ATP-dependent activity, acting on DNA catalytic activity, acting on DNA DNA translocase activity catalytic activity, acting on a nucleic acid chromatin extrusion motor activity catalytic activity ATP-dependent activity ATP-dependent H3-H4 histone complex chaperone activity catalytic activity, acting on a protein histone chaperone activity ATP-dependent chromatin remodeler activity H3-H4 histone complex chaperone activity protein carrier chaperone ATP-dependent histone chaperone activity ATP-dependent activity, acting on DNA catalytic activity, acting on DNA DNA translocase activity catalytic activity, acting on a nucleic acid chromatin extrusion motor activity catalytic activity ATP-dependent activity ATP-dependent H3-H4 histone complex chaperone activity catalytic activity, acting on a protein histone chaperone activity ATP-dependent chromatin remodeler activity H3-H4 histone complex chaperone activity protein carrier chaperone ATP-dependent histone chaperone activity molecular carrier activity cohesin loader activity DNA clamp loader activity ATP-dependent H2AZ histone chaperone activity nucleic acid conformation isomerase activity forked DNA-dependent helicase activity isomerase activity DNA helicase activity helicase activity macromolecular conformation isomerase activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding single-stranded DNA helicase activity 3'-5' DNA helicase activity single-stranded 3'-5' DNA helicase activity four-way junction helicase activity pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides cation binding metal ion binding DNA binding single-stranded DNA binding nucleic acid binding double-stranded DNA helicase activity	DNA-templated DNA replication sexual reproduction reproductive process meiotic cell cycle nuclear DNA replication cell cycle DNA replication primary metabolic process DNA metabolic process meiotic cell cycle process nucleic acid metabolic process nucleobase-containing compound metabolic process DNA replication premeiotic DNA replication metabolic process DNA-templated DNA replication sexual reproduction reproductive process meiotic cell cycle nuclear DNA replication cell cycle DNA replication primary metabolic process DNA metabolic process meiotic cell cycle process nucleic acid metabolic process nucleobase-containing compound metabolic process DNA replication premeiotic DNA replication metabolic process cellular process macromolecule metabolic process cell cycle cell cycle process developmental process multicellular organismal process gonad development reproductive system development sex differentiation animal organ development developmental process involved in reproduction multicellular organism development development of primary sexual characteristics anatomical structure development reproductive structure development system development cellular response to stimulus double-strand break repair response to stimulus DNA recombination double-strand break repair via break-induced replication cellular response to stress DNA damage response response to stress recombinational repair double-strand break repair via homologous recombination DNA repair DNA strand elongation DNA strand elongation involved in DNA replication locomotion nervous system development mitotic DNA replication DNA replication initiation cell cycle DNA replication initiation mitotic DNA replication initiation mitotic cell cycle nuclear cell cycle DNA replication initiation mitotic cell cycle process	protein-containing complex MCM complex intracellular organelle cellular anatomical structure intracellular anatomical structure organelle membraneless organelle intracellular membraneless organelle chromosome membrane-bounded organelle nucleus intracellular membrane-bounded organelle
F [auth 7]	DNA replication licensing factor MCM7	ATP-dependent activity, acting on DNA catalytic activity, acting on DNA DNA translocase activity catalytic activity, acting on a nucleic acid chromatin extrusion motor activity catalytic activity ATP-dependent activity ATP-dependent H3-H4 histone complex chaperone activity catalytic activity, acting on a protein histone chaperone activity ATP-dependent chromatin remodeler activity H3-H4 histone complex chaperone activity protein carrier chaperone ATP-dependent histone chaperone activity ATP-dependent activity, acting on DNA catalytic activity, acting on DNA DNA translocase activity catalytic activity, acting on a nucleic acid chromatin extrusion motor activity catalytic activity ATP-dependent activity ATP-dependent H3-H4 histone complex chaperone activity catalytic activity, acting on a protein histone chaperone activity ATP-dependent chromatin remodeler activity H3-H4 histone complex chaperone activity protein carrier chaperone ATP-dependent histone chaperone activity molecular carrier activity cohesin loader activity DNA clamp loader activity ATP-dependent H2AZ histone chaperone activity nucleic acid conformation isomerase activity forked DNA-dependent helicase activity isomerase activity DNA helicase activity helicase activity macromolecular conformation isomerase activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding single-stranded DNA helicase activity 3'-5' DNA helicase activity single-stranded 3'-5' DNA helicase activity four-way junction helicase activity pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides DNA binding single-stranded DNA binding nucleic acid binding double-stranded DNA helicase activity	nucleobase-containing compound metabolic process DNA-templated DNA replication DNA replication DNA replication initiation metabolic process cellular process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process sexual reproduction reproductive process meiotic cell cycle nuclear DNA replication nucleobase-containing compound metabolic process DNA-templated DNA replication DNA replication DNA replication initiation metabolic process cellular process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process sexual reproduction reproductive process meiotic cell cycle nuclear DNA replication cell cycle DNA replication meiotic cell cycle process premeiotic DNA replication cell cycle cell cycle process mitotic nuclear division organelle fission chromosome organization sister chromatid segregation mitotic cell cycle cellular component organization organelle organization nuclear division mitotic cell cycle process mitotic sister chromatid segregation nuclear chromosome segregation cellular component organization or biogenesis chromosome segregation cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly MCM complex assembly cellular response to stimulus double-strand break repair response to stimulus DNA recombination double-strand break repair via break-induced replication cellular response to stress DNA damage response response to stress recombinational repair double-strand break repair via homologous recombination DNA repair DNA strand elongation DNA strand elongation involved in DNA replication developmental process multicellular organism development multicellular organismal process embryo development ending in birth or egg hatching anatomical structure development embryo development	protein-containing complex MCM complex membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure organelle nucleus intracellular membrane-bounded organelle
R [auth L]	Protein TIPIN homolog	DNA binding binding nucleic acid binding	regulation of biological process cell population proliferation regulation of cellular process positive regulation of cell population proliferation regulation of cell population proliferation biological regulation positive regulation of biological process cellular process positive regulation of cellular process DNA-templated DNA replication DNA-templated DNA replication maintenance of fidelity primary metabolic process DNA metabolic process nucleic acid metabolic process regulation of biological process cell population proliferation regulation of cellular process positive regulation of cell population proliferation regulation of cell population proliferation biological regulation positive regulation of biological process cellular process positive regulation of cellular process DNA-templated DNA replication DNA-templated DNA replication maintenance of fidelity primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process DNA replication metabolic process macromolecule metabolic process replication fork processing cellular response to stimulus regulation of cell cycle phase transition response to stimulus signaling negative regulation of biological process negative regulation of cell cycle cell cycle phase transition intracellular signal transduction cell communication negative regulation of cellular process negative regulation of cell cycle phase transition signal transduction cell cycle DNA replication checkpoint signaling regulation of cell cycle cell cycle process regulation of cell cycle process DNA integrity checkpoint signaling negative regulation of cell cycle process cell cycle checkpoint signaling cell division regulation of primary metabolic process negative regulation of DNA-templated DNA replication negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of macromolecule metabolic process negative regulation of DNA replication negative regulation of metabolic process regulation of macromolecule metabolic process regulation of DNA-templated DNA replication replication fork arrest negative regulation of DNA metabolic process regulation of metabolic process regulation of DNA metabolic process regulation of DNA replication DNA damage checkpoint signaling mitotic cell cycle negative regulation of mitotic cell cycle regulation of mitotic cell cycle mitotic DNA integrity checkpoint signaling cellular response to stress response to stress mitotic DNA damage checkpoint signaling mitotic intra-S DNA damage checkpoint signaling mitotic cell cycle checkpoint signaling mitotic cell cycle process DNA damage response signal transduction in response to DNA damage	membrane-bounded organelle replication fork protection complex protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear replication fork intracellular membraneless organelle nuclear chromosome chromosome intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle membrane-bounded organelle replication fork protection complex protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear replication fork intracellular membraneless organelle nuclear chromosome chromosome intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle replication fork nuclear lumen cytoplasm chromatin
A [auth 2]	DNA replication licensing factor MCM2	nucleic acid conformation isomerase activity forked DNA-dependent helicase activity isomerase activity DNA helicase activity catalytic activity, acting on a nucleic acid helicase activity ATP-dependent activity ATP-dependent activity, acting on DNA catalytic activity, acting on DNA catalytic activity macromolecular conformation isomerase activity binding adenyl ribonucleotide binding nucleotide binding nucleic acid conformation isomerase activity forked DNA-dependent helicase activity isomerase activity DNA helicase activity catalytic activity, acting on a nucleic acid helicase activity ATP-dependent activity ATP-dependent activity, acting on DNA catalytic activity, acting on DNA catalytic activity macromolecular conformation isomerase activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding single-stranded DNA helicase activity 3'-5' DNA helicase activity single-stranded 3'-5' DNA helicase activity four-way junction helicase activity pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides cation binding metal ion binding DNA binding single-stranded DNA binding nucleic acid binding double-stranded DNA helicase activity	DNA-templated DNA replication sexual reproduction reproductive process meiotic cell cycle nuclear DNA replication cell cycle DNA replication primary metabolic process DNA metabolic process meiotic cell cycle process nucleic acid metabolic process nucleobase-containing compound metabolic process DNA replication premeiotic DNA replication metabolic process DNA-templated DNA replication sexual reproduction reproductive process meiotic cell cycle nuclear DNA replication cell cycle DNA replication primary metabolic process DNA metabolic process meiotic cell cycle process nucleic acid metabolic process nucleobase-containing compound metabolic process DNA replication premeiotic DNA replication metabolic process cellular process macromolecule metabolic process cell cycle cell cycle process cellular response to stimulus double-strand break repair response to stimulus DNA recombination double-strand break repair via break-induced replication cellular response to stress DNA damage response response to stress recombinational repair double-strand break repair via homologous recombination DNA repair mitotic DNA replication DNA replication initiation cell cycle DNA replication initiation mitotic DNA replication initiation mitotic cell cycle nuclear cell cycle DNA replication initiation mitotic cell cycle process	intracellular organelle cellular anatomical structure intracellular anatomical structure organelle membraneless organelle intracellular membraneless organelle chromosome condensed chromosome protein-containing complex MCM complex membrane-bounded organelle nucleus pronucleus intracellular membrane-bounded organelle
J [auth D]	DNA replication complex GINS protein SLD5	-	cellular response to stimulus double-strand break repair response to stimulus DNA recombination primary metabolic process DNA metabolic process double-strand break repair via break-induced replication nucleic acid metabolic process nucleobase-containing compound metabolic process cellular response to stress DNA damage response response to stress recombinational repair metabolic process cellular response to stimulus double-strand break repair response to stimulus DNA recombination primary metabolic process DNA metabolic process double-strand break repair via break-induced replication nucleic acid metabolic process nucleobase-containing compound metabolic process cellular response to stress DNA damage response response to stress recombinational repair metabolic process cellular process macromolecule metabolic process double-strand break repair via homologous recombination DNA repair DNA-templated DNA replication DNA replication	GINS complex membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome intracellular membraneless organelle chromosome intracellular membrane-bounded organelle intracellular organelle lumen GINS complex membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome intracellular membraneless organelle chromosome intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm organelle lumen organelle membraneless organelle nuclear lumen
K [auth E]	Cell division control protein 45 homolog	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding binding nucleic acid binding DNA replication origin binding chromatin binding single-stranded DNA binding	nucleobase-containing compound metabolic process DNA-templated DNA replication DNA replication DNA replication initiation metabolic process cellular process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process mitotic DNA replication DNA replication preinitiation complex assembly nuclear DNA replication cell cycle DNA replication nucleobase-containing compound metabolic process DNA-templated DNA replication DNA replication DNA replication initiation metabolic process cellular process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process mitotic DNA replication DNA replication preinitiation complex assembly nuclear DNA replication cell cycle DNA replication mitotic cell cycle cellular component organization cellular component biogenesis protein-DNA complex organization mitotic DNA replication preinitiation complex assembly cellular component assembly protein-containing complex assembly cell cycle cellular component organization or biogenesis cell cycle process protein-containing complex organization protein-DNA complex assembly mitotic cell cycle process cell division cellular response to stimulus double-strand break repair response to stimulus DNA recombination double-strand break repair via break-induced replication cellular response to stress DNA damage response response to stress recombinational repair double-strand break repair via homologous recombination DNA repair	membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm organelle lumen membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm organelle lumen organelle nuclear lumen
L [auth F], M [auth G], N [auth H]	Downstream Neighbor of SoN homolog	-	DNA-templated DNA replication nuclear DNA replication cell cycle DNA replication primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process DNA replication metabolic process cellular process macromolecule metabolic process cell cycle cell cycle process	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure organelle nucleus intracellular membrane-bounded organelle
O [auth I], P [auth J]	DNA Leading Strand Template	-	-	-
Q [auth K]	Protein timeless homolog	DNA binding binding nucleic acid binding	cellular component organization organelle organization chromosome organization sister chromatid cohesion cellular process cellular component organization or biogenesis cell cycle meiotic sister chromatid cohesion cell cycle process cellular response to stimulus response to stimulus primary metabolic process DNA metabolic process nucleic acid metabolic process cellular component organization organelle organization chromosome organization sister chromatid cohesion cellular process cellular component organization or biogenesis cell cycle meiotic sister chromatid cohesion cell cycle process cellular response to stimulus response to stimulus primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process cellular response to stress DNA damage response response to stress metabolic process macromolecule metabolic process DNA repair regulation of cellular process regulation of cell cycle phase transition signaling negative regulation of biological process negative regulation of cell cycle cell cycle phase transition intracellular signal transduction cell communication negative regulation of cellular process negative regulation of cell cycle phase transition signal transduction DNA replication checkpoint signaling regulation of cell cycle regulation of biological process regulation of cell cycle process biological regulation DNA integrity checkpoint signaling negative regulation of cell cycle process cell cycle checkpoint signaling cell division mitotic sister chromatid cohesion DNA-templated DNA replication maintenance of fidelity regulation of primary metabolic process negative regulation of DNA-templated DNA replication negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of macromolecule metabolic process DNA-templated DNA replication negative regulation of DNA replication negative regulation of metabolic process regulation of macromolecule metabolic process DNA replication regulation of DNA-templated DNA replication replication fork arrest negative regulation of DNA metabolic process regulation of metabolic process regulation of DNA metabolic process regulation of DNA replication developmental process multicellular organism development multicellular organismal process embryo development ending in birth or egg hatching anatomical structure development embryo development sexual reproduction reproductive process meiotic cell cycle regulation of cellular component organization regulation of chromosome organization regulation of organelle organization regulation of sister chromatid cohesion	membrane-bounded organelle replication fork protection complex protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear replication fork intracellular membraneless organelle nuclear chromosome chromosome intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle membrane-bounded organelle replication fork protection complex protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear replication fork intracellular membraneless organelle nuclear chromosome chromosome intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle replication fork nuclear lumen
S [auth M]	DNA Lagging Strand Template	-	-	-
B [auth 3]	DNA replication licensing factor MCM3	nucleic acid conformation isomerase activity forked DNA-dependent helicase activity isomerase activity DNA helicase activity catalytic activity, acting on a nucleic acid helicase activity ATP-dependent activity ATP-dependent activity, acting on DNA catalytic activity, acting on DNA catalytic activity macromolecular conformation isomerase activity binding adenyl ribonucleotide binding nucleotide binding nucleic acid conformation isomerase activity forked DNA-dependent helicase activity isomerase activity DNA helicase activity catalytic activity, acting on a nucleic acid helicase activity ATP-dependent activity ATP-dependent activity, acting on DNA catalytic activity, acting on DNA catalytic activity macromolecular conformation isomerase activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding single-stranded DNA helicase activity 3'-5' DNA helicase activity single-stranded 3'-5' DNA helicase activity four-way junction helicase activity pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides DNA binding single-stranded DNA binding nucleic acid binding double-stranded DNA helicase activity	DNA-templated DNA replication sexual reproduction reproductive process meiotic cell cycle nuclear DNA replication cell cycle DNA replication primary metabolic process DNA metabolic process meiotic cell cycle process nucleic acid metabolic process nucleobase-containing compound metabolic process DNA replication premeiotic DNA replication metabolic process DNA-templated DNA replication sexual reproduction reproductive process meiotic cell cycle nuclear DNA replication cell cycle DNA replication primary metabolic process DNA metabolic process meiotic cell cycle process nucleic acid metabolic process nucleobase-containing compound metabolic process DNA replication premeiotic DNA replication metabolic process cellular process macromolecule metabolic process cell cycle cell cycle process cellular response to stimulus double-strand break repair response to stimulus DNA recombination double-strand break repair via break-induced replication cellular response to stress DNA damage response response to stress recombinational repair double-strand break repair via homologous recombination DNA repair DNA strand elongation DNA strand elongation involved in DNA replication mitotic DNA replication DNA replication initiation cell cycle DNA replication initiation mitotic DNA replication initiation mitotic cell cycle nuclear cell cycle DNA replication initiation mitotic cell cycle process	intracellular organelle cellular anatomical structure intracellular anatomical structure organelle membraneless organelle intracellular membraneless organelle chromosome condensed chromosome protein-containing complex MCM complex membrane-bounded organelle nucleus pronucleus intracellular membrane-bounded organelle
D [auth 5]	DNA replication licensing factor mcm-5	ATP-dependent activity, acting on DNA catalytic activity, acting on DNA DNA translocase activity catalytic activity, acting on a nucleic acid chromatin extrusion motor activity catalytic activity ATP-dependent activity DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding binding nucleic acid binding DNA replication origin binding ATP-dependent activity, acting on DNA catalytic activity, acting on DNA DNA translocase activity catalytic activity, acting on a nucleic acid chromatin extrusion motor activity catalytic activity ATP-dependent activity DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding binding nucleic acid binding DNA replication origin binding ATP-dependent H3-H4 histone complex chaperone activity catalytic activity, acting on a protein histone chaperone activity ATP-dependent chromatin remodeler activity H3-H4 histone complex chaperone activity protein carrier chaperone ATP-dependent histone chaperone activity molecular carrier activity cohesin loader activity DNA clamp loader activity ATP-dependent H2AZ histone chaperone activity nucleic acid conformation isomerase activity forked DNA-dependent helicase activity isomerase activity DNA helicase activity helicase activity macromolecular conformation isomerase activity adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding single-stranded DNA helicase activity 3'-5' DNA helicase activity single-stranded 3'-5' DNA helicase activity four-way junction helicase activity pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides single-stranded DNA binding double-stranded DNA helicase activity	nucleobase-containing compound metabolic process DNA-templated DNA replication DNA replication DNA replication initiation metabolic process cellular process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process sexual reproduction reproductive process meiotic cell cycle nuclear DNA replication nucleobase-containing compound metabolic process DNA-templated DNA replication DNA replication DNA replication initiation metabolic process cellular process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process sexual reproduction reproductive process meiotic cell cycle nuclear DNA replication cell cycle DNA replication meiotic cell cycle process premeiotic DNA replication cell cycle cell cycle process cellular response to stimulus double-strand break repair response to stimulus DNA recombination double-strand break repair via break-induced replication cellular response to stress DNA damage response response to stress recombinational repair double-strand break repair via homologous recombination DNA repair	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol protein-containing complex MCM complex membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle
E [auth 6]	DNA replication licensing factor mcm-6	ATP-dependent activity, acting on DNA catalytic activity, acting on DNA DNA translocase activity catalytic activity, acting on a nucleic acid chromatin extrusion motor activity catalytic activity ATP-dependent activity ATP-dependent H3-H4 histone complex chaperone activity catalytic activity, acting on a protein histone chaperone activity ATP-dependent chromatin remodeler activity H3-H4 histone complex chaperone activity protein carrier chaperone ATP-dependent histone chaperone activity ATP-dependent activity, acting on DNA catalytic activity, acting on DNA DNA translocase activity catalytic activity, acting on a nucleic acid chromatin extrusion motor activity catalytic activity ATP-dependent activity ATP-dependent H3-H4 histone complex chaperone activity catalytic activity, acting on a protein histone chaperone activity ATP-dependent chromatin remodeler activity H3-H4 histone complex chaperone activity protein carrier chaperone ATP-dependent histone chaperone activity molecular carrier activity cohesin loader activity DNA clamp loader activity ATP-dependent H2AZ histone chaperone activity nucleic acid conformation isomerase activity forked DNA-dependent helicase activity isomerase activity DNA helicase activity helicase activity macromolecular conformation isomerase activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding single-stranded DNA helicase activity 3'-5' DNA helicase activity single-stranded 3'-5' DNA helicase activity four-way junction helicase activity pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides DNA binding single-stranded DNA binding nucleic acid binding double-stranded DNA helicase activity	nucleobase-containing compound metabolic process DNA-templated DNA replication DNA replication DNA replication initiation metabolic process cellular process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process sexual reproduction reproductive process meiotic cell cycle nuclear DNA replication nucleobase-containing compound metabolic process DNA-templated DNA replication DNA replication DNA replication initiation metabolic process cellular process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process sexual reproduction reproductive process meiotic cell cycle nuclear DNA replication cell cycle DNA replication meiotic cell cycle process premeiotic DNA replication cell cycle cell cycle process cellular response to stimulus double-strand break repair response to stimulus DNA recombination double-strand break repair via break-induced replication cellular response to stress DNA damage response response to stress recombinational repair double-strand break repair via homologous recombination DNA repair mitotic DNA replication mitotic cell cycle mitotic cell cycle process	protein-containing complex MCM complex membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure organelle nucleus intracellular membrane-bounded organelle
G [auth A]	Probable DNA replication complex GINS protein PSF1	-	mitotic DNA replication DNA-templated DNA replication DNA strand elongation involved in mitotic DNA replication nuclear DNA replication cell cycle DNA replication primary metabolic process DNA metabolic process DNA strand elongation involved in nuclear cell cycle DNA replication nucleic acid metabolic process mitotic cell cycle nucleobase-containing compound metabolic process DNA strand elongation DNA replication mitotic cell cycle process DNA strand elongation involved in cell cycle DNA replication mitotic DNA replication DNA-templated DNA replication DNA strand elongation involved in mitotic DNA replication nuclear DNA replication cell cycle DNA replication primary metabolic process DNA metabolic process DNA strand elongation involved in nuclear cell cycle DNA replication nucleic acid metabolic process mitotic cell cycle nucleobase-containing compound metabolic process DNA strand elongation DNA replication mitotic cell cycle process DNA strand elongation involved in cell cycle DNA replication metabolic process cellular process macromolecule metabolic process cell cycle DNA strand elongation involved in DNA replication cell cycle process	GINS complex membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome intracellular membraneless organelle chromosome intracellular membrane-bounded organelle intracellular organelle lumen GINS complex membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome intracellular membraneless organelle chromosome intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm organelle lumen organelle membraneless organelle nuclear lumen
H [auth B]	Probable DNA replication complex GINS protein PSF2	-	cellular response to stimulus double-strand break repair response to stimulus DNA recombination primary metabolic process DNA metabolic process double-strand break repair via break-induced replication nucleic acid metabolic process nucleobase-containing compound metabolic process cellular response to stress DNA damage response response to stress recombinational repair metabolic process cellular response to stimulus double-strand break repair response to stimulus DNA recombination primary metabolic process DNA metabolic process double-strand break repair via break-induced replication nucleic acid metabolic process nucleobase-containing compound metabolic process cellular response to stress DNA damage response response to stress recombinational repair metabolic process cellular process macromolecule metabolic process double-strand break repair via homologous recombination DNA repair DNA-templated DNA replication DNA replication	GINS complex membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome intracellular membraneless organelle chromosome intracellular membrane-bounded organelle intracellular organelle lumen GINS complex membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome intracellular membraneless organelle chromosome intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm organelle lumen organelle membraneless organelle nuclear lumen
I [auth C]	DNA replication complex GINS protein PSF3	-	mitotic DNA replication DNA-templated DNA replication DNA replication initiation cell cycle DNA replication initiation nuclear DNA replication cell cycle DNA replication primary metabolic process DNA metabolic process mitotic DNA replication initiation nucleic acid metabolic process mitotic cell cycle nucleobase-containing compound metabolic process nuclear cell cycle DNA replication initiation DNA replication mitotic cell cycle process mitotic DNA replication DNA-templated DNA replication DNA replication initiation cell cycle DNA replication initiation nuclear DNA replication cell cycle DNA replication primary metabolic process DNA metabolic process mitotic DNA replication initiation nucleic acid metabolic process mitotic cell cycle nucleobase-containing compound metabolic process nuclear cell cycle DNA replication initiation DNA replication mitotic cell cycle process metabolic process cellular process macromolecule metabolic process cell cycle cell cycle process	GINS complex membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome intracellular membraneless organelle chromosome intracellular membrane-bounded organelle intracellular organelle lumen GINS complex membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome intracellular membraneless organelle chromosome intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm organelle lumen organelle membraneless organelle nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
C [auth 4]	IPR031327	Mini-chromosome maintenance protein	Family
C [auth 4]	IPR018525	Mini-chromosome maintenance, conserved site	Conserved Site
C [auth 4]	IPR003593	AAA+ ATPase domain	Domain
C [auth 4]	IPR001208	MCM domain	Domain
C [auth 4]	IPR041562	MCM, AAA-lid domain	Domain
C [auth 4]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
C [auth 4]	IPR027925	MCM, N-terminal domain	Domain
C [auth 4]	IPR008047	Mini-chromosome maintenance complex protein 4	Family
C [auth 4]	IPR033762	MCM OB domain	Domain
C [auth 4]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
F [auth 7]	IPR031327	Mini-chromosome maintenance protein	Family
F [auth 7]	IPR008050	DNA replication licensing factor Mcm7	Family
F [auth 7]	IPR018525	Mini-chromosome maintenance, conserved site	Conserved Site
F [auth 7]	IPR003593	AAA+ ATPase domain	Domain
F [auth 7]	IPR001208	MCM domain	Domain
F [auth 7]	IPR041562	MCM, AAA-lid domain	Domain
F [auth 7]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
F [auth 7]	IPR027925	MCM, N-terminal domain	Domain
F [auth 7]	IPR033762	MCM OB domain	Domain
F [auth 7]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
R [auth L]	IPR012923	Chromosome segregation in meiosis protein 3	Domain
R [auth L]	IPR040038	TIPIN/Csm3/Swi3	Family
A [auth 2]	IPR031327	Mini-chromosome maintenance protein	Family
A [auth 2]	IPR018525	Mini-chromosome maintenance, conserved site	Conserved Site
A [auth 2]	IPR003593	AAA+ ATPase domain	Domain
A [auth 2]	IPR001208	MCM domain	Domain
A [auth 2]	IPR041562	MCM, AAA-lid domain	Domain
A [auth 2]	IPR008045	DNA replication licensing factor Mcm2	Family
A [auth 2]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A [auth 2]	IPR027925	MCM, N-terminal domain	Domain
A [auth 2]	IPR033762	MCM OB domain	Domain
A [auth 2]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
J [auth D]	IPR008591	GINS complex subunit Sld5	Family
J [auth D]	IPR021151	GINS subunit, domain A	Domain
J [auth D]	IPR038749	GINS complex protein Sld5, alpha-helical domain	Domain
J [auth D]	IPR031633	DNA replication complex GINS protein SLD5, C-terminal	Domain
J [auth D]	IPR036224	GINS, helical bundle-like domain superfamily	Homologous Superfamily
K [auth E]	IPR003874	CDC45	Family
L [auth F], M [auth G], N [auth H]	IPR024861	Donson	Family
Q [auth K]	IPR044998	Timeless	Family
Q [auth K]	IPR006906	Timeless, N-terminal	Domain
B [auth 3]	IPR031327	Mini-chromosome maintenance protein	Family
B [auth 3]	IPR018525	Mini-chromosome maintenance, conserved site	Conserved Site
B [auth 3]	IPR003593	AAA+ ATPase domain	Domain
B [auth 3]	IPR001208	MCM domain	Domain
B [auth 3]	IPR041562	MCM, AAA-lid domain	Domain
B [auth 3]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
B [auth 3]	IPR027925	MCM, N-terminal domain	Domain
B [auth 3]	IPR008046	DNA replication licensing factor Mcm3	Family
B [auth 3]	IPR033762	MCM OB domain	Domain
B [auth 3]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
D [auth 5]	IPR031327	Mini-chromosome maintenance protein	Family
D [auth 5]	IPR018525	Mini-chromosome maintenance, conserved site	Conserved Site
D [auth 5]	IPR001208	MCM domain	Domain
D [auth 5]	IPR041562	MCM, AAA-lid domain	Domain
D [auth 5]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
D [auth 5]	IPR054125	MCM5, C-terminal domain	Domain
D [auth 5]	IPR027925	MCM, N-terminal domain	Domain
D [auth 5]	IPR033762	MCM OB domain	Domain
D [auth 5]	IPR008048	DNA replication licensing factor Mcm5	Family
D [auth 5]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
E [auth 6]	IPR008049	DNA replication licensing factor Mcm6	Family
E [auth 6]	IPR041024	Mcm6, C-terminal winged-helix domain	Domain
E [auth 6]	IPR031327	Mini-chromosome maintenance protein	Family
E [auth 6]	IPR018525	Mini-chromosome maintenance, conserved site	Conserved Site
E [auth 6]	IPR001208	MCM domain	Domain
E [auth 6]	IPR041562	MCM, AAA-lid domain	Domain
E [auth 6]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
E [auth 6]	IPR027925	MCM, N-terminal domain	Domain
E [auth 6]	IPR033762	MCM OB domain	Domain
E [auth 6]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
G [auth A]	IPR021151	GINS subunit, domain A	Domain
G [auth A]	IPR005339	GINS complex, subunit Psf1	Family
G [auth A]	IPR036224	GINS, helical bundle-like domain superfamily	Homologous Superfamily
H [auth B]	IPR007257	DNA replication complex GINS protein Psf2	Family
H [auth B]	IPR021151	GINS subunit, domain A	Domain
H [auth B]	IPR036224	GINS, helical bundle-like domain superfamily	Homologous Superfamily
I [auth C]	IPR021151	GINS subunit, domain A	Domain
I [auth C]	IPR010492	GINS complex, subunit Psf3	Family
I [auth C]	IPR038437	GINS complex, subunit Psf3 superfamily	Homologous Superfamily
I [auth C]	IPR036224	GINS, helical bundle-like domain superfamily	Homologous Superfamily