8REW | pdb_00008rew

CryoEM structure of human GARP-lTGFbeta1 in complex with a Fab fragment derived from an activating antibody.

External Resource: Annotation

Domain Annotation: SCOP2 Classification
SAbDab Antibody Annotation
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	pro-TGF beta-like	8089966	3002405	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Cystine-knot cytokines	8038779	3000846	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	pro-TGF beta-like	8089966	3002405	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Cystine-knot cytokines	8038779	3000846	SCOP2B (2022-06-29)

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
G, H	Heavy Chain	IGHV3	-	transforming growth factor beta-1	SAbDab (2025-04-18)
F, I	Light Chain	IGLV8	Lambda	transforming growth factor beta-1	SAbDab (2025-04-18)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF00688	TGF-beta propeptide (TGFb_propeptide)	TGF-beta propeptide	-	Family
A, B, C, D	PF00019	Transforming growth factor beta like domain (TGF_beta)	Transforming growth factor beta like domain		Domain
E	PF13855	Leucine rich repeat (LRR_8)	Leucine rich repeat	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Transforming growth factor beta-1	transforming growth factor beta receptor binding protein binding binding signaling receptor binding type I transforming growth factor beta receptor binding cytokine receptor binding identical protein binding type III transforming growth factor beta receptor binding molecular transducer activity molecular function activator activity signaling receptor activity signaling receptor activator activity molecular function regulator activity cytokine activity transforming growth factor beta receptor binding protein binding binding signaling receptor binding type I transforming growth factor beta receptor binding cytokine receptor binding identical protein binding type III transforming growth factor beta receptor binding molecular transducer activity molecular function activator activity signaling receptor activity signaling receptor activator activity molecular function regulator activity cytokine activity signaling receptor regulator activity receptor ligand activity protein-containing complex binding enzyme regulator activity protein serine/threonine kinase activity protein serine/threonine kinase activator activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity protein kinase regulator activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups kinase activator activity enzyme activator activity protein kinase activator activity catalytic activity kinase regulator activity peptidase activity ubiquitin-like protein peptidase activity peptidase regulator activity hydrolase activity deubiquitinase activator activity peptidase activator activity deubiquitinase activity growth factor activity type II transforming growth factor beta receptor binding enzyme binding	cellular response to stimulus positive regulation of cell communication cell surface receptor protein serine/threonine kinase signaling pathway regulation of cellular process positive regulation of signal transduction response to stimulus signaling regulation of transmembrane receptor protein serine/threonine kinase signaling pathway positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette cellular response to stimulus positive regulation of cell communication cell surface receptor protein serine/threonine kinase signaling pathway regulation of cellular process positive regulation of signal transduction response to stimulus signaling regulation of transmembrane receptor protein serine/threonine kinase signaling pathway positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette signal transduction enzyme-linked receptor protein signaling pathway positive regulation of cellular process regulation of biological process regulation of signaling cell surface receptor signaling pathway biological regulation positive regulation of intracellular signal transduction positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway SMAD protein signal transduction regulation of response to stimulus regulation of cell communication cellular process regulation of SMAD protein signal transduction positive regulation of SMAD protein signal transduction positive regulation of signaling developmental process multicellular organismal process gland development animal organ development salivary gland development anatomical structure morphogenesis multicellular organism development gland morphogenesis salivary gland morphogenesis anatomical structure development animal organ morphogenesis exocrine system development system development negative regulation of biological process positive regulation of macromolecule biosynthetic process positive regulation of post-transcriptional gene silencing regulation of primary metabolic process nucleobase-containing compound metabolic process positive regulation of metabolic process post-transcriptional regulation of gene expression positive regulation of primary miRNA processing positive regulation of post-transcriptional gene silencing by RNA positive regulation of macromolecule metabolic process RNA processing negative regulation of metabolic process primary metabolic process regulation of miRNA processing primary miRNA processing regulation of gene expression miRNA-mediated post-transcriptional gene silencing negative regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process post-transcriptional gene silencing miRNA processing regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process RNA metabolic process regulation of miRNA-mediated gene silencing RNA biosynthetic process nucleic acid biosynthetic process positive regulation of miRNA-mediated gene silencing regulation of regulatory ncRNA processing regulation of gene silencing by regulatory ncRNA positive regulation of biosynthetic process negative regulation of cellular process regulation of post-transcriptional gene silencing by regulatory ncRNA positive regulation of miRNA processing negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of primary miRNA processing regulation of macromolecule metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process regulatory ncRNA-mediated post-transcriptional gene silencing regulatory ncRNA processing regulatory ncRNA-mediated gene silencing regulation of post-transcriptional gene silencing negative regulation of biosynthetic process positive regulation of gene expression reactive oxygen species metabolic process regulation of superoxide metabolic process positive regulation of reactive oxygen species metabolic process superoxide metabolic process superoxide anion generation positive regulation of superoxide anion generation regulation of superoxide anion generation regulation of reactive oxygen species metabolic process cellular response to nitrogen compound response to endogenous stimulus response to peptide hormone cellular response to peptide hormone stimulus response to oxygen-containing compound response to nitrogen compound cellular response to oxygen-containing compound cellular response to endogenous stimulus cellular response to chemical stimulus response to hormone response to chemical cellular response to insulin-like growth factor stimulus cellular response to hormone stimulus regulation of cell adhesion negative regulation of cell adhesion cell adhesion cell-cell adhesion negative regulation of cell-cell adhesion mediated by cadherin cell-cell adhesion mediated by cadherin negative regulation of cell-cell adhesion regulation of cell-cell adhesion regulation of cell-cell adhesion mediated by cadherin multicellular organismal-level homeostasis chemical homeostasis homeostatic process multicellular organismal-level chemical homeostasis surfactant homeostasis regulation of animal organ morphogenesis regulation of developmental process regulation of odontogenesis odontogenesis positive regulation of odontogenesis positive regulation of developmental process positive regulation of animal organ morphogenesis positive regulation of multicellular organismal process regulation of multicellular organismal process regulation of anatomical structure morphogenesis canonical Wnt signaling pathway Wnt signaling pathway positive regulation of DNA-templated transcription positive regulation of miRNA transcription positive regulation of miRNA metabolic process DNA-templated transcription regulation of RNA metabolic process miRNA transcription regulation of miRNA metabolic process regulation of nucleobase-containing compound metabolic process miRNA metabolic process regulation of RNA biosynthetic process positive regulation of nucleobase-containing compound metabolic process positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process regulation of DNA-templated transcription regulation of miRNA transcription cellular developmental process hemopoiesis cell activation cell development mononuclear cell differentiation lymphocyte activation lymphocyte differentiation leukocyte activation T cell activation immune system process cell differentiation regulatory T cell differentiation T cell differentiation leukocyte differentiation embryonic epithelial tube formation chordate embryonic development tube formation embryo development epithelial tube formation tube morphogenesis primary neural tube formation embryo development ending in birth or egg hatching epithelial tube morphogenesis morphogenesis of embryonic epithelium epithelium development neural tube development tube development embryonic morphogenesis morphogenesis of an epithelium nervous system development tissue development tissue morphogenesis neural tube closure neural tube formation anatomical structure formation involved in morphogenesis tube closure developmental maturation epithelial cell differentiation epithelial cell development columnar/cuboidal epithelial cell development anatomical structure maturation epithelial cell maturation cell maturation columnar/cuboidal epithelial cell differentiation columnar/cuboidal epithelial cell maturation response to laminar fluid shear stress response to stress response to fluid shear stress cell morphogenesis response to wounding regulation of vascular permeability system process circulatory system process positive regulation of vascular permeability vascular process in circulatory system regulation of biological quality blood circulation ribose phosphate metabolic process ATP metabolic process ATP biosynthetic process nucleotide biosynthetic process carbohydrate derivative metabolic process purine ribonucleotide biosynthetic process purine ribonucleoside triphosphate biosynthetic process ribonucleotide biosynthetic process purine nucleotide metabolic process ribonucleotide metabolic process purine nucleoside triphosphate biosynthetic process nucleobase-containing small molecule metabolic process purine-containing compound biosynthetic process purine ribonucleoside triphosphate metabolic process phosphate-containing compound metabolic process small molecule metabolic process phosphorus metabolic process ribose phosphate biosynthetic process ribonucleoside triphosphate metabolic process nucleoside phosphate metabolic process carbohydrate derivative biosynthetic process purine nucleoside triphosphate metabolic process nucleoside triphosphate biosynthetic process nucleotide metabolic process ribonucleoside triphosphate biosynthetic process purine-containing compound metabolic process organophosphate metabolic process organophosphate biosynthetic process nucleoside phosphate biosynthetic process nucleoside triphosphate metabolic process purine ribonucleotide metabolic process purine nucleotide biosynthetic process branching involved in mammary gland duct morphogenesis development of secondary female sexual characteristics mammary gland morphogenesis reproductive process mammary gland development branching morphogenesis of an epithelial tube mammary gland branching involved in thelarche developmental process involved in reproduction thelarche development of secondary sexual characteristics mammary gland duct morphogenesis mammary gland epithelium development morphogenesis of a branching structure morphogenesis of a branching epithelium cytokine production regulation of cytokine production interleukin-17 production negative regulation of interleukin-17 production negative regulation of cytokine production regulation of interleukin-17 production negative regulation of multicellular organismal process smooth muscle cell differentiation positive regulation of smooth muscle cell differentiation regulation of smooth muscle cell differentiation regulation of cell differentiation muscle cell differentiation positive regulation of muscle cell differentiation muscle structure development regulation of muscle cell differentiation positive regulation of cell differentiation Notch signaling pathway respiratory tube development bronchiole development lung development respiratory system development negative regulation of RNA biosynthetic process negative regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription negative regulation of RNA metabolic process fat cell differentiation negative regulation of developmental process negative regulation of fat cell differentiation negative regulation of cell differentiation regulation of fat cell differentiation regulation of cartilage development regulation of multicellular organismal development connective tissue development skeletal system development cartilage development cellular response to glucose stimulus intracellular glucose homeostasis response to hexose cellular response to carbohydrate stimulus cellular homeostasis response to monosaccharide response to carbohydrate response to glucose glucose homeostasis carbohydrate homeostasis cellular response to hexose stimulus intracellular chemical homeostasis cellular response to monosaccharide stimulus regulation of muscle tissue development skeletal muscle tissue development regulation of skeletal muscle tissue development striated muscle tissue development skeletal muscle organ development negative regulation of muscle organ development muscle tissue development muscle organ development negative regulation of skeletal muscle tissue development regulation of striated muscle tissue development negative regulation of muscle tissue development regulation of muscle organ development negative regulation of striated muscle tissue development regulation of leukocyte differentiation regulation of leukocyte activation regulation of cell activation positive regulation of T cell differentiation regulation of cell development positive regulation of cell activation positive regulation of leukocyte activation regulation of immune system process positive regulation of immune system process positive regulation of T cell activation positive regulation of cell development positive regulation of regulatory T cell differentiation regulation of leukocyte cell-cell adhesion positive regulation of leukocyte cell-cell adhesion leukocyte cell-cell adhesion positive regulation of cell-cell adhesion regulation of T cell differentiation positive regulation of lymphocyte activation positive regulation of hemopoiesis regulation of lymphocyte differentiation positive regulation of cell adhesion regulation of regulatory T cell differentiation regulation of T cell activation regulation of hemopoiesis positive regulation of leukocyte differentiation positive regulation of lymphocyte differentiation regulation of lymphocyte activation cellular response to aldehyde cellular response to acetaldehyde response to acetaldehyde cell population proliferation positive regulation of cell population proliferation regulation of cell population proliferation heart development heart valve development aortic valve development circulatory system development heart valve morphogenesis semi-lunar valve development aortic valve morphogenesis negative regulation of miRNA transcription negative regulation of miRNA metabolic process membrane protein intracellular domain proteolysis proteolysis membrane protein proteolysis protein metabolic process positive regulation of locomotion regulation of cell motility regulation of blood vessel endothelial cell migration endothelial cell migration positive regulation of cell migration positive regulation of blood vessel endothelial cell migration regulation of locomotion positive regulation of endothelial cell migration positive regulation of cell motility regulation of cell migration blood vessel endothelial cell migration regulation of endothelial cell migration cell migration cell motility locomotion myeloid leukocyte differentiation myeloid dendritic cell activation Langerhans cell differentiation myeloid leukocyte activation myeloid cell differentiation myeloid dendritic cell differentiation dendritic cell differentiation blood vessel morphogenesis vasculogenesis vasculature development blood vessel development embryonic organ development embryonic liver development positive regulation of endothelial cell apoptotic process positive regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death cell death positive regulation of apoptotic process endothelial cell apoptotic process apoptotic process programmed cell death regulation of endothelial cell apoptotic process positive regulation of interleukin-17 production positive regulation of cytokine production adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains immune response adaptive immune response osteoclast differentiation cranial suture morphogenesis craniofacial suture morphogenesis cranial skeletal system development skeletal system morphogenesis bone morphogenesis bone development frontal suture morphogenesis regulation of tumor necrosis factor production positive regulation of tumor necrosis factor superfamily cytokine production tumor necrosis factor superfamily cytokine production positive regulation of tumor necrosis factor production tumor necrosis factor production regulation of tumor necrosis factor superfamily cytokine production regulation of localization transport regulation of transport regulation of monoatomic ion transport regulation of sodium ion transport establishment of localization metal ion transport localization monoatomic ion transport regulation of metal ion transport monoatomic cation transport sodium ion transport lung alveolus development regulation of protein modification process positive regulation of phosphorylation regulation of protein phosphorylation positive regulation of protein metabolic process peptidyl-tyrosine modification positive regulation of phosphate metabolic process positive regulation of peptidyl-tyrosine phosphorylation positive regulation of protein modification process regulation of phosphate metabolic process peptidyl-amino acid modification protein modification process positive regulation of protein phosphorylation protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process regulation of peptidyl-tyrosine phosphorylation macromolecule modification regulation of phosphorylation regulation of phosphorus metabolic process peptidyl-tyrosine phosphorylation phospholipid homeostasis lipid homeostasis negative regulation of cell cycle cell cycle regulation of cell cycle neuroblast proliferation negative regulation of neural precursor cell proliferation regulation of neuroblast proliferation regulation of neurogenesis negative regulation of neuroblast proliferation regulation of nervous system development neurogenesis negative regulation of neurogenesis negative regulation of nervous system development regulation of neural precursor cell proliferation negative regulation of cell population proliferation generation of neurons negative regulation of cell development neural precursor cell proliferation response to sterol response to lipid response to alcohol response to cholesterol inorganic ion homeostasis intracellular calcium ion homeostasis calcium ion homeostasis intracellular monoatomic cation homeostasis monoatomic ion homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis cell surface receptor protein tyrosine kinase signaling pathway positive regulation of ERBB signaling pathway regulation of epidermal growth factor receptor signaling pathway epidermal growth factor receptor signaling pathway positive regulation of epidermal growth factor receptor signaling pathway regulation of ERBB signaling pathway ERBB signaling pathway positive regulation of cell division cell division regulation of cell division response to ketone response to steroid hormone cellular response to ketone cellular response to steroid hormone stimulus cellular response to dexamethasone stimulus response to glucocorticoid cellular response to glucocorticoid stimulus cellular response to corticosteroid stimulus response to corticosteroid cellular response to lipid response to dexamethasone protein localization cellular localization establishment of protein localization nitrogen compound transport regulation of protein localization nucleocytoplasmic transport positive regulation of nucleocytoplasmic transport nuclear transport positive regulation of establishment of protein localization regulation of protein localization to nucleus positive regulation of protein transport import into nucleus regulation of protein import into nucleus cellular macromolecule localization establishment of localization in cell protein import into nucleus positive regulation of intracellular transport regulation of intracellular transport positive regulation of protein localization to nucleus regulation of establishment of protein localization positive regulation of protein import into nucleus intracellular transport regulation of nucleocytoplasmic transport protein localization to nucleus regulation of protein transport establishment of protein localization to organelle positive regulation of transport regulation of cellular localization protein transport macromolecule localization protein localization to organelle positive regulation of protein localization regulation of intracellular protein transport positive regulation of intracellular protein transport intracellular protein transport cellular component biogenesis cellular component organization cellular component assembly extracellular matrix organization cellular component organization or biogenesis extracellular matrix assembly extracellular structure organization external encapsulating structure organization ventricular cardiac muscle tissue morphogenesis heart morphogenesis ventricular cardiac muscle tissue development cardiac chamber development cardiac chamber morphogenesis cardiac muscle tissue development muscle tissue morphogenesis cardiac ventricle morphogenesis cardiac muscle tissue morphogenesis cardiac ventricle development muscle organ morphogenesis regulation of branching involved in mammary gland duct morphogenesis regulation of morphogenesis of an epithelium regulation of morphogenesis of a branching structure receptor catabolic process catabolic process receptor metabolic process macromolecule catabolic process negative regulation of protein localization to plasma membrane regulation of protein localization to membrane negative regulation of protein localization protein localization to cell periphery protein localization to plasma membrane regulation of protein localization to cell periphery localization within membrane protein localization to membrane negative regulation of protein localization to membrane negative regulation of protein localization to cell periphery regulation of protein localization to plasma membrane regulation of vascular endothelial growth factor production vascular endothelial growth factor production positive regulation of vascular endothelial growth factor production head development face morphogenesis head morphogenesis face development body morphogenesis negative regulation of myoblast differentiation regulation of myoblast differentiation myoblast differentiation fibroblast proliferation regulation of fibroblast proliferation positive regulation of fibroblast proliferation regulation of fibroblast migration positive regulation of fibroblast migration fibroblast migration ameboidal-type cell migration wound healing connective tissue replacement involved in inflammatory response wound healing wound healing involved in inflammatory response defense response inflammatory response to wounding tissue remodeling connective tissue replacement inflammatory response positive regulation of epithelial cell proliferation regulation of epithelial cell proliferation epithelial cell proliferation regulation of vasculature development positive regulation of vasculature development ureteric bud development mesonephric epithelium development kidney epithelium development mesonephros development renal system development kidney development mesonephric tubule development oligodendrocyte development glial cell development central nervous system development gliogenesis oligodendrocyte differentiation glial cell differentiation positive regulation of MAPK cascade regulation of MAPK cascade MAPK cascade positive regulation of secretion by cell protein localization to extracellular region regulation of secretion by cell secretion by cell positive regulation of secretion secretion establishment of protein localization to extracellular region export from cell protein secretion positive regulation of protein secretion regulation of protein secretion regulation of secretion positive regulation of mononuclear cell migration regulation of mononuclear cell migration regulation of leukocyte migration positive regulation of leukocyte migration leukocyte migration mononuclear cell migration import into cell regulation of cellular component organization negative regulation of transport negative regulation of endocytosis vesicle-mediated transport negative regulation of phagocytosis phagocytosis regulation of endocytosis negative regulation of cellular component organization regulation of phagocytosis regulation of vesicle-mediated transport endocytosis negative regulation of biomineral tissue development regulation of biomineral tissue development biomineral tissue development foam cell differentiation macrophage derived foam cell differentiation branch elongation involved in mammary gland duct branching developmental growth axis elongation branch elongation of an epithelium growth developmental growth involved in morphogenesis response to xenobiotic stimulus immune system development lymph node development hematopoietic or lymphoid organ development protein export from nucleus nuclear export tolerance induction to self antigen tolerance induction chemotaxis regulation of response to external stimulus response to external stimulus regulation of chemotaxis positive regulation of chemotaxis positive regulation of response to external stimulus taxis regulation of tissue remodeling regulation of blood vessel remodeling blood vessel remodeling negative regulation of lymphocyte proliferation negative regulation of T cell proliferation negative regulation of leukocyte proliferation lymphocyte proliferation regulation of leukocyte proliferation negative regulation of T cell activation negative regulation of leukocyte cell-cell adhesion mononuclear cell proliferation negative regulation of leukocyte activation negative regulation of lymphocyte activation leukocyte proliferation negative regulation of mononuclear cell proliferation T cell proliferation regulation of lymphocyte proliferation negative regulation of cell activation regulation of T cell proliferation negative regulation of immune system process regulation of mononuclear cell proliferation lymphocyte mediated immunity regulation of immune effector process immune response to tumor cell negative regulation of immune response to tumor cell negative regulation of lymphocyte mediated immunity response to biotic stimulus negative regulation of natural killer cell mediated immunity regulation of natural killer cell mediated cytotoxicity directed against tumor cell target leukocyte mediated immunity regulation of natural killer cell mediated immune response to tumor cell natural killer cell mediated immunity regulation of natural killer cell mediated immunity negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target response to other organism regulation of innate immune response negative regulation of immune response negative regulation of immune effector process leukocyte mediated cytotoxicity natural killer cell mediated immune response to tumor cell immune effector process regulation of leukocyte mediated immunity defense response to other organism negative regulation of response to external stimulus negative regulation of defense response natural killer cell mediated cytotoxicity regulation of immune response regulation of cell killing regulation of defense response negative regulation of natural killer cell mediated cytotoxicity regulation of response to biotic stimulus regulation of natural killer cell mediated cytotoxicity biological process involved in interspecies interaction between organisms negative regulation of response to biotic stimulus negative regulation of response to tumor cell regulation of response to tumor cell regulation of response to stress innate immune response negative regulation of leukocyte mediated cytotoxicity response to external biotic stimulus negative regulation of cell killing response to tumor cell negative regulation of response to stimulus regulation of leukocyte mediated cytotoxicity defense response to symbiont regulation of immune response to tumor cell natural killer cell mediated cytotoxicity directed against tumor cell target negative regulation of natural killer cell mediated immune response to tumor cell regulation of lymphocyte mediated immunity negative regulation of leukocyte mediated immunity cell killing negative regulation of innate immune response response to salt regulation of smooth muscle cell proliferation smooth muscle cell proliferation positive regulation of smooth muscle cell proliferation muscle cell proliferation negative regulation of macrophage cytokine production myeloid leukocyte cytokine production cytokine production involved in immune response production of molecular mediator of immune response negative regulation of cytokine production involved in immune response regulation of cytokine production involved in immune response negative regulation of production of molecular mediator of immune response regulation of macrophage cytokine production regulation of production of molecular mediator of immune response macrophage cytokine production chondrocyte differentiation transcription by RNA polymerase II regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II carbohydrate derivative catabolic process hyaluronan catabolic process glycosaminoglycan metabolic process aminoglycan catabolic process glycosaminoglycan catabolic process hyaluronan metabolic process aminoglycan metabolic process cellular response to growth factor stimulus cellular response to transforming growth factor beta stimulus response to transforming growth factor beta transforming growth factor beta receptor signaling pathway response to growth factor transforming growth factor beta receptor superfamily signaling pathway sensory organ development retina vasculature development in camera-type eye eye development retina development in camera-type eye visual system development camera-type eye development sensory system development positive regulation of canonical NF-kappaB signal transduction canonical NF-kappaB signal transduction regulation of canonical NF-kappaB signal transduction positive regulation of ERK1 and ERK2 cascade ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade sexual reproduction multicellular organismal reproductive process germ cell migration gamete generation nephron tubule morphogenesis regulation of kidney development regulation of branching involved in ureteric bud morphogenesis nephron development renal tubule morphogenesis nephron morphogenesis nephron epithelium morphogenesis nephron tubule development ureteric bud morphogenesis positive regulation of morphogenesis of an epithelium branching involved in ureteric bud morphogenesis renal tubule development nephron epithelium development kidney morphogenesis positive regulation of branching involved in ureteric bud morphogenesis mesonephric tubule morphogenesis cell surface receptor signaling pathway via STAT positive regulation of receptor signaling pathway via STAT regulation of receptor signaling pathway via STAT regulation of epithelial to mesenchymal transition positive regulation of epithelial to mesenchymal transition mesenchyme development epithelial to mesenchymal transition mesenchymal cell differentiation positive regulation of cellular component organization positive regulation of cellular component biogenesis positive regulation of extracellular matrix organization regulation of cellular component biogenesis regulation of extracellular matrix assembly positive regulation of extracellular matrix assembly regulation of extracellular matrix organization regulation of cytoskeleton organization regulation of actin filament-based process actin cytoskeleton organization regulation of organelle organization organelle organization regulation of actin cytoskeleton organization actin filament-based process cytoskeleton organization animal organ regeneration liver development regeneration hepaticobiliary system development liver regeneration interleukin-23 production regulation of interleukin-23 production regulation of striated muscle cell differentiation regulation of cardiac muscle cell differentiation positive regulation of cardiocyte differentiation positive regulation of striated muscle cell differentiation positive regulation of cardiac muscle cell differentiation cardiac muscle cell differentiation cardiocyte differentiation regulation of cardiocyte differentiation striated muscle cell differentiation response to mechanical stimulus response to abiotic stimulus cellular response to mechanical stimulus cellular response to abiotic stimulus cellular response to external stimulus cellular response to environmental stimulus neuron apoptotic process response to immobilization stress myofibroblast differentiation positive regulation of nervous system development positive regulation of gliogenesis microglia differentiation regulation of macrophage differentiation regulation of microglia differentiation regulation of myeloid leukocyte differentiation positive regulation of myeloid leukocyte differentiation positive regulation of macrophage differentiation positive regulation of microglia differentiation regulation of gliogenesis positive regulation of neurogenesis regulation of myeloid cell differentiation macrophage differentiation regulation of glial cell differentiation positive regulation of glial cell differentiation positive regulation of myeloid cell differentiation regulation of canonical Wnt signaling pathway positive regulation of Wnt signaling pathway positive regulation of canonical Wnt signaling pathway regulation of Wnt signaling pathway ossification regulation of ossification negative regulation of ossification response to estradiol lens fiber cell differentiation lens development in camera-type eye regulation of inflammatory response positive regulation of inflammatory response positive regulation of defense response response to progesterone response to decreased oxygen levels cellular response to oxygen levels cellular response to hypoxia cellular response to decreased oxygen levels cellular response to stress response to hypoxia response to oxygen levels ear development inner ear development protein-containing complex organization positive regulation of protein-containing complex assembly regulation of protein-containing complex assembly protein-containing complex assembly regulation of cell cycle phase transition cell cycle phase transition exit from mitosis mitotic cell cycle regulation of mitotic cell cycle positive regulation of mitotic cell cycle phase transition positive regulation of exit from mitosis positive regulation of cell cycle process positive regulation of mitotic cell cycle cell cycle process mitotic nuclear division regulation of cell cycle process organelle fission positive regulation of cell cycle regulation of mitotic cell cycle phase transition nuclear division mitotic cell cycle process positive regulation of cell cycle phase transition regulation of exit from mitosis mitotic cell cycle phase transition response to ionizing radiation cellular response to ionizing radiation response to radiation cellular response to radiation regulation of growth negative regulation of cell growth regulation of cell growth cell growth negative regulation of growth extrinsic apoptotic signaling pathway apoptotic signaling pathway angiogenesis sprouting angiogenesis chemokine (C-X-C motif) ligand 2 production regulation of chemokine (C-X-C motif) ligand 2 production positive regulation of chemokine (C-X-C motif) ligand 2 production regulation of chemokine production chemokine production positive regulation of chemokine production mesenchymal stem cell proliferation regulation of stem cell proliferation positive regulation of mesenchymal stem cell proliferation regulation of mesenchymal stem cell proliferation positive regulation of stem cell proliferation stem cell proliferation negative regulation of locomotion negative regulation of endothelial cell migration negative regulation of blood vessel endothelial cell migration negative regulation of cell motility negative regulation of cell migration cellular response to low-density lipoprotein particle stimulus response to lipoprotein particle cellular response to lipoprotein particle stimulus cellular component disassembly negative regulation of extracellular matrix organization extracellular matrix disassembly negative regulation of extracellular matrix disassembly regulation of extracellular matrix disassembly negative regulation of epithelial cell proliferation collagen biosynthetic process regulation of collagen biosynthetic process regulation of collagen metabolic process positive regulation of collagen metabolic process positive regulation of collagen biosynthetic process collagen metabolic process positive regulation of transcription by RNA polymerase II enamel mineralization tooth mineralization odontogenesis of dentin-containing tooth amelogenesis regulation of tooth mineralization regulation of enamel mineralization muscle cell cellular homeostasis regulation of calcium ion transport calcium ion transport negative regulation of cation transmembrane transport regulation of release of sequestered calcium ion into cytosol inorganic ion transmembrane transport inorganic cation transmembrane transport maintenance of location transmembrane transport release of sequestered calcium ion into cytosol regulation of transmembrane transport negative regulation of calcium ion transmembrane transport monoatomic ion transmembrane transport negative regulation of monoatomic ion transport regulation of monoatomic ion transmembrane transport negative regulation of sequestering of calcium ion negative regulation of transmembrane transport maintenance of location in cell regulation of calcium ion transmembrane transport monoatomic cation transmembrane transport positive regulation of sequestering of calcium ion negative regulation of monoatomic ion transmembrane transport negative regulation of release of sequestered calcium ion into cytosol regulation of sequestering of calcium ion calcium ion transmembrane import into cytosol sequestering of calcium ion negative regulation of calcium ion transport regulation of monoatomic cation transmembrane transport calcium ion transmembrane transport multi-multicellular organism process female pregnancy multi-organism reproductive process interleukin-6 production positive regulation of interleukin-6 production regulation of interleukin-6 production digestive system development digestive tract development endoderm development leukocyte homeostasis T cell homeostasis homeostasis of number of cells lymphocyte homeostasis regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction phosphatidylinositol 3-kinase/protein kinase B signal transduction defense response to fungus response to fungus response to nutrient levels response to vitamin D response to nutrient response to vitamin neuroepithelial cell differentiation odontoblast differentiation myelination axon ensheathment ensheathment of neurons hematopoietic progenitor cell differentiation B cell activation involved in immune response positive regulation of immune response positive regulation of isotype switching to IgA isotypes positive regulation of DNA recombination positive regulation of immunoglobulin mediated immune response DNA recombination DNA metabolic process positive regulation of DNA metabolic process B cell mediated immunity positive regulation of production of molecular mediator of immune response regulation of DNA metabolic process immunoglobulin production positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains somatic cell DNA recombination somatic diversification of immunoglobulins involved in immune response somatic recombination of immunoglobulin gene segments regulation of immunoglobulin mediated immune response leukocyte activation involved in immune response regulation of B cell activation positive regulation of isotype switching positive regulation of immune effector process positive regulation of immunoglobulin production regulation of isotype switching isotype switching to IgA isotypes somatic diversification of immune receptors via germline recombination within a single locus regulation of DNA recombination positive regulation of leukocyte mediated immunity cell activation involved in immune response somatic diversification of immune receptors positive regulation of adaptive immune response somatic recombination of immunoglobulin genes involved in immune response regulation of adaptive immune response regulation of B cell mediated immunity somatic diversification of immunoglobulins isotype switching immunoglobulin production involved in immunoglobulin-mediated immune response positive regulation of lymphocyte mediated immunity regulation of isotype switching to IgA isotypes positive regulation of B cell mediated immunity regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains lymphocyte activation involved in immune response B cell activation immunoglobulin mediated immune response positive regulation of B cell activation regulation of immunoglobulin production regulation of hyaluronan biosynthetic process regulation of polysaccharide metabolic process negative regulation of hyaluronan biosynthetic process polysaccharide metabolic process glycosaminoglycan biosynthetic process regulation of carbohydrate metabolic process negative regulation of carbohydrate metabolic process carbohydrate metabolic process polysaccharide biosynthetic process carbohydrate biosynthetic process hyaluronan biosynthetic process regulation of polysaccharide biosynthetic process aminoglycan biosynthetic process regulation of carbohydrate biosynthetic process cell junction organization cell-cell junction organization cellular response to virus response to virus	cellular anatomical structure extracellular region extracellular space cell periphery plasma membrane membrane extracellular matrix external encapsulating structure collagen-containing extracellular matrix intracellular anatomical structure cytoplasm somatodendritic compartment cell body neuronal cell body cellular anatomical structure extracellular region extracellular space cell periphery plasma membrane membrane extracellular matrix external encapsulating structure collagen-containing extracellular matrix intracellular anatomical structure cytoplasm somatodendritic compartment cell body neuronal cell body membrane-bounded organelle Golgi apparatus membrane-enclosed lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen Golgi lumen intracellular organelle organelle lumen organelle cell surface vesicle lumen intracellular vesicle cytoplasmic vesicle lumen secretory granule lumen cytoplasmic vesicle secretory granule secretory vesicle platelet alpha granule vesicle platelet alpha granule lumen axon cell projection neuron projection plasma membrane bounded cell projection blood microparticle nucleus
E	Transforming growth factor beta activator LRRC32	transforming growth factor beta binding protein binding binding growth factor binding cytokine binding molecular transducer activity molecular function activator activity signaling receptor binding signaling receptor activity signaling receptor activator activity molecular function inhibitor activity molecular function regulator activity signaling receptor regulator activity receptor ligand activity transforming growth factor beta binding protein binding binding growth factor binding cytokine binding molecular transducer activity molecular function activator activity signaling receptor binding signaling receptor activity signaling receptor activator activity molecular function inhibitor activity molecular function regulator activity signaling receptor regulator activity receptor ligand activity receptor ligand inhibitor activity	multicellular organismal process regulation of cellular process negative regulation of biological process negative regulation of cellular process cytokine production regulation of cytokine production regulation of multicellular organismal process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process negative regulation of metabolic process biological regulation negative regulation of cytokine production regulation of macromolecule metabolic process multicellular organismal process regulation of cellular process negative regulation of biological process negative regulation of cellular process cytokine production regulation of cytokine production regulation of multicellular organismal process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process negative regulation of metabolic process biological regulation negative regulation of cytokine production regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process metabolic process cellular process macromolecule metabolic process negative regulation of multicellular organismal process regulation of metabolic process negative regulation of lymphocyte proliferation regulation of leukocyte activation regulation of cell activation negative regulation of T cell proliferation negative regulation of cell adhesion negative regulation of leukocyte proliferation T cell activation lymphocyte proliferation regulation of immune system process regulation of leukocyte proliferation cell population proliferation negative regulation of T cell activation negative regulation of leukocyte cell-cell adhesion regulation of cell population proliferation mononuclear cell proliferation negative regulation of cell-cell adhesion regulation of leukocyte cell-cell adhesion negative regulation of leukocyte activation regulation of activated T cell proliferation lymphocyte activation negative regulation of lymphocyte activation leukocyte proliferation leukocyte cell-cell adhesion leukocyte activation activated T cell proliferation negative regulation of mononuclear cell proliferation cell adhesion cell-cell adhesion regulation of cell-cell adhesion T cell proliferation regulation of lymphocyte proliferation negative regulation of cell population proliferation regulation of cell adhesion cell activation regulation of T cell activation negative regulation of cell activation regulation of T cell proliferation negative regulation of activated T cell proliferation negative regulation of immune system process immune system process regulation of mononuclear cell proliferation regulation of lymphocyte activation developmental process anatomical structure development secondary palate development roof of mouth development positive regulation of biological process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of gene expression positive regulation of biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process cellular response to stimulus cellular response to growth factor stimulus cell surface receptor protein serine/threonine kinase signaling pathway response to stimulus cell surface receptor signaling pathway signaling cellular response to transforming growth factor beta stimulus response to endogenous stimulus cell communication cellular response to endogenous stimulus response to transforming growth factor beta transforming growth factor beta receptor signaling pathway response to growth factor transforming growth factor beta receptor superfamily signaling pathway signal transduction enzyme-linked receptor protein signaling pathway protein localization localization establishment of protein localization cellular localization cellular macromolecule localization macromolecule localization establishment of protein localization to extracellular region establishment of localization protein localization to extracellular region	cell periphery cellular anatomical structure cell surface membrane plasma membrane external side of plasma membrane side of membrane extracellular matrix external encapsulating structure extracellular region extracellular space membrane-bounded organelle intracellular anatomical structure nucleus cell periphery cellular anatomical structure cell surface membrane plasma membrane external side of plasma membrane side of membrane extracellular matrix external encapsulating structure extracellular region extracellular space membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen
G, H	hFab LHT-22, Heavy Chain	-	-	-
F, I	hFab LHT-22, Light Chain	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR003939	Transforming growth factor beta-1 proprotein	Family
A, B, C, D	IPR029034	Cystine-knot cytokine	Homologous Superfamily
A, B, C, D	IPR001839	Transforming growth factor-beta, C-terminal	Domain
A, B, C, D	IPR016319	Transforming growth factor-beta	Family
A, B, C, D	IPR015615	Transforming growth factor-beta-related	Family
A, B, C, D	IPR017948	Transforming growth factor beta, conserved site	Conserved Site
A, B, C, D	IPR001111	TGF-beta, propeptide	Domain
E	IPR000372	Leucine-rich repeat N-terminal domain	Domain
E	IPR001611	Leucine-rich repeat	Repeat
E	IPR003591	Leucine-rich repeat, typical subtype	Repeat
E	IPR032675	Leucine-rich repeat domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: P01137	Camurati-Engelmann disease cystic fibrosis sarcoidosis essential thrombocythemia kidney disease pneumonia cleft palate myocardial infarction duodenal ulcer aortic valve insufficiency IgA glomerulonephritis nephrotic syndrome autoimmune hepatitis osteoporosis squamous cell carcinoma Camurati-Engelmann disease cystic fibrosis sarcoidosis essential thrombocythemia kidney disease pneumonia cleft palate myocardial infarction duodenal ulcer aortic valve insufficiency IgA glomerulonephritis nephrotic syndrome autoimmune hepatitis osteoporosis squamous cell carcinoma myopathy asthma oral submucous fibrosis calcinosis Duchenne muscular dystrophy colorectal cancer endomyocardial fibrosis Inflammation non-alcoholic fatty liver disease extrahepatic cholestasis occupational asthma osteoarthritis focal segmental glomerulosclerosis chronic kidney disease tubular adenocarcinoma diabetic neuropathy Peyronie disease dry eye syndrome allergic disease ureteral obstruction posterior leukoencephalopathy syndrome hypertensive disorder epilepsy inflammatory bowel disease proteinuria pulmonary emphysema brain disease skin cancer granular cell carcinoma carcinosarcoma diabetic autonomic neuropathy acute lung injury diabetic polyneuropathy hyperplasia urticaria prostate cancer intervertebral disc degenerative disorder pulmonary fibrosis sarcomatoid carcinoma carcinoma skin neoplasm acromicric dysplasia squamous papilloma papilloma chronic beryllium disease malignant pancreatic neoplasm adenocarcinoma chronic obstructive pulmonary disease type 2 diabetes mellitus alcoholic liver cirrhosis pleural disease cirrhosis of liver uremia postmenopausal osteoporosis congenital diaphragmatic hernia cribriform carcinoma Becker muscular dystrophy bipolar disorder depressive disorder schizophrenia lung disease glioblastoma malignant ependymoma pancreatic ductal adenocarcinoma papillomatosis hepatitis maturity-onset diabetes of the young ulcerative colitis colorectal carcinoma primary biliary cholangitis cribriform carcinoma of breast lung benign neoplasm gastric carcinoma cancer osteosarcoma malignant glioma acute kidney failure pancreatic neoplasm heart disease medulloblastoma pilocytic astrocytoma undifferentiated carcinoma muscle tissue disease Duchenne and Becker muscular dystrophy pneumonitis idiopathic interstitial pneumonia atypical teratoid rhabdoid tumor corneal dystrophy lung carcinoma diabetes mellitus geleophysic dysplasia malignant mesothelioma diabetic kidney disease cerebrovascular disorder hepatocellular carcinoma muscular disease astrocytic tumor idiopathic pulmonary fibrosis
E	Pharos: Q14392	pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia ulcerative colitis adrenal cortex carcinoma asthma breast fibroadenoma endometriosis inflammatory bowel disease lung cancer non-small cell lung carcinoma pancreatic intraductal papillary-mucinous carcinoma psoriasis allergic rhinitis atopic eczema Crohn disease pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia ulcerative colitis adrenal cortex carcinoma asthma breast fibroadenoma endometriosis inflammatory bowel disease lung cancer non-small cell lung carcinoma pancreatic intraductal papillary-mucinous carcinoma psoriasis allergic rhinitis atopic eczema Crohn disease gastroesophageal reflux disease interstitial cystitis lung carcinoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm rheumatoid arthritis alopecia areata breast cancer cystic fibrosis herpes zoster lung adenocarcinoma malignant pancreatic neoplasm

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