Annotations: 8TCF

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Integrin alpha N-terminal domain	8041564	3000314	SCOP2B (2022-06-29)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF01839	FG-GAP repeat (FG-GAP)	FG-GAP repeat	-	Repeat
B	PF00362	Integrin beta chain VWA domain (Integrin_beta)	Integrin beta chain VWA domain	Integrins have been found in animals and their homologues have also been found in cyanobacteria, probably due to horizontal gene transfer [1]. This domain corresponds to the integrin beta VWA domain.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Integrin alpha-V heavy chain	molecular transducer activity coreceptor activity signaling receptor activity protein binding binding extracellular matrix protein binding fibronectin binding opsonin binding cation binding ion binding metal ion binding small molecule binding virus receptor activity exogenous protein binding molecular transducer activity coreceptor activity signaling receptor activity protein binding binding extracellular matrix protein binding fibronectin binding opsonin binding cation binding ion binding metal ion binding small molecule binding virus receptor activity exogenous protein binding extracellular matrix binding calcium channel activity monoatomic cation transmembrane transporter activity voltage-gated calcium channel activity gated channel activity monoatomic ion channel activity voltage-gated channel activity voltage-gated monoatomic ion channel activity voltage-gated monoatomic cation channel activity monoatomic cation channel activity passive transmembrane transporter activity calcium ion transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity transmembrane transporter activity enzyme binding protease binding transforming growth factor beta binding growth factor binding cytokine binding cell adhesion molecule binding protein-containing complex binding integrin binding signaling receptor binding kinase binding protein kinase C binding protein kinase binding	biological process involved in interspecies interaction between organisms symbiont entry into host cell viral process symbiont entry into host viral life cycle entry into host cell by a symbiont-containing vacuole biological process involved in interaction with host biological process involved in symbiotic interaction regulation of localization regulation of biological process negative regulation of lipid transport transport regulation of transport biological regulation biological process involved in interspecies interaction between organisms symbiont entry into host cell viral process symbiont entry into host viral life cycle entry into host cell by a symbiont-containing vacuole biological process involved in interaction with host biological process involved in symbiotic interaction regulation of localization regulation of biological process negative regulation of lipid transport transport regulation of transport biological regulation negative regulation of biological process lipid localization lipid transport negative regulation of transport regulation of lipid transport establishment of localization negative regulation of lipid localization localization regulation of lipid localization macromolecule localization cell adhesion substrate adhesion-dependent cell spreading cell-substrate adhesion cellular process multicellular organismal process biosynthetic process cytokine production metabolic process macromolecule metabolic process gene expression macromolecule biosynthetic process transforming growth factor beta production cell migration cell motility regulation of cellular process lipid storage regulation of lipid storage negative regulation of lipid storage negative regulation of cellular process nutrient storage monoatomic ion transmembrane transport inorganic ion transmembrane transport calcium ion transport metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport monoatomic ion transport monoatomic cation transport calcium ion transmembrane transport cellular response to stimulus signal transduction in absence of ligand response to stimulus cell surface receptor signaling pathway signaling cell death extrinsic apoptotic signaling pathway cell communication apoptotic signaling pathway extrinsic apoptotic signaling pathway in absence of ligand signal transduction apoptotic process programmed cell death cell population proliferation positive regulation of cell population proliferation positive regulation of osteoblast proliferation positive regulation of biological process osteoblast proliferation regulation of cell population proliferation regulation of osteoblast proliferation positive regulation of cellular process import into cell regulation of cellular component organization regulation of phagocytosis regulation of vesicle-mediated transport vesicle-mediated transport cellular component organization phagocytosis cellular component organization or biogenesis endocytosis regulation of endocytosis positive regulation of cell communication regulation of signaling positive regulation of signal transduction positive regulation of intracellular signal transduction regulation of signal transduction intracellular signal transduction positive regulation of response to stimulus regulation of intracellular signal transduction regulation of response to stimulus regulation of cell communication positive regulation of signaling negative regulation of endocytosis negative regulation of cellular component organization negative regulation of receptor-mediated endocytosis regulation of receptor-mediated endocytosis negative regulation of molecular function regulation of molecular function negative regulation of low-density lipoprotein receptor activity receptor-mediated endocytosis developmental process wound healing epithelium development morphogenesis of an epithelium epiboly involved in wound healing tissue development morphogenesis of an epithelial sheet wound healing, spreading of epidermal cells tissue morphogenesis anatomical structure morphogenesis response to stress anatomical structure development epiboly wound healing, spreading of cells response to wounding chemotaxis negative chemotaxis taxis response to chemical response to external stimulus locomotion negative regulation of signaling regulation of programmed cell death negative regulation of cell communication negative regulation of extrinsic apoptotic signaling pathway negative regulation of apoptotic signaling pathway negative regulation of response to stimulus negative regulation of programmed cell death regulation of apoptotic process negative regulation of signal transduction regulation of extrinsic apoptotic signaling pathway negative regulation of apoptotic process regulation of apoptotic signaling pathway negative regulation of lipoprotein metabolic process regulation of protein metabolic process lipoprotein metabolic process negative regulation of metabolic process primary metabolic process regulation of macromolecule metabolic process regulation of primary metabolic process regulation of lipoprotein metabolic process protein metabolic process regulation of metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process heterotypic cell-cell adhesion cell-cell adhesion apoptotic cell clearance modulation by symbiont of entry into host negative regulation of entry of bacterium into host cell entry of bacterium into host cell regulation of entry of bacterium into host cell regulation of biological process involved in symbiotic interaction cell-matrix adhesion regulation of developmental process cellular developmental process negative regulation of developmental process macrophage derived foam cell differentiation regulation of cell differentiation negative regulation of macrophage derived foam cell differentiation foam cell differentiation cell differentiation regulation of macrophage derived foam cell differentiation negative regulation of cell differentiation positive regulation of cytosolic calcium ion concentration regulation of biological quality blood vessel morphogenesis tube development angiogenesis vasculature development circulatory system development multicellular organism development tube morphogenesis anatomical structure formation involved in morphogenesis blood vessel development system development apolipoprotein A-I-mediated signaling pathway intracellular signaling cassette MAPK cascade ERK1 and ERK2 cascade formation of primary germ layer embryonic morphogenesis embryo development gastrulation endoderm development endoderm formation endodermal cell differentiation integrin-mediated signaling pathway cell adhesion mediated by integrin positive regulation of cell adhesion regulation of cell adhesion vasculogenesis positive regulation of locomotion regulation of cell motility positive regulation of cell migration regulation of locomotion positive regulation of cell motility regulation of cell migration small GTPase-mediated signal transduction regulation of small GTPase mediated signal transduction positive regulation of small GTPase mediated signal transduction	membrane-bounded organelle intracellular anatomical structure membrane intracellular vesicle intracellular membrane-bounded organelle endomembrane system specific granule membrane intracellular organelle cytoplasmic vesicle membrane cellular anatomical structure bounding membrane of organelle vesicle membrane cytoplasmic vesicle organelle membrane-bounded organelle intracellular anatomical structure membrane intracellular vesicle intracellular membrane-bounded organelle endomembrane system specific granule membrane intracellular organelle cytoplasmic vesicle membrane cellular anatomical structure bounding membrane of organelle vesicle membrane cytoplasmic vesicle organelle secretory granule secretory vesicle cytoplasm vesicle organelle membrane secretory granule membrane specific granule cell periphery protein-containing complex plasma membrane protein complex plasma membrane membrane protein complex alphav-beta3 integrin-PKCalpha complex cell surface external side of plasma membrane side of membrane receptor complex integrin alphav-beta5 complex integrin complex plasma membrane signaling receptor complex protein complex involved in cell adhesion integrin alphav-beta8 complex extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space extracellular membrane-bounded organelle cytosol plasma membrane bounded cell projection cell projection actin-based cell projection plasma membrane region microvillus microvillus membrane cell projection membrane alphav-beta3 integrin-HMGB1 complex alphav-beta3 integrin-IGF-1-IGF1R complex integrin alphav-beta3 complex anchoring junction cell junction focal adhesion cell-substrate junction ruffle cell leading edge leading edge membrane ruffle membrane phagocytic vesicle endocytic vesicle integrin alphav-beta1 complex lamellipodium membrane lamellipodium integrin alphav-beta6 complex filopodium membrane filopodium
B	Integrin beta-8	protein binding binding extracellular matrix protein binding cell adhesion molecule binding protein-containing complex binding integrin binding signaling receptor binding cation binding ion binding metal ion binding small molecule binding	developmental process multicellular organism development multicellular organismal process skeletal system development connective tissue development anatomical structure development animal organ development tissue development cartilage development system development cell adhesion cell-matrix adhesion cell-substrate adhesion cellular process developmental process multicellular organism development multicellular organismal process skeletal system development connective tissue development anatomical structure development animal organ development tissue development cartilage development system development cell adhesion cell-matrix adhesion cell-substrate adhesion cellular process response to stimulus immune response immune system process regulation of biosynthetic process regulation of biological process regulation of cellular process biological regulation positive regulation of biological process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process positive regulation of macromolecule biosynthetic process regulation of gene expression positive regulation of metabolic process biosynthetic process positive regulation of gene expression positive regulation of biosynthetic process regulation of macromolecule biosynthetic process metabolic process positive regulation of macromolecule metabolic process macromolecule metabolic process regulation of metabolic process positive regulation of cellular process cellular response to stimulus integrin-mediated signaling pathway cell surface receptor signaling pathway signaling cell communication signal transduction hard palate development secondary palate development roof of mouth development ceramide metabolic process membrane lipid metabolic process glycosphingolipid metabolic process glycolipid metabolic process liposaccharide metabolic process carbohydrate derivative metabolic process sphingolipid metabolic process primary metabolic process amide metabolic process ganglioside metabolic process lipid metabolic process placenta blood vessel development placenta development vasculature development circulatory system development blood vessel development myeloid leukocyte differentiation cellular developmental process myeloid dendritic cell activation hemopoiesis Langerhans cell differentiation cell activation cell development mononuclear cell differentiation myeloid leukocyte activation leukocyte activation myeloid cell differentiation cell differentiation myeloid dendritic cell differentiation dendritic cell differentiation leukocyte differentiation blood vessel morphogenesis tube development vasculogenesis anatomical structure morphogenesis tube morphogenesis regulation of developmental process angiogenesis regulation of vasculature development positive regulation of developmental process regulation of multicellular organismal process regulation of anatomical structure morphogenesis regulation of multicellular organismal development positive regulation of angiogenesis positive regulation of vasculature development regulation of angiogenesis anatomical structure formation involved in morphogenesis positive regulation of multicellular organismal process biological process involved in interspecies interaction between organisms response to other organism response to external stimulus response to external biotic stimulus response to virus response to biotic stimulus cell-cell adhesion negative regulation of metabolic process negative regulation of biological process negative regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of cellular process negative regulation of macromolecule metabolic process cellular response to growth factor stimulus cell surface receptor protein serine/threonine kinase signaling pathway cellular response to transforming growth factor beta stimulus response to endogenous stimulus cellular response to endogenous stimulus response to transforming growth factor beta transforming growth factor beta receptor signaling pathway response to growth factor transforming growth factor beta receptor superfamily signaling pathway enzyme-linked receptor protein signaling pathway	cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction protein-containing complex plasma membrane protein complex membrane plasma membrane membrane protein complex receptor complex cell periphery integrin complex plasma membrane signaling receptor complex cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction protein-containing complex plasma membrane protein complex membrane plasma membrane membrane protein complex receptor complex cell periphery integrin complex plasma membrane signaling receptor complex protein complex involved in cell adhesion integrin alphav-beta8 complex extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle cell surface
C	Minibinder B8_BP_dslf	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR013517	FG-GAP repeat	Repeat
A	IPR048286	Integrin alpha, third immunoglobulin-like domain	Domain
A	IPR013649	Integrin alpha, first immunoglubulin-like domain	Domain
A	IPR048285	Integrin alpha, second immunoglobulin-like domain	Domain
A	IPR032695	Integrin domain superfamily	Homologous Superfamily
A	IPR013519	Integrin alpha beta-propellor	Repeat
A	IPR000413	Integrin alpha chain	Family
A	IPR028994	Integrin alpha, N-terminal	Homologous Superfamily
A	IPR018184	Integrin alpha chain, C-terminal cytoplasmic region, conserved site	Conserved Site
B	IPR033760	Integrin beta N-terminal	Domain
B	IPR013111	EGF-like domain, extracellular	Domain
B	IPR015812	Integrin beta subunit	Family
B	IPR002369	Integrin beta subunit, VWA domain	Domain
B	IPR016201	PSI domain	Domain
B	IPR000742	EGF-like domain	Domain
B	IPR036465	von Willebrand factor A-like domain superfamily	Homologous Superfamily
B	IPR032695	Integrin domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P06756	Acute Cerebrovascular Accidents glioblastoma intracerebral hemorrhage myopathy osteosarcoma rheumatoid arthritis breast cancer cerebrovascular disorder hereditary spastic paraplegia large cell medulloblastoma nasopharyngeal carcinoma ovarian cancer tuberculosis diabetes mellitus inflammatory bowel disease Acute Cerebrovascular Accidents glioblastoma intracerebral hemorrhage myopathy osteosarcoma rheumatoid arthritis breast cancer cerebrovascular disorder hereditary spastic paraplegia large cell medulloblastoma nasopharyngeal carcinoma ovarian cancer tuberculosis diabetes mellitus inflammatory bowel disease medulloblastoma non-small cell lung carcinoma pilocytic astrocytoma
B	Pharos: P26012	inflammatory bowel disease endometriosis pilocytic astrocytoma Prostate cancer, familial spina bifida allergic rhinitis breast cancer lung carcinoma malignant glioma osteosarcoma primary biliary cholangitis prostate carcinoma tuberculosis astrocytic tumor chronic obstructive pulmonary disease inflammatory bowel disease endometriosis pilocytic astrocytoma Prostate cancer, familial spina bifida allergic rhinitis breast cancer lung carcinoma malignant glioma osteosarcoma primary biliary cholangitis prostate carcinoma tuberculosis astrocytic tumor chronic obstructive pulmonary disease large cell medulloblastoma malignant colon neoplasm non-small cell lung carcinoma ovarian cancer primitive neuroectodermal tumor psoriasis atypical teratoid rhabdoid tumor cystic fibrosis glioblastoma lung cancer malignant ependymoma oligodendroglioma

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Integrin Adhesion Receptors	Human Integrin αvβ8, in complex with minibinder B8_BP_dsulf

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.