8H8R

Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Oxidized State

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: mpstruc
Protein Modification Annotation

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Cytochrome c oxidase subunit I-like	8035426	3000653	SCOP2B (2022-06-29)
N	SCOP2B Superfamily	Cytochrome c oxidase subunit I-like	8035426	3000653	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	Mitochondrial cytochrome c oxidase subunit VIIa	8035438	3000606	SCOP2B (2022-06-29)
W	SCOP2B Superfamily	Mitochondrial cytochrome c oxidase subunit VIIa	8035438	3000606	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	Mitochondrial cytochrome c oxidase subunit VIIb	8035440	3000613	SCOP2B (2022-06-29)
X	SCOP2B Superfamily	Mitochondrial cytochrome c oxidase subunit VIIb	8035440	3000613	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	Mitochondrial cytochrome c oxidase subunit VIIc (aka VIIIa)	8035441	3000624	SCOP2B (2022-06-29)
Y	SCOP2B Superfamily	Mitochondrial cytochrome c oxidase subunit VIIc (aka VIIIa)	8035441	3000624	SCOP2B (2022-06-29)
M	SCOP2B Superfamily	Mitochondrial cytochrome c oxidase subunit VIIIb (aka IX)	8035443	3000633	SCOP2B (2022-06-29)
Z	SCOP2B Superfamily	Mitochondrial cytochrome c oxidase subunit VIIIb (aka IX)	8035443	3000633	SCOP2B (2022-06-29)
O	SCOP2B Superfamily	Cupredoxins	8035427	3000886	SCOP2B (2022-06-29)
O	SCOP2B Superfamily	Cytochrome c oxidase subunit II-like, transmembrane region	8035428	3000692	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Cytochrome c oxidase subunit II-like, transmembrane region	8035428	3000692	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Cupredoxins	8035427	3000886	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Cytochrome c oxidase subunit III-like	8035429	3000671	SCOP2B (2022-06-29)
P	SCOP2B Superfamily	Cytochrome c oxidase subunit III-like	8035429	3000671	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Mitochondrial cytochrome c oxidase subunit IV	8035430	3000582	SCOP2B (2022-06-29)
Q	SCOP2B Superfamily	Mitochondrial cytochrome c oxidase subunit IV	8035430	3000582	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Cytochrome c oxidase subunit E	8035431	3001402	SCOP2B (2022-06-29)
R	SCOP2B Superfamily	Cytochrome c oxidase subunit E	8035431	3001402	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Rubredoxin-like	8035432	3001257	SCOP2B (2022-06-29)
S	SCOP2B Superfamily	Rubredoxin-like	8035432	3001257	SCOP2B (2022-06-29)
T	SCOP2B Superfamily	Mitochondrial cytochrome c oxidase subunit VIa	8035433	3000592	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Mitochondrial cytochrome c oxidase subunit VIa	8035433	3000592	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Cytochrome c oxidase subunit h	8035435	3000395	SCOP2B (2022-06-29)
U	SCOP2B Superfamily	Cytochrome c oxidase subunit h	8035435	3000395	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	Mitochondrial cytochrome c oxidase subunit VIc	8035437	3000598	SCOP2B (2022-06-29)
V	SCOP2B Superfamily	Mitochondrial cytochrome c oxidase subunit VIc	8035437	3000598	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	COX1	e8h8rA1	A: alpha superhelices	X: Cytochrome c oxidase subunit I-like	H: Cytochrome c oxidase subunit I-like (From Topology)	T: Cytochrome c oxidase subunit I-like	F: COX1	ECOD (1.6)
N	COX1	e8h8rN1	A: alpha superhelices	X: Cytochrome c oxidase subunit I-like	H: Cytochrome c oxidase subunit I-like (From Topology)	T: Cytochrome c oxidase subunit I-like	F: COX1	ECOD (1.6)
J	COX7a	e8h8rJ1	A: extended segments	X: Mitochondrial cytochrome c oxidase subunit VIIa (From Topology)	H: Mitochondrial cytochrome c oxidase subunit VIIa (From Topology)	T: Mitochondrial cytochrome c oxidase subunit VIIa	F: COX7a	ECOD (1.6)
W	COX7a	e8h8rW1	A: extended segments	X: Mitochondrial cytochrome c oxidase subunit VIIa (From Topology)	H: Mitochondrial cytochrome c oxidase subunit VIIa (From Topology)	T: Mitochondrial cytochrome c oxidase subunit VIIa	F: COX7a	ECOD (1.6)
K	COX7B	e8h8rK1	A: extended segments	X: Mitochondrial cytochrome c oxidase subunit VIIb (From Topology)	H: Mitochondrial cytochrome c oxidase subunit VIIb (From Topology)	T: Mitochondrial cytochrome c oxidase subunit VIIb	F: COX7B	ECOD (1.6)
X	COX7B	e8h8rX1	A: extended segments	X: Mitochondrial cytochrome c oxidase subunit VIIb (From Topology)	H: Mitochondrial cytochrome c oxidase subunit VIIb (From Topology)	T: Mitochondrial cytochrome c oxidase subunit VIIb	F: COX7B	ECOD (1.6)
L	COX7C	e8h8rL1	A: extended segments	X: Mitochondrial cytochrome c oxidase subunit VIIc (aka VIIIa) (From Topology)	H: Mitochondrial cytochrome c oxidase subunit VIIc (aka VIIIa) (From Topology)	T: Mitochondrial cytochrome c oxidase subunit VIIc (aka VIIIa)	F: COX7C	ECOD (1.6)
Y	COX7C	e8h8rY1	A: extended segments	X: Mitochondrial cytochrome c oxidase subunit VIIc (aka VIIIa) (From Topology)	H: Mitochondrial cytochrome c oxidase subunit VIIc (aka VIIIa) (From Topology)	T: Mitochondrial cytochrome c oxidase subunit VIIc (aka VIIIa)	F: COX7C	ECOD (1.6)
M	COX8	e8h8rM1	A: extended segments	X: Mitochondrial cytochrome c oxidase subunit VIIIb (aka IX) (From Topology)	H: Mitochondrial cytochrome c oxidase subunit VIIIb (aka IX) (From Topology)	T: Mitochondrial cytochrome c oxidase subunit VIIIb (aka IX)	F: COX8	ECOD (1.6)
Z	COX8	e8h8rZ1	A: extended segments	X: Mitochondrial cytochrome c oxidase subunit VIIIb (aka IX) (From Topology)	H: Mitochondrial cytochrome c oxidase subunit VIIIb (aka IX) (From Topology)	T: Mitochondrial cytochrome c oxidase subunit VIIIb (aka IX)	F: COX8	ECOD (1.6)
O	COX2	e8h8rO2	A: beta sandwiches	X: Cupredoxin-like	H: Cupredoxin-related (From Topology)	T: Cupredoxin-related	F: COX2	ECOD (1.6)
O	COX2_TM	e8h8rO1	A: extended segments	X: Cytochrome c oxidase subunit II-like, transmembrane region (From Topology)	H: Cytochrome c oxidase subunit II-like, transmembrane region (From Topology)	T: Cytochrome c oxidase subunit II-like, transmembrane region	F: COX2_TM	ECOD (1.6)
B	COX2	e8h8rB2	A: beta sandwiches	X: Cupredoxin-like	H: Cupredoxin-related (From Topology)	T: Cupredoxin-related	F: COX2	ECOD (1.6)
B	COX2_TM	e8h8rB1	A: extended segments	X: Cytochrome c oxidase subunit II-like, transmembrane region (From Topology)	H: Cytochrome c oxidase subunit II-like, transmembrane region (From Topology)	T: Cytochrome c oxidase subunit II-like, transmembrane region	F: COX2_TM	ECOD (1.6)
C	COX3	e8h8rC1	A: alpha bundles	X: Cytochrome c oxidase subunit III-like (From Topology)	H: Cytochrome c oxidase subunit III-like (From Topology)	T: Cytochrome c oxidase subunit III-like	F: COX3	ECOD (1.6)
P	COX3	e8h8rP1	A: alpha bundles	X: Cytochrome c oxidase subunit III-like (From Topology)	H: Cytochrome c oxidase subunit III-like (From Topology)	T: Cytochrome c oxidase subunit III-like	F: COX3	ECOD (1.6)
D	COX4	e8h8rD1	A: extended segments	X: Mitochondrial cytochrome c oxidase subunit IV (From Topology)	H: Mitochondrial cytochrome c oxidase subunit IV (From Topology)	T: Mitochondrial cytochrome c oxidase subunit IV	F: COX4	ECOD (1.6)
Q	COX4	e8h8rQ1	A: extended segments	X: Mitochondrial cytochrome c oxidase subunit IV (From Topology)	H: Mitochondrial cytochrome c oxidase subunit IV (From Topology)	T: Mitochondrial cytochrome c oxidase subunit IV	F: COX4	ECOD (1.6)
E	COX5A	e8h8rE1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Cytochrome c oxidase subunit E (From Topology)	T: Cytochrome c oxidase subunit E	F: COX5A	ECOD (1.6)
R	COX5A	e8h8rR1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Cytochrome c oxidase subunit E (From Topology)	T: Cytochrome c oxidase subunit E	F: COX5A	ECOD (1.6)
F	COX5B	e8h8rF1	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Cytochrome c oxidase Subunit F	F: COX5B	ECOD (1.6)
S	COX5B	e8h8rS1	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Cytochrome c oxidase Subunit F	F: COX5B	ECOD (1.6)
T	COX6A	e8h8rT1	A: extended segments	X: Mitochondrial cytochrome c oxidase subunit VIa (From Topology)	H: Mitochondrial cytochrome c oxidase subunit VIa (From Topology)	T: Mitochondrial cytochrome c oxidase subunit VIa	F: COX6A	ECOD (1.6)
G	COX6A	e8h8rG1	A: extended segments	X: Mitochondrial cytochrome c oxidase subunit VIa (From Topology)	H: Mitochondrial cytochrome c oxidase subunit VIa (From Topology)	T: Mitochondrial cytochrome c oxidase subunit VIa	F: COX6A	ECOD (1.6)
H	COX6B	e8h8rH1	A: few secondary structure elements	X: Cytochrome c oxidase subunit h (From Topology)	H: Cytochrome c oxidase subunit h (From Topology)	T: Cytochrome c oxidase subunit h	F: COX6B	ECOD (1.6)
U	COX6B	e8h8rU1	A: few secondary structure elements	X: Cytochrome c oxidase subunit h (From Topology)	H: Cytochrome c oxidase subunit h (From Topology)	T: Cytochrome c oxidase subunit h	F: COX6B	ECOD (1.6)
I	COX6C	e8h8rI1	A: extended segments	X: Mitochondrial cytochrome c oxidase subunit VIc (From Topology)	H: Mitochondrial cytochrome c oxidase subunit VIc (From Topology)	T: Mitochondrial cytochrome c oxidase subunit VIc	F: COX6C	ECOD (1.6)
V	COX6C	e8h8rV1	A: extended segments	X: Mitochondrial cytochrome c oxidase subunit VIc (From Topology)	H: Mitochondrial cytochrome c oxidase subunit VIc (From Topology)	T: Mitochondrial cytochrome c oxidase subunit VIc	F: COX6C	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, N	PF00115	Cytochrome C and Quinol oxidase polypeptide I (COX1)	Cytochrome C and Quinol oxidase polypeptide I	-	Family
J, W	PF02238	Cytochrome c oxidase subunit VII (COX7a)	Cytochrome c oxidase subunit VII	-	Family
M, Z	PF02285	Cytochrome oxidase c subunit VIII (COX8)	Cytochrome oxidase c subunit VIII	-	Family
B, O	PF00116	Cytochrome C oxidase subunit II, periplasmic domain (COX2)	Cytochrome C oxidase subunit II, periplasmic domain	-	Domain
B, O	PF02790	Cytochrome C oxidase subunit II, transmembrane domain (COX2_TM)	Cytochrome C oxidase subunit II, transmembrane domain	-	Family
C, P	PF00510	Cytochrome c oxidase subunit III (COX3)	Cytochrome c oxidase subunit III	-	Family
D, Q	PF02936	Cytochrome c oxidase subunit IV (COX4)	Cytochrome c oxidase subunit IV	-	Family
H, U	PF02297	Cytochrome oxidase c subunit VIb (COX6B)	Cytochrome oxidase c subunit VIb	Cytochrome c oxidase, a 13 sub-unit complex, EC:1.9.3.1 is the terminal oxidase in the mitochondrial electron transport chain. This family is composed of the potentially heme-binding subunit IVb of the oxidase.	Domain
I, V	PF02937	Cytochrome c oxidase subunit VIc (COX6C)	Cytochrome c oxidase subunit VIc	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, N	Cytochrome c oxidase subunit 1	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity cytochrome-c oxidase activity electron transfer activity active monoatomic ion transmembrane transporter activity oxidoreductase activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity oxidoreductase activity, acting on a heme group of donors inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity cytochrome-c oxidase activity electron transfer activity active monoatomic ion transmembrane transporter activity oxidoreductase activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity oxidoreductase activity, acting on a heme group of donors inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity catalytic activity binding organic cyclic compound binding tetrapyrrole binding heme binding cation binding ion binding metal ion binding small molecule binding	aerobic respiration cellular respiration aerobic electron transport chain oxidative phosphorylation energy derivation by oxidation of organic compounds ATP synthesis coupled electron transport electron transport chain generation of precursor metabolites and energy mitochondrial electron transport, cytochrome c to oxygen respiratory electron transport chain metabolic process cellular process mitochondrial ATP synthesis coupled electron transport electron transport coupled proton transport aerobic respiration cellular respiration aerobic electron transport chain oxidative phosphorylation energy derivation by oxidation of organic compounds ATP synthesis coupled electron transport electron transport chain generation of precursor metabolites and energy mitochondrial electron transport, cytochrome c to oxygen respiratory electron transport chain metabolic process cellular process mitochondrial ATP synthesis coupled electron transport electron transport coupled proton transport transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization energy coupled proton transmembrane transport, against electrochemical gradient monoatomic ion transport monoatomic cation transport	membrane-bounded organelle mitochondrial membrane intracellular anatomical structure organelle inner membrane mitochondrion membrane intracellular membrane-bounded organelle mitochondrial inner membrane intracellular organelle organelle envelope cellular anatomical structure mitochondrial envelope organelle cytoplasm membrane-bounded organelle mitochondrial membrane intracellular anatomical structure organelle inner membrane mitochondrion membrane intracellular membrane-bounded organelle mitochondrial inner membrane intracellular organelle organelle envelope cellular anatomical structure mitochondrial envelope organelle cytoplasm organelle membrane respiratory chain complex protein-containing complex catalytic complex cytochrome complex membrane protein complex respiratory chain complex IV transporter complex transmembrane transporter complex oxidoreductase complex
J, W	Cytochrome c oxidase subunit 7A1	oxidoreductase activity catalytic activity	aerobic respiration cellular respiration oxidative phosphorylation regulation of biological process regulation of cellular process energy derivation by oxidation of organic compounds biological regulation regulation of generation of precursor metabolites and energy generation of precursor metabolites and energy regulation of cellular respiration regulation of aerobic respiration regulation of oxidative phosphorylation metabolic process cellular process aerobic respiration cellular respiration oxidative phosphorylation regulation of biological process regulation of cellular process energy derivation by oxidation of organic compounds biological regulation regulation of generation of precursor metabolites and energy generation of precursor metabolites and energy regulation of cellular respiration regulation of aerobic respiration regulation of oxidative phosphorylation metabolic process cellular process regulation of metabolic process aerobic electron transport chain ATP synthesis coupled electron transport electron transport chain mitochondrial electron transport, cytochrome c to oxygen respiratory electron transport chain mitochondrial ATP synthesis coupled electron transport cellular component organization cellular component biogenesis organelle organization cellular component assembly mitochondrial respirasome assembly protein-containing complex organization protein-containing complex assembly cellular component organization or biogenesis mitochondrion organization	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope organelle membrane respiratory chain complex protein-containing complex catalytic complex cytochrome complex membrane protein complex respiratory chain complex IV transporter complex transmembrane transporter complex oxidoreductase complex
K, X	Cytochrome c oxidase subunit 7B, mitochondrial	-	aerobic respiration cellular respiration aerobic electron transport chain oxidative phosphorylation energy derivation by oxidation of organic compounds ATP synthesis coupled electron transport electron transport chain generation of precursor metabolites and energy mitochondrial electron transport, cytochrome c to oxygen respiratory electron transport chain metabolic process cellular process mitochondrial ATP synthesis coupled electron transport developmental process aerobic respiration cellular respiration aerobic electron transport chain oxidative phosphorylation energy derivation by oxidation of organic compounds ATP synthesis coupled electron transport electron transport chain generation of precursor metabolites and energy mitochondrial electron transport, cytochrome c to oxygen respiratory electron transport chain metabolic process cellular process mitochondrial ATP synthesis coupled electron transport developmental process multicellular organism development multicellular organismal process central nervous system development anatomical structure development nervous system development system development	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope organelle membrane respiratory chain complex protein-containing complex catalytic complex cytochrome complex membrane protein complex respiratory chain complex IV transporter complex transmembrane transporter complex oxidoreductase complex
L, Y	Cytochrome c oxidase subunit 7C, mitochondrial	-	aerobic respiration cellular respiration aerobic electron transport chain oxidative phosphorylation energy derivation by oxidation of organic compounds ATP synthesis coupled electron transport electron transport chain generation of precursor metabolites and energy mitochondrial electron transport, cytochrome c to oxygen respiratory electron transport chain metabolic process cellular process mitochondrial ATP synthesis coupled electron transport	membrane-bounded organelle mitochondrial membrane intracellular anatomical structure organelle inner membrane mitochondrion membrane intracellular membrane-bounded organelle mitochondrial inner membrane intracellular organelle organelle envelope cellular anatomical structure mitochondrial envelope organelle cytoplasm membrane-bounded organelle mitochondrial membrane intracellular anatomical structure organelle inner membrane mitochondrion membrane intracellular membrane-bounded organelle mitochondrial inner membrane intracellular organelle organelle envelope cellular anatomical structure mitochondrial envelope organelle cytoplasm organelle membrane respiratory chain complex protein-containing complex catalytic complex cytochrome complex membrane protein complex respiratory chain complex IV transporter complex transmembrane transporter complex oxidoreductase complex
M, Z	Cytochrome c oxidase subunit 8B, mitochondrial	-	aerobic respiration cellular respiration aerobic electron transport chain oxidative phosphorylation energy derivation by oxidation of organic compounds ATP synthesis coupled electron transport electron transport chain generation of precursor metabolites and energy mitochondrial electron transport, cytochrome c to oxygen respiratory electron transport chain metabolic process cellular process mitochondrial ATP synthesis coupled electron transport	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope organelle membrane respiratory chain complex protein-containing complex catalytic complex cytochrome complex membrane protein complex respiratory chain complex IV transporter complex transmembrane transporter complex oxidoreductase complex
B, O	Cytochrome c oxidase subunit 2	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity cytochrome-c oxidase activity electron transfer activity active monoatomic ion transmembrane transporter activity oxidoreductase activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity oxidoreductase activity, acting on a heme group of donors inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity cytochrome-c oxidase activity electron transfer activity active monoatomic ion transmembrane transporter activity oxidoreductase activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity oxidoreductase activity, acting on a heme group of donors inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity catalytic activity cation binding transition metal ion binding copper ion binding ion binding binding metal ion binding small molecule binding	aerobic respiration cellular respiration oxidative phosphorylation energy derivation by oxidation of organic compounds respiratory electron transport chain ATP synthesis coupled electron transport electron transport chain metabolic process cellular process generation of precursor metabolites and energy	membrane-bounded organelle mitochondrial membrane intracellular anatomical structure organelle inner membrane mitochondrion membrane intracellular membrane-bounded organelle mitochondrial inner membrane intracellular organelle organelle envelope cellular anatomical structure mitochondrial envelope organelle cytoplasm membrane-bounded organelle mitochondrial membrane intracellular anatomical structure organelle inner membrane mitochondrion membrane intracellular membrane-bounded organelle mitochondrial inner membrane intracellular organelle organelle envelope cellular anatomical structure mitochondrial envelope organelle cytoplasm organelle membrane respiratory chain complex protein-containing complex catalytic complex cytochrome complex membrane protein complex respiratory chain complex IV transporter complex transmembrane transporter complex oxidoreductase complex
C, P	Cytochrome c oxidase subunit 3	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity cytochrome-c oxidase activity electron transfer activity active monoatomic ion transmembrane transporter activity oxidoreductase activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity oxidoreductase activity, acting on a heme group of donors inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity cytochrome-c oxidase activity electron transfer activity active monoatomic ion transmembrane transporter activity oxidoreductase activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity oxidoreductase activity, acting on a heme group of donors inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity catalytic activity	respiratory chain complex IV assembly cytochrome complex assembly cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis aerobic respiration cellular respiration aerobic electron transport chain oxidative phosphorylation energy derivation by oxidation of organic compounds respiratory chain complex IV assembly cytochrome complex assembly cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis aerobic respiration cellular respiration aerobic electron transport chain oxidative phosphorylation energy derivation by oxidation of organic compounds ATP synthesis coupled electron transport electron transport chain generation of precursor metabolites and energy mitochondrial electron transport, cytochrome c to oxygen respiratory electron transport chain metabolic process mitochondrial ATP synthesis coupled electron transport	membrane-bounded organelle mitochondrial membrane intracellular anatomical structure organelle inner membrane mitochondrion membrane intracellular membrane-bounded organelle mitochondrial inner membrane intracellular organelle organelle envelope cellular anatomical structure mitochondrial envelope organelle cytoplasm membrane-bounded organelle mitochondrial membrane intracellular anatomical structure organelle inner membrane mitochondrion membrane intracellular membrane-bounded organelle mitochondrial inner membrane intracellular organelle organelle envelope cellular anatomical structure mitochondrial envelope organelle cytoplasm organelle membrane respiratory chain complex protein-containing complex catalytic complex cytochrome complex membrane protein complex respiratory chain complex IV transporter complex transmembrane transporter complex oxidoreductase complex
D, Q	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity cytochrome-c oxidase activity electron transfer activity active monoatomic ion transmembrane transporter activity oxidoreductase activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity oxidoreductase activity, acting on a heme group of donors inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity cytochrome-c oxidase activity electron transfer activity active monoatomic ion transmembrane transporter activity oxidoreductase activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity oxidoreductase activity, acting on a heme group of donors inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity catalytic activity	aerobic respiration cellular respiration aerobic electron transport chain oxidative phosphorylation energy derivation by oxidation of organic compounds ATP synthesis coupled electron transport electron transport chain generation of precursor metabolites and energy mitochondrial electron transport, cytochrome c to oxygen respiratory electron transport chain metabolic process cellular process mitochondrial ATP synthesis coupled electron transport	membrane-bounded organelle mitochondrial membrane intracellular anatomical structure organelle inner membrane mitochondrion membrane intracellular membrane-bounded organelle mitochondrial inner membrane intracellular organelle organelle envelope cellular anatomical structure mitochondrial envelope organelle cytoplasm membrane-bounded organelle mitochondrial membrane intracellular anatomical structure organelle inner membrane mitochondrion membrane intracellular membrane-bounded organelle mitochondrial inner membrane intracellular organelle organelle envelope cellular anatomical structure mitochondrial envelope organelle cytoplasm organelle membrane respiratory chain complex protein-containing complex catalytic complex cytochrome complex membrane protein complex respiratory chain complex IV transporter complex transmembrane transporter complex oxidoreductase complex
E, R	Cytochrome c oxidase subunit 5A	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity cytochrome-c oxidase activity electron transfer activity active monoatomic ion transmembrane transporter activity oxidoreductase activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity oxidoreductase activity, acting on a heme group of donors inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity cytochrome-c oxidase activity electron transfer activity active monoatomic ion transmembrane transporter activity oxidoreductase activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity oxidoreductase activity, acting on a heme group of donors inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity catalytic activity cation binding ion binding binding metal ion binding small molecule binding	aerobic respiration cellular respiration aerobic electron transport chain oxidative phosphorylation energy derivation by oxidation of organic compounds ATP synthesis coupled electron transport electron transport chain generation of precursor metabolites and energy mitochondrial electron transport, cytochrome c to oxygen respiratory electron transport chain metabolic process cellular process mitochondrial ATP synthesis coupled electron transport	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope organelle membrane respiratory chain complex protein-containing complex catalytic complex cytochrome complex membrane protein complex respiratory chain complex IV transporter complex transmembrane transporter complex oxidoreductase complex
F, S	Cytochrome c oxidase subunit 5B, mitochondrial	cation binding ion binding binding metal ion binding small molecule binding	aerobic respiration cellular respiration aerobic electron transport chain oxidative phosphorylation energy derivation by oxidation of organic compounds ATP synthesis coupled electron transport electron transport chain generation of precursor metabolites and energy mitochondrial electron transport, cytochrome c to oxygen respiratory electron transport chain metabolic process cellular process mitochondrial ATP synthesis coupled electron transport	membrane-bounded organelle mitochondrial membrane intracellular anatomical structure organelle inner membrane mitochondrion membrane intracellular membrane-bounded organelle mitochondrial inner membrane intracellular organelle organelle envelope cellular anatomical structure mitochondrial envelope organelle cytoplasm membrane-bounded organelle mitochondrial membrane intracellular anatomical structure organelle inner membrane mitochondrion membrane intracellular membrane-bounded organelle mitochondrial inner membrane intracellular organelle organelle envelope cellular anatomical structure mitochondrial envelope organelle cytoplasm organelle membrane respiratory chain complex protein-containing complex catalytic complex cytochrome complex membrane protein complex respiratory chain complex IV transporter complex transmembrane transporter complex oxidoreductase complex
G, T	Cytochrome c oxidase subunit 6A2, mitochondrial	oxidoreductase activity catalytic activity enzyme regulator activity molecular function regulator activity	aerobic respiration cellular respiration aerobic electron transport chain oxidative phosphorylation energy derivation by oxidation of organic compounds ATP synthesis coupled electron transport electron transport chain generation of precursor metabolites and energy mitochondrial electron transport, cytochrome c to oxygen respiratory electron transport chain metabolic process cellular process mitochondrial ATP synthesis coupled electron transport	membrane-bounded organelle mitochondrial membrane intracellular anatomical structure organelle inner membrane mitochondrion membrane intracellular membrane-bounded organelle mitochondrial inner membrane intracellular organelle organelle envelope cellular anatomical structure mitochondrial envelope organelle cytoplasm membrane-bounded organelle mitochondrial membrane intracellular anatomical structure organelle inner membrane mitochondrion membrane intracellular membrane-bounded organelle mitochondrial inner membrane intracellular organelle organelle envelope cellular anatomical structure mitochondrial envelope organelle cytoplasm organelle membrane respiratory chain complex protein-containing complex catalytic complex cytochrome complex membrane protein complex respiratory chain complex IV transporter complex transmembrane transporter complex oxidoreductase complex
H, U	Cytochrome c oxidase subunit 6B1	-	aerobic respiration cellular respiration oxidative phosphorylation energy derivation by oxidation of organic compounds metabolic process cellular process generation of precursor metabolites and energy	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope organelle membrane respiratory chain complex protein-containing complex catalytic complex cytochrome complex membrane protein complex respiratory chain complex IV transporter complex transmembrane transporter complex oxidoreductase complex
I, V	Cytochrome c oxidase subunit 6C	-	aerobic respiration cellular respiration oxidative phosphorylation energy derivation by oxidation of organic compounds metabolic process cellular process generation of precursor metabolites and energy	membrane-bounded organelle mitochondrial membrane intracellular anatomical structure organelle inner membrane mitochondrion membrane intracellular membrane-bounded organelle mitochondrial inner membrane intracellular organelle organelle envelope cellular anatomical structure mitochondrial envelope organelle cytoplasm membrane-bounded organelle mitochondrial membrane intracellular anatomical structure organelle inner membrane mitochondrion membrane intracellular membrane-bounded organelle mitochondrial inner membrane intracellular organelle organelle envelope cellular anatomical structure mitochondrial envelope organelle cytoplasm organelle membrane respiratory chain complex protein-containing complex catalytic complex cytochrome complex membrane protein complex respiratory chain complex IV transporter complex transmembrane transporter complex oxidoreductase complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, N	IPR036927	Cytochrome c oxidase-like, subunit I superfamily	Homologous Superfamily
A, N	IPR000883	Cytochrome c oxidase subunit I	Family
A, N	IPR023615	Cytochrome c oxidase, subunit I, copper-binding site	Binding Site
A, N	IPR023616	Cytochrome c oxidase-like, subunit I domain	Domain
A, N	IPR033944	Cytochrome c oxidase subunit I domain	Domain
J, W	IPR003177	Cytochrome c oxidase subunit VIIa, metazoa	Family
J, W	IPR036539	Cytochrome c oxidase, subunit VIIa superfamily	Homologous Superfamily
J, W	IPR039297	Cytochrome c oxidase subunit VII	Family
K, X	IPR023272	Cytochrome C oxidase, subunit VIIB domain superfamily	Homologous Superfamily
K, X	IPR008433	Cytochrome C oxidase, subunit VIIB	Family
L, Y	IPR036636	Cytochrome c oxidase subunit VIIc superfamily	Homologous Superfamily
L, Y	IPR004202	Cytochrome c oxidase subunit VIIc	Family
M, Z	IPR003205	Cytochrome c oxidase, subunit 8	Family
M, Z	IPR036548	Cytochrome c oxidase, subunit 8 superfamily	Homologous Superfamily
B, O	IPR011759	Cytochrome C oxidase subunit II, transmembrane domain	Domain
B, O	IPR036257	Cytochrome C oxidase subunit II, transmembrane domain superfamily	Homologous Superfamily
B, O	IPR034210	Cytochrome c oxidase subunit 2, C-terminal	Domain
B, O	IPR045187	Cytochrome c/quinol oxidase subunit II	Family
B, O	IPR002429	Cytochrome c oxidase subunit II-like C-terminal	Domain
B, O	IPR008972	Cupredoxin	Homologous Superfamily
B, O	IPR001505	Copper centre Cu(A)	Binding Site
B, O	IPR014222	Cytochrome c oxidase, subunit II	Domain
C, P	IPR035973	Cytochrome c oxidase subunit III-like superfamily	Homologous Superfamily
C, P	IPR013833	Cytochrome c oxidase, subunit III, 4-helical bundle	Homologous Superfamily
C, P	IPR000298	Cytochrome c oxidase subunit III-like	Domain
C, P	IPR033945	Cytochrome c oxidase subunit III domain	Domain
C, P	IPR024791	Cytochrome c oxidase subunit III	Family
D, Q	IPR004203	Cytochrome c oxidase subunit IV family	Family
D, Q	IPR013288	Cytochrome c oxidase subunit IV	Family
D, Q	IPR036639	Cytochrome c oxidase subunit IV superfamily	Homologous Superfamily
E, R	IPR003204	Cytochrome c oxidase, subunit Va/VI	Family
E, R	IPR036545	Cytochrome c oxidase, subunit Va/VI superfamily	Homologous Superfamily
F, S	IPR002124	Cytochrome c oxidase, subunit Vb	Family
F, S	IPR036972	Cytochrome c oxidase, subunit Vb superfamily	Homologous Superfamily
G, T	IPR018507	Cytochrome c oxidase, subunit VIa, conserved site	Conserved Site
G, T	IPR036418	Cytochrome c oxidase, subunit VIa superfamily	Homologous Superfamily
G, T	IPR001349	Cytochrome c oxidase, subunit VIa	Family
H, U	IPR036549	Cytochrome c oxidase subunit 6B/Cytochrome c oxidase assembly factor 6-like superfamily	Homologous Superfamily
H, U	IPR048280	Cytochrome oxidase c subunit VIb-like	Family
H, U	IPR003213	Cytochrome c oxidase, subunit VIb	Family
I, V	IPR037169	Mitochondrial cytochrome c oxidase subunit VIc/VIIs superfamily	Homologous Superfamily
I, V	IPR051389	Cytochrome c oxidase subunit VIc	Family
I, V	IPR034884	Mitochondrial cytochrome c oxidase subunit VIc/VIIs	Family

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Electron Transport Chain Complexes: Complex IV (Cytochrome C Oxidase)	Cytochrome C Oxidase with bound Ca²⁺, fully oxidized state

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
A, N	FME	Parent Component: MET RESID: AA0021 , AA0566 PSI-MOD : N-formyl-L-methionine residue MOD:00030 , N-formyl-L-methionine (Met) MOD:00482 , N-[(L-histidin-1'-yl)methyl]-L-methionine (fMet) MOD:01890 , N-[(L-histidin-1'-yl)methyl]-L-methionine (Met) MOD:01891
B, O	FME	Parent Component: MET RESID: AA0021 , AA0566 , AA0021 , AA0566 PSI-MOD : N-formyl-L-methionine residue MOD:00030 , N-formyl-L-methionine (Met) MOD:00482 , N-[(L-histidin-1'-yl)methyl]-L-methionine (fMet) MOD:01890 , N-[(L-histidin-1'-yl)methyl]-L-methionine (Met) MOD:01891 , N-formyl-L-methionine residue MOD:00030 , N-formyl-L-methionine (Met) MOD:00482 , N-[(L-histidin-1'-yl)methyl]-L-methionine (fMet) MOD:01890 , N-[(L-histidin-1'-yl)methyl]-L-methionine (Met) MOD:01891