9BRZ | pdb_00009brz

V0-only V-ATPase and synaptophysin complex in mouse brain isolated synaptic vesicles

External Resource: Annotation

Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD
Membrane Protein Annotation: mpstruc

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth c]	V-type proton ATPase subunit S1	small GTPase binding protein binding binding enzyme binding GTPase binding transporter activator activity molecular function activator activity molecular function regulator activity transporter regulator activity ATPase activator activity ATPase regulator activity	intracellular iron ion homeostasis inorganic ion homeostasis cellular homeostasis chemical homeostasis homeostatic process intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis synaptic vesicle maturation cellular localization transport monoatomic ion transmembrane transport intracellular iron ion homeostasis inorganic ion homeostasis cellular homeostasis chemical homeostasis homeostatic process intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis synaptic vesicle maturation cellular localization transport monoatomic ion transmembrane transport synaptic vesicle cycle vesicle-mediated transport vesicle-mediated transport in synapse monoatomic cation transmembrane transport vesicle organization cellular component organization localization establishment of localization in cell monoatomic ion transport cellular component organization or biogenesis synaptic vesicle lumen acidification monoatomic cation transport developmental process proton transmembrane transport inorganic ion transmembrane transport developmental maturation establishment of localization inorganic cation transmembrane transport transmembrane transport organelle organization neuron cellular homeostasis cellular process cellular response to stimulus cellular response to chemical stimulus response to stimulus cellular response to oxygen levels response to chemical response to oxygen levels response to abiotic stimulus cellular response to increased oxygen levels response to increased oxygen levels multicellular organismal process myeloid leukocyte differentiation cellular developmental process hemopoiesis animal organ development cell development osteoclast development multicellular organism development skeletal system development myeloid cell differentiation cell differentiation bone cell development osteoclast differentiation anatomical structure development myeloid cell development bone development system development leukocyte differentiation protein localization establishment of protein localization nitrogen compound transport establishment of protein localization to plasma membrane endocytic recycling cellular macromolecule localization protein localization to cell periphery establishment of protein localization to membrane protein localization to plasma membrane intracellular transport localization within membrane protein localization to membrane endosomal transport vesicle-mediated transport to the plasma membrane endosome to plasma membrane protein transport protein transport macromolecule localization intracellular protein transport	membrane-bounded organelle intracellular anatomical structure membrane intracellular membrane-bounded organelle intracellular organelle bounding membrane of organelle cellular anatomical structure organelle endoplasmic reticulum-Golgi intermediate compartment membrane endoplasmic reticulum-Golgi intermediate compartment cytoplasm organelle membrane endosome membrane endosome membrane-bounded organelle intracellular anatomical structure membrane intracellular membrane-bounded organelle intracellular organelle bounding membrane of organelle cellular anatomical structure organelle endoplasmic reticulum-Golgi intermediate compartment membrane endoplasmic reticulum-Golgi intermediate compartment cytoplasm organelle membrane endosome membrane endosome intracellular vesicle endomembrane system cytoplasmic vesicle membrane vesicle membrane cytoplasmic vesicle vesicle synapse transport vesicle membrane presynapse synaptic vesicle synaptic vesicle membrane cell junction transport vesicle exocytic vesicle membrane secretory vesicle exocytic vesicle coated vesicle membrane clathrin-coated vesicle coated vesicle clathrin-coated vesicle membrane organelle subcompartment endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum endoplasmic reticulum membrane
B [auth b]	V-type proton ATPase 21 kDa proteolipid subunit c''	monoatomic cation transmembrane transporter activity P-type transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity ATPase-coupled monoatomic cation transmembrane transporter activity P-type proton-exporting transporter activity ATP-dependent activity P-type ion transporter activity active monoatomic ion transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity monoatomic cation transmembrane transporter activity P-type transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity ATPase-coupled monoatomic cation transmembrane transporter activity P-type proton-exporting transporter activity ATP-dependent activity P-type ion transporter activity active monoatomic ion transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled ion transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism	transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport	ATPase dependent transmembrane transport complex protein-containing complex ATPase complex catalytic complex membrane membrane protein complex proton-transporting V-type ATPase complex transporter complex proton-transporting two-sector ATPase complex, proton-transporting domain cation-transporting ATPase complex cellular anatomical structure proton-transporting two-sector ATPase complex transmembrane transporter complex proton-transporting V-type ATPase, V0 domain ATPase dependent transmembrane transport complex protein-containing complex ATPase complex catalytic complex membrane membrane protein complex proton-transporting V-type ATPase complex transporter complex proton-transporting two-sector ATPase complex, proton-transporting domain cation-transporting ATPase complex cellular anatomical structure proton-transporting two-sector ATPase complex transmembrane transporter complex proton-transporting V-type ATPase, V0 domain membrane-bounded organelle intracellular anatomical structure endosome intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle organelle cytoplasm vesicle vacuolar proton-transporting V-type ATPase, V0 domain bounding membrane of organelle vacuolar membrane vacuole vacuolar proton-transporting V-type ATPase complex organelle membrane coated vesicle membrane cytoplasmic vesicle membrane vesicle membrane clathrin-coated vesicle coated vesicle clathrin-coated vesicle membrane
C [auth d]	V-type proton ATPase subunit d 1	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity protein-containing complex binding binding	intracellular iron ion homeostasis inorganic ion homeostasis cellular homeostasis chemical homeostasis homeostatic process intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis synaptic vesicle maturation cellular localization transport monoatomic ion transmembrane transport intracellular iron ion homeostasis inorganic ion homeostasis cellular homeostasis chemical homeostasis homeostatic process intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis synaptic vesicle maturation cellular localization transport monoatomic ion transmembrane transport synaptic vesicle cycle vesicle-mediated transport vesicle-mediated transport in synapse monoatomic cation transmembrane transport vesicle organization cellular component organization localization establishment of localization in cell monoatomic ion transport cellular component organization or biogenesis synaptic vesicle lumen acidification monoatomic cation transport developmental process proton transmembrane transport inorganic ion transmembrane transport developmental maturation establishment of localization inorganic cation transmembrane transport transmembrane transport organelle organization neuron cellular homeostasis cellular process cellular response to stimulus cellular response to chemical stimulus response to stimulus cellular response to oxygen levels response to chemical response to oxygen levels response to abiotic stimulus cellular response to increased oxygen levels response to increased oxygen levels organelle assembly plasma membrane bounded cell projection organization cell projection organization plasma membrane bounded cell projection assembly cellular component biogenesis cellular component assembly cilium assembly cilium organization cell projection assembly	membrane-bounded organelle intracellular anatomical structure early endosome endosome intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cellular anatomical structure cytoplasmic vesicle organelle cytoplasm vesicle ATPase dependent transmembrane transport complex membrane-bounded organelle intracellular anatomical structure early endosome endosome intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cellular anatomical structure cytoplasmic vesicle organelle cytoplasm vesicle ATPase dependent transmembrane transport complex protein-containing complex ATPase complex catalytic complex membrane membrane protein complex proton-transporting V-type ATPase complex transporter complex proton-transporting two-sector ATPase complex, proton-transporting domain cation-transporting ATPase complex proton-transporting two-sector ATPase complex transmembrane transporter complex proton-transporting V-type ATPase, V0 domain vacuolar membrane lytic vacuole vacuole lytic vacuole membrane bounding membrane of organelle lysosomal membrane organelle membrane lysosome cell periphery apical part of cell plasma membrane plasma membrane region apical plasma membrane vacuolar proton-transporting V-type ATPase, V0 domain vacuolar proton-transporting V-type ATPase complex centrosome microtubule organizing center cytoskeleton membraneless organelle intracellular membraneless organelle microtubule cytoskeleton synapse transport vesicle membrane presynapse vesicle membrane synaptic vesicle synaptic vesicle membrane cell junction transport vesicle exocytic vesicle membrane cytoplasmic vesicle membrane secretory vesicle exocytic vesicle axon neuron projection axon terminus plasma membrane bounded cell projection cell projection distal axon neuron projection terminus coated vesicle membrane clathrin-coated vesicle coated vesicle clathrin-coated vesicle membrane
D [auth f]	Ribonuclease kappa	endonuclease activity nuclease activity hydrolase activity, acting on ester bonds catalytic activity, acting on RNA RNA endonuclease activity catalytic activity, acting on a nucleic acid RNA nuclease activity hydrolase activity catalytic activity	transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport homeostatic process biological regulation transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport homeostatic process biological regulation intracellular pH reduction regulation of intracellular pH vesicle organization cellular component organization organelle organization cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis regulation of pH monoatomic ion homeostasis endosome organization intracellular chemical homeostasis cellular component organization or biogenesis regulation of biological quality endosomal lumen acidification monoatomic cation homeostasis endomembrane system organization regulation of cellular pH intracellular monoatomic ion homeostasis import into cell receptor-mediated endocytosis endocytosis vesicle-mediated transport receptor-mediated endocytosis of virus by host cell biological process involved in interspecies interaction between organisms viral life cycle biological process involved in interaction with host biological process involved in symbiotic interaction symbiont entry into host cell viral process symbiont entry into host endocytosis involved in viral entry into host cell	cellular anatomical structure endomembrane system ATPase dependent transmembrane transport complex membrane-bounded organelle protein-containing complex ATPase complex intracellular anatomical structure vacuolar proton-transporting V-type ATPase, V0 domain membrane protein complex proton-transporting V-type ATPase complex transporter complex intracellular organelle bounding membrane of organelle proton-transporting two-sector ATPase complex cellular anatomical structure endomembrane system ATPase dependent transmembrane transport complex membrane-bounded organelle protein-containing complex ATPase complex intracellular anatomical structure vacuolar proton-transporting V-type ATPase, V0 domain membrane protein complex proton-transporting V-type ATPase complex transporter complex intracellular organelle bounding membrane of organelle proton-transporting two-sector ATPase complex proton-transporting V-type ATPase, V0 domain vacuolar membrane catalytic complex membrane vacuole intracellular membrane-bounded organelle proton-transporting two-sector ATPase complex, proton-transporting domain vacuolar proton-transporting V-type ATPase complex cation-transporting ATPase complex transmembrane transporter complex organelle cytoplasm organelle membrane intracellular vesicle coated vesicle membrane cytoplasmic vesicle membrane vesicle membrane cytoplasmic vesicle clathrin-coated vesicle coated vesicle vesicle clathrin-coated vesicle membrane
E [auth g], F [auth h], G [auth i], H [auth j], I [auth k], E [auth g], F [auth h], G [auth i], H [auth j], I [auth k], J [auth l], K [auth m], L [auth n], M [auth o]	V-type proton ATPase 16 kDa proteolipid subunit c	monoatomic cation transmembrane transporter activity P-type transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity ATPase-coupled monoatomic cation transmembrane transporter activity P-type proton-exporting transporter activity ATP-dependent activity P-type ion transporter activity active monoatomic ion transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity monoatomic cation transmembrane transporter activity P-type transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity ATPase-coupled monoatomic cation transmembrane transporter activity P-type proton-exporting transporter activity ATP-dependent activity P-type ion transporter activity active monoatomic ion transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled ion transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism ubiquitin protein ligase binding protein binding binding ubiquitin-like protein ligase binding enzyme binding	homeostatic process intracellular pH reduction regulation of intracellular pH cellular component organization lysosome organization vacuolar acidification lysosomal lumen acidification intracellular monoatomic cation homeostasis regulation of pH monoatomic ion homeostasis intracellular chemical homeostasis cellular component organization or biogenesis regulation of biological quality monoatomic cation homeostasis homeostatic process intracellular pH reduction regulation of intracellular pH cellular component organization lysosome organization vacuolar acidification lysosomal lumen acidification intracellular monoatomic cation homeostasis regulation of pH monoatomic ion homeostasis intracellular chemical homeostasis cellular component organization or biogenesis regulation of biological quality monoatomic cation homeostasis regulation of lysosomal lumen pH regulation of cellular pH intracellular monoatomic ion homeostasis vacuole organization lytic vacuole organization biological regulation organelle organization cellular homeostasis chemical homeostasis cellular process cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction cell communication positive regulation of response to stimulus positive regulation of Wnt signaling pathway signal transduction Wnt signaling pathway positive regulation of cellular process regulation of biological process regulation of signaling cell surface receptor signaling pathway regulation of Wnt signaling pathway regulation of response to stimulus regulation of cell communication positive regulation of signaling synaptic vesicle maturation cellular localization transport monoatomic ion transmembrane transport synaptic vesicle cycle vesicle-mediated transport vesicle-mediated transport in synapse monoatomic cation transmembrane transport vesicle organization localization establishment of localization in cell monoatomic ion transport synaptic vesicle lumen acidification monoatomic cation transport developmental process proton transmembrane transport inorganic ion transmembrane transport developmental maturation establishment of localization inorganic cation transmembrane transport transmembrane transport neuron cellular homeostasis	ATPase dependent transmembrane transport complex protein-containing complex ATPase complex catalytic complex membrane membrane protein complex proton-transporting V-type ATPase complex transporter complex proton-transporting two-sector ATPase complex, proton-transporting domain cation-transporting ATPase complex cellular anatomical structure proton-transporting two-sector ATPase complex transmembrane transporter complex proton-transporting V-type ATPase, V0 domain ATPase dependent transmembrane transport complex protein-containing complex ATPase complex catalytic complex membrane membrane protein complex proton-transporting V-type ATPase complex transporter complex proton-transporting two-sector ATPase complex, proton-transporting domain cation-transporting ATPase complex cellular anatomical structure proton-transporting two-sector ATPase complex transmembrane transporter complex proton-transporting V-type ATPase, V0 domain membrane-bounded organelle intracellular anatomical structure vacuolar proton-transporting V-type ATPase, V0 domain intracellular organelle bounding membrane of organelle vacuolar membrane vacuole intracellular membrane-bounded organelle vacuolar proton-transporting V-type ATPase complex organelle cytoplasm organelle membrane synapse intracellular vesicle transport vesicle membrane endomembrane system presynapse cytoplasmic vesicle vesicle membrane synaptic vesicle synaptic vesicle membrane cell junction vesicle transport vesicle exocytic vesicle membrane cytoplasmic vesicle membrane secretory vesicle exocytic vesicle coated vesicle membrane clathrin-coated vesicle coated vesicle clathrin-coated vesicle membrane
N [auth p]	Renin receptor cytoplasmic fragment	molecular transducer activity signaling receptor activity	regulation of systemic arterial blood pressure by renin-angiotensin regulation of systemic arterial blood pressure by hormone multicellular organismal process peptide hormone processing regulation of systemic arterial blood pressure mediated by a chemical signal system process signaling receptor ligand precursor processing protein maturation circulatory system process proteolysis amide metabolic process protein metabolic process regulation of biological quality blood circulation regulation of systemic arterial blood pressure by renin-angiotensin regulation of systemic arterial blood pressure by hormone multicellular organismal process peptide hormone processing regulation of systemic arterial blood pressure mediated by a chemical signal system process signaling receptor ligand precursor processing protein maturation circulatory system process proteolysis amide metabolic process protein metabolic process regulation of biological quality blood circulation regulation of blood pressure regulation of hormone levels biological regulation regulation of systemic arterial blood pressure by circulatory renin-angiotensin primary metabolic process gene expression macromolecule biosynthetic process hormone metabolic process regulation of systemic arterial blood pressure endocrine process biosynthetic process regulation of angiotensin levels in blood protein processing metabolic process cellular process macromolecule metabolic process angiotensin maturation homeostatic process intracellular pH reduction regulation of intracellular pH cellular component organization lysosome organization vacuolar acidification lysosomal lumen acidification intracellular monoatomic cation homeostasis regulation of pH monoatomic ion homeostasis intracellular chemical homeostasis cellular component organization or biogenesis monoatomic cation homeostasis regulation of lysosomal lumen pH regulation of cellular pH intracellular monoatomic ion homeostasis vacuole organization lytic vacuole organization organelle organization cellular homeostasis chemical homeostasis cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction cell communication positive regulation of response to stimulus positive regulation of Wnt signaling pathway signal transduction Wnt signaling pathway positive regulation of cellular process regulation of biological process regulation of signaling cell surface receptor signaling pathway regulation of Wnt signaling pathway regulation of response to stimulus regulation of cell communication positive regulation of signaling synaptic vesicle maturation cellular localization transport monoatomic ion transmembrane transport synaptic vesicle cycle vesicle-mediated transport vesicle-mediated transport in synapse monoatomic cation transmembrane transport vesicle organization localization establishment of localization in cell monoatomic ion transport synaptic vesicle lumen acidification monoatomic cation transport developmental process proton transmembrane transport inorganic ion transmembrane transport developmental maturation establishment of localization inorganic cation transmembrane transport transmembrane transport neuron cellular homeostasis anatomical structure morphogenesis head development anatomical structure development head morphogenesis body morphogenesis epithelium development neural tube development tube development chordate embryonic development anterior/posterior pattern specification pattern specification process nervous system development embryo development tissue development regionalization multicellular organism development embryo development ending in birth or egg hatching rostrocaudal neural tube patterning neural tube patterning system development regulation of transforming growth factor beta production transforming growth factor beta1 production regulation of transforming growth factor beta1 production positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process cytokine production regulation of cytokine production regulation of multicellular organismal process positive regulation of macromolecule metabolic process positive regulation of transforming growth factor beta1 production transforming growth factor beta production regulation of biosynthetic process regulation of macromolecule metabolic process regulation of gene expression positive regulation of gene expression positive regulation of multicellular organismal process regulation of macromolecule biosynthetic process positive regulation of transforming growth factor beta production positive regulation of cytokine production regulation of metabolic process regulation of MAPK cascade intracellular signal transduction regulation of intracellular signal transduction intracellular signaling cassette MAPK cascade regulation of canonical Wnt signaling pathway canonical Wnt signaling pathway positive regulation of canonical Wnt signaling pathway central nervous system maturation central nervous system development anatomical structure maturation pigmentation eye pigmentation developmental pigmentation	cell periphery postsynapse cellular anatomical structure postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region synaptic membrane vacuolar membrane membrane-bounded organelle autophagosome membrane intracellular anatomical structure cell periphery postsynapse cellular anatomical structure postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region synaptic membrane vacuolar membrane membrane-bounded organelle autophagosome membrane intracellular anatomical structure vacuole intracellular membrane-bounded organelle autophagosome intracellular organelle bounding membrane of organelle organelle cytoplasm organelle membrane cell surface external side of plasma membrane side of membrane lytic vacuole lytic vacuole membrane lysosomal membrane lysosome ATPase dependent transmembrane transport complex protein-containing complex ATPase complex vacuolar proton-transporting V-type ATPase, V0 domain membrane protein complex proton-transporting V-type ATPase complex transporter complex proton-transporting two-sector ATPase complex proton-transporting V-type ATPase, V0 domain catalytic complex proton-transporting two-sector ATPase complex, proton-transporting domain vacuolar proton-transporting V-type ATPase complex cation-transporting ATPase complex transmembrane transporter complex dendritic spine somatodendritic compartment neuron projection membrane dendrite membrane dendritic tree cell leading edge neuron spine neuron projection leading edge membrane plasma membrane bounded cell projection dendritic spine membrane cell projection dendrite cell projection membrane endosome membrane endosome intracellular vesicle endomembrane system cytoplasmic vesicle membrane vesicle membrane cytoplasmic vesicle vesicle transport vesicle membrane presynapse synaptic vesicle synaptic vesicle membrane transport vesicle exocytic vesicle membrane secretory vesicle exocytic vesicle axon coated vesicle membrane clathrin-coated vesicle coated vesicle clathrin-coated vesicle membrane organelle subcompartment endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum endoplasmic reticulum membrane
O [auth s]	Synaptophysin	syntaxin-1 binding protein binding binding SNARE binding syntaxin binding sterol binding alcohol binding steroid binding lipid binding cholesterol binding small molecule binding SH2 domain binding protein domain specific binding identical protein binding	cellular response to stimulus regulation of opioid receptor signaling pathway regulation of biological process regulation of signaling regulation of cellular process response to stimulus signaling biological regulation regulation of signal transduction cell communication G protein-coupled opioid receptor signaling pathway regulation of response to stimulus regulation of cell communication G protein-coupled receptor signaling pathway cellular response to stimulus regulation of opioid receptor signaling pathway regulation of biological process regulation of signaling regulation of cellular process response to stimulus signaling biological regulation regulation of signal transduction cell communication G protein-coupled opioid receptor signaling pathway regulation of response to stimulus regulation of cell communication G protein-coupled receptor signaling pathway cellular process signal transduction regulation of G protein-coupled receptor signaling pathway localization import into cell transport endocytosis establishment of localization vesicle-mediated transport regulation of neuronal synaptic plasticity regulation of synaptic plasticity trans-synaptic signaling regulation of short-term neuronal synaptic plasticity modulation of chemical synaptic transmission cell-cell signaling chemical synaptic transmission synaptic signaling regulation of trans-synaptic signaling anterograde trans-synaptic signaling regulation of biological quality regulation of long-term neuronal synaptic plasticity cellular localization regulated exocytosis regulation of cellular component organization synaptic vesicle priming regulation of synaptic vesicle priming synaptic vesicle cycle synaptic vesicle exocytosis vesicle-mediated transport in synapse cellular component organization cellular component biogenesis regulation of protein-containing complex assembly cellular component assembly secretion by cell signal release establishment of localization in cell protein-containing complex assembly cellular component organization or biogenesis neurotransmitter secretion protein-containing complex organization secretion export from cell neurotransmitter transport regulation of cellular component biogenesis signal release from synapse exocytosis exocytic process	presynapse cellular anatomical structure synapse cell junction presynaptic active zone membrane axon neuron projection axon terminus plasma membrane bounded cell projection cell projection distal axon terminal bouton neuron projection terminus presynapse cellular anatomical structure synapse cell junction presynaptic active zone membrane axon neuron projection axon terminus plasma membrane bounded cell projection cell projection distal axon terminal bouton neuron projection terminus clathrin-sculpted glutamate transport vesicle membrane-bounded organelle clathrin-sculpted vesicle intracellular anatomical structure intracellular vesicle transport vesicle membrane endomembrane system intracellular organelle bounding membrane of organelle cytoplasmic vesicle vesicle membrane clathrin-coated vesicle coated vesicle vesicle clathrin-coated vesicle membrane clathrin-sculpted glutamate transport vesicle membrane transport vesicle intracellular membrane-bounded organelle cytoplasmic vesicle membrane coated vesicle membrane organelle cytoplasm organelle membrane cell periphery plasma membrane presynaptic membrane plasma membrane region synaptic membrane neuromuscular junction excitatory synapse Schaffer collateral - CA1 synapse perinuclear region of cytoplasm synaptic vesicle synaptic vesicle membrane exocytic vesicle membrane secretory vesicle exocytic vesicle
P [auth e]	V-type proton ATPase subunit e 2	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity	synaptic vesicle maturation cellular localization homeostatic process transport monoatomic ion transmembrane transport synaptic vesicle cycle vesicle-mediated transport vesicle-mediated transport in synapse monoatomic cation transmembrane transport vesicle organization cellular component organization localization establishment of localization in cell monoatomic ion transport synaptic vesicle maturation cellular localization homeostatic process transport monoatomic ion transmembrane transport synaptic vesicle cycle vesicle-mediated transport vesicle-mediated transport in synapse monoatomic cation transmembrane transport vesicle organization cellular component organization localization establishment of localization in cell monoatomic ion transport cellular component organization or biogenesis synaptic vesicle lumen acidification monoatomic cation transport developmental process proton transmembrane transport inorganic ion transmembrane transport developmental maturation establishment of localization inorganic cation transmembrane transport transmembrane transport organelle organization cellular homeostasis neuron cellular homeostasis cellular process	membrane-bounded organelle intracellular anatomical structure synapse intracellular vesicle transport vesicle membrane endomembrane system intracellular organelle presynapse cellular anatomical structure bounding membrane of organelle cytoplasmic vesicle vesicle membrane synaptic vesicle synaptic vesicle membrane membrane-bounded organelle intracellular anatomical structure synapse intracellular vesicle transport vesicle membrane endomembrane system intracellular organelle presynapse cellular anatomical structure bounding membrane of organelle cytoplasmic vesicle vesicle membrane synaptic vesicle synaptic vesicle membrane cell junction vesicle transport vesicle membrane exocytic vesicle membrane intracellular membrane-bounded organelle cytoplasmic vesicle membrane organelle secretory vesicle cytoplasm organelle membrane exocytic vesicle ATPase dependent transmembrane transport complex protein-containing complex ATPase complex vacuolar proton-transporting V-type ATPase, V0 domain membrane protein complex proton-transporting V-type ATPase complex transporter complex proton-transporting two-sector ATPase complex proton-transporting V-type ATPase, V0 domain vacuolar membrane catalytic complex vacuole proton-transporting two-sector ATPase complex, proton-transporting domain vacuolar proton-transporting V-type ATPase complex cation-transporting ATPase complex transmembrane transporter complex coated vesicle membrane clathrin-coated vesicle coated vesicle clathrin-coated vesicle membrane
Q [auth a]	V-type proton ATPase 116 kDa subunit a 1	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity ATPase binding protein binding binding enzyme binding	regulation of biological process catabolic process regulation of cellular process macroautophagy autophagy biological regulation regulation of catabolic process regulation of autophagy regulation of macroautophagy cellular process metabolic process process utilizing autophagic mechanism regulation of metabolic process synaptic vesicle maturation regulation of biological process catabolic process regulation of cellular process macroautophagy autophagy biological regulation regulation of catabolic process regulation of autophagy regulation of macroautophagy cellular process metabolic process process utilizing autophagic mechanism regulation of metabolic process synaptic vesicle maturation cellular localization homeostatic process transport monoatomic ion transmembrane transport synaptic vesicle cycle vesicle-mediated transport vesicle-mediated transport in synapse monoatomic cation transmembrane transport vesicle organization cellular component organization localization establishment of localization in cell monoatomic ion transport cellular component organization or biogenesis synaptic vesicle lumen acidification monoatomic cation transport developmental process proton transmembrane transport inorganic ion transmembrane transport developmental maturation establishment of localization inorganic cation transmembrane transport transmembrane transport organelle organization cellular homeostasis neuron cellular homeostasis	membrane-bounded organelle intracellular anatomical structure pigment granule intracellular vesicle intracellular membrane-bounded organelle intracellular organelle melanosome cellular anatomical structure cytoplasmic vesicle organelle cytoplasm vesicle Golgi apparatus endomembrane system membrane-bounded organelle intracellular anatomical structure pigment granule intracellular vesicle intracellular membrane-bounded organelle intracellular organelle melanosome cellular anatomical structure cytoplasmic vesicle organelle cytoplasm vesicle Golgi apparatus endomembrane system nucleus membrane-enclosed lumen intracellular organelle lumen nuclear speck nuclear body nucleoplasm organelle lumen nuclear lumen ATPase dependent transmembrane transport complex protein-containing complex ATPase complex vacuolar proton-transporting V-type ATPase, V0 domain membrane protein complex proton-transporting V-type ATPase complex transporter complex bounding membrane of organelle proton-transporting two-sector ATPase complex proton-transporting V-type ATPase, V0 domain vacuolar membrane catalytic complex membrane vacuole proton-transporting two-sector ATPase complex, proton-transporting domain vacuolar proton-transporting V-type ATPase complex cation-transporting ATPase complex transmembrane transporter complex organelle membrane cytosol perinuclear region of cytoplasm cell periphery plasma membrane synapse transport vesicle membrane presynapse vesicle membrane synaptic vesicle synaptic vesicle membrane cell junction transport vesicle exocytic vesicle membrane cytoplasmic vesicle membrane secretory vesicle exocytic vesicle coated vesicle membrane clathrin-coated vesicle coated vesicle clathrin-coated vesicle membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth c]	IPR046755	V-type proton ATPase subunit S1, luminal domain	Domain
A [auth c]	IPR008388	V0 complex accessory subunit Ac45	Family
A [auth c]	IPR046756	V-type proton ATPase subunit S1/VOA1, transmembrane domain	Domain
B [auth b]	IPR035921	F/V-ATP synthase subunit C superfamily	Homologous Superfamily
B [auth b]	IPR002379	V-ATPase proteolipid subunit C-like domain	Domain
B [auth b]	IPR000245	V-ATPase proteolipid subunit	Family
C [auth d]	IPR036079	V-type ATP synthase subunit c/d subunit superfamily	Homologous Superfamily
C [auth d]	IPR035067	V-type ATPase subunit C/d	Homologous Superfamily
C [auth d]	IPR044911	V-type ATP synthase c/d subunit, domain 3 superfamily	Homologous Superfamily
C [auth d]	IPR016727	ATPase, V0 complex, subunit d	Family
C [auth d]	IPR002843	ATPase, V0 complex, c/d subunit	Family
D [auth f]	IPR026770	Ribonuclease kappa	Family
E [auth g], F [auth h], G [auth i], H [auth j], I [auth k], E [auth g], F [auth h], G [auth i], H [auth j], I [auth k], J [auth l], K [auth m], L [auth n], M [auth o]	IPR035921	F/V-ATP synthase subunit C superfamily	Homologous Superfamily
E [auth g], F [auth h], G [auth i], H [auth j], I [auth k], E [auth g], F [auth h], G [auth i], H [auth j], I [auth k], J [auth l], K [auth m], L [auth n], M [auth o]	IPR002379	V-ATPase proteolipid subunit C-like domain	Domain
E [auth g], F [auth h], G [auth i], H [auth j], I [auth k], E [auth g], F [auth h], G [auth i], H [auth j], I [auth k], J [auth l], K [auth m], L [auth n], M [auth o]	IPR011555	V-ATPase proteolipid subunit C, eukaryotic	Family
E [auth g], F [auth h], G [auth i], H [auth j], I [auth k], E [auth g], F [auth h], G [auth i], H [auth j], I [auth k], J [auth l], K [auth m], L [auth n], M [auth o]	IPR000245	V-ATPase proteolipid subunit	Family
N [auth p]	IPR012493	Renin receptor-like	Family
O [auth s]	IPR001285	Synaptophysin/synaptoporin	Family
O [auth s]	IPR008253	Marvel domain	Domain
P [auth e]	IPR017385	ATPase, V0 complex, subunit e1/e2, metazoa	Family
P [auth e]	IPR008389	ATPase, V0 complex, subunit e1/e2	Family
Q [auth a]	IPR026028	ATPase, V0 complex, subunit 116kDa, eukaryotic	Family
Q [auth a]	IPR002490	V-type ATPase, V0 complex, 116kDa subunit family	Family

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A [auth c], B [auth b], C [auth d], D [auth f], E [auth g] A [auth c], B [auth b], C [auth d], D [auth f], E [auth g], F [auth h], G [auth i], H [auth j], I [auth k], J [auth l], K [auth m], L [auth n], M [auth o], N [auth p], O [auth s], P [auth e], Q [auth a]	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A [auth c], B [auth b], C [auth d], D [auth f], E [auth g] A [auth c], B [auth b], C [auth d], D [auth f], E [auth g], F [auth h], G [auth i], H [auth j], I [auth k], J [auth l], K [auth m], L [auth n], M [auth o], N [auth p], O [auth s], P [auth e], Q [auth a]	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A [auth c], B [auth b], C [auth d], D [auth f], E [auth g] A [auth c], B [auth b], C [auth d], D [auth f], E [auth g], F [auth h], G [auth i], H [auth j], I [auth k], J [auth l], K [auth m], L [auth n], M [auth o], N [auth p], O [auth s], P [auth e], Q [auth a]	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Vacuolar ATPase (V-ATPase)	V-ATPase, state 1 with synaptophysin in brain isolated synaptic vesicles