RCSB PDB: Search

1WA9 \| pdb_00001wa9	Download File View File

Crystal Structure of the PAS repeat region of the Drosophila clock protein PERIOD

Yildiz, O., Doi, M., Yujnovsky, I., Cardone, L., Berndt, A., Hennig, S., Schulze, S., Urbanke, C., Sassone-Corsi, P., Wolf, E.

(2005) Mol Cell 17: 69

Released	2005-01-12
Method	X-RAY DIFFRACTION 3.15 Å
Organisms	Drosophila melanogaster
Macromolecule	PERIOD CIRCADIAN PROTEIN (protein)

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2WXF \| pdb_00002wxf	Download File View File

The crystal structure of the murine class IA PI 3-kinase p110delta in complex with PIK-39.

Berndt, A., Miller, S., Williams, O., Lee, D.D., Houseman, B.T., Pacold, J.I., Gorrec, F., Hon, W.-C., Liu, Y., Rommel, C., Gaillard, P., Ruckle, T., Schwarz, M.K., Shokat, K.M., Shaw, J.P., Williams, R.L.

(2010) Nat Chem Biol 6: 117

Released	2010-01-12
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Mus musculus
Macromolecule	PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM (protein)
Unique Ligands	039

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2WXG \| pdb_00002wxg	Download File View File

The crystal structure of the murine class IA PI 3-kinase p110delta in complex with SW13.

Berndt, A., Miller, S., Williams, O., Lee, D.D., Houseman, B.T., Pacold, J.I., Gorrec, F., Hon, W.-C., Liu, Y., Rommel, C., Gaillard, P., Ruckle, T., Schwarz, M.K., Shokat, K.M., Shaw, J.P., Williams, R.L.

(2010) Nat Chem Biol 6: 117

Released	2010-01-12
Method	X-RAY DIFFRACTION 2 Å
Organisms	Mus musculus
Macromolecule	PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM (protein)
Unique Ligands	ZZN

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2WXH \| pdb_00002wxh	Download File View File

The crystal structure of the murine class IA PI 3-kinase p110delta in complex with SW14.

Berndt, A., Miller, S., Williams, O., Lee, D.D., Houseman, B.T., Pacold, J.I., Gorrec, F., Hon, W.-C., Liu, Y., Rommel, C., Gaillard, P., Ruckle, T., Schwarz, M.K., Shokat, K.M., Shaw, J.P., Williams, R.L.

(2010) Nat Chem Biol 6: 117

Released	2010-01-12
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Mus musculus
Macromolecule	PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM (protein)
Unique Ligands	ZZO

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2WXI \| pdb_00002wxi	Download File View File

The crystal structure of the murine class IA PI 3-kinase p110delta in complex with SW30.

Berndt, A., Miller, S., Williams, O., Lee, D.D., Houseman, B.T., Pacold, J.I., Gorrec, F., Hon, W.-C., Liu, Y., Rommel, C., Gaillard, P., Ruckle, T., Schwarz, M.K., Shokat, K.M., Shaw, J.P., Williams, R.L.

(2010) Nat Chem Biol 6: 117

Released	2010-01-12
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Mus musculus
Macromolecule	PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM (protein)
Unique Ligands	GOL, S30

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2WXJ \| pdb_00002wxj	Download File View File

The crystal structure of the murine class IA PI 3-kinase p110delta in complex with INK654.

Berndt, A., Miller, S., Williams, O., Lee, D.D., Houseman, B.T., Pacold, J.I., Gorrec, F., Hon, W.-C., Liu, Y., Rommel, C., Gaillard, P., Ruckle, T., Schwarz, M.K., Shokat, K.M., Shaw, J.P., Williams, R.L.

(2010) Nat Chem Biol 6: 117

Released	2010-01-12
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Mus musculus
Macromolecule	PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM (protein)
Unique Ligands	RW3

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2WXK \| pdb_00002wxk	Download File View File

The crystal structure of the murine class IA PI 3-kinase p110delta in complex with INK666.

Berndt, A., Miller, S., Williams, O., Lee, D.D., Houseman, B.T., Pacold, J.I., Gorrec, F., Hon, W.-C., Liu, Y., Rommel, C., Gaillard, P., Ruckle, T., Schwarz, M.K., Shokat, K.M., Shaw, J.P., Williams, R.L.

(2010) Nat Chem Biol 6: 117

Released	2010-01-12
Method	X-RAY DIFFRACTION 2.9 Å
Organisms	Mus musculus
Macromolecule	PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM (protein)
Unique Ligands	RW4

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2WXL \| pdb_00002wxl	Download File View File

The crystal structure of the murine class IA PI 3-kinase p110delta in complex with ZSTK474.

Berndt, A., Miller, S., Williams, O., Lee, D.D., Houseman, B.T., Pacold, J.I., Gorrec, F., Hon, W.-C., Liu, Y., Rommel, C., Gaillard, P., Ruckle, T., Schwarz, M.K., Shokat, K.M., Shaw, J.P., Williams, R.L.

(2010) Nat Chem Biol 6: 117

Released	2010-01-12
Method	X-RAY DIFFRACTION 1.99 Å
Organisms	Mus musculus
Macromolecule	PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM (protein)
Unique Ligands	ZS4

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2WXM \| pdb_00002wxm	Download File View File

The crystal structure of the murine class IA PI 3-kinase p110delta in complex with DL06.

Berndt, A., Miller, S., Williams, O., Lee, D.D., Houseman, B.T., Pacold, J.I., Gorrec, F., Hon, W.-C., Liu, Y., Rommel, C., Gaillard, P., Ruckle, T., Schwarz, M.K., Shokat, K.M., Shaw, J.P., Williams, R.L.

(2010) Nat Chem Biol 6: 117

Released	2010-01-12
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Mus musculus
Macromolecule	PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM (protein)
Unique Ligands	ZZM

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2WXN \| pdb_00002wxn	Download File View File

The crystal structure of the murine class IA PI 3-kinase p110delta in complex with DL07.

Berndt, A., Miller, S., Williams, O., Lee, D.D., Houseman, B.T., Pacold, J.I., Gorrec, F., Hon, W.-C., Liu, Y., Rommel, C., Gaillard, P., Ruckle, T., Schwarz, M.K., Shokat, K.M., Shaw, J.P., Williams, R.L.

(2010) Nat Chem Biol 6: 117

Released	2010-01-12
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Mus musculus
Macromolecule	PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM (protein)
Unique Ligands	DLN

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2WXO \| pdb_00002wxo	Download File View File

The crystal structure of the murine class IA PI 3-kinase p110delta in complex with AS5.

Berndt, A., Miller, S., Williams, O., Lee, D.D., Houseman, B.T., Pacold, J.I., Gorrec, F., Hon, W.-C., Liu, Y., Rommel, C., Gaillard, P., Ruckle, T., Schwarz, M.K., Shokat, K.M., Shaw, J.P., Williams, R.L.

(2010) Nat Chem Biol 6: 117

Released	2010-01-12
Method	X-RAY DIFFRACTION 2.49 Å
Organisms	Mus musculus
Macromolecule	PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM (protein)
Unique Ligands	ZZP

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2WXP \| pdb_00002wxp	Download File View File

The crystal structure of the murine class IA PI 3-kinase p110delta in complex with GDC-0941.

Berndt, A., Miller, S., Williams, O., Lee, D.D., Houseman, B.T., Pacold, J.I., Gorrec, F., Hon, W.-C., Liu, Y., Rommel, C., Gaillard, P., Ruckle, T., Schwarz, M.K., Shokat, K.M., Shaw, J.P., Williams, R.L.

(2010) Nat Chem Biol 6: 117

Released	2010-01-12
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Mus musculus
Macromolecule	PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM (protein)
Unique Ligands	GD9

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2WXQ \| pdb_00002wxq	Download File View File

The crystal structure of the murine class IA PI 3-kinase p110delta in complex with AS15.

Berndt, A., Miller, S., Williams, O., Lee, D.D., Houseman, B.T., Pacold, J.I., Gorrec, F., Hon, W.-C., Liu, Y., Rommel, C., Gaillard, P., Ruckle, T., Schwarz, M.K., Shokat, K.M., Shaw, J.P., Williams, R.L.

(2010) Nat Chem Biol 6: 117

Released	2010-01-12
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Mus musculus
Macromolecule	PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM (protein)
Unique Ligands	ZZQ

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2WXR \| pdb_00002wxr	Download File View File

The crystal structure of the murine class IA PI 3-kinase p110delta.

Berndt, A., Miller, S., Williams, O., Lee, D.D., Houseman, B.T., Pacold, J.I., Gorrec, F., Hon, W.-C., Liu, Y., Rommel, C., Gaillard, P., Ruckle, T., Schwarz, M.K., Shokat, K.M., Shaw, J.P., Williams, R.L.

(2010) Nat Chem Biol 6: 117

Released	2010-01-12
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Mus musculus
Macromolecule	PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM (protein)

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2X38 \| pdb_00002x38	Download File View File

The crystal structure of the murine class IA PI 3-kinase p110delta in complex with IC87114.

Berndt, A., Miller, S., Williams, O., Lee, D.D., Houseman, B.T., Pacold, J.I., Gorrec, F., Hon, W.-C., Liu, Y., Rommel, C., Gaillard, P., Ruckle, T., Schwarz, M.K., Shokat, K.M., Shaw, J.P., Williams, R.L.

(2010) Nat Chem Biol 6: 117

Released	2010-02-02
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Mus musculus
Macromolecule	PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM (protein)
Unique Ligands	IC8

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4A55 \| pdb_00004a55	Download File View File

Crystal structure of p110alpha in complex with iSH2 of p85alpha and the inhibitor PIK-108

Hon, W.-C., Berndt, A., Williams, R.L.

(2012) Oncogene 31: 3655

Released	2011-12-28
Method	X-RAY DIFFRACTION 3.5 Å
Organisms	Homo sapiens Mus musculus
Macromolecule	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA (protein) PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (protein)
Unique Ligands	P08

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4K03 \| pdb_00004k03	Download File View File

Crystal structure of Drosophila Cryprochrome

Berndt, A., Wolf, E.

(2013) Cell 153: 1394-1405

Released	2013-06-26
Method	X-RAY DIFFRACTION 3.2 Å
Organisms	Drosophila melanogaster
Macromolecule	Cryptochrome-1 (protein)
Unique Ligands	FAD

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5FVM \| pdb_00005fvm	Download File View File

Cryo electron microscopy of a complex of Tor and Lst8

Baretic, D., Berndt, A., Ohashi, Y., Johnson, C.M., Williams, R.L.

(2016) Nat Commun 7: 11016

Released	2016-04-20
Method	ELECTRON MICROSCOPY 6.7 Å
Organisms	Kluyveromyces marxianus
Macromolecule	SERINE/THREONINE-PROTEIN KINASE TOR2 (protein) TARGET OF RAPAMYCIN COMPLEX SUBUNIT LST8 (protein)

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5NGB \| pdb_00005ngb	Download File View File

X-Ray Diffraction Crystal Structure of the murine PI3K p110delta in complex with a pan inhibitor

Berndt, A., Williams, R.L.

(2017) ChemMedChem 12: 1542-1554

Released	2017-09-13
Method	X-RAY DIFFRACTION 2.9 Å
Organisms	Mus musculus
Macromolecule	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (protein)
Unique Ligands	8WH

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6SB0 \| pdb_00006sb0	Download File View File

cryo-EM structure of mTORC1 bound to PRAS40-fused active RagA/C GTPases

Anandapadamanaban, M., Berndt, A., Masson, G.R., Perisic, O., Williams, R.L.

(2019) Science 366: 203-210

Released	2019-10-16
Method	ELECTRON MICROSCOPY 5.5 Å
Organisms	Homo sapiens
Macromolecule	Unique protein chains: 6
Unique Ligands	GDP, GTP

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6SB2 \| pdb_00006sb2	Download File View File

cryo-EM structure of mTORC1 bound to active RagA/C GTPases

Anandapadamanaban, M., Berndt, A., Masson, G.R., Perisic, O., Williams, R.L.

(2019) Science 366: 203-210

Released	2019-10-16
Method	ELECTRON MICROSCOPY 6.2 Å
Organisms	Homo sapiens
Macromolecule	Ras-related GTP-binding protein A (protein) Ras-related GTP-binding protein C (protein) Regulatory-associated protein of mTOR (protein) Target of rapamycin complex subunit LST8 (protein) mTOR,Serine/threonine-protein kinase mTOR,mTOR,Serine/threonine-protein kinase mTOR (protein)
Unique Ligands	GDP, GTP

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7OWG \| pdb_00007owg	Download File View File

human DEPTOR in a complex with mutant human mTORC1 A1459P

Heimhalt, M., Berndt, A., Wagstaff, J., Anandapadamanaban, M., Perisic, O., Maslen, S., McLaughlin, S., Yu, W.-H., Masson, G.R., Boland, A., Ni, X., Yamashita, K., Murshudov, G.N., Skehel, M., Freund, S.M., Williams, R.L.

(2021) Elife 10:

Released	2021-09-08
Method	ELECTRON MICROSCOPY 4.7 Å
Organisms	Homo sapiens
Macromolecule	DEP domain-containing mTOR-interacting protein (protein) Regulatory-associated protein of mTOR (protein) Serine/threonine-protein kinase mTOR (protein) Target of rapamycin complex subunit LST8 (protein)

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

1WA9 | pdb_00001wa9

2WXF | pdb_00002wxf

2WXG | pdb_00002wxg

2WXH | pdb_00002wxh

2WXI | pdb_00002wxi

2WXJ | pdb_00002wxj

2WXK | pdb_00002wxk

2WXL | pdb_00002wxl

2WXM | pdb_00002wxm

2WXN | pdb_00002wxn

2WXO | pdb_00002wxo

2WXP | pdb_00002wxp

2WXQ | pdb_00002wxq

2WXR | pdb_00002wxr

2X38 | pdb_00002x38

4A55 | pdb_00004a55

4K03 | pdb_00004k03

5FVM | pdb_00005fvm

5NGB | pdb_00005ngb

6SB0 | pdb_00006sb0

6SB2 | pdb_00006sb2

7OWG | pdb_00007owg