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233,605 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Structure Author = "Mapelli, M."

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Search Summary

This query matches 22 Structures.

Refinements

Structure Determination Methodology

experimental (22)

Scientific Name of Source Organism

	Homo sapiens (14)
	Drosophila melanogaster (5)
	Bos taurus (2)
	Xenopus laevis (2)
	Human alphaherpesvirus 1 (1)
	synthetic construct (1)

Taxonomy

	Eukaryota (21)
	Duplodnaviria (1)
	other sequences (1)

Experimental Method

X-RAY DIFFRACTION (22)

Polymer Entity Type

Protein (22)

Refinement Resolution (Å)

	0.5 - 1.0 (1)
	1.5 - 2.0 (6)
	2.0 - 2.5 (8)
	2.5 - 3.0 (3)
	3.0 - 3.5 (3)
	4.0 - 4.5 (1)

Release Date

	2000 - 2004 (5)
	2005 - 2009 (5)
	2010 - 2014 (3)
	2015 - 2019 (5)
	2020 - 2024 (4)

Enzyme Classification Name

Transferases (6)

Symmetry Type

	Asymmetric (20)
	Cyclic (3)

SCOP Classification

	Alpha and beta proteins (a+b) (10)
	All alpha proteins (4)
	All beta proteins (2)
	Small proteins (2)
	Coiled coil proteins (1)
	Artifacts (1)
	Multi-domain proteins (alpha and beta) (1)

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1 to 22 of 22 Structures

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1GO4 \| pdb_00001go4	Download File View File

Crystal structure of Mad1-Mad2 reveals a conserved Mad2 binding motif in Mad1 and Cdc20.

Sironi, L., Mapelli, M., Jeang, K.T., Musacchio, A.

(2002) EMBO J 21: 2496-2506

Released	2002-05-16
Method	X-RAY DIFFRACTION 2.05 Å
Organisms	Homo sapiens
Macromolecule	Mitotic spindle assembly checkpoint protein MAD1 (protein) Mitotic spindle assembly checkpoint protein MAD2A (protein)

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1UNG \| pdb_00001ung	Download File View File

Structural mechanism for the inhibition of CDK5-p25 by roscovitine, aloisine and indirubin.

Mapelli, M., Crovace, C., Massimiliano, L., Musacchio, A.

(2005) J Med Chem 48: 671

Released	2004-11-10
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Homo sapiens
Macromolecule	CELL DIVISION PROTEIN KINASE 5 (protein) CYCLIN-DEPENDENT KINASE 5 ACTIVATOR 1 (protein)
Unique Ligands	ALH

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1UNH \| pdb_00001unh	Download File View File

Structural mechanism for the inhibition of CDK5-p25 by roscovitine, aloisine and indirubin.

Mapelli, M., Crovace, C., Massimiliano, L., Musacchio, A.

(2005) J Med Chem 48: 671

Released	2004-11-10
Method	X-RAY DIFFRACTION 2.35 Å
Organisms	Homo sapiens
Macromolecule	CYCLIN-DEPENDENT KINASE 5 (protein) CYCLIN-DEPENDENT KINASE 5 ACTIVATOR 1 (protein)
Unique Ligands	IXM

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1UNL \| pdb_00001unl	Download File View File

Structural mechanism for the inhibition of CD5-p25 from the roscovitine, aloisine and indirubin.

Mapelli, M., Crovace, C., Massimiliano, L., Musacchio, A.

(2005) J Med Chem 48: 671

Released	2004-11-10
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens
Macromolecule	CYCLIN-DEPENDENT KINASE 5 (protein) CYCLIN-DEPENDENT KINASE 5 ACTIVATOR 1 (protein)
Unique Ligands	RRC

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1URJ \| pdb_00001urj	Download File View File

Single stranded DNA-binding protein(ICP8) from Herpes simplex virus-1

Panjikar, S., Mapelli, M., Tucker, P.A.

(2005) J Biological Chem 280: 2990-2997

Released	2004-11-11
Method	X-RAY DIFFRACTION 3 Å
Organisms	Human alphaherpesvirus 1
Macromolecule	MAJOR DNA-BINDING PROTEIN (protein)
Unique Ligands	HG, ZN

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2BFX \| pdb_00002bfx	Download File View File

Mechanism of Aurora-B activation by INCENP and inhibition by Hesperadin.

Sessa, F., Mapelli, M., Ciferri, C., Tarricone, C., Areces, L.B., Schneider, T.R., Stukenberg, P.T., Musacchio, A.

(2005) Mol Cell 18: 379

Released	2005-05-03
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Xenopus laevis
Macromolecule	AURORA KINASE B-A (protein) INNER CENTROMERE PROTEIN A (protein)

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2BFY \| pdb_00002bfy	Download File View File

Complex of Aurora-B with INCENP and Hesperadin.

Sessa, F., Mapelli, M., Ciferri, C., Tarricone, C., Areces, L.B., Schneider, T.R., Stukenberg, P.T., Musacchio, A.

(2005) Mol Cell 18: 379

Released	2005-05-03
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Xenopus laevis
Macromolecule	AURORA KINASE B-A (protein) INNER CENTROMERE PROTEIN A (protein)
Unique Ligands	H1N

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2C7M \| pdb_00002c7m	Download File View File

Human Rabex-5 residues 1-74 in complex with Ubiquitin

Penengo, L., Mapelli, M., Murachelli, A.G., Confalioneri, S., Magri, L., Musacchio, A., Di Fiore, P.P., Polo, S., Schneider, T.R.

(2006) Cell 124: 1183-1195

Released	2006-02-15
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Bos taurus Homo sapiens
Macromolecule	RAB GUANINE NUCLEOTIDE EXCHANGE FACTOR 1 (protein) UBIQUITIN (protein)
Unique Ligands	ZN

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2C7N \| pdb_00002c7n	Download File View File

Human Rabex-5 residues 1-74 in complex with Ubiquitin

Penengo, L., Mapelli, M., Murachelli, A.G., Confalioneri, S., Magri, L., Musacchio, A., Di Fiore, P.P., Polo, S., Schneider, T.R.

(2006) Cell 124: 1183

Released	2006-02-15
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Bos taurus Homo sapiens
Macromolecule	RAB GUANINE NUCLEOTIDE EXCHANGE FACTOR 1 (protein) UBIQUITIN (protein)
Unique Ligands	ZN

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2V64 \| pdb_00002v64	Download File View File

Crystallographic structure of the conformational dimer of the Spindle Assembly Checkpoint protein Mad2.

Mapelli, M., Massimiliano, L., Santaguida, S., Musacchio, A.

(2007) Cell 131: 730

Released	2007-11-27
Method	X-RAY DIFFRACTION 2.9 Å
Organisms	Homo sapiens synthetic construct
Macromolecule	MBP1 (protein) MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2A (protein)

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3O0G \| pdb_00003o0g	Download File View File

Crystal Structure of Cdk5:p25 in complex with an ATP analogue

Mapelli, M.

(2005) Chem Biol 12: 811-823

Released	2011-01-26
Method	X-RAY DIFFRACTION 1.95 Å
Organisms	Homo sapiens
Macromolecule	Cell division protein kinase 5 (protein) Cyclin-dependent kinase 5 activator 1 (protein)
Unique Ligands	3O0

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4A1S \| pdb_00004a1s	Download File View File

Crystallographic structure of the Pins:Insc complex

Culurgioni, S., Alfieri, A., Pendolino, V., Laddomada, F., Mapelli, M.

(2011) Proc Natl Acad Sci U S A 108: 20998

Released	2012-03-28
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Drosophila melanogaster
Macromolecule	PARTNER OF INSCUTEABLE (protein) RE60102P (protein)

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4A7J \| pdb_00004a7j	Download File View File

Symmetric Dimethylation of H3 Arginine 2 is a Novel Histone Mark that Supports Euchromatin Maintenance

Migliori, V., Muller, J., Phalke, S., Low, D., Bezzi, M., ChuenMok, W., Gunaratne, J., Capasso, P., Bassi, C., Cecatiello, V., DeMarco, A., Blackstock, W., Kuznetsov, V., Amati, B., Mapelli, M., Guccione, E.

(2012) Nat Struct Mol Biol 19: 136

Released	2012-01-11
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Homo sapiens
Macromolecule	HISTONE H3.1T (protein) WD REPEAT-CONTAINING PROTEIN 5 (protein)

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5A6C \| pdb_00005a6c	Download File View File

Concomitant binding of Afadin to LGN and F-actin directs planar spindle orientation

Carminati, M., Gallini, S., Pirovano, L., Alfieri, A., Bisi, S., Mapelli, M.

(2016) Nat Struct Mol Biol 23: 155

Released	2015-12-30
Method	X-RAY DIFFRACTION 2.901 Å
Organisms	Homo sapiens
Macromolecule	G-PROTEIN-SIGNALING MODULATOR 2, AFADIN (protein)
Unique Ligands	SO4

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5A7D \| pdb_00005a7d	Download File View File

Tetrameric assembly of LGN with Inscuteable

Culurgioni, S., Mari, S., Bonetto, G., Gallini, S., Brennich, M., Round, A., Mapelli, M.

To be published

Released	2016-08-03
Method	X-RAY DIFFRACTION 3.4 Å
Organisms	Drosophila melanogaster
Macromolecule	INSCUTEABLE (protein) PINS (protein)

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5NJJ \| pdb_00005njj	Download File View File

PTB domain of human Numb isoform-1

Mapelli, M., Di Fiore, P.P.

(2018) J Cell Biol 217: 745-762

Released	2017-12-13
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Homo sapiens
Macromolecule	ALA-TYR-ILE-GLY-PRO-PTR-LEU (protein) Protein numb homolog (protein)
Unique Ligands	SO4

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5NJK \| pdb_00005njk	Download File View File

PTB domain of human Numb isoform-1

Mapelli, M., Di Fiore, P.P.

(2018) J Cell Biol 217: 745-762

Released	2017-12-13
Method	X-RAY DIFFRACTION 3.13 Å
Organisms	Homo sapiens
Macromolecule	ALA-TYR-ILE-GLY-PRO-PTR-LEU (protein) Protein numb homolog (protein)
Unique Ligands	SO4

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6HC2 \| pdb_00006hc2	Download File View File

Crystal structure of NuMA/LGN hetero-hexamers

Pasqualato, S., Culurgioni, S., Foadi, J., Alfieri, A., Mapelli, M.

(2019) Nat Commun 10: 2208-2208

Released	2019-05-29
Method	X-RAY DIFFRACTION 4.31 Å
Organisms	Homo sapiens
Macromolecule	G-protein-signaling modulator 2 (protein) Nuclear mitotic apparatus protein 1 (protein)

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6QJA \| pdb_00006qja	Download File View File

Organizational principles of the NuMA-Dynein interaction interface and implications for mitotic spindle functions

Renna, C., Rizzelli, F., Carminati, M., Gaddoni, C., Pirovano, L., Cecatiello, V., Pasqualato, S., Mapelli, M.

(2020) Structure 28: 820-829.e6

Released	2020-02-05
Method	X-RAY DIFFRACTION 1.54 Å
Organisms	Homo sapiens
Macromolecule	Nuclear mitotic apparatus protein 1 (protein)
Unique Ligands	CL, MG

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6ZSY \| pdb_00006zsy	Download File View File

Crystal structure of the Grindelwald extracellular domain complex

Palmerini, V., Cecatiello, V., Pasqualato, S., Mapelli, M.

(2021) Nat Commun 12: 2070-2070

Released	2021-03-31
Method	X-RAY DIFFRACTION 0.926 Å
Organisms	Drosophila melanogaster
Macromolecule	Protein grindelwald (protein)

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6ZSZ \| pdb_00006zsz	Download File View File

Crystal structure of the Grindelwald extracellular domain complex

Palmerini, V., Cecatiello, V., Pasqualato, S., Mapelli, M.

(2021) Nat Commun 12: 2070-2070

Released	2021-03-31
Method	X-RAY DIFFRACTION 1.92 Å
Organisms	Drosophila melanogaster
Macromolecule	Protein grindelwald (protein)

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6ZT0 \| pdb_00006zt0	Download File View File

Crystal structure of the Eiger TNF domain/Grindelwald extracellular domain complex

Palmerini, V., Cecatiello, V., Pasqualato, S., Mapelli, M.

(2021) Nat Commun 12: 2070-2070

Released	2021-03-03
Method	X-RAY DIFFRACTION 2.02 Å
Organisms	Drosophila melanogaster
Macromolecule	Protein eiger (protein) Protein grindelwald (protein)
Unique Ligands	EDO

1 to 22 of 22 Structures

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

1GO4 | pdb_00001go4

1UNG | pdb_00001ung

1UNH | pdb_00001unh

1UNL | pdb_00001unl

1URJ | pdb_00001urj

2BFX | pdb_00002bfx

2BFY | pdb_00002bfy

2C7M | pdb_00002c7m

2C7N | pdb_00002c7n

2V64 | pdb_00002v64

3O0G | pdb_00003o0g

4A1S | pdb_00004a1s

4A7J | pdb_00004a7j

5A6C | pdb_00005a6c

5A7D | pdb_00005a7d

5NJJ | pdb_00005njj

5NJK | pdb_00005njk

6HC2 | pdb_00006hc2

6QJA | pdb_00006qja

6ZSY | pdb_00006zsy

6ZSZ | pdb_00006zsz

6ZT0 | pdb_00006zt0