RCSB PDB: Search

2JJD \| pdb_00002jjd	Download File View File

Protein Tyrosine Phosphatase, Receptor Type, E isoform

Elkins, J.M., Ugochukwu, E., Alfano, I., Barr, A.J., Bunkoczi, G., King, O.N.F., Filippakopoulos, P., Savitsky, P., Salah, E., Pike, A., Johansson, C., Das, S., Burgess-Brown, N.A., Gileadi, O., von Delft, F., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Knapp, S.

(2009) Cell 136: 352

Released	2008-04-08
Method	X-RAY DIFFRACTION 3.2 Å
Organisms	Homo sapiens
Macromolecule	RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE EPSILON (protein)
Unique Ligands	CL

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4TWK \| pdb_00004twk	Download File View File

Crystal structure of human two pore domain potassium ion channel TREK1 (K2P2.1)

Pike, A.C.W., Dong, Y.Y., Tessitore, A., Goubin, S., Strain-Damerell, C., Mukhopadhyay, S., Kupinska, K., Wang, D., Chalk, R., Berridge, G., Grieben, M., Shrestha, L., Ang, J.H., Mackenzie, A., Quigley, A., Bushell, S.R., Shintre, C.A., Faust, B., Chu, A., Dong, L., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Burgess-Brown, N.A., Carpenter, E.P.

To be published

Released	2014-08-06
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Homo sapiens
Macromolecule	Potassium channel subfamily K member 2 (protein)
Unique Ligands	37X, K, MG, NAG

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4UIJ \| pdb_00004uij	Download File View File

Crystal structure of the BTB domain of KCTD13

Pinkas, D.M., Sanvitale, C.E., Sorell, F.J., Solcan, N., Goubin, S., Canning, P., Williams, E., Chaikuad, A., Dixon Clarke, S.E., Tallant, C., Fonseca, M., Chalk, R., Doutch, J., Krojer, T., Burgess-Brown, N.A., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.

(2017) Biochem J 474: 3747-3761

Released	2015-11-04
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Homo sapiens
Macromolecule	BTB/POZ DOMAIN-CONTAINING ADAPTER FOR CUL3-MEDIATED RHOA DEGRADATION PROTEIN 1 (protein)
Unique Ligands	CL

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4UYI \| pdb_00004uyi	Download File View File

Crystal structure of the BTB domain of human SLX4 (BTBD12)

Pinkas, D.M., Sanvitale, C.E., Strain-Damerell, C., Fairhead, M., Wang, D., Tallant, C., Cooper, C.D.O., Sorrell, F.J., Kopec, J., Chaikuad, A., Fitzpatrick, F., Pike, A.C.W., Hozjan, V., Ying, Z., Roos, A.K., Savitsky, P., Bradley, A., Nowak, R., Filippakopoulos, P., Krojer, T., Burgess-Brown, N.A., Marsden, B.D., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.

To be published

Released	2014-10-01
Method	X-RAY DIFFRACTION 1.86 Å
Organisms	Homo sapiens
Macromolecule	STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX4 (protein)

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4XDJ \| pdb_00004xdj	Download File View File

Crystal structure of human two pore domain potassium ion channel TREK2 (K2P10.1) in an alternate conformation (FORM 2)

Pike, A.C.W., Dong, Y.Y., Mackenzie, A., Mukhopadhyay, S., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Burgess-Brown, N.A., Carpenter, E.P., Structural Genomics Consortium (SGC)

(2015) Science 347: 1256-1259

Released	2015-03-18
Method	X-RAY DIFFRACTION 3.8 Å
Organisms	Homo sapiens
Macromolecule	POTASSIUM CHANNEL SUBFAMILY K MEMBER 10 (protein)
Unique Ligands	K, PC1, TRD

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4XDK \| pdb_00004xdk	Download File View File

Crystal structure of human two pore domain potassium ion channel TREK2 (K2P10.1) in complex with norfluoxetine

Pike, A.C.W., Dong, Y.Y., Mackenzie, A., Mukhopadhyay, S., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Burgess-Brown, N.A., Carpenter, E.P., Structural Genomics Consortium (SGC)

(2015) Science 347: 1256-1259

Released	2015-03-18
Method	X-RAY DIFFRACTION 3.6 Å
Organisms	Homo sapiens
Macromolecule	Potassium channel subfamily K member 10 (protein)
Unique Ligands	405, 408, K, PC1

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4XDL \| pdb_00004xdl	Download File View File

Crystal structure of human two pore domain potassium ion channel TREK2 (K2P10.1) in complex with a brominated fluoxetine derivative.

Mackenzie, A., Pike, A.C.W., Dong, Y.Y., Mukhopadhyay, S., Ruda, G.F., Brennan, P.E., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Burgess-Brown, N.A., Carpenter, E.P., Structural Genomics Consortium (SGC)

(2015) Science 347: 1256-1259

Released	2015-03-18
Method	X-RAY DIFFRACTION 3.5 Å
Organisms	Homo sapiens
Macromolecule	Potassium channel subfamily K member 10 (protein)
Unique Ligands	40D, CD, K, PC1

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5A15 \| pdb_00005a15	Download File View File

Crystal structure of the BTB domain of human KCTD16

Pinkas, D.M., Sanvitale, C.E., Solcan, N., Goubin, S., Canning, P., Dixon Clarke, S.E., Talon, R., Wiggers, H.J., Fitzpatrick, F., Tallant, C., Kopec, J., Chalk, R., Doutch, J., Krojer, T., Burgess-Brown, N.A., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.

(2017) Biochem J 474: 3747-3761

Released	2015-11-04
Method	X-RAY DIFFRACTION 2.76 Å
Organisms	Homo sapiens
Macromolecule	BTB/POZ DOMAIN-CONTAINING PROTEIN KCTD16 (protein)

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5A1F \| pdb_00005a1f	Download File View File

Crystal structure of the catalytic domain of PLU1 in complex with N-oxalylglycine.

Srikannathasan, V., Johansson, C., Strain-Damerell, C., Gileadi, C., Szykowska, A., Kupinska, K., Kopec, J., Krojer, T., Steuber, H., von Delft, F., Burgess-Brown, N.A., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Oppermann, U.

(2016) Nat Chem Biol 12: 539

Released	2015-05-06
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens
Macromolecule	LYSINE-SPECIFIC DEMETHYLASE 5B, LYSINE-SPECIFIC DEMETHYLASE 5B (protein)
Unique Ligands	EDO, EPE, MN, OGA, PO4, ZN

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5A1H \| pdb_00005a1h	Download File View File

Crystal structure of human Spindlin3

Srikannathasan, V., Gileadi, C., Johansson, C., Shrestha, L., Tallon, R., Burgess-Brown, N.A., von Delft, F., Arrowsmith, C.H., Bountra, C., Edwards, A., Oppermann, U.

To be published

Released	2015-06-17
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	SPINDLIN-3 (protein)

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5A3P \| pdb_00005a3p	Download File View File

Crystal structure of the catalytic domain of human PLU1 (JARID1B).

Nowak, R., Srikannathasan, V., Johansson, C., Gileadi, C., Tallant, C., Kupinska, K., Strain-Damerell, C., Szykowska, A., von Delft, F., Burgess-Brown, N.A., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Oppermann, U.

(2016) Nat Chem Biol 12: 539

Released	2015-06-10
Method	X-RAY DIFFRACTION 2.008 Å
Organisms	Homo sapiens
Macromolecule	LYSINE-SPECIFIC DEMETHYLASE 5B (protein)
Unique Ligands	EDO, EPE, MN, ZN

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5A3W \| pdb_00005a3w	Download File View File

Crystal structure of human PLU-1 (JARID1B) in complex with Pyridine-2, 6-dicarboxylic Acid (PDCA)

Srikannathasan, V., Johansson, C., Gileadi, C., Kopec, J., Strain-Damerell, C., Kupinska, K., Burgess-Brown, N.A., von Delft, F., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Oppermann, U.

(2016) Nat Chem Biol 12: 539

Released	2015-06-17
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	LYSINE-SPECIFIC DEMETHYLASE 5B (protein)
Unique Ligands	EDO, EPE, MN, NA, PD2, PO4, ZN

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5A6R \| pdb_00005a6r	Download File View File

Crystal structure of the BTB domain of human KCTD17

Pinkas, D.M., Sorrell, F., Sanvitale, C.E., Goubin, S., Williams, E., Newman, J.A., Pearce, N.M., Neshich, I., Pike, A.C.W., MacKenzie, A., Quigley, A., Faust, B., Carpenter, E.P., Tallant, C., Kopec, J., Chalk, R., Krojer, T., Burgess-Brown, N.A., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.

(2017) Biochem J 474: 3747-3761

Released	2015-11-04
Method	X-RAY DIFFRACTION 2.85 Å
Organisms	Homo sapiens
Macromolecule	BTB/POZ DOMAIN-CONTAINING PROTEIN KCTD17 (protein)

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5C65 \| pdb_00005c65	Download File View File

Structure of the human glucose transporter GLUT3 / SLC2A3

Pike, A.C.W., Quigley, A., Chu, A., Tessitore, A., Xia, X., Mukhopadhyay, S., Wang, D., Kupinska, K., Strain-Damerell, C., Chalk, R., Burgess-Brown, N.A., Edwards, A.M., Arrowsmith, C.H., Bountra, C., Carpenter, E.P., Structural Genomics Consortium (SGC)

To be published

Released	2015-07-08
Method	X-RAY DIFFRACTION 2.65 Å
Organisms	Homo sapiens
Macromolecule	Solute carrier family 2, facilitated glucose transporter member 3 (protein)
Unique Ligands	37X, Y01

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5FUP \| pdb_00005fup	Download File View File

Crystal structure of human JARID1B in complex with 2-oxoglutarate.

Nowak, R., Srikannathasan, V., Johansson, C., Gileadi, C., Kupinska, K., Strain-Damerell, C., Szykowska, A., Talon, R., von Delft, F., Burgess-Brown, N.A., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Oppermann, U.

(2016) Nat Chem Biol 12: 539

Released	2016-03-23
Method	X-RAY DIFFRACTION 2.15 Å
Organisms	Homo sapiens
Macromolecule	LYSINE-SPECIFIC DEMETHYLASE 5B (protein)
Unique Ligands	AKG, CL, EDO, EPE, MN, ZN

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5FV3 \| pdb_00005fv3	Download File View File

Crystal structure of human JARID1B construct c2 in complex with N- Oxalylglycine.

Nowak, R., Srikannathasan, V., Johansson, C., Gileadi, C., Kupinska, K., Strain-Damerell, C., Szykowska, A., Talon, R., von Delft, F., Burgess-Brown, N.A., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Oppermann, U.

(2016) Nat Chem Biol 12: 539

Released	2016-02-17
Method	X-RAY DIFFRACTION 2.37 Å
Organisms	Homo sapiens
Macromolecule	LYSINE-SPECIFIC DEMETHYLASE 5B, LYSINE-SPECIFIC DEMETHYLASE 5B (protein)
Unique Ligands	CL, DMS, EDO, EPE, MN, OGA, ZN

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5FWJ \| pdb_00005fwj	Download File View File

Crystal structure of human JARID1C in complex with KDM5-C49

Srikannathasan, V., Szykowska, A., Strain-Damerell, C., Kopec, J., Nowak, R., Gileadi, C., Johansson, C., Kupinska, K., Burgess-Brown, N.A., Shrestha, L., Dong, W., von Delft, F., Arrowsmith, C.H., Bountra, C., Edwards, A., Huber, K., Oppermann, U.

(2016) Nat Chem Biol 12: 539

Released	2016-04-13
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens
Macromolecule	HISTONE DEMETHYLASE JARID1C (protein)
Unique Ligands	MG, MMK, MN, ZN

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5FY4 \| pdb_00005fy4	Download File View File

Crystal structure of the catalytic domain of human JARID1B in complex with succinate

Nowak, R., Srikannathasan, V., Johansson, C., Gileadi, C., Kupinska, K., Strain-Damerell, C., Szykowska, A., von Delft, F., Burgess-Brown, N.A., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Oppermann, U.

To be published

Released	2017-03-22
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens
Macromolecule	LYSINE-SPECIFIC DEMETHYLASE 5B (protein)
Unique Ligands	EDO, FUM, MN, ZN

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5FY5 \| pdb_00005fy5	Download File View File

Crystal structure of the catalytic domain of human JARID1B in complex with fumarate

Nowak, R., Srikannathasan, V., Johansson, C., Gileadi, C., Kupinska, K., Strain-Damerell, C., Szykowska, A., von Delft, F., Burgess-Brown, N.A., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Oppermann, U.

To be published

Released	2017-03-22
Method	X-RAY DIFFRACTION 2.47 Å
Organisms	Homo sapiens
Macromolecule	LYSINE-SPECIFIC DEMETHYLASE 5B (protein)
Unique Ligands	EDO, EPE, FUM, MN, ZN

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5FY9 \| pdb_00005fy9	Download File View File

Crystal structure of the catalytic domain of human JARID1B in complex with pyruvate

Nowak, R., Srikannathasan, V., Johansson, C., Gileadi, C., Kupinska, K., Strain-Damerell, C., Szykowska, A., von Delft, F., Burgess-Brown, N.A., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Oppermann, U.

To be published

Released	2017-03-22
Method	X-RAY DIFFRACTION 2.03 Å
Organisms	Homo sapiens
Macromolecule	LYSINE-SPECIFIC DEMETHYLASE 5B, LYSINE-SPECIFIC DEMETHYLASE 5B (protein)
Unique Ligands	EDO, EPE, MN, PYR, ZN

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5FYB \| pdb_00005fyb	Download File View File

Crystal structure of the catalytic domain of human JARID1B in complex with MC1648

Nowak, R., Srikannathasan, V., Rotili, D., Johansson, C., Gileadi, C., Kupinska, K., Strain-Damerell, C., Szykowska, A., von Delft, F., Burgess-Brown, N.A., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Oppermann, U.

To be published

Released	2017-03-29
Method	X-RAY DIFFRACTION 1.87 Å
Organisms	Homo sapiens
Macromolecule	LYSINE-SPECIFIC DEMETHYLASE 5B, LYSINE-SPECIFIC DEMETHYLASE 5B (protein)
Unique Ligands	77J, DMS, EDO, MN, ZN

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5FYS \| pdb_00005fys	Download File View File

Crystal structure of the catalytic domain of human JARID1B in complex with D-2-hydroxyglutarate

Nowak, R., Kopec, J., Johansson, C., Gileadi, C., Kupinska, K., Strain-Damerell, C., Szykowska, A., von Delft, F., Burgess-Brown, N.A., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Oppermann, U.

To be published

Released	2017-03-22
Method	X-RAY DIFFRACTION 1.89 Å
Organisms	Homo sapiens
Macromolecule	LYSINE-SPECIFIC DEMETHYLASE 5B (protein)
Unique Ligands	2HG, CL, EDO, EPE, MN, ZN

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5FYT \| pdb_00005fyt	Download File View File

Crystal structure of the catalytic domain of human JARID1B in complex with 3D fragment (5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-yl)acetic acid (N09996a)

Nowak, R., Krojer, T., Johansson, C., Pearce, N., Gileadi, C., Kupinska, K., Strain-Damerell, C., Szykowska, A., Burgess-Brown, N.A., Arrowsmith, C.H., Bountra, C., Edwards, A.M., von Delft, F., Brennan, P.E., Oppermann, U.

To be published

Released	2016-03-23
Method	X-RAY DIFFRACTION 1.87 Å
Organisms	Homo sapiens
Macromolecule	LYSINE-SPECIFIC DEMETHYLASE 5B (protein)
Unique Ligands	CL, DMS, EDO, MN, PO4, WQS, ZN

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5FYU \| pdb_00005fyu	Download File View File

Crystal structure of the catalytic domain of human JARID1B in complex with 3D fragment 3-Amino-4-methyl-1,3-dihydro-2H-indol-2-one (N10042a)

Nowak, R., Krojer, T., Johansson, C., Pearce, N., Gileadi, C., Kupinska, K., Strain-Damerell, C., Szykowska, A., Burgess-Brown, N.A., Arrowsmith, C.H., Bountra, C., Edwards, A.M., von Delft, F., Brennan, P.E., Oppermann, U.

To be published

Released	2016-03-23
Method	X-RAY DIFFRACTION 2.06 Å
Organisms	Homo sapiens
Macromolecule	LYSINE-SPECIFIC DEMETHYLASE 5B (protein)
Unique Ligands	BY4, CL, DMS, EDO, MN, PO4, ZN

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5FYV \| pdb_00005fyv	Download File View File

Crystal structure of the catalytic domain of human JARID1B in complex with oxaloacetate

Nowak, R., Kopec, J., Johansson, C., Gileadi, C., Kupinska, K., Strain-Damerell, C., Szykowska, A., von Delft, F., Burgess-Brown, N.A., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Oppermann, U.

To be published

Released	2017-03-22
Method	X-RAY DIFFRACTION 1.87 Å
Organisms	Homo sapiens
Macromolecule	LYSINE-SPECIFIC DEMETHYLASE 5B (protein)
Unique Ligands	CL, EDO, EPE, MN, OAA, PO4, ZN

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Structure Determination Methodology

Scientific Name of Source Organism

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Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Membrane Protein Annotation

Symmetry Type

SCOP Classification

2JJD | pdb_00002jjd

4TWK | pdb_00004twk

4UIJ | pdb_00004uij

4UYI | pdb_00004uyi

4XDJ | pdb_00004xdj

4XDK | pdb_00004xdk

4XDL | pdb_00004xdl

5A15 | pdb_00005a15

5A1F | pdb_00005a1f

5A1H | pdb_00005a1h

5A3P | pdb_00005a3p

5A3W | pdb_00005a3w

5A6R | pdb_00005a6r

5C65 | pdb_00005c65

5FUP | pdb_00005fup

5FV3 | pdb_00005fv3

5FWJ | pdb_00005fwj

5FY4 | pdb_00005fy4

5FY5 | pdb_00005fy5

5FY9 | pdb_00005fy9

5FYB | pdb_00005fyb

5FYS | pdb_00005fys

5FYT | pdb_00005fyt

5FYU | pdb_00005fyu

5FYV | pdb_00005fyv