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233,605 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Citation Author = "Cantrelle, F.X."

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Search Summary

This query matches 36 Structures.

Refinements

Structure Determination Methodology

experimental (36)

Scientific Name of Source Organism

	Homo sapiens (24)
	Drosophila melanogaster (4)
	Lama glama (4)
	Severe acute respiratory syndrome coronavirus 2 (4)
	synthetic construct (4)
	Bos taurus (3)
	Oryctolagus cuniculus (3)
	Salmonella enterica subsp. enterica serovar Typhimurium (2)
	Hepacivirus hominis (1)
	Rattus norvegicus (1)

Taxonomy

	Eukaryota (29)
	Riboviria (5)
	other sequences (4)
	Bacteria (2)

Experimental Method

	X-RAY DIFFRACTION (31)
	SOLUTION NMR (5)

Polymer Entity Type

Protein (36)

Refinement Resolution (Å)

	1.0 - 1.5 (5)
	1.5 - 2.0 (15)
	2.0 - 2.5 (6)
	2.5 - 3.0 (4)
	3.0 - 3.5 (1)

Release Date

	2010 - 2014 (5)
	2015 - 2019 (16)
	2020 - 2024 (15)

Enzyme Classification Name

	Hydrolases (12)
	Oxidoreductases (15)
	Transferases (1)

Symmetry Type

	Asymmetric (29)
	Cyclic (8)

SCOP Classification

	All beta proteins (7)
	Alpha and beta proteins (a/b) (4)

AllSelected

1 to 25 of 36 Structures

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3SJH \| pdb_00003sjh	Download File View File

Crystal Structure of a chimera containing the N-terminal domain (residues 8-29) of drosophila Ciboulot and the C-terminal domain (residues 18-44) of bovine Thymosin-beta4, bound to G-actin-ATP-Latrunculin A

Renault, L., Husson, C., Carlier, M.F., Didry, D.

(2012) EMBO J 31: 1000-1013

Released	2012-01-25
Method	X-RAY DIFFRACTION 1.75 Å
Organisms	Bos taurus Drosophila melanogaster Oryctolagus cuniculus
Macromolecule	Actin, alpha skeletal muscle (protein) Ciboulot/Thymosin beta-4 chimeric protein (protein)
Unique Ligands	ATP, LAR, MG

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3U8X \| pdb_00003u8x	Download File View File

Crystal Structure of a chimera containing the N-terminal domain (residues 8-29) of drosophila Ciboulot and the C-terminal domain (residues 18-44) of bovine Thymosin-beta4, bound to G-actin-ATP

Renault, L., Husson, C., Carlier, M.F., Didry, D.

(2012) EMBO J 31: 1000-1013

Released	2012-01-25
Method	X-RAY DIFFRACTION 2 Å
Organisms	Bos taurus Drosophila melanogaster Oryctolagus cuniculus
Macromolecule	Actin, alpha skeletal muscle (protein) Thymosin beta-4 (protein)
Unique Ligands	ATP, MG

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3U9D \| pdb_00003u9d	Download File View File

Crystal Structure of a chimera containing the N-terminal domain (residues 8-24) of drosophila Ciboulot and the C-terminal domain (residues 13-44) of bovine Thymosin-beta4, bound to G-actin-ATP

Renault, L., Husson, C., Carlier, M.F., Didry, D.

(2012) EMBO J 31: 1000-1013

Released	2012-01-25
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Bos taurus Drosophila melanogaster Rattus norvegicus
Macromolecule	Actin, alpha skeletal muscle (protein) Thymosin beta-4, Chimeric protein (protein)
Unique Ligands	ATP, MG

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3U9Z \| pdb_00003u9z	Download File View File

Crystal structure between actin and a protein construct containing the first beta-thymosin domain of drosophila ciboulot (residues 2-58) with the three mutations N26D/Q27K/D28S

Renault, L., Husson, C., Carlier, M.F., Didry, D.

(2012) EMBO J 31: 1000-1013

Released	2012-01-25
Method	X-RAY DIFFRACTION 2.09 Å
Organisms	Drosophila melanogaster Oryctolagus cuniculus
Macromolecule	Actin, alpha skeletal muscle (protein) Ciboulot, isoform A (protein)
Unique Ligands	ADP, MG

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4IFH \| pdb_00004ifh	Download File View File

Crystal structure of human insulin degrading enzyme (IDE) in complex with compound BDM44619

Liang, W.G., Guo, Q., Deprez, R., Deprez, B., Tang, W.

(2015) Nat Commun 6: 8250-8250

Released	2013-12-18
Method	X-RAY DIFFRACTION 3.286 Å
Organisms	Homo sapiens
Macromolecule	Insulin-degrading enzyme (protein)
Unique Ligands	1EF, ZN

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4NXO \| pdb_00004nxo	Download File View File

Crystal Structure of Insulin Degrading Enzyme in complex with BDM44768

Liang, W.G., Deprez, R., Deprez, B., Tang, W.

(2015) Nat Commun 6: 8250-8250

Released	2015-10-07
Method	X-RAY DIFFRACTION 2.73 Å
Organisms	Homo sapiens
Macromolecule	Insulin-degrading enzyme (protein)
Unique Ligands	1PE, 2H7, DIO, EDO, EPE, PEG, ZN

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4RE9 \| pdb_00004re9	Download File View File

Crystal structure of human insulin degrading enzyme (IDE) in complex with compound 71290

Liang, W.G., Deprez, R., Deprez, B., Tang, W.J.

(2015) Nat Commun 6: 8250-8250

Released	2015-09-30
Method	X-RAY DIFFRACTION 2.908 Å
Organisms	Homo sapiens
Macromolecule	Insulin-degrading enzyme (protein)
Unique Ligands	1PE, 3M9, EDO, EPE, PEG, ZN

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5IXF \| pdb_00005ixf	Download File View File

Solution structure of the STAM2 SH3 with AMSH derived peptide complex

Hologne, M., Cantrelle, F.X., Trivelli, X., Walker, O.

(2016) J Mol Biology 428: 4544-4558

Released	2016-12-07
Method	SOLUTION NMR
Organisms	Homo sapiens
Macromolecule	STAM-binding protein (protein) Signal transducing adapter molecule 2 (protein)

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5L9B \| pdb_00005l9b	Download File View File

HIF PROLYL HYDROXYLASE 2 (PHD2/ EGLN1) IN COMPLEX WITH 2-OXOGLUTARATE (2OG) AND HIF-1ALPHA CODD (556-574)

Chowdhury, R., Schofield, C.J.

(2016) Nat Commun 7: 12673-12673

Released	2016-08-31
Method	X-RAY DIFFRACTION 1.95 Å
Organisms	Homo sapiens
Macromolecule	Egl nine homolog 1 (protein) Hypoxia-inducible factor 1-alpha (protein)
Unique Ligands	AKG, MN

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5L9R \| pdb_00005l9r	Download File View File

HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with N-oxalylglycine (NOG)

Chowdhury, R., Schofield, C.J.

(2016) Nat Commun 7: 12673-12673

Released	2016-08-31
Method	X-RAY DIFFRACTION 1.81 Å
Organisms	Homo sapiens
Macromolecule	Egl nine homolog 1 (protein)
Unique Ligands	GOL, MN, OGA, PG4, SO4

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5L9V \| pdb_00005l9v	Download File View File

HIF prolyl hydroxylase 2 (PHD2-R281C/P317C) cross-linked to HIF-1alpha NODD-L397C/D412C and N-oxalylglycine (NOG) (complex-1)

Chowdhury, R., Schofield, C.J.

(2016) Nat Commun 7: 12673-12673

Released	2016-08-31
Method	X-RAY DIFFRACTION 1.829 Å
Organisms	Homo sapiens
Macromolecule	Egl nine homolog 1 (protein) Hypoxia-inducible factor 1-alpha (protein)
Unique Ligands	MN, OGA

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5LA9 \| pdb_00005la9	Download File View File

HIF prolyl hydroxylase 2 (PHD2-R281C/V314C) cross-linked to HIF-1alpha NODD-L397C/D412C and N-oxalylglycine (NOG) (complex-2)

Chowdhury, R., Schofield, C.J.

(2016) Nat Commun 7: 12673-12673

Released	2016-08-31
Method	X-RAY DIFFRACTION 2.813 Å
Organisms	Homo sapiens
Macromolecule	Egl nine homolog 1 (protein) Hypoxia-inducible factor 1-alpha (protein)
Unique Ligands	MN, OGA, SO4

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5LAS \| pdb_00005las	Download File View File

HIF prolyl hydroxylase 2 (PHD2-R281C/P317C/R396T) cross-linked to HIF-1alpha NODD-L397C/D412C and N-oxalylglycine (NOG) (complex-3)

Chowdhury, R., Schofield, C.J.

(2016) Nat Commun 7: 12673-12673

Released	2016-08-31
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens
Macromolecule	Egl nine homolog 1 (protein) Hypoxia-inducible factor 1-alpha (protein)
Unique Ligands	MN, OGA

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5LAT \| pdb_00005lat	Download File View File

HIF prolyl hydroxylase 2 (PHD2/EGLN1) P317R variant in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/UN9)

Chowdhury, R., Schofield, C.J.

(2016) Nat Commun 7: 12673-12673

Released	2016-08-31
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Homo sapiens
Macromolecule	Egl nine homolog 1 (protein)
Unique Ligands	BCT, GOL, MN, UN9

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5LB6 \| pdb_00005lb6	Download File View File

HIF prolyl hydroxylase 2 (PHD2/EGLN1) R371H variant in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/UN9)

Chowdhury, R., Schofield, C.J.

(2016) Nat Commun 7: 12673-12673

Released	2016-08-31
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Homo sapiens
Macromolecule	Egl nine homolog 1 (protein)
Unique Ligands	GOL, MN, SO4, UN9

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5LBB \| pdb_00005lbb	Download File View File

HIF prolyl hydroxylase 2 (PHD2/EGLN1) R396T variant in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/UN9)

Chowdhury, R., Schofield, C.J.

(2016) Nat Commun 7: 12673-12673

Released	2016-08-31
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Homo sapiens
Macromolecule	Egl nine homolog 1 (protein)
Unique Ligands	BCT, MN, UN9

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5LBC \| pdb_00005lbc	Download File View File

HIF prolyl hydroxylase 2 (PHD2/EGLN1) I280V/R281L/I292V variant in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/FG2216)

Chowdhury, R., Schofield, C.J.

(2016) Nat Commun 7: 12673-12673

Released	2016-08-31
Method	X-RAY DIFFRACTION 1.816 Å
Organisms	Homo sapiens
Macromolecule	Egl nine homolog 1 (protein)
Unique Ligands	BCT, CL, GOL, MN, SO4, UN9

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5LBE \| pdb_00005lbe	Download File View File

HIF prolyl hydroxylase 2 (PHD2/EGLN1) G294E variant in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/FG2216)

Chowdhury, R., Schofield, C.J.

(2016) Nat Commun 7: 12673-12673

Released	2016-08-31
Method	X-RAY DIFFRACTION 1.749 Å
Organisms	Homo sapiens
Macromolecule	Egl nine homolog 1 (protein)
Unique Ligands	BCT, MN, UN9

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5LBF \| pdb_00005lbf	Download File View File

HIF prolyl hydroxylase 2 (PHD2/EGLN1) K293K/G294E variant in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/FG2216)

Chowdhury, R., Schofield, C.J.

(2016) Nat Commun 7: 12673-12673

Released	2016-08-31
Method	X-RAY DIFFRACTION 1.8995 Å
Organisms	Homo sapiens
Macromolecule	Egl nine homolog 1 (protein)
Unique Ligands	BCT, MN, SO4, UN9

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5ODD \| pdb_00005odd	Download File View File

HUMAN MED26 N-TERMINAL DOMAIN (1-92)

Lens, Z., Cantrelle, F.-X., Perruzini, R., Dewitte, F., Hanoulle, X., Villeret, V., Verger, A., Landrieu, I.

(2016) Biomol NMR Assign 10: 233-236

Released	2017-11-29
Method	SOLUTION NMR
Organisms	Homo sapiens
Macromolecule	Mediator of RNA polymerase II transcription subunit 26 (protein)

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6HT4 \| pdb_00006ht4	Download File View File

NMR Structure of NS5A-D2 (JFH1) peptide (304-323)

Dujardin, M., Cantrelle, F.X., Lippens, G., Hanoulle, X.

(2019) J Biological Chem 294: 13171-13185

Released	2019-07-24
Method	SOLUTION NMR
Organisms	Hepacivirus hominis
Macromolecule	NS5A (protein)

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6YW1 \| pdb_00006yw1	Download File View File

HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with 2OG and RaPID-derived silent allosteric cyclic peptide 3C (14-mer)

Chowdhury, R., Schofield, C.J.

(2020) Sci Rep 10: 21964-21964

Released	2020-12-30
Method	X-RAY DIFFRACTION 1.46 Å
Organisms	Homo sapiens synthetic construct
Macromolecule	Egl nine homolog 1 (protein) PHD2-SPECIFIC RaPID CYCLIC PEPTIDE 3C (14-MER) (protein)
Unique Ligands	AKG, BCT, MN

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6YW2 \| pdb_00006yw2	Download File View File

HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with bicyclic FG2216 and RaPID-derived cyclic peptide 3C (14-mer)

Chowdhury, R., Schofield, C.J.

(2020) Sci Rep 10: 21964-21964

Released	2020-12-30
Method	X-RAY DIFFRACTION 2.14 Å
Organisms	Homo sapiens synthetic construct
Macromolecule	Egl nine homolog 1 (protein) PHD2-SPECIFIC RaPID CYCLIC PEPTIDE 3C (14-MER) (protein)
Unique Ligands	MN, UN9

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6YW3 \| pdb_00006yw3	Download File View File

HIF PROLYL HYDROXYLASE 2 (PHD2/ EGLN1) in complex with N-Oxalyl Glycine (NOG), HIF-1ALPHA CODD (556-574) and a RaPID-derived cyclic peptide 3C (14-mer)

Chowdhury, R., Schofield, C.J.

(2020) Sci Rep 10: 21964-21964

Released	2020-12-30
Method	X-RAY DIFFRACTION 2.279 Å
Organisms	Homo sapiens synthetic construct
Macromolecule	Egl nine homolog 1 (protein) Hypoxia-inducible factor 1-alpha (protein) PHD2-SPECIFIC RaPID CYCLIC PEPTIDE 3C (14-MER) (protein)
Unique Ligands	GOL, MN, OGA, SO4

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6YW4 \| pdb_00006yw4	Download File View File

HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with N-oxalylglycine (NOG) and a RaPID-derived silent allosteric cyclic peptide 3C (14-mer)

Chowdhury, R., Schofield, C.J.

(2020) Sci Rep 10: 21964-21964

Released	2020-12-30
Method	X-RAY DIFFRACTION 1.528 Å
Organisms	Homo sapiens synthetic construct
Macromolecule	Egl nine homolog 1 (protein) PHD2-SPECIFIC RaPID CYCLIC PEPTIDE 3C (14-MER) (protein)
Unique Ligands	MN, OGA, SO4

1 to 25 of 36 Structures

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

3SJH | pdb_00003sjh

3U8X | pdb_00003u8x

3U9D | pdb_00003u9d

3U9Z | pdb_00003u9z

4IFH | pdb_00004ifh

4NXO | pdb_00004nxo

4RE9 | pdb_00004re9

5IXF | pdb_00005ixf

5L9B | pdb_00005l9b

5L9R | pdb_00005l9r

5L9V | pdb_00005l9v

5LA9 | pdb_00005la9

5LAS | pdb_00005las

5LAT | pdb_00005lat

5LB6 | pdb_00005lb6

5LBB | pdb_00005lbb

5LBC | pdb_00005lbc

5LBE | pdb_00005lbe

5LBF | pdb_00005lbf

5ODD | pdb_00005odd

6HT4 | pdb_00006ht4

6YW1 | pdb_00006yw1

6YW2 | pdb_00006yw2

6YW3 | pdb_00006yw3

6YW4 | pdb_00006yw4