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233,605 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Citation Author = "Cardozo, M."

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Search Summary

This query matches 29 Structures.

Refinements

Structure Determination Methodology

experimental (29)

Scientific Name of Source Organism

Homo sapiens (29)

Taxonomy

Eukaryota (29)

Experimental Method

	X-RAY DIFFRACTION (28)
	SOLUTION NMR (1)

Polymer Entity Type

Protein (29)

Refinement Resolution (Å)

	1.0 - 1.5 (2)
	1.5 - 2.0 (9)
	2.0 - 2.5 (6)
	2.5 - 3.0 (10)
	3.0 - 3.5 (1)

Release Date

	2010 - 2014 (9)
	2015 - 2019 (20)

Enzyme Classification Name

	Transferases (8)
	Oxidoreductases (1)

Symmetry Type

	Asymmetric (28)
	Cyclic (8)

SCOP Classification

	Membrane and cell surface proteins and peptides (13)
	Alpha and beta proteins (a+b) (9)
	All alpha proteins (7)
	All beta proteins (7)
	Artifacts (3)
	Alpha and beta proteins (a/b) (1)

AllSelected

1 to 25 of 29 Structures

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3OQ1 \| pdb_00003oq1	Download File View File

Crystal Structure of 11beta-Hydroxysteroid Dehydrogenase-1 (11b-HSD1) in Complex with Diarylsulfone Inhibitor

Wang, Z., Sudom, A., Walker, N.P.

(2010) Bioorg Med Chem Lett 20: 7071-7075

Released	2011-07-20
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Homo sapiens
Macromolecule	Corticosteroid 11-beta-dehydrogenase isozyme 1 (protein)
Unique Ligands	3OQ, NAP

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4DT6 \| pdb_00004dt6	Download File View File

Co-crystal structure of eIF4E with inhibitor

Min, X., Johnstone, S., Walker, N., Wang, Z.

(2012) J Med Chem 55: 3837-3851

Released	2012-04-11
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Homo sapiens
Macromolecule	Eukaryotic translation initiation factor 4E (protein)
Unique Ligands	6LI, EDO, GOL

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4DUM \| pdb_00004dum	Download File View File

Co-crystal structure of eIF4E with inhibitor

Min, X., Johnstone, S., Walker, N., Wang, Z.

(2012) J Med Chem 55: 3837-3851

Released	2012-04-11
Method	X-RAY DIFFRACTION 2.95 Å
Organisms	Homo sapiens
Macromolecule	Eukaryotic translation initiation factor 4E (protein)
Unique Ligands	EDO, HLI

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4FJY \| pdb_00004fjy	Download File View File

Crystal structure of PI3K-gamma in complex with quinoline-indoline inhibitor 24f

Whittington, D.A., Tang, J., Yakowec, P.

(2012) J Med Chem 55: 7667-7685

Released	2012-10-24
Method	X-RAY DIFFRACTION 2.9 Å
Organisms	Homo sapiens
Macromolecule	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (protein)
Unique Ligands	FJY, SO4

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4FJZ \| pdb_00004fjz	Download File View File

Crystal structure of PI3K-gamma in complex with pyrrolo-pyridine inhibitor 63

Whittington, D.A., Tang, J., Yakowec, P.

(2012) J Med Chem 55: 7667-7685

Released	2012-10-24
Method	X-RAY DIFFRACTION 3 Å
Organisms	Homo sapiens
Macromolecule	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (protein)
Unique Ligands	4FJ, SO4

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4L02 \| pdb_00004l02	Download File View File

Crystal Structure of SphK1 with inhibitor

Min, X., Walker, N., Wang, Z.

(2013) Bioorg Med Chem Lett 23: 4608-4616

Released	2013-07-24
Method	X-RAY DIFFRACTION 2.75 Å
Organisms	Homo sapiens
Macromolecule	Sphingosine kinase 1 (protein)
Unique Ligands	1V2

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4WWN \| pdb_00004wwn	Download File View File

Crystal structure of human PI3K-gamma in complex with (S)-N-(1-(7-fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine AMG319 inhibitor

Whittington, D.A., Tang, J., Yakowec, P.

(2015) J Med Chem 58: 480-511

Released	2014-12-17
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Homo sapiens
Macromolecule	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (protein)
Unique Ligands	3VC, SO4

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4WWO \| pdb_00004wwo	Download File View File

Crystal structure of human PI3K-gamma in complex with phenylquinoline inhibitor N-{(1S)-1-[8-chloro-2-(3-fluorophenyl)quinolin-3-yl]ethyl}-9H-purin-6-amine

Whittington, D.A., Tang, J., Yakowec, P.

(2015) J Med Chem 58: 480-511

Released	2014-12-17
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Homo sapiens
Macromolecule	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (protein)
Unique Ligands	3VD, SO4

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4WWP \| pdb_00004wwp	Download File View File

Crystal structure of human PI3K-gamma in complex with pyridinylquinoline inhibitor N-{(1S)-1-[8-chloro-2-(2-methylpyridin-3-yl)quinolin-3-yl]ethyl}-9H-purin-6-amine

Whittington, D.A., Tang, J., Yakowec, P.

(2015) J Med Chem 58: 480-511

Released	2014-12-17
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (protein)
Unique Ligands	3VE, GOL, SO4

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5EDS \| pdb_00005eds	Download File View File

Crystal structure of human PI3K-gamma in complex with benzimidazole inhibitor 5

Whittington, D.A., Tang, J., Yakowec, P.

(2016) J Med Chem 59: 431-447

Released	2015-12-30
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Homo sapiens
Macromolecule	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (protein)
Unique Ligands	5MT, SO4

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5KAE \| pdb_00005kae	Download File View File

Crystal structure of human PI3K-gamma in complex with quinoline-containing inhibitor 5g

Whittington, D.A., Tang, J., Yakowec, P.

To be published

Released	2017-06-21
Method	X-RAY DIFFRACTION 2.65 Å
Organisms	Homo sapiens
Macromolecule	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (protein)
Unique Ligands	6RF, SO4

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6M90 \| pdb_00006m90	Download File View File

Monophosphorylated pSer33 b-Catenin peptide, b-TrCP/Skp1, NRX-2776 ternary complex

Simonetta, K.R., Clifton, M.C., Walter, R.L., Ranieri, G.M., Carter, J.J.

(2019) Nat Commun 10: 1402-1402

Released	2019-04-03
Method	X-RAY DIFFRACTION 2.05 Å
Organisms	Homo sapiens
Macromolecule	Catenin beta-1 (protein) F-box/WD repeat-containing protein 1A (protein) Skp1 (protein)
Unique Ligands	J91, PO4

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6M91 \| pdb_00006m91	Download File View File

Monophosphorylated pSer33 b-Catenin peptide, b-TrCP/Skp1, NRX-103094 ternary complex

Simonetta, K.R., Clifton, M.C., Walter, R.L., Ranieri, G.M., Carter, J.J.

(2019) Nat Commun 10: 1402-1402

Released	2019-04-03
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	Catenin beta-1 (protein) F-box/WD repeat-containing protein 1A (protein) S-phase kinase-associated protein 1 (protein)
Unique Ligands	CL, J97, PO4

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6M92 \| pdb_00006m92	Download File View File

Monophosphorylated pSer33 b-Catenin peptide, b-TrCP/Skp1, NRX-2663 ternary complex

Simonetta, K.R., Clifton, M.C., Walter, R.L., Ranieri, G.M., Carter, J.J., Lee, S.J.

(2019) Nat Commun 10: 1402-1402

Released	2019-04-03
Method	X-RAY DIFFRACTION 2.35 Å
Organisms	Homo sapiens
Macromolecule	Catenin beta-1 (protein) F-box/WD repeat-containing protein 1A (protein) S-phase kinase-associated protein 1 (protein)
Unique Ligands	J8V, PO4

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6M93 \| pdb_00006m93	Download File View File

Monophosphorylated pSer33 b-Catenin peptide, b-TrCP/Skp1, NRX-1933 ternary complex

Simonetta, K.R., Clifton, M.C., Walter, R.L., Ranieri, G.M., Lee, S.J.

(2019) Nat Commun 10: 1402-1402

Released	2019-04-03
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Homo sapiens
Macromolecule	Catenin beta-1 (protein) F-box/WD repeat-containing protein 1A (protein) S-phase kinase-associated protein 1 (protein)
Unique Ligands	J8Y, PO4

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6M94 \| pdb_00006m94	Download File View File

Monophosphorylated pSer33 b-Catenin peptide bound to b-TrCP/Skp1 Complex

Simonetta, K.R., Clifton, M.C., Walter, R.L., Ranieri, G.M., Carter, J.J.

(2019) Nat Commun 10: 1402-1402

Released	2019-04-03
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Homo sapiens
Macromolecule	Catenin beta-1 (protein) F-box/WD repeat-containing protein 1A (protein) S-phase kinase-associated protein 1 (protein)
Unique Ligands	DMS, PO4

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6O6F \| pdb_00006o6f	Download File View File

Co-crystal structure of Mcl1 with inhibitor

Huang, X.

(2018) Cancer Discov 8: 1582-1597

Released	2019-05-15
Method	X-RAY DIFFRACTION 1.6 Å
Organisms	Homo sapiens
Macromolecule	Induced myeloid leukemia cell differentiation protein Mcl-1 (protein)
Unique Ligands	LOD

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6O6G \| pdb_00006o6g	Download File View File

Co-crystal structure of Mcl1 with inhibitor

Huang, X.

(2018) Cancer Discov 8: 1582-1597

Released	2019-05-15
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	Induced myeloid leukemia cell differentiation protein Mcl-1 (protein)
Unique Ligands	LOJ

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6OQB \| pdb_00006oqb	Download File View File

Co-crystal structure of Mcl1 with inhibitor 10

Huang, X.

(2018) Cancer Discov 8: 1582-1597

Released	2019-05-15
Method	X-RAY DIFFRACTION 1.6 Å
Organisms	Homo sapiens
Macromolecule	Induced myeloid leukemia cell differentiation protein Mcl-1 (protein)
Unique Ligands	N0J

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6OQD \| pdb_00006oqd	Download File View File

Crystal structure of Mcl1 with inhibitor 8

Huang, X.

(2018) Cancer Discov 8: 1582-1597

Released	2019-05-15
Method	X-RAY DIFFRACTION 1.48 Å
Organisms	Homo sapiens
Macromolecule	Induced myeloid leukemia cell differentiation protein Mcl-1 (protein)
Unique Ligands	N0M

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6OQN \| pdb_00006oqn	Download File View File

Crystal structure of Mcl1 with inhibitor 7

Huang, X.

(2018) Cancer Discov 8: 1582-1597

Released	2019-05-15
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Homo sapiens
Macromolecule	Induced myeloid leukemia cell differentiation protein Mcl-1 (protein)
Unique Ligands	N0P

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6OVC \| pdb_00006ovc	Download File View File

hMcl1 inhibitor complex

Poppe, L.

(2018) Cancer Discov 8: 1582-1597

Released	2019-05-22
Method	SOLUTION NMR
Organisms	Homo sapiens
Macromolecule	Induced myeloid leukemia cell differentiation protein Mcl-1 (protein)
Unique Ligands	N8J

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6UD2 \| pdb_00006ud2	Download File View File

co-crystal structure of compound 1 bound to human Mcl-1

Huang, X., Whittington, D.

(2019) J Med Chem 62: 10258-10271

Released	2019-12-04
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Homo sapiens
Macromolecule	Induced myeloid leukemia cell differentiation protein Mcl-1 (protein)
Unique Ligands	Q4D

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6UDI \| pdb_00006udi	Download File View File

X-ray co-crystal structure of compound 20 with Mcl-1

Huang, X., Whittington, D.

(2019) J Med Chem 62: 10258-10271

Released	2019-12-04
Method	X-RAY DIFFRACTION 1.94 Å
Organisms	Homo sapiens
Macromolecule	Induced myeloid leukemia cell differentiation protein Mcl-1 (protein)
Unique Ligands	Q4S

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6UDT \| pdb_00006udt	Download File View File

X-ray co-crystal structure of compound 10 bound to human Mcl-1

Huang, X., Whittington, D.

(2019) J Med Chem 62: 10258-10271

Released	2019-12-04
Method	X-RAY DIFFRACTION 1.5 Å
Organisms	Homo sapiens
Macromolecule	Induced myeloid leukemia cell differentiation protein Mcl-1 (protein)
Unique Ligands	Q4V

1 to 25 of 29 Structures

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

3OQ1 | pdb_00003oq1

4DT6 | pdb_00004dt6

4DUM | pdb_00004dum

4FJY | pdb_00004fjy

4FJZ | pdb_00004fjz

4L02 | pdb_00004l02

4WWN | pdb_00004wwn

4WWO | pdb_00004wwo

4WWP | pdb_00004wwp

5EDS | pdb_00005eds

5KAE | pdb_00005kae

6M90 | pdb_00006m90

6M91 | pdb_00006m91

6M92 | pdb_00006m92

6M93 | pdb_00006m93

6M94 | pdb_00006m94

6O6F | pdb_00006o6f

6O6G | pdb_00006o6g

6OQB | pdb_00006oqb

6OQD | pdb_00006oqd

6OQN | pdb_00006oqn

6OVC | pdb_00006ovc

6UD2 | pdb_00006ud2

6UDI | pdb_00006udi

6UDT | pdb_00006udt