QUERY: Citation Author = "Congreve, M."
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Search Summary This query matches 18 Structures.
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1 to 18 of 18 Structures
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3LC5 | pdb_00003lc5

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Selective Benzothiophine Inhibitors of Factor IXa

Wang, S., Beck, R.

(2010) J Med Chem 53: 1473-1482

Released2010-02-23
Method
X-RAY DIFFRACTION 2.62 Å
Organisms
Macromolecule
Unique LigandsCA, IZX
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4AUA | pdb_00004aua

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Liganded X-ray crystal structure of cyclin dependent kinase 6 (CDK6)

Cho, Y.S., Angove, H., Brain, C., Chen, C.H.T., Cheng, R., Chopra, R., Chung, K., Congreve, M., Dagostin, C., Davis, D., Feltell, R., Giraldes, J., Hiscock, S., Kim, S., Kovats, S., Lagu, B., Lewry, K., Loo, A., Lu, Y., Luzzio, M., Maniara, W., Mcmenamin, R., Mortenson, P., Benning, R., O'Reilly, M., Rees, D., Shen, J., Smith, T., Wang, Y., Williams, G., Woolford, A., Wrona, W., Xu, M., Yang, F., Howard, S.

(2012) ACS Med Chem Lett 3: 445-449

Released2013-02-06
Method
X-RAY DIFFRACTION 2.31 Å
Organisms
Macromolecule
Unique Ligands4AU
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4EZ5 | pdb_00004ez5

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CDK6 (monomeric) in complex with inhibitor

Chopra, R., Xu, M.

(2012) ACS Med Chem Lett 3: 445-449

Released2013-02-06
Method
X-RAY DIFFRACTION 2.7 Å
Organisms
Macromolecule
Unique Ligands0RS
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6TV3 | pdb_00006tv3

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HumRadA1 in complex with 3-amino-2-naphthoic acid

Marsh, M.E., Hyvonen, M.

(2021) Cell Chem Biol 28: 835

Released2021-01-27
Method
X-RAY DIFFRACTION 1.5 Å
Organisms
Macromolecule
Unique LigandsGOL, NYE, PO4
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6TW3 | pdb_00006tw3

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HumRadA2 in complex with Naphthyl-HPA fragment-peptide chimera

Marsh, M.E., Fischer, G., Scott, D.E., Coyne, A.G., Skidmore, J., Abell, C., Hyvonen, M.

(2021) Cell Chem Biol 28: 835

Released2021-01-27
Method
X-RAY DIFFRACTION 1.352 Å
Organisms
Macromolecule
Unique LigandsO0E, PO4
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6TW4 | pdb_00006tw4

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HumRadA22F in complex with compound 6

Marsh, M.E., Scott, D.E., Coyne, A.G., Skidmore, J., Abell, C., Hyvonen, M.

(2021) Cell Chem Biol 28: 835

Released2021-01-27
Method
X-RAY DIFFRACTION 1.73 Å
Organisms
Macromolecule
Unique LigandsCA, NZW
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6TW9 | pdb_00006tw9

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HumRadA22F in complex with CAM833

Fischer, G., Marsh, M.E., Scott, D.E., Coyne, A.G., Skidmore, J., Abell, C., Hyvonen, M.

(2021) Cell Chem Biol 28: 835

Released2021-01-27
Method
X-RAY DIFFRACTION 1.52 Å
Organisms
Macromolecule
Unique LigandsCA, GOL, O08
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6XTW | pdb_00006xtw

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HumRadA33F in complex with peptidic inhibitor 6

Fischer, G., Marsh, M.E., Scott, D.E., Coyne, A.G., Skidmore, J., Abell, C., Hyvonen, M.

(2021) Cell Chem Biol 28: 835

Released2021-01-27
Method
X-RAY DIFFRACTION 2.31 Å
Organisms
Macromolecule
Unique LigandsNZW, SO4
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8C14 | pdb_00008c14

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Aurora A kinase in complex with TPX2-inhibitor 9

Fischer, G., Rocaboy, M., Blaszczyk, B., Moschetti, T., Wang, X., Scott, D.E., Coyne, A.G., Dagostin, C., Rooney, T., Bayly, A., Feng, J., Asteian, A., Alcaide-Lopez, A., Stockwell, S., Skidmore, J., Venkitaraman, A.R., Abell, C., Blundell, T.L., Hyvonen, M.

(2024) J Med Chem 67: 15521-15536

Released2024-01-10
Method
X-RAY DIFFRACTION 1.93 Å
Organisms
Macromolecule
Unique LigandsACT, ADP, CL, DMS, GOL, MG, SO4, T0L, T5L
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8C15 | pdb_00008c15

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Aurora A kinase in complex with TPX2-inhibitor 3

Fischer, G., Rocaboy, M., Blaszczyk, B., Moschetti, T., Wang, X., Scott, D.E., Coyne, A.G., Dagostin, C., Rooney, T., Bayly, A., Feng, J., Asteian, A., Alcaide-Lopez, A., Stockwell, S., Skidmore, J., Venkitaraman, A.R., Abell, C., Blundell, T.L., Hyvonen, M.

(2024) J Med Chem 67: 15521-15536

Released2024-01-10
Method
X-RAY DIFFRACTION 2.41 Å
Organisms
Macromolecule
Unique LigandsACT, ADP, DMS, MG, SO4, T4C, T5L
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8C1D | pdb_00008c1d

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Aurora A kinase in complex with TPX2-inhibitor 9

Fischer, G., Rocaboy, M., Blaszczyk, B., Moschetti, T., Wang, X., Scott, D.E., Coyne, A.G., Dagostin, C., Rooney, T., Bayly, A., Feng, J., Asteian, A., Alcaide-Lopez, A., Stockwell, S., Skidmore, J., Venkitaraman, A.R., Abell, C., Blundell, T.L., Hyvonen, M.

(2024) J Med Chem 67: 15521-15536

Released2024-01-10
Method
X-RAY DIFFRACTION 2.115 Å
Organisms
Macromolecule
Unique LigandsACT, ADP, DMS, MG, SO4, T2F, T5L
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8C1E | pdb_00008c1e

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Aurora A kinase in complex with TPX2-inhibitor 9

Fischer, G., Rocaboy, M., Blaszczyk, B., Moschetti, T., Wang, X., Scott, D.E., Coyne, A.G., Dagostin, C., Rooney, T., Bayly, A., Feng, J., Asteian, A., Alcaide-Lopez, A., Stockwell, S., Skidmore, J., Venkitaraman, A.R., Abell, C., Blundell, T.L., Hyvonen, M.

(2024) J Med Chem 67: 15521-15536

Released2024-01-10
Method
X-RAY DIFFRACTION 2.798 Å
Organisms
Macromolecule
Unique LigandsATP, MG, T0X
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8C1F | pdb_00008c1f

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Aurora A kinase in complex with TPX2-inhibitor 6

Fischer, G., Rocaboy, M., Blaszczyk, B., Moschetti, T., Wang, X., Scott, D.E., Coyne, A.G., Dagostin, C., Rooney, T., Bayly, A., Feng, J., Asteian, A., Alcaide-Lopez, A., Stockwell, S., Skidmore, J., Venkitaraman, A.R., Abell, C., Blundell, T.L., Hyvonen, M.

(2024) J Med Chem 67: 15521-15536

Released2024-01-10
Method
X-RAY DIFFRACTION 1.924 Å
Organisms
Macromolecule
Unique LigandsADP, DMS, GOL, MG, SO4, T2O, T5L
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8C1G | pdb_00008c1g

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Aurora A kinase in complex with TPX2-inhibitor 7

Fischer, G., Rocaboy, M., Blaszczyk, B., Moschetti, T., Wang, X., Scott, D.E., Coyne, A.G., Dagostin, C., Rooney, T., Bayly, A., Feng, J., Asteian, A., Alcaide-Lopez, A., Stockwell, S., Skidmore, J., Venkitaraman, A.R., Abell, C., Blundell, T.L., Hyvonen, M.

(2024) J Med Chem 67: 15521-15536

Released2024-01-10
Method
X-RAY DIFFRACTION 1.96 Å
Organisms
Macromolecule
Unique LigandsACT, ADP, DMS, GOL, MG, SO4, T3I, T5L
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8C1H | pdb_00008c1h

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Aurora A kinase in complex with TPX2-inhibitor 8

Fischer, G., Rocaboy, M., Blaszczyk, B., Moschetti, T., Wang, X., Scott, D.E., Coyne, A.G., Dagostin, C., Rooney, T., Bayly, A., Feng, J., Asteian, A., Alcaide-Lopez, A., Stockwell, S., Skidmore, J., Venkitaraman, A.R., Abell, C., Blundell, T.L., Hyvonen, M.

(2024) J Med Chem 67: 15521-15536

Released2024-01-10
Method
X-RAY DIFFRACTION 2.233 Å
Organisms
Macromolecule
Unique LigandsACT, ADP, CL, DMS, MG, SO4, T3U, T5L
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8C1I | pdb_00008c1i

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Aurora A kinase in complex with TPX2-inhibitor 10

Fischer, G., Rocaboy, M., Blaszczyk, B., Moschetti, T., Wang, X., Scott, D.E., Coyne, A.G., Dagostin, C., Rooney, T., Bayly, A., Feng, J., Asteian, A., Alcaide-Lopez, A., Stockwell, S., Skidmore, J., Venkitaraman, A.R., Abell, C., Blundell, T.L., Hyvonen, M.

(2024) J Med Chem 67: 15521-15536

Released2024-01-10
Method
X-RAY DIFFRACTION 2.81 Å
Organisms
Macromolecule
Unique LigandsACT, ADP, DMS, MG, SO4, T1L, T5L
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8C1K | pdb_00008c1k

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Aurora A kinase in complex with TPX2-inhibitor CAM2602

Fischer, G., Rocaboy, M., Blaszczyk, B., Moschetti, T., Wang, X., Scott, D.E., Coyne, A.G., Dagostin, C., Rooney, T., Bayly, A., Feng, J., Asteian, A., Alcaide-Lopez, A., Stockwell, S., Skidmore, J., Venkitaraman, A.R., Abell, C., Blundell, T.L., Hyvonen, M.

(2024) J Med Chem 67: 15521-15536

Released2024-01-10
Method
X-RAY DIFFRACTION 2.43 Å
Organisms
Macromolecule
Unique LigandsACT, ADP, DMS, MG, SO4, T4O, T5L
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8C1M | pdb_00008c1m

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Aurora A kinase in complex with TPX2-inhibitor 2

Fischer, G., Rocaboy, M., Blaszczyk, B., Moschetti, T., Wang, X., Scott, D.E., Coyne, A.G., Dagostin, C., Rooney, T., Bayly, A., Feng, J., Asteian, A., Alcaide-Lopez, A., Stockwell, S., Skidmore, J., Venkitaraman, A.R., Abell, C., Blundell, T.L., Hyvonen, M.

(2024) J Med Chem 67: 15521-15536

Released2024-01-10
Method
X-RAY DIFFRACTION 2.84 Å
Organisms
Macromolecule
Unique LigandsADP, MG, T4X
1 to 18 of 18 Structures
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