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233,605 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Citation Author = "Hiscock, S.D."

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Search Summary

This query matches 32 Structures.

Refinements

Structure Determination Methodology

experimental (32)

Scientific Name of Source Organism

	Homo sapiens (22)
	Hepatitis C virus (isolate BK) (10)

Taxonomy

	Eukaryota (22)
	Riboviria (10)

Experimental Method

X-RAY DIFFRACTION (32)

Polymer Entity Type

Protein (32)

Refinement Resolution (Å)

	1.5 - 2.0 (15)
	2.0 - 2.5 (9)
	2.5 - 3.0 (8)

Release Date

	2010 - 2014 (9)
	2015 - 2019 (3)
	2020 - 2024 (14)
	2025 - 2029 (6)

Enzyme Classification Name

	Hydrolases (24)
	Transferases (2)

Symmetry Type

	Asymmetric (22)
	Cyclic (10)

SCOP Classification

Alpha and beta proteins (a+b) (2)

AllSelected

1 to 25 of 32 Structures

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4AUA \| pdb_00004aua	Download File View File

Liganded X-ray crystal structure of cyclin dependent kinase 6 (CDK6)

Cho, Y.S., Angove, H., Brain, C., Chen, C.H.T., Cheng, R., Chopra, R., Chung, K., Congreve, M., Dagostin, C., Davis, D., Feltell, R., Giraldes, J., Hiscock, S., Kim, S., Kovats, S., Lagu, B., Lewry, K., Loo, A., Lu, Y., Luzzio, M., Maniara, W., Mcmenamin, R., Mortenson, P., Benning, R., O'Reilly, M., Rees, D., Shen, J., Smith, T., Wang, Y., Williams, G., Woolford, A., Wrona, W., Xu, M., Yang, F., Howard, S.

(2012) ACS Med Chem Lett 3: 445-449

Released	2013-02-06
Method	X-RAY DIFFRACTION 2.31 Å
Organisms	Homo sapiens
Macromolecule	CYCLIN-DEPENDENT KINASE 6 (protein)
Unique Ligands	4AU

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4B6E \| pdb_00004b6e	Download File View File

Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function

Saalau-Bethell, S.M., Woodhead, A.J., Chessari, G., Carr, M.G., Coyle, J., Graham, B., Hiscock, S.D., Murray, C.W., Pathuri, P., Rich, S.J., Richardson, C.J., Williams, P.A., Jhoti, H.

(2012) Nat Chem Biol 8: 920

Released	2012-10-03
Method	X-RAY DIFFRACTION 2.46 Å
Organisms	Hepatitis C virus (isolate BK)
Macromolecule	NON-STRUCTURAL PROTEIN 4A, SERINE PROTEASE NS3 (protein)
Unique Ligands	10L, SO4

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4B6F \| pdb_00004b6f	Download File View File

Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function

Saalau-Bethell, S.M., Woodhead, A.J., Chessari, G., Carr, M.G., Coyle, J., Graham, B., Hiscock, S.D., Murray, C.W., Pathuri, P., Rich, S.J., Richardson, C.J., Williams, P.A., Jhoti, H.

(2012) Nat Chem Biol 8: 920

Released	2012-10-03
Method	X-RAY DIFFRACTION 2.89 Å
Organisms	Hepatitis C virus (isolate BK)
Macromolecule	NON-STRUCTURAL PROTEIN 4A, SERINE PROTEASE NS3 (protein)
Unique Ligands	20L, SO4

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4B71 \| pdb_00004b71	Download File View File

Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function

Saalau-Bethell, S.M., Woodhead, A.J., Chessari, G., Carr, M.G., Coyle, J., Graham, B., Hiscock, S.D., Murray, C.W., Pathuri, P., Rich, S.J., Richardson, C.J., Williams, P.A., Jhoti, H.

(2012) Nat Chem Biol 8: 920

Released	2012-10-03
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Hepatitis C virus (isolate BK)
Macromolecule	NON-STRUCTURAL PROTEIN 4A, SERINE PROTEASE NS3 (protein)
Unique Ligands	DJL

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4B73 \| pdb_00004b73	Download File View File

Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function

Saalau-Bethell, S.M., Woodhead, A.J., Chessari, G., Carr, M.G., Coyle, J., Graham, B., Hiscock, S.D., Murray, C.W., Pathuri, P., Rich, S.J., Richardson, C.J., Williams, P.A., Jhoti, H.

(2012) Nat Chem Biol 8: 920

Released	2012-10-03
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Hepatitis C virus (isolate BK)
Macromolecule	NON-STRUCTURAL PROTEIN 4A, SERINE PROTEASE NS3 (protein)
Unique Ligands	4VA

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4B74 \| pdb_00004b74	Download File View File

Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function

Saalau-Bethell, S.M., Woodhead, A.J., Chessari, G., Carr, M.G., Coyle, J., Graham, B., Hiscock, S.D., Murray, C.W., Pathuri, P., Rich, S.J., Richardson, C.J., Williams, P.A., Jhoti, H.

(2012) Nat Chem Biol 8: 920

Released	2012-10-03
Method	X-RAY DIFFRACTION 2.18 Å
Organisms	Hepatitis C virus (isolate BK)
Macromolecule	NON-STRUCTURAL PROTEIN 4A, SERINE PROTEASE NS3 (protein)
Unique Ligands	1LH

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4B75 \| pdb_00004b75	Download File View File

Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function

Saalau-Bethell, S.M., Woodhead, A.J., Chessari, G., Carr, M.G., Coyle, J., Graham, B., Hiscock, S.D., Murray, C.W., Pathuri, P., Rich, S.J., Richardson, C.J., Williams, P.A., Jhoti, H.

(2012) Nat Chem Biol 8: 920

Released	2012-10-03
Method	X-RAY DIFFRACTION 2.53 Å
Organisms	Hepatitis C virus (isolate BK)
Macromolecule	NON-STRUCTURAL PROTEIN 4A, SERINE PROTEASE NS3 (protein)
Unique Ligands	4VA

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4B76 \| pdb_00004b76	Download File View File

Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function

Saalau-Bethell, S.M., Woodhead, A.J., Chessari, G., Carr, M.G., Coyle, J., Graham, B., Hiscock, S.D., Murray, C.W., Pathuri, P., Rich, S.J., Richardson, C.J., Williams, P.A., Jhoti, H.

(2012) Nat Chem Biol 8: 920

Released	2012-10-03
Method	X-RAY DIFFRACTION 2.14 Å
Organisms	Hepatitis C virus (isolate BK)
Macromolecule	NON-STRUCTURAL PROTEIN 4A, SERINE PROTEASE NS3 (protein)
Unique Ligands	PW1

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4EZ5 \| pdb_00004ez5	Download File View File

CDK6 (monomeric) in complex with inhibitor

Chopra, R., Xu, M.

(2012) ACS Med Chem Lett 3: 445-449

Released	2013-02-06
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Homo sapiens
Macromolecule	Cyclin-dependent kinase 6 (protein)
Unique Ligands	0RS

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5FPS \| pdb_00005fps	Download File View File

Structure of hepatitis C virus (HCV) full-length NS3 complex with small-molecule ligand 3-aminobenzene-1,2-dicarboxylic acid (AT1246) in an alternate binding site.

Jhoti, H., Ludlow, R.F., Saini, H.K., Tickle, I.J., Verdonk, M., Williams, P.A.

(2015) Proc Natl Acad Sci U S A 112: 15910

Released	2015-12-23
Method	X-RAY DIFFRACTION 2.68 Å
Organisms	Hepatitis C virus (isolate BK)
Macromolecule	HEPATITIS C VIRUS FULL-LENGTH NS3 COMPLEX (protein)
Unique Ligands	UP8

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5FPT \| pdb_00005fpt	Download File View File

Structure of hepatitis C virus (HCV) full-length NS3 complex with small-molecule ligand 2-(1-methyl-1H-indol-3-yl)acetic acid (AT3437) in an alternate binding site.

Jhoti, H., Ludlow, R.F., Saini, H.K., Tickle, I.J., Verdonk, M., Pathuri, P., Williams, P.A.

(2015) Proc Natl Acad Sci U S A 112: 15910

Released	2015-12-23
Method	X-RAY DIFFRACTION 2.72 Å
Organisms	Hepatitis C virus (isolate BK)
Macromolecule	HEPATITIS C VIRUS FULL-LENGTH NS3 COMPLEX (protein)
Unique Ligands	3VY

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5FPY \| pdb_00005fpy	Download File View File

Structure of hepatitis C virus (HCV) full-length NS3 complex with small-molecule ligand 5-bromo-1-methyl-1H-indole-2-carboxylic acid (AT21457) in an alternate binding site.

Davies, T.G., Jhoti, H., Ludlow, R.F., Saini, H.K., Tickle, I.J., Verdonk, M.

(2015) Proc Natl Acad Sci U S A 112: 15910

Released	2015-12-23
Method	X-RAY DIFFRACTION 2.52 Å
Organisms	Hepatitis C virus (isolate BK)
Macromolecule	SERINE PROTEASE NS3 (protein)
Unique Ligands	R2N

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8QM4 \| pdb_00008qm4	Download File View File

Potential drug binding sites for translation initiation factor eIF4E

Cleasby, A.

(2024) Nat Commun 15: 10037-10037

Released	2025-01-15
Method	X-RAY DIFFRACTION 1.849 Å
Organisms	Homo sapiens
Macromolecule	Eukaryotic translation initiation factor 4E (protein)
Unique Ligands	DMS, PGE, W5B

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8QM5 \| pdb_00008qm5	Download File View File

Potential drug binding sites for translation initiation factor eIF4E

Cleasby, A.

(2024) Nat Commun 15: 10037-10037

Released	2025-01-15
Method	X-RAY DIFFRACTION 1.889 Å
Organisms	Homo sapiens
Macromolecule	Eukaryotic translation initiation factor 4E (protein)
Unique Ligands	PGE, W4U

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8QM6 \| pdb_00008qm6	Download File View File

Potential drug binding sites for translation initiation factor eIF4E

Cleasby, A.

(2024) Nat Commun 15: 10037-10037

Released	2025-01-15
Method	X-RAY DIFFRACTION 1.93 Å
Organisms	Homo sapiens
Macromolecule	Eukaryotic translation initiation factor 4E (protein)
Unique Ligands	DMS, PEG, PGE, W2N, W4B

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8QM7 \| pdb_00008qm7	Download File View File

Potential drug binding sites for translation initiation factor eIF4E

Cleasby, A.

(2024) Nat Commun 15: 10037-10037

Released	2025-01-15
Method	X-RAY DIFFRACTION 2.191 Å
Organisms	Homo sapiens
Macromolecule	Eukaryotic translation initiation factor 4E (protein)
Unique Ligands	DMS, PEG, PGE, W5K

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8QM8 \| pdb_00008qm8	Download File View File

Potential drug binding sites for translation initiation factor eIF4E

Cleasby, A.

(2024) Nat Commun 15: 10037-10037

Released	2025-01-15
Method	X-RAY DIFFRACTION 1.585 Å
Organisms	Homo sapiens
Macromolecule	Eukaryotic translation initiation factor 4E (protein)
Unique Ligands	DMS, PEG, PGE, W4K

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8QM9 \| pdb_00008qm9	Download File View File

Potential drug binding sites for translation initiation factor eIF4E

Cleasby, A.

(2024) Nat Commun 15: 10037-10037

Released	2025-01-15
Method	X-RAY DIFFRACTION 1.973 Å
Organisms	Homo sapiens
Macromolecule	Eukaryotic translation initiation factor 4E (protein)
Unique Ligands	DMS, EDO, PEG, W4K

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8RZW \| pdb_00008rzw	Download File View File

A fragment-based inhibitor of SHP2

Cleasby, A., Price, A.

(2024) J Med Chem 67: 4655-4675

Released	2024-03-20
Method	X-RAY DIFFRACTION 2.02 Å
Organisms	Homo sapiens
Macromolecule	Tyrosine-protein phosphatase non-receptor type 11 (protein)
Unique Ligands	A1H4N

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8RZY \| pdb_00008rzy	Download File View File

A fragment-based inhibitor of SHP2

Cleasby, A., Price, A.

(2024) J Med Chem 67: 4655-4675

Released	2024-03-20
Method	X-RAY DIFFRACTION 1.91 Å
Organisms	Homo sapiens
Macromolecule	Tyrosine-protein phosphatase non-receptor type 11 (protein)
Unique Ligands	A1H4L, DMS

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8S01 \| pdb_00008s01	Download File View File

A fragment-based inhibitor of SHP2

Cleasby, A., Price, A.

(2024) J Med Chem 67: 4655-4675

Released	2024-03-20
Method	X-RAY DIFFRACTION 2.17 Å
Organisms	Homo sapiens
Macromolecule	Tyrosine-protein phosphatase non-receptor type 11 (protein)
Unique Ligands	A1H4J

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8S04 \| pdb_00008s04	Download File View File

A fragment-based inhibitor of SHP2

Cleasby, A., Price, A.

(2024) J Med Chem 67: 4655-4675

Released	2024-03-20
Method	X-RAY DIFFRACTION 1.89 Å
Organisms	Homo sapiens
Macromolecule	Tyrosine-protein phosphatase non-receptor type 11 (protein)
Unique Ligands	A1H4I

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8S06 \| pdb_00008s06	Download File View File

A fragment-based inhibitor of SHP2

Cleasby, A., Price, A.

(2024) J Med Chem 67: 4655-4675

Released	2024-03-20
Method	X-RAY DIFFRACTION 2.19 Å
Organisms	Homo sapiens
Macromolecule	Tyrosine-protein phosphatase non-receptor type 11 (protein)
Unique Ligands	A1H4M

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8S07 \| pdb_00008s07	Download File View File

A fragment-based inhibitor of SHP2

Cleasby, A., Price, A.

(2024) J Med Chem 67: 4655-4675

Released	2024-03-20
Method	X-RAY DIFFRACTION 1.83 Å
Organisms	Homo sapiens
Macromolecule	Tyrosine-protein phosphatase non-receptor type 11 (protein)
Unique Ligands	A1H4K, DMS, FMT

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8S0H \| pdb_00008s0h	Download File View File

A fragment-based inhibitor of SHP2

Cleasby, A., Price, A.

(2024) J Med Chem 67: 4655-4675

Released	2024-03-20
Method	X-RAY DIFFRACTION 1.99 Å
Organisms	Homo sapiens
Macromolecule	Tyrosine-protein phosphatase non-receptor type 11 (protein)
Unique Ligands	A1H4Q

1 to 25 of 32 Structures

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

4AUA | pdb_00004aua

4B6E | pdb_00004b6e

4B6F | pdb_00004b6f

4B71 | pdb_00004b71

4B73 | pdb_00004b73

4B74 | pdb_00004b74

4B75 | pdb_00004b75

4B76 | pdb_00004b76

4EZ5 | pdb_00004ez5

5FPS | pdb_00005fps

5FPT | pdb_00005fpt

5FPY | pdb_00005fpy

8QM4 | pdb_00008qm4

8QM5 | pdb_00008qm5

8QM6 | pdb_00008qm6

8QM7 | pdb_00008qm7

8QM8 | pdb_00008qm8

8QM9 | pdb_00008qm9

8RZW | pdb_00008rzw

8RZY | pdb_00008rzy

8S01 | pdb_00008s01

8S04 | pdb_00008s04

8S06 | pdb_00008s06

8S07 | pdb_00008s07

8S0H | pdb_00008s0h