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233,605 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Citation Author = "Liang, J."

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Search Summary

This query matches 172 Structures.

Refinements

Structure Determination Methodology

experimental (172)

Scientific Name of Source Organism

	Homo sapiens (85)
	Severe acute respiratory syndrome coronavirus 2 (18)
	Mycobacterium tuberculosis H37Rv (16)
	Mycolicibacterium smegmatis MC2 155 (13)
	Mus musculus (11)
	Escherichia coli (7)
	Lama glama (7)
	Staphylococcus aureus (5)
	Arabidopsis thaliana (4)
	Lentilactobacillus kefiri (4)

More...

Taxonomy

	Eukaryota (103)
	Bacteria (63)
	Riboviria (21)
	other sequences (4)

Experimental Method

	X-RAY DIFFRACTION (98)
	ELECTRON MICROSCOPY (73)
	SOLUTION NMR (1)

Polymer Entity Type

	Protein (172)
	DNA (3)
	RNA (2)

Refinement Resolution (Å)

	1.0 - 1.5 (1)
	1.5 - 2.0 (23)
	2.0 - 2.5 (45)
	2.5 - 3.0 (41)
	3.0 - 3.5 (41)
	3.5 - 4.0 (18)
	4.0 - 4.5 (1)
	> 4.5 (1)

Release Date

	1990 - 1994 (3)
	1995 - 1999 (4)
	2000 - 2004 (3)
	2005 - 2009 (6)
	2010 - 2014 (21)
	2015 - 2019 (25)
	2020 - 2024 (101)
	2025 - 2029 (9)

Enzyme Classification Name

	Transferases (35)
	Oxidoreductases (22)
	Hydrolases (24)
	Translocases (10)
	Isomerases (9)
	Ligases (3)
	Lyases (1)

Membrane Protein Annotation

	PDBTM (49)
	mpstruc (24)
	MemProtMD (23)
	OPM (20)

Symmetry Type

	Asymmetric (126)
	Cyclic (41)
	Dihedral (7)

SCOP Classification

	Alpha and beta proteins (a+b) (30)
	All alpha proteins (13)
	Alpha and beta proteins (a/b) (10)
	Artifacts (12)
	Membrane and cell surface proteins and peptides (2)
	All beta proteins (3)

AllSelected

1 to 25 of 172 Structures

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1CMI \| pdb_00001cmi	Download File View File

STRUCTURE OF THE HUMAN PIN/LC8 DIMER WITH A BOUND PEPTIDE

Liang, J., Guo, W., Jaffery, S., Snyder, S., Clardy, J.

(1999) Nat Struct Biol 6: 735-740

Released	2000-02-21
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Homo sapiens Mus musculus
Macromolecule	Dynein light chain 1, cytoplasmic (protein) Nitric oxide synthase 1 (protein)

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1FKG \| pdb_00001fkg	Download File View File

DESIGN, SYNTHESIS, AND KINETIC EVALUATION OF HIGH-AFFINITY FKBP LIGANDS, AND THE X-RAY CRYSTAL STRUCTURES OF THEIR COMPLEXES WITH FKBP12

Holt, D.A., Luengo, J.I., Yamashita, D.S., Oh, H.-J., Konialian, A.L., Yen, H.-K., Rozamus, L.W., Brandt, M., Bossard, M.J., Levy, M.A., Eggleston, D.S., Stout, T.J., Liang, J., Schultz, L.W., Clardy, J.

(1993) J Am Chem Soc 115: 9925-9938

Released	1994-01-31
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	FK506 BINDING PROTEIN (protein)
Unique Ligands	SB3

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1FKH \| pdb_00001fkh	Download File View File

DESIGN, SYNTHESIS, AND KINETIC EVALUATION OF HIGH-AFFINITY FKBP LIGANDS, AND THE X-RAY CRYSTAL STRUCTURES OF THEIR COMPLEXES WITH FKBP12

(1993) J Am Chem Soc 115: 9925-9938

Released	1994-01-31
Method	X-RAY DIFFRACTION 1.95 Å
Organisms	Homo sapiens
Macromolecule	FK506 BINDING PROTEIN (protein)
Unique Ligands	SBX

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1FKI \| pdb_00001fki	Download File View File

DESIGN, SYNTHESIS, AND KINETIC EVALUATION OF HIGH-AFFINITY FKBP LIGANDS, AND THE X-RAY CRYSTAL STRUCTURES OF THEIR COMPLEXES WITH FKBP12

(1993) J Am Chem Soc 115: 9925-9938

Released	1994-01-31
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens
Macromolecule	FK506 BINDING PROTEIN (protein)
Unique Ligands	SB1

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1NSG \| pdb_00001nsg	Download File View File

THE STRUCTURE OF THE IMMUNOPHILIN-IMMUNOSUPPRESSANT FKBP12-RAPAMYCIN COMPLEX INTERACTING WITH HUMAN FRAP

Liang, J., Choi, J., Clardy, J.

(1999) Acta Crystallogr D Biol Crystallogr 55: 736-744

Released	1998-03-18
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens
Macromolecule	FK506-BINDING PROTEIN (protein) FKBP-RAPAMYCIN ASSOCIATED PROTEIN (FRAP) (protein)
Unique Ligands	RAD

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1PBK \| pdb_00001pbk	Download File View File

HOMOLOGOUS DOMAIN OF HUMAN FKBP25

Liang, J., Hung, D.T., Schreiber, S.L., Clardy, J.

(1996) J Am Chem Soc 118: 1231-1232

Released	1996-10-14
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Homo sapiens
Macromolecule	FKBP25 (protein)
Unique Ligands	RAP

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1PHT \| pdb_00001pht	Download File View File

PHOSPHATIDYLINOSITOL 3-KINASE P85-ALPHA SUBUNIT SH3 DOMAIN, RESIDUES 1-85

Liang, J., Chen, J.K., Schreiber, S.L., Clardy, J.

(1996) J Mol Biology 257: 632-643

Released	1995-12-07
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	PHOSPHATIDYLINOSITOL 3-KINASE P85-ALPHA SUBUNIT (protein)

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1ZRR \| pdb_00001zrr	Download File View File

Residual Dipolar Coupling Refinement of Acireductone Dioxygenase from Klebsiella

Pochapsky, T.C., Pochapsky, S.S., Ju, T., Hoefler, C., Liang, J.

(2006) J Biomol NMR 34: 117-127

Released	2005-12-06
Method	SOLUTION NMR
Organisms	Klebsiella oxytoca
Macromolecule	E-2/E-2' protein (protein)
Unique Ligands	NI

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2FAP \| pdb_00002fap	Download File View File

THE STRUCTURE OF THE IMMUNOPHILIN-IMMUNOSUPPRESSANT FKBP12-(C16)-ETHOXY RAPAMYCIN COMPLEX INTERACTING WITH HUMA

Liang, J., Choi, J., Clardy, J.

(1999) Acta Crystallogr D Biol Crystallogr 55: 736-744

Released	1999-05-18
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens
Macromolecule	FK506-BINDING PROTEIN (protein) FRAP (protein)
Unique Ligands	RAD

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3COH \| pdb_00003coh	Download File View File

Crystal structure of Aurora-A in complex with a pentacyclic inhibitor

Wiesmann, C., Raswson, T.E., Cochran, A.G.

(2008) J Med Chem 51: 4465-4475

Released	2009-02-17
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Homo sapiens
Macromolecule	Serine/threonine-protein kinase 6 (protein)
Unique Ligands	83H

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3FAP \| pdb_00003fap	Download File View File

ATOMIC STRUCTURES OF THE RAPAMYCIN ANALOGS IN COMPLEX WITH BOTH HUMAN FKBP12 AND FRB DOMAIN OF FRAP

Liang, J., Clardy, J.

(1999) Acta Crystallogr D Biol Crystallogr 55: 736-744

Released	2000-09-13
Method	X-RAY DIFFRACTION 1.85 Å
Organisms	Homo sapiens
Macromolecule	FK506-BINDING PROTEIN (protein) FKBP12-RAPAMYCIN ASSOCIATED PROTEIN (protein)
Unique Ligands	ARD

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3H0Y \| pdb_00003h0y	Download File View File

Aurora A in complex with a bisanilinopyrimidine

Wiesmann, C., Ultsch, M.H., Cochran, A.G.

(2009) J Med Chem 52: 3300-3307

Released	2009-07-07
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Homo sapiens
Macromolecule	Serine/threonine-protein kinase 6 (protein)
Unique Ligands	48B, SO4

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3H0Z \| pdb_00003h0z	Download File View File

Aurora A in complex with a bisanilinopyrimidine

Wiesmann, C., Ultsch, M.H., Cochran, A.G.

(2009) J Med Chem 52: 3300-3307

Released	2009-07-07
Method	X-RAY DIFFRACTION 2.92 Å
Organisms	Homo sapiens
Macromolecule	Serine/threonine-protein kinase 6 (protein)
Unique Ligands	45B

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3H10 \| pdb_00003h10	Download File View File

Aurora A inhibitor complex

Wiesmann, C., Ultsch, M.H., Cochran, A.G.

(2009) J Med Chem 52: 3300-3307

Released	2009-07-07
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens
Macromolecule	Serine/threonine-protein kinase 6 (protein)
Unique Ligands	97B

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3IMX \| pdb_00003imx	Download File View File

Crystal Structure of human glucokinase in complex with a synthetic activator

Stams, T., Vash, B.

(2009) J Med Chem 52: 6142-6152

Released	2009-10-06
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	Glucokinase (protein)
Unique Ligands	B84, GLC, NA

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3NYX \| pdb_00003nyx	Download File View File

Non-phosphorylated TYK2 JH1 domain with Quinoline-Thiadiazole-Thiophene Inhibitor

Eigenbrot, C., Ultsch, M.

(2011) Proteins 79: 393-401

Released	2010-10-20
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Homo sapiens
Macromolecule	Non-receptor tyrosine-protein kinase TYK2 (protein)
Unique Ligands	DTT, TZ1

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3NZ0 \| pdb_00003nz0	Download File View File

Non-phosphorylated TYK2 kinase with CMP6

Eigenbrot, C., Ultsch, M.

(2011) Proteins 79: 393-401

Released	2010-10-20
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	Non-receptor tyrosine-protein kinase TYK2 (protein)
Unique Ligands	IZA

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3PZ7 \| pdb_00003pz7	Download File View File

Crystal structure of Ccd1-DIX domain

Liu, Y.T., Wang, J.W., Chen, L., Wu, J.W.

To be published

Released	2010-12-29
Method	X-RAY DIFFRACTION 2.441 Å
Organisms	Homo sapiens
Macromolecule	Dixin (protein)
Unique Ligands	EDO

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3PZ8 \| pdb_00003pz8	Download File View File

Crystal structure of Dvl1-DIX(Y17D) mutant

Dan, Q.J., Chen, L., Zhang, Y.Y., Liu, Y.T., Wu, J.W.

To be published

Released	2010-12-29
Method	X-RAY DIFFRACTION 2.873 Å
Organisms	Mus musculus
Macromolecule	Segment polarity protein dishevelled homolog DVL-1 (protein)

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3VAX \| pdb_00003vax	Download File View File

Crystal structure of DndA from streptomyces lividans

Zhang, Z., Chen, F., Lin, K., Wu, G.

(2012) PLoS One 7: e36635-e36635

Released	2013-01-02
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Streptomyces lividans
Macromolecule	Putative uncharacterized protein dndA (protein)
Unique Ligands	PLP

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4DXB \| pdb_00004dxb	Download File View File

2.29A structure of the engineered MBP TEM-1 fusion protein RG13 in complex with zinc, P1 space group

van den Akker, F., Ke, W.

(2012) PLoS One 7: e39168-e39168

Released	2012-08-08
Method	X-RAY DIFFRACTION 2.29 Å
Organisms	Escherichia coli
Macromolecule	Maltose-binding periplasmic protein, Beta-lactamase TEM chimera (protein)
Unique Ligands	ZN

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4DXC \| pdb_00004dxc	Download File View File

Crystal structure of the engineered MBP TEM-1 fusion protein RG13, C2 space group

van den Akker, F., Ke, W.

(2012) PLoS One 7: e39168-e39168

Released	2012-08-08
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Escherichia coli
Macromolecule	Maltose-binding periplasmic protein, Beta-lactamase TEM chimera (protein)
Unique Ligands	ZN

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4FAP \| pdb_00004fap	Download File View File

ATOMIC STRUCTURES OF THE RAPAMYCIN ANALOGS IN COMPLEX WITH BOTH HUMAN FKBP12 AND FRB DOMAIN OF FRAP

Liang, J., Clardy, J.

(1999) Acta Crystallogr D Biol Crystallogr 55: 736-744

Released	2000-09-13
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Homo sapiens
Macromolecule	FK506-BINDING PROTEIN (protein) FKBP12-RAPAMYCIN ASSOCIATED PROTEIN (protein)
Unique Ligands	ARD

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4GFM \| pdb_00004gfm	Download File View File

JAK2 kinase (JH1 domain) with 2,6-DICHLORO-N-(2-OXO-2,5-DIHYDROPYRIDIN-4-YL)BENZAMIDE

Eigenbrot, C., Ultsch, M.

(2013) Eur J Med Chem 67: 175-187

Released	2013-06-19
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Homo sapiens
Macromolecule	Tyrosine-protein kinase JAK2 (protein)
Unique Ligands	0X2

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4GFO \| pdb_00004gfo	Download File View File

TYK2 kinase (JH1 domain) with 2,6-DICHLORO-N-(2-OXO-2,5-DIHYDROPYRIDIN-4-YL)BENZAMIDE

Eigenbrot, C., Ultsch, M.

(2013) Eur J Med Chem 67: 175-187

Released	2013-06-19
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Homo sapiens
Macromolecule	Non-receptor tyrosine-protein kinase TYK2 (protein)
Unique Ligands	0X2, EDO, GOL, SO4

1 to 25 of 172 Structures

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Membrane Protein Annotation

Symmetry Type

SCOP Classification

1CMI | pdb_00001cmi

1FKG | pdb_00001fkg

1FKH | pdb_00001fkh

1FKI | pdb_00001fki

1NSG | pdb_00001nsg

1PBK | pdb_00001pbk

1PHT | pdb_00001pht

1ZRR | pdb_00001zrr

2FAP | pdb_00002fap

3COH | pdb_00003coh

3FAP | pdb_00003fap

3H0Y | pdb_00003h0y

3H0Z | pdb_00003h0z

3H10 | pdb_00003h10

3IMX | pdb_00003imx

3NYX | pdb_00003nyx

3NZ0 | pdb_00003nz0

3PZ7 | pdb_00003pz7

3PZ8 | pdb_00003pz8

3VAX | pdb_00003vax

4DXB | pdb_00004dxb

4DXC | pdb_00004dxc

4FAP | pdb_00004fap

4GFM | pdb_00004gfm

4GFO | pdb_00004gfo