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233,605 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Citation Author = "Mesters, J.R."

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Search Summary

This query matches 72 Structures.

Refinements

Structure Determination Methodology

experimental (72)

Scientific Name of Source Organism

	Coxsackievirus B3 (13)
	enterovirus D68 (9)
	Homo sapiens (7)
	Escherichia coli (5)
	Gallus gallus (5)
	Severe acute respiratory syndrome-related coronavirus (4)
	Aquifex aeolicus (3)
	Human coronavirus 229E (3)
	Fulvia fulva (2)
	Human immunodeficiency virus 1 (2)

More...

Taxonomy

	Riboviria (38)
	Eukaryota (17)
	Bacteria (14)
	Archaea (4)

Experimental Method

X-RAY DIFFRACTION (72)

Polymer Entity Type

Protein (72)

Refinement Resolution (Å)

	1.0 - 1.5 (3)
	1.5 - 2.0 (23)
	2.0 - 2.5 (35)
	2.5 - 3.0 (10)
	3.5 - 4.0 (1)

Release Date

	2000 - 2004 (7)
	2005 - 2009 (20)
	2010 - 2014 (32)
	2015 - 2019 (8)
	2020 - 2024 (5)

Enzyme Classification Name

	Hydrolases (50)
	Oxidoreductases (6)
	Transferases (4)

Membrane Protein Annotation

	mpstruc (2)
	OPM (1)

Symmetry Type

	Cyclic (51)
	Asymmetric (19)
	Dihedral (6)

SCOP Classification

	All beta proteins (36)
	Alpha and beta proteins (a/b) (19)
	Artifacts (26)
	All alpha proteins (6)
	Alpha and beta proteins (a+b) (3)

AllSelected

1 to 25 of 72 Structures

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1EXM \| pdb_00001exm	Download File View File

CRYSTAL STRUCTURE OF THERMUS THERMOPHILUS ELONGATION FACTOR TU (EF-TU) IN COMPLEX WITH THE GTP ANALOGUE GPPNHP.

Hogg, T., Mesters, J.R., Hilgenfeld, R.

(2000) The Ribosome: Structure, Function, Antibiotics, And Cellular Interactions 28: 347-357

Released	2000-06-07
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Thermus thermophilus
Macromolecule	ELONGATION FACTOR TU (EF-TU) (protein)
Unique Ligands	GNP, MG

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1HA3 \| pdb_00001ha3	Download File View File

ELONGATION FACTOR TU IN COMPLEX WITH aurodox

Vogeley, L., Palm, G.J., Mesters, J.R., Hilgenfeld, R.

(2001) J Biological Chem 276: 17149

Released	2001-05-15
Method	X-RAY DIFFRACTION 2 Å
Organisms	Thermus thermophilus HB8
Macromolecule	ELONGATION FACTOR TU (protein)
Unique Ligands	BME, GDP, MAU, MG

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1IZH \| pdb_00001izh	Download File View File

Inhibitor of HIV protease with unusual binding mode potently inhibiting multi-resistant protease mutants

Weber, J., Mesters, J.R., Lepsik, M., Prejdova, J., Svec, M., Sponarova, J., Mlcochova, P., Skalicka, K., Strisovsky, K., Uhlikova, T., Soucek, M., Machala, L., Stankova, M., Vondrasek, J., Klimkait, T., Kraeusslich, H.-G., Hilgenfeld, R., Konvalinka, J.

(2002) J Mol Biology 324: 739-754

Released	2002-12-23
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Human immunodeficiency virus 1
Macromolecule	proteinase (protein)
Unique Ligands	Q50

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1IZI \| pdb_00001izi	Download File View File

Inhibitor of HIV protease with unusual binding mode potently inhibiting multi-resistant protease mutants

(2002) J Mol Biology 324: 739-754

Released	2002-12-23
Method	X-RAY DIFFRACTION 2.15 Å
Organisms	Human immunodeficiency virus 1
Macromolecule	proteinase (protein)
Unique Ligands	CL, Q50

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1LVO \| pdb_00001lvo	Download File View File

Structure of coronavirus main proteinase reveals combination of a chymotrypsin fold with an extra alpha-helical domain

Anand, K., Palm, G.J., Mesters, J.R., Siddell, S.G., Ziebuhr, J., Hilgenfeld, R.

(2002) EMBO J 21: 3213-3224

Released	2002-07-17
Method	X-RAY DIFFRACTION 1.96 Å
Organisms	Transmissible gastroenteritis virus
Macromolecule	Replicase, hydrolase domain (protein)
Unique Ligands	DIO, MRD, SO4

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1P9S \| pdb_00001p9s	Download File View File

Coronavirus Main Proteinase (3CLpro) Structure: Basis for Design of anti-SARS Drugs

Anand, K., Ziebuhr, J., Wadhwani, P., Mesters, J.R., Hilgenfeld, R.

(2003) Science 300: 1763-1767

Released	2003-05-20
Method	X-RAY DIFFRACTION 2.54 Å
Organisms	Human coronavirus 229E
Macromolecule	Replicase polyprotein 1ab (protein)
Unique Ligands	DIO

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1P9U \| pdb_00001p9u	Download File View File

Coronavirus Main Proteinase (3CLpro) Structure: Basis for Design of anti-SARS Drugs

Anand, K., Ziebuhr, J., Wadhwani, P., Mesters, J.R., Hilgenfeld, R.

(2003) Science 300: 1763-1767

Released	2003-05-20
Method	X-RAY DIFFRACTION 2.37 Å
Organisms	Transmissible gastroenteritis virus
Macromolecule	PHQ-VNSTLQ-CHLOROMETHYLKETONE INHIBITOR (protein) putative coronavirus nsp2 (3CL-PRO) (protein)
Unique Ligands	MRD, SO4

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2BX3 \| pdb_00002bx3	Download File View File

Crystal Structure of SARS Coronavirus Main Proteinase (P43212)

Verschueren, K.H.G., Mesters, J.R., Hilgenfeld, R.

(2005) J Mol Biology 354: 25

Released	2005-09-26
Method	X-RAY DIFFRACTION 2 Å
Organisms	SARS coronavirus Sin2774
Macromolecule	3C-like proteinase nsp5 (protein)

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2BX4 \| pdb_00002bx4	Download File View File

Crystal Structure of SARS Coronavirus Main Proteinase (P21212)

Verschueren, K.H.G., Mesters, J.R., Bigalke, J., Hilgenfeld, R.

(2005) J Mol Biology 354: 25

Released	2005-09-26
Method	X-RAY DIFFRACTION 2.79 Å
Organisms	SARS coronavirus Sin2774
Macromolecule	3C-like proteinase nsp5 (protein)

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2C6C \| pdb_00002c6c	Download File View File

membrane-bound glutamate carboxypeptidase II (GCPII) in complex with GPI-18431 (S)-2-(4-iodobenzylphosphonomethyl)-pentanedioic acid

Mesters, J.R., Barinka, C., Li, W., Tsukamoto, T., Majer, P., Slusher, B.S., Konvalinka, J., Hilgenfeld, R.

(2006) EMBO J 25: 1375

Released	2006-02-15
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	GLUTAMATE CARBOXYPEPTIDASE II (protein)
Unique Ligands	24I, CA, CL, NAG, ZN
Unique branched monosaccharides	MAN, NAG

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2C6G \| pdb_00002c6g	Download File View File

Membrane-bound glutamate carboxypeptidase II (GCPII) with bound glutamate

Mesters, J.R., Barinka, C., Li, W., Tsukamoto, T., Majer, P., Slusher, B.S., Konvalinka, J., Hilgenfeld, R.

(2006) EMBO J 25: 1375-1384

Released	2006-02-15
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens
Macromolecule	GLUTAMATE CARBOXYPEPTIDASE II (protein)
Unique Ligands	CA, CL, GLU, NAG, ZN
Unique branched monosaccharides	BMA, MAN, NAG

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2C6P \| pdb_00002c6p	Download File View File

Membrane-bound glutamate carboxypeptidase II (GCPII) in complex with phosphate anion

Mesters, J.R., Barinka, C., Li, W., Tsukamoto, T., Majer, P., Slusher, B.S., Konvalinka, J., Hilgenfeld, R.

(2006) EMBO J 25: 1375

Released	2006-02-15
Method	X-RAY DIFFRACTION 2.39 Å
Organisms	Homo sapiens
Macromolecule	GLUTAMATE CARBOXYPEPTIDASE II (protein)
Unique Ligands	CA, CL, NAG, PO4, ZN
Unique branched monosaccharides	BMA, NAG

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2CIJ \| pdb_00002cij	Download File View File

membrane-bound glutamate carboxypeptidase II (GCPII) with bound methionine

Barinka, C., Plechanovova, A., Rulisek, L., Mlcochova, P., Majer, P., Slusher, B.S., Hilgenfeld, R., Mesters, J.R., Konvalinka, J.

(2011) Handbook Of Metalloproteins 4: 681

Released	2007-03-27
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	GLUTAMATE CARBOXYPEPTIDASE II (protein)
Unique Ligands	CA, CL, MET, NAG, ZN
Unique branched monosaccharides	BMA, MAN, NAG

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2D6B \| pdb_00002d6b	Download File View File

Novel Bromate Species trapped within a Protein Crystal

Ondracek, J., Mesters, J.R.

(2006) Acta Crystallogr D Biol Crystallogr 62: 996-1001

Released	2005-11-29
Method	X-RAY DIFFRACTION 1.25 Å
Organisms	Gallus gallus
Macromolecule	lysozyme C (protein)
Unique Ligands	202, CL, NA

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2J97 \| pdb_00002j97	Download File View File

Human coronavirus 229E non structural protein 9 (Nsp9)

Ponnusamy, R., Mesters, J.R., Moll, R., Hilgenfeld, R.

(2008) J Mol Biology 383: 1081

Released	2007-11-27
Method	X-RAY DIFFRACTION 1.75 Å
Organisms	Human coronavirus 229E
Macromolecule	REPLICASE POLYPROTEIN 1AB (protein)
Unique Ligands	MPD, SO4

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2J98 \| pdb_00002j98	Download File View File

Human coronavirus 229E non structural protein 9 cys69ala mutant (Nsp9)

Ponnusamy, R., Mesters, J.R., Moll, R., Hilgenfeld, R.

(2008) J Mol Biology 383: 1081

Released	2007-11-27
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Human coronavirus 229E
Macromolecule	REPLICASE POLYPROTEIN 1AB (protein)
Unique Ligands	DTT

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2JBJ \| pdb_00002jbj	Download File View File

membrane-bound glutamate carboxypeptidase II (GCPII) in complex with 2-PMPA (2-phosphonoMethyl-pentanedioic acid)

Mesters, J.R., Henning, K., Hilgenfeld, R.

(2007) Acta Crystallogr D Biol Crystallogr 63: 508

Released	2006-12-18
Method	X-RAY DIFFRACTION 2.19 Å
Organisms	Homo sapiens
Macromolecule	GLUTAMATE CARBOXYPEPTIDASE 2 (protein)
Unique Ligands	CA, CL, G88, NAG, ZN
Unique branched monosaccharides	BMA, MAN, NAG

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2JBK \| pdb_00002jbk	Download File View File

membrane-bound glutamate carboxypeptidase II (GCPII) in complex with quisqualic acid (quisqualate, alpha-amino-3,5-dioxo-1,2,4- oxadiazolidine-2-propanoic acid)

Mesters, J.R., Henning, K., Hilgenfeld, R.

(2007) Acta Crystallogr D Biol Crystallogr 63: 508

Released	2006-12-18
Method	X-RAY DIFFRACTION 2.99 Å
Organisms	Homo sapiens
Macromolecule	GLUTAMATE CARBOXYPEPTIDASE 2 (protein)
Unique Ligands	CA, CL, NAG, QUS, ZN
Unique branched monosaccharides	BMA, MAN, NAG

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2R96 \| pdb_00002r96	Download File View File

Crystal structure of E. coli WrbA in complex with FMN

Kuta Smatanova, I., Wolfova, J., Brynda, J., Mesters, J.R., Grandori, R., Carey, J.

(2009) Biochim Biophys Acta 1794: 1288-1298

Released	2008-09-23
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Escherichia coli
Macromolecule	Flavoprotein WrbA (protein)
Unique Ligands	EDO, FMN

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2R97 \| pdb_00002r97	Download File View File

Crystal structure of E. coli WrbA in complex with FMN

Kuta Smatanova, I., Wolfova, J., Brynda, J., Mesters, J.R., Grandori, R., Carey, J.

(2009) Biochim Biophys Acta 1794: 1288-1298

Released	2008-09-23
Method	X-RAY DIFFRACTION 2 Å
Organisms	Escherichia coli
Macromolecule	Flavoprotein WrbA (protein)
Unique Ligands	FMN

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2RG1 \| pdb_00002rg1	Download File View File

Crystal structure of E. coli WrbA apoprotein

Kuta Smatanova, I., Wolfova, J., Brynda, J., Lapkouski, M., Mesters, J.R., Grandori, R., Carey, J.

(2009) Biochim Biophys Acta 1794: 1288-1298

Released	2008-10-14
Method	X-RAY DIFFRACTION 1.85 Å
Organisms	Escherichia coli
Macromolecule	Flavoprotein WrbA (protein)
Unique Ligands	CL

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2V6N \| pdb_00002v6n	Download File View File

Crystal structures of the SARS-coronavirus main proteinase inactivated by benzotriazole compounds

Verschueren, K.H.G., Pumpor, K., Anemueller, S., Mesters, J.R., Hilgenfeld, R.

(2008) Chem Biol 15: 597

Released	2008-07-01
Method	X-RAY DIFFRACTION 1.98 Å
Organisms	Severe acute respiratory syndrome-related coronavirus
Macromolecule	REPLICASE POLYPROTEIN 1AB (protein)
Unique Ligands	MES, SO4, XP1

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2VB0 \| pdb_00002vb0	Download File View File

Crystal structure of coxsackievirus B3 proteinase 3C

Anand, K., Mesters, J.R., Goerlach, R., Zell, R., Hilgenfeld, R.

To be published

Released	2008-10-28
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Coxsackievirus B3 (strain Nancy)
Macromolecule	POLYPROTEIN 3BCD (protein)
Unique Ligands	CL

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2VJ1 \| pdb_00002vj1	Download File View File

A Structural View of the Inactivation of the SARS-Coronavirus Main Proteinase by Benzotriazole Esters

Verschueren, K.H.G., Pumpor, K., Anemueller, S., Mesters, J.R., Hilgenfeld, R.

(2008) Chem Biol 15: 597

Released	2008-07-01
Method	X-RAY DIFFRACTION 2.25 Å
Organisms	Severe acute respiratory syndrome-related coronavirus
Macromolecule	SARS CORONAVIRUS MAIN PROTEINASE (protein)
Unique Ligands	BEZ, DMS, XP1