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233,605 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Citation Author = "Powers, J.P."

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Search Summary

This query matches 31 Structures.

Refinements

Structure Determination Methodology

experimental (31)

Scientific Name of Source Organism

	Homo sapiens (25)
	Hepacivirus hominis (3)
	Bos taurus (2)
	Limulus polyphemus (1)

Taxonomy

	Eukaryota (25)
	Eukaryota (eukaryotes) (3)
	Riboviria (3)

Experimental Method

	X-RAY DIFFRACTION (28)
	SOLUTION NMR (3)

Polymer Entity Type

Protein (31)

Refinement Resolution (Å)

	1.5 - 2.0 (4)
	2.0 - 2.5 (14)
	2.5 - 3.0 (10)

Release Date

	2000 - 2004 (2)
	2005 - 2009 (12)
	2010 - 2014 (7)
	2020 - 2024 (10)

Enzyme Classification Name

	Hydrolases (7)
	Transferases (13)
	Oxidoreductases (8)
	Ligases (5)

Membrane Protein Annotation

OPM (1)

Symmetry Type

	Asymmetric (16)
	Cyclic (15)
	Dihedral (3)

SCOP Classification

	Alpha and beta proteins (a/b) (8)
	Artifacts (8)
	All alpha proteins (7)
	Alpha and beta proteins (a+b) (4)
	Multi-domain proteins (alpha and beta) (3)
	Peptides (2)
	All beta proteins (1)

AllSelected

1 to 25 of 31 Structures

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1QX9 \| pdb_00001qx9	Download File View File

Structure of a cyclic indolicidin peptide derivative with higher charge

Rozek, A., Powers, J.P., Friedrich, C.L., Hancock, R.E.

(2003) Biochemistry 42: 14130-14138

Released	2003-12-30
Method	SOLUTION NMR
Organisms	Bos taurus
Macromolecule	INDOLICIDIN DERIVATIVE (protein)

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1QXQ \| pdb_00001qxq	Download File View File

STRUCTURE OF AN INDOLICIDIN PEPTIDE DERIVATIVE WITH HIGHER CHARGE

Rozek, A., Powers, J.P., Friedrich, C.L., Hancock, R.E.

(2003) Biochemistry 42: 14130-14138

Released	2003-12-30
Method	SOLUTION NMR
Organisms	Bos taurus
Macromolecule	INDOLICIDIN DERIVATIVE (protein)

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1X7K \| pdb_00001x7k	Download File View File

PV5 nmr solution structure

Powers, J.P., Tan, A., Ramamoorthy, A., Hancock, R.E.

(2005) Biochemistry 44: 15504-15513

Released	2005-07-26
Method	SOLUTION NMR
Organisms	Limulus polyphemus
Macromolecule	Polyphemusin I (protein)

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2AWZ \| pdb_00002awz	Download File View File

Hepatitis C Virus NS5b RNA Polymerase in complex with a covalent inhibitor (5h)

Powers, J.P., Piper, D.E., Li, Y., Mayorga, V., Anzola, J., Chen, J.M., Jaen, J.C., Lee, G., Liu, J., Peterson, M.G., Tonn, G.R., Ye, Q., Walker, N.P., Wang, Z.

(2006) J Med Chem 49: 1034-1046

Released	2006-01-24
Method	X-RAY DIFFRACTION 2.15 Å
Organisms	Hepacivirus hominis
Macromolecule	Genome polyprotein (protein)
Unique Ligands	5H, SO4

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2AX0 \| pdb_00002ax0	Download File View File

Hepatitis C Virus NS5b RNA Polymerase in complex with a covalent inhibitor (5x)

Powers, J.P., Piper, D.E., Li, Y., Mayorga, V., Anzola, J., Chen, J.M., Jaen, J.C., Lee, G., Liu, J., Peterson, M.G., Tonn, G.R., Ye, Q., Walker, N.P., Wang, Z.

(2006) J Med Chem 49: 1034-1046

Released	2006-01-24
Method	X-RAY DIFFRACTION 2 Å
Organisms	Hepacivirus hominis
Macromolecule	Genome polyprotein (protein)
Unique Ligands	5X, SO4

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2AX1 \| pdb_00002ax1	Download File View File

Hepatitis C Virus NS5b RNA Polymerase in complex with a covalent inhibitor (5ee)

Powers, J.P., Piper, D.E., Li, Y., Mayorga, V., Anzola, J., Chen, J.M., Jaen, J.C., Lee, G., Liu, J., Peterson, M.G., Tonn, G.R., Ye, Q., Walker, N.P., Wang, Z.

(2006) J Med Chem 49: 1034-1046

Released	2006-01-24
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Hepacivirus hominis
Macromolecule	Genome polyprotein (protein)
Unique Ligands	5EE, SO4

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2NRU \| pdb_00002nru	Download File View File

Crystal structure of IRAK-4

Wang, Z., Liu, J., Walker, N.P.C.

(2006) Structure 14: 1835-1844

Released	2006-12-12
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	Interleukin-1 receptor-associated kinase 4 (protein)
Unique Ligands	SO4, T12

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2NRY \| pdb_00002nry	Download File View File

Crystal structure of IRAK-4

Wang, Z., Liu, J., Walker, N.P.C.

(2006) Structure 14: 1835-1844

Released	2006-12-12
Method	X-RAY DIFFRACTION 2.15 Å
Organisms	Homo sapiens
Macromolecule	interleukin-1 receptor-associated kinase 4 (protein)
Unique Ligands	STU

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3CZR \| pdb_00003czr	Download File View File

Crystal Structure of Human 11-beta-Hydroxysteroid Dehydrogenase (HSD1) in Complex with Arylsulfonylpiperazine Inhibitor

Wang, Z., Sudom, A., Walker, N.P.

(2008) Bioorg Med Chem Lett 18: 3513-3516

Released	2008-06-17
Method	X-RAY DIFFRACTION 2.35 Å
Organisms	Homo sapiens
Macromolecule	Corticosteroid 11-beta-dehydrogenase isozyme 1 (protein)
Unique Ligands	3CZ, CPS, NAP

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3D3E \| pdb_00003d3e	Download File View File

Crystal Structure of Human 11-beta-Hydroxysteroid Dehydrogenase (HSD1) in Complex with Benzamide Inhibitor

Wang, Z., Sudom, A., Liu, J., Walker, N.P.

(2008) J Med Chem 51: 3953-3960

Released	2008-07-01
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Homo sapiens
Macromolecule	Corticosteroid 11-beta-dehydrogenase isozyme 1 (protein)
Unique Ligands	D3E, NAP

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3D4N \| pdb_00003d4n	Download File View File

Crystal Structure of Human 11-beta-Hydroxysteroid Dehydrogenase (HSD1) in Complex with Sulfonamide Inhibitor

Wang, Z., Liu, J., Sudom, A., Walker, N.P.

(2008) J Med Chem 51: 3953-3960

Released	2008-07-22
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Homo sapiens
Macromolecule	Corticosteroid 11-beta-dehydrogenase isozyme 1 (protein)
Unique Ligands	D4N, NAP

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3D5Q \| pdb_00003d5q	Download File View File

Crystal Structure of 11b-HSD1 in Complex with Triazole Inhibitor

Wang, Z., Liu, J., Sudom, A., Walker, N.P.C.

(2008) Bioorg Med Chem 16: 8922-8931

Released	2008-10-07
Method	X-RAY DIFFRACTION 2.55 Å
Organisms	Homo sapiens
Macromolecule	Corticosteroid 11-beta-dehydrogenase isozyme 1 (protein)
Unique Ligands	NAP, T30

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3FCO \| pdb_00003fco	Download File View File

Crystal Structure of 11beta-Hydroxysteroid Dehydrogenase 1 (11b-HSD1) in Complex with Benzamide Inhibitor

Wang, Z., Sudom, A., Walker, N.P.

(2009) Bioorg Med Chem Lett 19: 1446-1450

Released	2009-12-01
Method	X-RAY DIFFRACTION 2.65 Å
Organisms	Homo sapiens
Macromolecule	Corticosteroid 11-beta-dehydrogenase isozyme 1 (protein)
Unique Ligands	IIG, NAP

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3FRJ \| pdb_00003frj	Download File View File

Crystal Structure of 11b-Hydroxysteroid Dehydrogenase-1 (11b-HSD1) in Complex with Piperidyl Benzamide Inhibitor

Wang, Z., Sudom, A., Walker, N.P.

(2009) Bioorg Med Chem Lett 19: 1797-1801

Released	2009-06-16
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Homo sapiens
Macromolecule	Corticosteroid 11-beta-Dehydrogenase, Isozyme 1 (protein)
Unique Ligands	A49, NAP

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3OQ1 \| pdb_00003oq1	Download File View File

Crystal Structure of 11beta-Hydroxysteroid Dehydrogenase-1 (11b-HSD1) in Complex with Diarylsulfone Inhibitor

Wang, Z., Sudom, A., Walker, N.P.

(2010) Bioorg Med Chem Lett 20: 7071-7075

Released	2011-07-20
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Homo sapiens
Macromolecule	Corticosteroid 11-beta-dehydrogenase isozyme 1 (protein)
Unique Ligands	3OQ, NAP

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3PDJ \| pdb_00003pdj	Download File View File

Crystal Structure of Human 11-beta-Hydroxysteroid Dehydrogenase 1 (11b-HSD1) in Complex with 4,4-Disubstituted Cyclohexylbenzamide Inhibitor

Wang, Z., Sudom, A., Walker, N.P.

(2011) Bioorg Med Chem Lett 21: 405-410

Released	2011-10-05
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Homo sapiens
Macromolecule	Corticosteroid 11-beta-dehydrogenase isozyme 1 (protein)
Unique Ligands	3PJ, NAP

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4JV7 \| pdb_00004jv7	Download File View File

Co-crystal structure of MDM2 with inhibitor (2S,5R,6S)-2-benzyl-5,6-bis(4-bromophenyl)-4-methylmorpholin-3-one

Huang, X., Gonzalez-Lopez de Turiso, F., Sun, D., Yosup, R., Bartberger, M.D., Beck, H.P., Cannon, J., Shaffer, P., Oliner, J.D., Olson, S.H., Medina, J.C.

(2013) J Med Chem 56: 4053-4070

Released	2013-05-01
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens
Macromolecule	E3 ubiquitin-protein ligase Mdm2 (protein)
Unique Ligands	1MN, SO4

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4JV9 \| pdb_00004jv9	Download File View File

Co-crystal structure of MDM2 with inhibitor (2S,5R,6S)-2-benzyl-5,6-bis(4-chlorophenyl)-4-methylmorpholin-3-one

Huang, X., Gonzalez-Lopez de Turiso, F., Sun, D., Yosup, R., Bartberger, M.D., Beck, H.P., Cannon, J., Shaffer, P., Oliner, J.D., Olson, S.H., Medina, J.C.

(2013) J Med Chem 56: 4053-4070

Released	2013-05-01
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Homo sapiens
Macromolecule	E3 ubiquitin-protein ligase Mdm2 (protein)
Unique Ligands	1MO, SO4

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4JVE \| pdb_00004jve	Download File View File

Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid

Huang, X., Gonzalez-Lopez de Turiso, F., Sun, D., Yosup, R., Bartberger, M.D., Beck, H.P., Cannon, J., Shaffer, P., Oliner, J.D., Olson, S.H., Medina, J.C.

(2013) J Med Chem 56: 4053-4070

Released	2013-05-01
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Homo sapiens
Macromolecule	E3 ubiquitin-protein ligase Mdm2 (protein)
Unique Ligands	1MQ

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4JVR \| pdb_00004jvr	Download File View File

Co-crystal structure of MDM2 with inhibitor (2'S,3R,4'S,5'R)-N-(2-aminoethyl)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxamide

Huang, X., Gonzalez-Lopez de Turiso, F., Sun, D., Yosup, R., Bartberger, M.D., Beck, H.P., Cannon, J., Shaffer, P., Oliner, J.D., Olson, S.H., Medina, J.C.

(2013) J Med Chem 56: 4053-4070

Released	2013-05-01
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Homo sapiens
Macromolecule	E3 ubiquitin-protein ligase Mdm2 (protein)
Unique Ligands	1MT

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4JWR \| pdb_00004jwr	Download File View File

Co-crystal structure of MDM2 with inhibitor {(2S,5R,6S)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-[(2S)-1-hydroxybutan-2-yl]-3-oxomorpholin-2-yl}acetic acid

Shaffer, P.L.

(2013) J Med Chem 56: 4053-4070

Released	2013-05-01
Method	X-RAY DIFFRACTION 2.35 Å
Organisms	Homo sapiens
Macromolecule	E3 ubiquitin-protein ligase Mdm2 (protein)
Unique Ligands	1MY

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6XRL \| pdb_00006xrl	Download File View File

Crystal structure of human PI3K-gamma in complex with inhibitor IPI-549

Walker, N.P., Jeffrey, J.L.

(2020) J Med Chem 63: 11235-11257

Released	2020-09-16
Method	X-RAY DIFFRACTION 2.99 Å
Organisms	Homo sapiens
Macromolecule	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (protein)
Unique Ligands	SO4, V7Y

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6XRM \| pdb_00006xrm	Download File View File

Crystal structure of human PI3K-gamma in complex with Compound 4

Walker, N.P., Jeffrey, J.L.

(2020) J Med Chem 63: 11235-11257

Released	2020-09-16
Method	X-RAY DIFFRACTION 2.88 Å
Organisms	Homo sapiens
Macromolecule	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (protein)
Unique Ligands	SO4, V81

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6XRN \| pdb_00006xrn	Download File View File

Crystal structure of human PI3K-gamma in complex with Compound 17

Walker, N.P., Jeffrey, J.L.

(2022) J Med Chem 65: 1418-1444

Released	2021-11-03
Method	X-RAY DIFFRACTION 2.96 Å
Organisms	Homo sapiens
Macromolecule	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (protein)
Unique Ligands	V84