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233,605 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Citation Author = "Seidler, P.M."

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Search Summary

This query matches 22 Structures.

Refinements

Structure Determination Methodology

experimental (22)

Scientific Name of Source Organism

	Homo sapiens (11)
	Severe acute respiratory syndrome coronavirus 2 (4)
	Canis lupus familiaris (3)
	Oryctolagus cuniculus (3)
	Camelus dromedarius (1)

Taxonomy

	Eukaryota (18)
	Riboviria (4)

Experimental Method

	X-RAY DIFFRACTION (17)
	ELECTRON MICROSCOPY (3)
	ELECTRON CRYSTALLOGRAPHY (2)

Polymer Entity Type

Protein (22)

Refinement Resolution (Å)

	1.0 - 1.5 (10)
	1.5 - 2.0 (4)
	2.0 - 2.5 (2)
	2.5 - 3.0 (2)
	3.0 - 3.5 (2)
	3.5 - 4.0 (2)

Release Date

	2010 - 2014 (2)
	2015 - 2019 (3)
	2020 - 2024 (17)

Enzyme Classification Name

Hydrolases (2)

Symmetry Type

	Asymmetric (11)
	Cyclic (10)
	Helical (1)

SCOP Classification

	All beta proteins (2)
	Alpha and beta proteins (a+b) (2)

AllSelected

1 to 22 of 22 Structures

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3O0I \| pdb_00003o0i	Download File View File

Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor PU-H54

Seidler, P.M., Gewirth, D.T.

(2013) Nat Chem Biol 9: 677-684

Released	2011-10-05
Method	X-RAY DIFFRACTION 1.47 Å
Organisms	Homo sapiens
Macromolecule	HSP90AA1 protein (protein)
Unique Ligands	P54

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3O2F \| pdb_00003o2f	Download File View File

Structure of the N-domain of GRP94 bound to the HSP90 inhibitor PU-H54

Seidler, P.M., Gewirth, D.T.

(2013) Nat Chem Biol 9: 677-684

Released	2011-10-05
Method	X-RAY DIFFRACTION 2 Å
Organisms	Canis lupus familiaris
Macromolecule	Endoplasmin (protein)
Unique Ligands	GOL, IPA, P54

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5V5B \| pdb_00005v5b	Download File View File

KVQIINKKLD, Structure of the amyloid spine from microtubule associated protein tau Repeat 2

Seidler, P.M., Sawaya, M.R., Rodriguez, J.A., Eisenberg, D.S., Cascio, D., Boyer, D.R.

(2018) Nat Chem 10: 170-176

Released	2018-02-07
Method	ELECTRON CRYSTALLOGRAPHY 1.5 Å
Organisms	Homo sapiens
Macromolecule	Microtubule-associated protein tau (protein)

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5V5C \| pdb_00005v5c	Download File View File

VQIINK, Structure of the amyloid-spine from microtubule associated protein tau Repeat 2

Seidler, P.M., Sawaya, M.R., Rodriguez, J.A., Eisenberg, D.S., Cascio, D., Boyer, D.R.

(2018) Nat Chem 10: 170-176

Released	2018-02-07
Method	ELECTRON CRYSTALLOGRAPHY 1.25 Å
Organisms	Homo sapiens
Macromolecule	Microtubule-associated protein tau (protein)

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6ODG \| pdb_00006odg	Download File View File

SVQIVY, Crystal Structure of a tau protein fragment

Eisenberg, D.S., Boyer, D.R., Sawaya, M.R., Seidler, P.M.

(2019) J Biological Chem 294: 16451-16464

Released	2019-10-02
Method	X-RAY DIFFRACTION 1 Å
Organisms	Homo sapiens
Macromolecule	Microtubule-associated protein tau (protein)

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6PIL \| pdb_00006pil	Download File View File

Antibody scFv-M204 monomeric state

Abskharon, R., Sawaya, M.R., Seidler, P.M., Cascio, D., Eisenberg, D.S.

(2020) J Biological Chem 295: 10662-10676

Released	2020-06-24
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Oryctolagus cuniculus
Macromolecule	scFv-M204 antibody (protein)
Unique Ligands	CL

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6PK8 \| pdb_00006pk8	Download File View File

Antibody scFv-M204 dimeric state

Abskharon, R., Sawaya, M.R., Seidler, P.M., Cascio, D., Eisenberg, D.S.

(2020) J Biological Chem 295: 10662-10676

Released	2020-06-24
Method	X-RAY DIFFRACTION 2.91 Å
Organisms	Oryctolagus cuniculus
Macromolecule	scFv-M204 antibody (protein)
Unique Ligands	SO4

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6PSC \| pdb_00006psc	Download File View File

Antibody scFv-M204 trimeric state

Abskharon, R., Sawaya, M.R., Seidler, P.M., Cascio, D., Eisenberg, D.S.

(2020) J Biological Chem 295: 10662-10676

Released	2020-06-17
Method	X-RAY DIFFRACTION 3.6 Å
Organisms	Oryctolagus cuniculus
Macromolecule	scFv-M204 antibody (protein)

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7K3C \| pdb_00007k3c	Download File View File

SGMGGIT segment 58-64 from Keratin-8

Murray, K.A., Sawaya, M.R., Eisenberg, D.S.

(2022) Nat Struct Mol Biol 29: 529-536

Released	2021-11-10
Method	X-RAY DIFFRACTION 1.1 Å
Organisms	Homo sapiens
Macromolecule	SGMGGIT segment 58-64 from the low complexity domain of Keratin-8 (protein)
Unique Ligands	EOH, PGE

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7K3X \| pdb_00007k3x	Download File View File

SGMGCIT segment 58-64 from Keratin-8 with G62C mutation

Murray, K.A., Sawaya, M.R., Eisenberg, D.S.

(2022) Nat Struct Mol Biol 29: 529-536

Released	2021-11-10
Method	X-RAY DIFFRACTION 1.705 Å
Organisms	Homo sapiens
Macromolecule	SGMGCIT segment 58-64 from Keratin-8 with G62C mutation (protein)
Unique Ligands	IPA

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7K3Y \| pdb_00007k3y	Download File View File

GGYAGAS segment 52-58 from Keratin-8

Murray, K.A., Sawaya, M.R., Eisenberg, D.S.

(2022) Nat Struct Mol Biol 29: 529-536

Released	2021-11-10
Method	X-RAY DIFFRACTION 1.1 Å
Organisms	Homo sapiens
Macromolecule	GGYAGAS segment 52-58 from the low complexity domain of Keratin-8 (protein)

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7LTU \| pdb_00007ltu	Download File View File

AALALL SEGMENT FROM THE NUCLEOPROTEIN OF SARS-COV-2, RESIDUES 217-222, CRYSTAL FORM 1

Zee, C.-T., Sawaya, M.R., Rodriguez, J.A., Eisenberg, D.S.

(2021) bioRxiv

Released	2021-03-17
Method	X-RAY DIFFRACTION 1.122 Å
Organisms	Severe acute respiratory syndrome coronavirus 2
Macromolecule	AALALL SEGMENT FROM THE NUCLEOPROTEIN OF SARS-COV-2,RESIDUES 217-222 (protein)
Unique Ligands	TFA

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7LUX \| pdb_00007lux	Download File View File

AALALL segment from the Nucleoprotein of SARS-CoV-2, residues 217-222, crystal form 2

Lu, J., Zee, C.-T., Sawaya, M.R., Rodriguez, J.A., Eisenberg, D.S.

(2021) bioRxiv

Released	2021-03-17
Method	X-RAY DIFFRACTION 1.303 Å
Organisms	Severe acute respiratory syndrome coronavirus 2
Macromolecule	Nucleoprotein AALALL (protein)
Unique Ligands	PG4

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7LUZ \| pdb_00007luz	Download File View File

GQTVTK segment from the Nucleoprotein of SARS-CoV-2, residues 243-248

Balbirnie, M., Sawaya, M.R., Eisenberg, D.S., Cascio, D.

(2021) bioRxiv

Released	2021-03-17
Method	X-RAY DIFFRACTION 1.101 Å
Organisms	Severe acute respiratory syndrome coronavirus 2
Macromolecule	Nucleoprotein GQTVTK (protein)

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7LV2 \| pdb_00007lv2	Download File View File

GSQASS segment from the Nucleoprotein of SARS-CoV-2, residues 179-184

Hou, K., Sawaya, M.R., Eisenberg, D.S., Cascio, D.

(2021) bioRxiv

Released	2021-03-17
Method	X-RAY DIFFRACTION 1.301 Å
Organisms	Severe acute respiratory syndrome coronavirus 2
Macromolecule	Nucleoprotein GSQASS (protein)

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7UPE \| pdb_00007upe	Download File View File

Tau Paired Helical Filament from Alzheimer's Disease not incubated with EGCG

Seidler, P.M., Murray, K.A., Boyer, D.R., Ge, P., Sawaya, M.R., Eisenberg, D.S.

(2022) Nat Commun 13: 5451-5451

Released	2022-09-28
Method	ELECTRON MICROSCOPY 3.4 Å
Organisms	Homo sapiens
Macromolecule	Isoform Tau-F of Microtubule-associated protein tau (protein)

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7UPF \| pdb_00007upf	Download File View File

Tau Paired Helical Filament from Alzheimer's Disease incubated 1 hr. with EGCG

Seidler, P.M., Murray, K.A., Boyer, D.R., Ge, P., Sawaya, M.R., Eisenberg, D.S.

(2022) Nat Commun 13: 5451-5451

Released	2022-09-28
Method	ELECTRON MICROSCOPY 3.3 Å
Organisms	Homo sapiens
Macromolecule	Isoform Tau-F of Microtubule-associated protein tau (protein)

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7UPG \| pdb_00007upg	Download File View File

Tau Paired Helical Filament from Alzheimer's Disease incubated with EGCG for 3 hours

Seidler, P.M., Murray, K.A., Boyer, D.R., Ge, P., Sawaya, M.R., Eisenberg, D.S.

(2022) Nat Commun 13: 5451-5451

Released	2022-09-28
Method	ELECTRON MICROSCOPY 3.8 Å
Organisms	Homo sapiens
Macromolecule	Isoform Tau-F of Microtubule-associated protein tau (protein)
Unique Ligands	KDH

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8FQ7 \| pdb_00008fq7	Download File View File

Nanobody with WIW inserted in CDR3 loop to Inhibit Growth of Alzheimer's Tau fibrils

Abskharon, R., Sawaya, M.R., Cascio, D.C., Eisenberg, D.S.

(2023) Proc Natl Acad Sci U S A 120: e2300258120-e2300258120

Released	2023-10-04
Method	X-RAY DIFFRACTION 1.4 Å
Organisms	Camelus dromedarius
Macromolecule	Nanobody with WIW insert in CDR3 loop to target tau fibrils (protein)
Unique Ligands	GOL

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8SBT \| pdb_00008sbt	Download File View File

Structure of human Hsp90-alpha bound to purine inhibitor PU-H36

Que, N.S., Gewirth, D.T.

(2025) Proteins 93: 654-672

Released	2024-10-09
Method	X-RAY DIFFRACTION 1.5 Å
Organisms	Homo sapiens
Macromolecule	Heat shock protein HSP 90-alpha (protein)
Unique Ligands	MG, ZUY

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8SSV \| pdb_00008ssv	Download File View File

Crystal structure of Grp94 N-terminal domain bound to the purine inhibitor PU-H71.

Que, N.L.S., Gewirth, D.T.

(2025) Proteins 93: 654-672

Released	2024-11-06
Method	X-RAY DIFFRACTION 1.72 Å
Organisms	Canis lupus familiaris
Macromolecule	Endoplasmin (protein)
Unique Ligands	ACT, CA, H71, MG, PEG, PG4