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233,605 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Citation Author = "Sharff, A."

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Search Summary

This query matches 30 Structures.

Refinements

Structure Determination Methodology

experimental (30)

Scientific Name of Source Organism

	Homo sapiens (15)
	Severe acute respiratory syndrome-related coronavirus (3)
	Micromonospora chersina (2)
	Pseudomonas aeruginosa (2)
	dengue virus type 3 (2)
	synthetic construct (2)
	Arabidopsis thaliana (1)
	Aspergillus oryzae (1)
	Aspergillus oryzae RIB40 (1)
	Escherichia coli (1)

More...

Taxonomy

	Eukaryota (18)
	Bacteria (7)
	Riboviria (5)
	other sequences (2)
	Eukaryota (eukaryotes) (1)

Experimental Method

X-RAY DIFFRACTION (30)

Polymer Entity Type

	Protein (29)
	RNA (1)

Refinement Resolution (Å)

	1.0 - 1.5 (4)
	1.5 - 2.0 (9)
	2.0 - 2.5 (9)
	2.5 - 3.0 (5)
	3.0 - 3.5 (3)

Release Date

	2000 - 2004 (1)
	2005 - 2009 (4)
	2010 - 2014 (19)
	2015 - 2019 (2)
	2020 - 2024 (4)

Enzyme Classification Name

	Transferases (12)
	Oxidoreductases (2)
	Hydrolases (2)
	Isomerases (2)
	Lyases (2)

Membrane Protein Annotation

	MemProtMD (1)
	OPM (1)
	PDBTM (1)
	mpstruc (1)

Symmetry Type

	Asymmetric (17)
	Cyclic (12)
	Dihedral (2)

SCOP Classification

	Alpha and beta proteins (a+b) (15)
	Artifacts (8)
	All beta proteins (2)
	All alpha proteins (2)
	Alpha and beta proteins (a/b) (3)
	Membrane and cell surface proteins and peptides (1)
	Small proteins (3)

AllSelected

1 to 25 of 30 Structures

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1EK9 \| pdb_00001ek9	Download File View File

2.1A X-RAY STRUCTURE OF TOLC: AN INTEGRAL OUTER MEMBRANE PROTEIN AND EFFLUX PUMP COMPONENT FROM ESCHERICHIA COLI

Koronakis, V., Sharff, A.J., Koronakis, E., Luisi, B., Hughes, C.

(2000) Nature 405: 914-919

Released	2000-06-28
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Escherichia coli
Macromolecule	OUTER MEMBRANE PROTEIN TOLC (protein)

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2UV4 \| pdb_00002uv4	Download File View File

Crystal Structure of a CBS domain pair from the regulatory gamma1 subunit of human AMPK in complex with AMP

Day, P., Sharff, A., PArra, L., Cleasby, A., Williams, M., Horer, S., Nar, H., Redemann, N., Tickle, I., Yon, J.

(2007) Acta Crystallogr D Biol Crystallogr 63: 587

Released	2007-05-08
Method	X-RAY DIFFRACTION 1.33 Å
Organisms	Homo sapiens
Macromolecule	5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT GAMMA-1 (protein)
Unique Ligands	AMP

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2UV5 \| pdb_00002uv5	Download File View File

Crystal Structure of a CBS domain pair from the regulatory gamma1 subunit of human AMPK in complex with AMP

Day, P., Sharff, A., Parra, L., Cleasby, A., Williams, M., Horer, S., Nar, H., Redemann, N., Tickle, I., Yon, J.

(2007) Acta Crystallogr D Biol Crystallogr 63: 587

Released	2007-05-08
Method	X-RAY DIFFRACTION 1.69 Å
Organisms	Homo sapiens
Macromolecule	5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT GAMMA-1 (protein)
Unique Ligands	AMZ

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2UV6 \| pdb_00002uv6	Download File View File

Crystal Structure of a CBS domain pair from the regulatory gamma1 subunit of human AMPK in complex with AMP

Day, P., Sharff, A., Parra, L., Cleasby, A., Williams, M., Horer, S., Nar, H., Redemann, N., Tickle, I., Yon, J.

(2007) Acta Crystallogr D Biol Crystallogr 63: 587

Released	2007-05-08
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT GAMMA-1 (protein)
Unique Ligands	AMP

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2UV7 \| pdb_00002uv7	Download File View File

Crystal Structure of a CBS domain pair from the regulatory gamma1 subunit of human AMPK in complex with AMP

Day, P., Sharff, A., Parra, L., Cleasby, A., Williams, M., Horer, S., Nar, H., Redemann, N., Tickle, I., Yon, J.

(2007) Acta Crystallogr D Biol Crystallogr 63: 587

Released	2007-05-08
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT GAMMA-1 (protein)
Unique Ligands	AMP

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2XEM \| pdb_00002xem	Download File View File

Induced-fit and allosteric effects upon polyene binding revealed by crystal structures of the Dynemicin thioesterase

Liew, C.W., Sharff, A., Kotaka, M., Kong, R., Bricogne, G., Liang, Z.X., Lescar, J.

(2010) J Mol Biology 404: 291

Released	2010-10-13
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Micromonospora chersina
Macromolecule	DYNE7 (protein)
Unique Ligands	SSV

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2XFL \| pdb_00002xfl	Download File View File

Induced-fit and allosteric effects upon polyene binding revealed by crystal structures of the Dynemicin thioesterase

Liew, C.W., Sharff, A., Kotaka, M., Kong, R., Sun, H., Bricogne, G., Liang, Z., Lescar, J.

(2010) J Mol Biology 404: 291

Released	2010-10-13
Method	X-RAY DIFFRACTION 2.9 Å
Organisms	Micromonospora chersina
Macromolecule	DYNE7 (protein)

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2XYQ \| pdb_00002xyq	Download File View File

Crystal structure of the nsp16 nsp10 SARS coronavirus complex

Decroly, E., Debarnot, C., Ferron, F., Bouvet, M., Coutard, B., Imbert, I., Gluais, L., Papageorgiou, N., Ortiz-Lombardia, M., Lescar, J., Canard, B.

(2011) PLoS Pathog 7: 2059

Released	2011-10-19
Method	X-RAY DIFFRACTION 2 Å
Organisms	Severe acute respiratory syndrome-related coronavirus
Macromolecule	NON-STRUCTURAL PROTEIN 10 (protein) PUTATIVE 2'-O-METHYL TRANSFERASE (protein)
Unique Ligands	CL, MG, NA, SAH, ZN

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2XYR \| pdb_00002xyr	Download File View File

Crystal structure of the nsp16 nsp10 SARS coronavirus complex

Decroly, E., Debarnot, C., Ferron, F., Bouvet, M., Coutard, B., Imbert, I., Gluais, L., Papageorgiou, N., Ortiz-Lombardia, M., Lescar, J., Canard, B.

(2011) PLoS Pathog 7: 2059

Released	2011-10-26
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Severe acute respiratory syndrome-related coronavirus
Macromolecule	NON-STRUCTURAL PROTEIN 10 (protein) PUTATIVE 2'-O-METHYL TRANSFERASE (protein)
Unique Ligands	CL, MG, NA, SFG, ZN

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2XYV \| pdb_00002xyv	Download File View File

Crystal structure of the nsp16 nsp10 SARS coronavirus complex

Decroly, E., Debarnot, C., Ferron, F., Bouvet, M., Coutard, B., Imbert, I., Gluais, L., Papageorgiou, N., Ortiz-Lombardia, M., Lescar, J., Canard, B.

(2011) PLoS Pathog 7: 2059

Released	2011-10-26
Method	X-RAY DIFFRACTION 2.06 Å
Organisms	Severe acute respiratory syndrome-related coronavirus
Macromolecule	NON-STRUCTURAL PROTEIN 10 (protein) PUTATIVE 2'-O-METHYL TRANSFERASE (protein)
Unique Ligands	CL, MG, NA, SAH, ZN

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3RF3 \| pdb_00003rf3	Download File View File

Shigella IpaA-VBS3 in complex with human vinculin

Park, H., Sharff, A., Izard, T.

(2011) J Biological Chem 286: 23214-23221

Released	2011-04-27
Method	X-RAY DIFFRACTION 1.61 Å
Organisms	Homo sapiens Shigella flexneri
Macromolecule	Invasin ipaA (protein) Vinculin (protein)
Unique Ligands	CAC

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3S90 \| pdb_00003s90	Download File View File

Human vinculin head domain Vh1 (residues 1-252) in complex with murine talin (VBS33; residues 1512-1546)

Yogesha, S.D., Sharff, A., Bricogne, G., Izard, T.

(2011) Protein Sci 20: 1471-1476

Released	2011-06-22
Method	X-RAY DIFFRACTION 1.97 Å
Organisms	Homo sapiens Mus musculus
Macromolecule	Talin-1 (protein) Vinculin (protein)

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3SYU \| pdb_00003syu	Download File View File

Re-refined coordinates for pdb entry 1det - ribonuclease T1 carboxymethylated at GLU 58 in complex with 2'GMP

Smart, O.S., Womack, T.O., Bricogne, G.

(2012) Acta Crystallogr D Biol Crystallogr 68: 368-380

Released	2012-03-28
Method	X-RAY DIFFRACTION 1.95 Å
Organisms	Aspergillus oryzae RIB40
Macromolecule	Guanyl-specific ribonuclease T1 (protein)
Unique Ligands	2GP, NA, UNX

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3URP \| pdb_00003urp	Download File View File

Re-refinement of PDB entry 5RNT - ribonuclease T1 with guanosine-3',5'-diphosphate and phosphate ion bound

Smart, O.S., Womack, T.O., Flensburg, C., Keller, P., Sharff, A., Paciorek, W., Vonrhein, C., Bricogne, G.

(2012) Acta Crystallogr D Biol Crystallogr 68: 368-380

Released	2012-03-28
Method	X-RAY DIFFRACTION 3.19 Å
Organisms	Aspergillus oryzae
Macromolecule	Guanyl-specific ribonuclease T1 (protein)
Unique Ligands	PGP, PO4, UNX

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3V56 \| pdb_00003v56	Download File View File

Re-refinement of PDB entry 1OSG - Complex between BAFF and a BR3 derived peptide presented in a beta-hairpin scaffold - reveals an additonal copy of the peptide.

Smart, O.S., Womack, T.O., Flensburg, C., Keller, P., Sharff, A., Paciorek, W., Vonrhein, C., Bricogne, G.

(2012) Acta Crystallogr D Biol Crystallogr 68: 368-380

Released	2012-03-28
Method	X-RAY DIFFRACTION 3 Å
Organisms	Homo sapiens
Macromolecule	BR3 derived peptive (protein) Tumor necrosis factor ligand superfamily member 13B (protein)
Unique Ligands	SO4

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4CTJ \| pdb_00004ctj	Download File View File

DENGUE 3 NS5 METHYLTRANSFERASE BOUND TO S-ADENOSYL METHIONINE AND FRAGMENT 3A9

Barral, K., Bricogne, G., Sharff, A.

(2014) Antiviral Res 106: 61

Released	2014-04-16
Method	X-RAY DIFFRACTION 1.47 Å
Organisms	dengue virus type 3
Macromolecule	NON-STRUCTURAL PROTEIN 5 (protein)
Unique Ligands	3A9, NA, SAM

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4CTK \| pdb_00004ctk	Download File View File

DENGUE 3 NS5 METHYLTRANSFERASE BOUND TO S-ADENOSYL METHIONINE AND FRAGMENT 2A4

Barral, K., Bricogne, G., Sharff, A.

(2014) Antiviral Res 106: 61

Released	2014-04-16
Method	X-RAY DIFFRACTION 1.53 Å
Organisms	dengue virus type 3
Macromolecule	POLYPROTEIN (protein)
Unique Ligands	DMS, NA, SAM, SVN

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4D2P \| pdb_00004d2p	Download File View File

Structure of MELK in complex with inhibitors

Johnson, C.N., Berdini, V., Beke, L., Bonnet, P., Brehmer, D., Coyle, J.E., Day, P.J., Frederickson, M., Freyne, E.J.E., Gilissen, R.A.H.J., Hamlett, C.C.F., Howard, S., Meerpoel, L., McMenamin, R., Patel, S., Rees, D.C., Sharff, A., Sommen, F., Wu, T., Linders, J.T.M.

(2015) ACS Med Chem Lett 6: 25

Released	2014-10-08
Method	X-RAY DIFFRACTION 2.55 Å
Organisms	Homo sapiens
Macromolecule	MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE (protein)
Unique Ligands	6Z7

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4D2T \| pdb_00004d2t	Download File View File

Structure of MELK in complex with inhibitors

(2015) ACS Med Chem Lett 6: 25

Released	2014-10-15
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Homo sapiens
Macromolecule	MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE (protein)
Unique Ligands	3I7

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4D2V \| pdb_00004d2v	Download File View File

Structure of MELK in complex with inhibitors

(2015) ACS Med Chem Lett 6: 25

Released	2014-10-15
Method	X-RAY DIFFRACTION 2.45 Å
Organisms	Homo sapiens
Macromolecule	MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE (protein)
Unique Ligands	45R

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4D2W \| pdb_00004d2w	Download File View File

Structure of MELK in complex with inhibitors

(2015) ACS Med Chem Lett 6: 25

Released	2014-10-08
Method	X-RAY DIFFRACTION 1.92 Å
Organisms	Homo sapiens
Macromolecule	MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE (protein)
Unique Ligands	NF5