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233,605 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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Search Summary

This query matches 13 Structures.

Refinements

Structure Determination Methodology

experimental (13)

Scientific Name of Source Organism

	Xanthomonas campestris pv. campestris str. ATCC 33913 (4)
	Xanthomonas campestris pv. campestris (3)
	Saccharomyces cerevisiae (2)
	Escherichia coli (1)
	Escherichia coli K-12 (1)
	Pseudomonas aeruginosa (1)
	Saccharopolyspora erythraea (1)

Taxonomy

	Bacteria (11)
	Eukaryota (2)

Experimental Method

X-RAY DIFFRACTION (13)

Polymer Entity Type

Protein (13)

Refinement Resolution (Å)

	1.5 - 2.0 (5)
	2.0 - 2.5 (4)
	2.5 - 3.0 (2)
	4.0 - 4.5 (2)

Release Date

	1995 - 1999 (1)
	2000 - 2004 (1)
	2005 - 2009 (3)
	2010 - 2014 (3)
	2015 - 2019 (4)
	2020 - 2024 (1)

Enzyme Classification Name

	Transferases (13)
	Oxidoreductases (2)
	Hydrolases (2)
	Lyases (2)

Symmetry Type

Cyclic (13)

SCOP Classification

Alpha and beta proteins (a/b) (2)

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1 to 13 of 13 Structures

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1B3N \| pdb_00001b3n	Download File View File

BETA-KETOACYL CARRIER PROTEIN SYNTHASE AS A DRUG TARGET, IMPLICATIONS FROM THE CRYSTAL STRUCTURE OF A COMPLEX WITH THE INHIBITOR CERULENIN.

Moche, M., Schneider, G., Edwards, P., Dehesh, K., Lindqvist, Y.

(1999) J Biological Chem 274: 6031-6034

Released	1999-04-06
Method	X-RAY DIFFRACTION 2.65 Å
Organisms	Escherichia coli K-12
Macromolecule	PROTEIN (KETOACYL ACYL CARRIER PROTEIN SYNTHASE 2) (protein)
Unique Ligands	CER

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1FJ8 \| pdb_00001fj8	Download File View File

THE STRUCTURE OF BETA-KETOACYL-[ACYL CARRIER PROTEIN] SYNTHASE I IN COMPLEX WITH CERULENIN, IMPLICATIONS FOR DRUG DESIGN

Price, A.C., Choi, K., Heath, R.J., Li, Z., White, S.W., Rock, C.O.

(2001) J Biological Chem 276: 6551-6559

Released	2000-08-23
Method	X-RAY DIFFRACTION 2.27 Å
Organisms	Escherichia coli
Macromolecule	BETA-KETOACYL-[ACYL CARRIER PROTEIN] SYNTHASE I (protein)
Unique Ligands	CER

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2QO3 \| pdb_00002qo3	Download File View File

Crystal Structure of [KS3][AT3] didomain from module 3 of 6-deoxyerthronolide B synthase

Khosla, C., Cane, E.D., Tang, Y., Chen, Y.A., Kim, C.Y.

(2007) Chem Biol 14: 931-943

Released	2007-09-04
Method	X-RAY DIFFRACTION 2.59 Å
Organisms	Saccharopolyspora erythraea
Macromolecule	EryAII Erythromycin polyketide synthase modules 3 and 4 (protein)
Unique Ligands	ACT, CER, CL

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2VKZ \| pdb_00002vkz	Download File View File

Structure of the cerulenin-inhibited fungal fatty acid synthase type I multienzyme complex

Johansson, P., Wiltschi, B., Kumari, P., Kessler, B., Vonrhein, C., Vonck, J., Oesterhelt, D., Grininger, M.

(2008) Proc Natl Acad Sci U S A 105: 12803

Released	2008-08-12
Method	X-RAY DIFFRACTION 4 Å
Organisms	Saccharomyces cerevisiae
Macromolecule	FATTY ACID SYNTHASE SUBUNIT ALPHA (protein) FATTY ACID SYNTHASE SUBUNIT BETA (protein)
Unique Ligands	CER, FMN

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3HMJ \| pdb_00003hmj	Download File View File

Saccharomyces cerevisiae FAS type I

Johansson, P., Mulinacci, B., Koestler, C., Vollrath, R., Oesterhelt, D., Grininger, M.

(2009) Structure 17: 1063-1074

Released	2009-09-01
Method	X-RAY DIFFRACTION 4 Å
Organisms	Saccharomyces cerevisiae
Macromolecule	Fatty acid synthase subunit alpha (protein) Fatty acid synthase subunit beta (protein)
Unique Ligands	CER, FMN

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3S20 \| pdb_00003s20	Download File View File

Crystal structure of cerulenin bound Xanthomonas campestri OleA (soak)

Goblirsch, B.R., Wilmot, C.M.

(2012) Biochemistry 51: 4138-4146

Released	2012-05-16
Method	X-RAY DIFFRACTION 1.8796 Å
Organisms	Xanthomonas campestris pv. campestris
Macromolecule	3-oxoacyl-[ACP] synthase III (protein)
Unique Ligands	CER, PEG

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3S21 \| pdb_00003s21	Download File View File

Crystal structure of cerulenin bound Xanthomonas campestri OleA (co-crystal)

Goblirsch, B.R., Wilmot, C.M.

(2012) Biochemistry 51: 4138-4146

Released	2012-05-09
Method	X-RAY DIFFRACTION 1.7001 Å
Organisms	Xanthomonas campestris pv. campestris
Macromolecule	3-oxoacyl-[ACP] synthase III (protein)
Unique Ligands	CER, GOL, MN

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3S23 \| pdb_00003s23	Download File View File

Crystal structure of cerulenin bound Xanthomonas campestri oleA (co-crystal) Xe Derivative

Goblirsch, B.R., Wilmot, C.M.

(2012) Biochemistry 51: 4138-4146

Released	2012-05-09
Method	X-RAY DIFFRACTION 1.9484 Å
Organisms	Xanthomonas campestris pv. campestris
Macromolecule	3-oxoacyl-[ACP] synthase III (protein)
Unique Ligands	CER, GOL, MN, XE

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5VXE \| pdb_00005vxe	Download File View File

Crystal structure of Xanthomonas campestris OleA E117A bound with Cerulenin

Jensen, M.R., Wilmot, C.M.

(2017) Biochem J 474: 3871-3886

Released	2017-10-25
Method	X-RAY DIFFRACTION 1.66 Å
Organisms	Xanthomonas campestris pv. campestris str. ATCC 33913
Macromolecule	3-oxoacyl-[ACP] synthase III (protein)
Unique Ligands	CER, GOL, MN

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5VXG \| pdb_00005vxg	Download File View File

Crystal structure of Xanthomonas campestris OleA E117Q bound with Cerulenin

Jensen, M.R., Wilmot, C.M.

(2017) Biochem J 474: 3871-3886

Released	2017-10-25
Method	X-RAY DIFFRACTION 2.07 Å
Organisms	Xanthomonas campestris pv. campestris str. ATCC 33913
Macromolecule	3-oxoacyl-[ACP] synthase III (protein)
Unique Ligands	CER, MN

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5VXI \| pdb_00005vxi	Download File View File

Crystal structure of Xanthomonas campestris OleA E117D bound with Cerulenin

Jensen, M.R., Wilmot, C.M.

(2017) Biochem J 474: 3871-3886

Released	2017-10-25
Method	X-RAY DIFFRACTION 2.08 Å
Organisms	Xanthomonas campestris pv. campestris str. ATCC 33913
Macromolecule	3-oxoacyl-[ACP] synthase III (protein)
Unique Ligands	CER, MN

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6B2U \| pdb_00006b2u	Download File View File

Crystal structure of Xanthomonas campestris OleA H285N with Cerulenin

Jensen, M.R., Goblirsch, B.R., Esler, M.A., Christenson, J.K., Mohamed, F.A., Wackett, L.P., Wilmot, C.M.

To be published

Released	2018-02-28
Method	X-RAY DIFFRACTION 2.04 Å
Organisms	Xanthomonas campestris pv. campestris str. ATCC 33913
Macromolecule	3-oxoacyl-[ACP] synthase III (protein)
Unique Ligands	CER, MN

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8QM1 \| pdb_00008qm1	Download File View File

wild type Pa.FabF in complex cerulenin

Georgiou, C., Brenk, R., Espeland, L.O.

(2023) ChemRxiv

Released	2024-01-10
Method	X-RAY DIFFRACTION 1.91 Å
Organisms	Pseudomonas aeruginosa
Macromolecule	3-oxoacyl-[acyl-carrier-protein] synthase 2 (protein)
Unique Ligands	CER, DMS, FMT, PO4

1 to 13 of 13 Structures

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1B3N | pdb_00001b3n

BETA-KETOACYL CARRIER PROTEIN SYNTHASE AS A DRUG TARGET, IMPLICATIONS FROM THE CRYSTAL STRUCTURE OF A COMPLEX WITH THE INHIBITOR CERULENIN.

1FJ8 | pdb_00001fj8

THE STRUCTURE OF BETA-KETOACYL-[ACYL CARRIER PROTEIN] SYNTHASE I IN COMPLEX WITH CERULENIN, IMPLICATIONS FOR DRUG DESIGN

2QO3 | pdb_00002qo3

Crystal Structure of [KS3][AT3] didomain from module 3 of 6-deoxyerthronolide B synthase

2VKZ | pdb_00002vkz

Structure of the cerulenin-inhibited fungal fatty acid synthase type I multienzyme complex

3HMJ | pdb_00003hmj

Saccharomyces cerevisiae FAS type I

3S20 | pdb_00003s20

Crystal structure of cerulenin bound Xanthomonas campestri OleA (soak)

3S21 | pdb_00003s21

Crystal structure of cerulenin bound Xanthomonas campestri OleA (co-crystal)

3S23 | pdb_00003s23

Crystal structure of cerulenin bound Xanthomonas campestri oleA (co-crystal) Xe Derivative

5VXE | pdb_00005vxe

Crystal structure of Xanthomonas campestris OleA E117A bound with Cerulenin

5VXG | pdb_00005vxg

Crystal structure of Xanthomonas campestris OleA E117Q bound with Cerulenin

5VXI | pdb_00005vxi

Crystal structure of Xanthomonas campestris OleA E117D bound with Cerulenin

6B2U | pdb_00006b2u

Crystal structure of Xanthomonas campestris OleA H285N with Cerulenin

8QM1 | pdb_00008qm1

wild type Pa.FabF in complex cerulenin

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

1B3N | pdb_00001b3n

1FJ8 | pdb_00001fj8

2QO3 | pdb_00002qo3

2VKZ | pdb_00002vkz

3HMJ | pdb_00003hmj

3S20 | pdb_00003s20

3S21 | pdb_00003s21

3S23 | pdb_00003s23

5VXE | pdb_00005vxe

5VXG | pdb_00005vxg

5VXI | pdb_00005vxi

6B2U | pdb_00006b2u

8QM1 | pdb_00008qm1