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233,605 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Chemical ID(s) = IMP

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Search Summary

This query matches 197 Structures.

Refinements

Structure Determination Methodology

experimental (197)

Scientific Name of Source Organism

	Homo sapiens (46)
	Oryctolagus cuniculus (29)
	Mycolicibacterium thermoresistibile ATCC 19527 (11)
	Escherichia coli (8)
	Bacillus anthracis (6)
	Bacillus anthracis str. Ames (6)
	Escherichia coli K-12 (6)
	Clostridium perfringens ATCC 13124 (5)
	Mycobacterium tuberculosis H37Rv (5)
	Mycolicibacterium smegmatis MC2 155 (5)

More...

Taxonomy

	Eukaryota (100)
	Bacteria (93)
	Archaea (3)
	Duplodnaviria (1)
	other sequences (1)

Experimental Method

	X-RAY DIFFRACTION (160)
	ELECTRON MICROSCOPY (37)

Polymer Entity Type

	Protein (197)
	RNA (1)

Refinement Resolution (Å)

	1.0 - 1.5 (5)
	1.5 - 2.0 (59)
	2.0 - 2.5 (69)
	2.5 - 3.0 (40)
	3.0 - 3.5 (16)
	3.5 - 4.0 (7)
	4.0 - 4.5 (1)

Release Date

	1990 - 1994 (1)
	1995 - 1999 (10)
	2000 - 2004 (16)
	2005 - 2009 (11)
	2010 - 2014 (30)
	2015 - 2019 (61)
	2020 - 2024 (56)
	2025 - 2029 (12)

Enzyme Classification Name

	Oxidoreductases (117)
	Hydrolases (19)
	Transferases (41)
	Ligases (16)
	Isomerases (1)
	Lyases (1)

Symmetry Type

	Cyclic (128)
	Dihedral (63)
	Asymmetric (20)

SCOP Classification

	Alpha and beta proteins (a/b) (111)
	Artifacts (32)
	Alpha and beta proteins (a+b) (6)
	All alpha proteins (2)
	Multi-domain proteins (alpha and beta) (1)

AllSelected

1 to 25 of 197 Structures

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1ABB \| pdb_00001abb	Download File View File

CONTROL OF PHOSPHORYLASE B CONFORMATION BY A MODIFIED COFACTOR: CRYSTALLOGRAPHIC STUDIES ON R-STATE GLYCOGEN PHOSPHORYLASE RECONSTITUTED WITH PYRIDOXAL 5'-DIPHOSPHATE

Leonidas, D.D., Oikonomakos, N.G., Papageorgiou, A.C., Acharya, K.R., Barford, D., Johnson, L.N.

(1992) Protein Sci 1: 1112-1122

Released	1993-10-31
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Oryctolagus cuniculus
Macromolecule	GLYCOGEN PHOSPHORYLASE B (protein)
Unique Ligands	IMP, PDP, SO4

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1B4D \| pdb_00001b4d	Download File View File

AMIDOCARBAMATE INHIBITOR OF GLYCOGEN PHOSPHORYLASE

Tsitsanou, K.E., Oikonomakos, N.G., Zographos, S.E., Skamnaki, V.T., Gregoriou, M., Watson, K.A., Johnson, L.N., Fleet, G.W.J.

(1999) Protein Sci 8: 741-749

Released	1998-12-23
Method	X-RAY DIFFRACTION 2 Å
Organisms	Oryctolagus cuniculus
Macromolecule	PROTEIN (GLYCOGEN PHOSPHORYLASE B) (protein)
Unique Ligands	CRA, IMP, PLP

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1CE8 \| pdb_00001ce8	Download File View File

CARBAMOYL PHOSPHATE SYNTHETASE FROM ESCHERICHIS COLI WITH COMPLEXED WITH THE ALLOSTERIC LIGAND IMP

Thoden, J.B., Raushel, F.M., Holden, H.M.

(1999) J Biological Chem 274: 22502-22507

Released	1999-07-26
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Escherichia coli
Macromolecule	PROTEIN (CARBAMOYL-PHOSPHATE SYNTHASE) (protein)
Unique Ligands	ADP, CL, IMP, K, MN, NET, ORN, PO4

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1CH8 \| pdb_00001ch8	Download File View File

STRUCTURE OF ADENYLOSUCCINATE SYNTHETASE FROM E. COLI COMPLEXED WITH A STRINGENT EFFECTOR, PPG2':3'P

Hou, Z., Cashel, M., Fromm, H.J., Honzatko, R.B.

(1999) J Biological Chem 274: 17505-17510

Released	1999-12-29
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Escherichia coli K-12
Macromolecule	PROTEIN (ADENYLOSUCCINATE SYNTHETASE) (protein)
Unique Ligands	GPX, HDA, IMP, MG, NO3

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1CIB \| pdb_00001cib	Download File View File

STRUCTURE OF ADENYLOSUCCINATE SYNTHETASE FROM E. COLI COMPLEXED WITH GDP, IMP, HADACIDIN, AND NO3

Hou, Z., Cashel, M., Fromm, H.J., Honzatko, R.B.

(1999) J Biological Chem 274: 17505-17510

Released	2000-04-05
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Escherichia coli K-12
Macromolecule	ADENYLOSUCCINATE SYNTHETASE (protein)
Unique Ligands	GDP, HDA, IMP, MG, NO3

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1FTQ \| pdb_00001ftq	Download File View File

STRUCTURES OF GLYCOGEN PHOSPHORYLASE-INHIBITOR COMPLEXES AND THE IMPLICATIONS FOR STRUCTURE-BASED DRUG DESIGN

Watson, K.A., Tsitsanou, K.E., Gregoriou, M., Zographos, S.E., Skamnaki, V.T., Oikonomakos, N.G., Fleet, G.W., Johnson, L.N.

(2005) Proteins 61: 966-983

Released	2000-10-04
Method	X-RAY DIFFRACTION 2.35 Å
Organisms	Oryctolagus cuniculus
Macromolecule	GLYCOGEN PHOSPHORYLASE (protein)
Unique Ligands	GL2, IMP, PLP

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1G9S \| pdb_00001g9s	Download File View File

CRYSTAL STRUCTURE OF A COMPLEX BETWEEN E.COLI HPRT AND IMP

Guddat, L.W., Vos, S., Martin, J.L., Keough, D.T., de Jersey, J.

(2002) Protein Sci 11: 1626-1638

Released	2002-08-28
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Escherichia coli
Macromolecule	HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE (protein)
Unique Ligands	IMP, N

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1GFZ \| pdb_00001gfz	Download File View File

FLAVOPIRIDOL INHIBITS GLYCOGEN PHOSPHORYLASE BY BINDING AT THE INHIBITOR SITE

Oikonomakos, N.G., Zographos, S.E., Skamnaki, V.T., Tsitsanou, K.E., Johnson, L.N.

(2000) J Biological Chem 275: 34566-34573

Released	2000-07-26
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Oryctolagus cuniculus
Macromolecule	GLYCOGEN PHOSPHORYLASE (protein)
Unique Ligands	CFF, IMP, PLP

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1GG8 \| pdb_00001gg8	Download File View File

DESIGN OF INHIBITORS OF GLYCOGEN PHOSPHORYLASE: A STUDY OF ALPHA-AND BETA-C-GLUCOSIDES AND 1-THIO-BETA-D-GLUCOSE COMPOUNDS

Watson, K.A., Mitchell, E.P., Johnson, L.N., Son, J.C., Bichard, C.J., Orchard, M.G., Fleet, G.W., Oikonomakos, N.G., Leonidas, D.D., Kontou, M., Papageorgiou, A.C.

(1994) Biochemistry 33: 5745-5758

Released	2000-08-23
Method	X-RAY DIFFRACTION 2.31 Å
Organisms	Oryctolagus cuniculus
Macromolecule	PROTEIN (GLYCOGEN PHOSPHORYLASE) (protein)
Unique Ligands	GLG, IMP, PLP

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1GIM \| pdb_00001gim	Download File View File

CRYSTAL STRUCTURE OF ADENYLOSUCCINATE SYNTHETASE FROM ESCHERICHIA COLI COMPLEXED WITH GDP, IMP, HADACIDIN, NO3-, AND MG2+. DATA COLLECTED AT 100K (PH 6.5)

Poland, B.W., Fromm, H.J., Honzatko, R.B.

(1996) J Mol Biology 264: 1013-1027

Released	1996-12-23
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Escherichia coli
Macromolecule	ADENYLOSUCCINATE SYNTHETASE (protein)
Unique Ligands	GDP, HDA, IMP, MG, NO3

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1GIN \| pdb_00001gin	Download File View File

CRYSTAL STRUCTURE OF ADENYLOSUCCINATE SYNTHETASE FROM ESCHERICHIA COLI COMPLEXED WITH GDP, IMP, HADACIDIN, NO3-, AND MG2+. DATA COLLECTED AT 298K (PH 6.5).

Poland, B.W., Fromm, H.J., Honzatko, R.B.

(1996) J Mol Biology 264: 1013-1027

Released	1997-02-12
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Escherichia coli
Macromolecule	ADENYLOSUCCINATE SYNTHETASE (protein)
Unique Ligands	GDP, HDA, IMP, MG, NO3

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1IWE \| pdb_00001iwe	Download File View File

IMP Complex of the Recombinant Mouse-Muscle Adenylosuccinate Synthetase

Iancu, C.V., Borza, T., Fromm, H.J., Honzatko, R.B.

(2002) J Biological Chem 277: 26779-26787

Released	2002-08-28
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Mus musculus
Macromolecule	Adenylosuccinate Synthetase (protein)
Unique Ligands	ACT, IMP, MG

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1JR1 \| pdb_00001jr1	Download File View File

Crystal structure of Inosine Monophosphate Dehydrogenase in complex with Mycophenolic Acid

Sintchak, M.D., Fleming, M.A., Futer, O., Raybuck, S.A., Chambers, S.P., Caron, P.R., Murcko, M.A., Wilson, K.P.

(1996) Cell 85: 921-930

Released	2001-09-05
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Cricetulus griseus
Macromolecule	Inosine-5'-Monophosphate Dehydrogenase 2 (protein)
Unique Ligands	IMP, K, MOA

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1KJX \| pdb_00001kjx	Download File View File

IMP Complex of E. Coli Adenylosuccinate Synthetase

Hou, Z., Wang, W., Fromm, H.J., Honzatko, R.B.

(2002) J Biological Chem 277: 5970-5976

Released	2002-03-20
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Escherichia coli K-12
Macromolecule	Adenylosuccinate Synthetase (protein)
Unique Ligands	IMP

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1KKB \| pdb_00001kkb	Download File View File

Complex of Escherichia coli Adenylosuccinate Synthetase with IMP and Hadacidin

Hou, Z., Wang, W., Fromm, H.J., Honzatko, R.B.

(2002) J Biological Chem 277: 5970-5976

Released	2002-03-20
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Escherichia coli K-12
Macromolecule	Adenylosuccinate Synthetase (protein)
Unique Ligands	HDA, IMP

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1KKF \| pdb_00001kkf	Download File View File

Complex of E. coli Adenylosuccinate Synthetase with IMP, Hadacidin, Pyrophosphate, and Mg

Hou, Z., Wang, W., Fromm, H.J., Honzatko, R.B.

(2002) J Biological Chem 277: 5970-5976

Released	2002-03-20
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Escherichia coli K-12
Macromolecule	Adenylosuccinate Synthetase (protein)
Unique Ligands	DPO, HDA, IMP, MG

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1LRT \| pdb_00001lrt	Download File View File

CRYSTAL STRUCTURE OF TERNARY COMPLEX OF TRITRICHOMONAS FOETUS INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE: STRUCTURAL CHARACTERIZATION OF NAD+ SITE IN MICROBIAL ENZYME

Gan, L., Petsko, G.A., Hedstrom, L.

(2003) Biochemistry 41: 13309-13317

Released	2003-07-07
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Tritrichomonas suis
Macromolecule	INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (protein)
Unique Ligands	BOG, IMP, K, TAD, TRS

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1ME9 \| pdb_00001me9	Download File View File

Inosine Monophosphate Dehydrogenase (IMPDH) From Tritrichomonas Foetus with IMP bound

Prosise, G.L., Luecke, H.

(2003) J Mol Biology 326: 517-527

Released	2003-08-12
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Tritrichomonas suis
Macromolecule	INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (protein)
Unique Ligands	IMP, K

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1MEH \| pdb_00001meh	Download File View File

Inosine Monophosphate Dehydrogenase (IMPDH) From Tritrichomonas Foetus with IMP and MOA bound

Prosise, G.L., Luecke, H.

(2003) J Mol Biology 326: 517-527

Released	2003-08-12
Method	X-RAY DIFFRACTION 1.95 Å
Organisms	Tritrichomonas suis
Macromolecule	INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (protein)
Unique Ligands	IMP, K, MOA

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1P17 \| pdb_00001p17	Download File View File

Hypoxanthine Phosphoribosyltransferase from Trypanosoma cruzi, K68R mutant, complexed with the product IMP

Medrano, F.J., Eakin, A.E., Craig III, S.P.

(2004) J Mol Biology 335: 905-921

Released	2004-05-18
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Trypanosoma cruzi
Macromolecule	hypoxanthine phosphoribosyltransferase (protein)
Unique Ligands	IMP

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1P19 \| pdb_00001p19	Download File View File

Hypoxanthine Phosphoribosyltransferase from Trypanosoma cruzi, in complex with the product IMP

Medrano, F.J., Eakin, A.E., Craig III, S.P.

(2004) J Mol Biology 335: 905-921

Released	2004-05-18
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Trypanosoma cruzi
Macromolecule	hypoxanthine phosphoribosyltransferase (protein)
Unique Ligands	IMP

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1QK4 \| pdb_00001qk4	Download File View File

TOXOPLASMA GONDII HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE IMP COMPLEX

Heroux, A., White, E.L., Ross, L.J., Borhani, D.W.

(1999) Biochemistry 38: 14485

Released	1999-10-17
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Toxoplasma gondii RH
Macromolecule	HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE (protein)
Unique Ligands	IMP

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1YFZ \| pdb_00001yfz	Download File View File

Novel IMP Binding in Feedback Inhibition of Hypoxanthine-Guanine Phosphoribosyltransferase from Thermoanaerobacter tengcongensis

Chen, Q., Liang, Y., Su, X., Gu, X., Zheng, X., Luo, M.

(2005) J Mol Biology 348: 1199-1210

Released	2005-05-10
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Caldanaerobacter subterraneus subsp. tengcongensis MB4
Macromolecule	Hypoxanthine-guanine phosphoribosyltransferase (protein)
Unique Ligands	ACT, IMP, MG

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1Z6D \| pdb_00001z6d	Download File View File

Ribonuclease A- IMP complex

Hatzopoulos, G.N., Leonidas, D.D., Kardakaris, R., Kobe, J., Oikonomakos, N.G.

(2005) FEBS J 272: 3988-4001

Released	2005-08-16
Method	X-RAY DIFFRACTION 1.54 Å
Organisms	Bos taurus
Macromolecule	Ribonuclease pancreatic (protein)
Unique Ligands	IMP

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1ZFJ \| pdb_00001zfj	Download File View File

INOSINE MONOPHOSPHATE DEHYDROGENASE (IMPDH; EC 1.1.1.205) FROM STREPTOCOCCUS PYOGENES

Zhang, R., Evans, G., Rotella, F.J., Westbrook, E.M., Beno, D., Huberman, E., Joachimiak, A., Collart, F.R.

(1999) Biochemistry 38: 4691-4700

Released	2000-03-29
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Streptococcus pyogenes
Macromolecule	INOSINE MONOPHOSPHATE DEHYDROGENASE (protein)
Unique Ligands	IMP

1 to 25 of 197 Structures

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

1ABB | pdb_00001abb

1B4D | pdb_00001b4d

1CE8 | pdb_00001ce8

1CH8 | pdb_00001ch8

1CIB | pdb_00001cib

1FTQ | pdb_00001ftq

1G9S | pdb_00001g9s

1GFZ | pdb_00001gfz

1GG8 | pdb_00001gg8

1GIM | pdb_00001gim

1GIN | pdb_00001gin

1IWE | pdb_00001iwe

1JR1 | pdb_00001jr1

1KJX | pdb_00001kjx

1KKB | pdb_00001kkb

1KKF | pdb_00001kkf

1LRT | pdb_00001lrt

1ME9 | pdb_00001me9

1MEH | pdb_00001meh

1P17 | pdb_00001p17

1P19 | pdb_00001p19

1QK4 | pdb_00001qk4

1YFZ | pdb_00001yfz

1Z6D | pdb_00001z6d

1ZFJ | pdb_00001zfj