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233,605 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Gene Name = "CDKN2"

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Search Summary

This query matches 140 Structures.

Refinements

Structure Determination Methodology

experimental (140)

Scientific Name of Source Organism

	Homo sapiens (140)
	Bos taurus (5)
	Mus musculus (2)
	synthetic construct (2)
	Lama glama (1)

Taxonomy

	Eukaryota (140)
	other sequences (2)

Experimental Method

	X-RAY DIFFRACTION (133)
	ELECTRON MICROSCOPY (7)

Polymer Entity Type

Protein (140)

Refinement Resolution (Å)

	0.5 - 1.0 (1)
	1.0 - 1.5 (22)
	1.5 - 2.0 (59)
	2.0 - 2.5 (31)
	2.5 - 3.0 (16)
	3.0 - 3.5 (6)
	3.5 - 4.0 (5)

Release Date

	2005 - 2009 (1)
	2010 - 2014 (41)
	2015 - 2019 (45)
	2020 - 2024 (52)
	2025 - 2029 (1)

Enzyme Classification Name

	Transferases (139)
	Hydrolases (1)

Symmetry Type

	Asymmetric (138)
	Cyclic (2)

SCOP Classification

	Alpha and beta proteins (a+b) (95)
	All alpha proteins (31)
	Artifacts (38)

AllSelected

1 to 25 of 140 Structures

Page 1 of 6

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2CCI \| pdb_00002cci	Download File View File

Crystal structure of phospho-CDK2 Cyclin A in complex with a peptide containing both the substrate and recruitment sites of CDC6

Cheng, K.Y., Noble, M.E.M., Skamnaki, V., Brown, N.R., Lowe, E.D., Kontogiannis, L., Shen, K., Cole, P.A., Siligardi, G., Johnson, L.N.

(2006) J Biological Chem 281: 23167-23179

Released	2006-05-03
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Homo sapiens
Macromolecule	Cell division control protein 6 homolog (protein) Cyclin-A2 (protein) Cyclin-dependent kinase 2 (protein)
Unique Ligands	ATP, MG

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3ULI \| pdb_00003uli	Download File View File

Human Cyclin Dependent Kinase 2 (CDK2) bound to azabenzimidazole derivative

Larsen, N.A., Tucker, J.A., Wang, T.

(2012) Bioorg Med Chem Lett 22: 2063-2069

Released	2013-08-14
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	Cyclin-dependent kinase 2 (protein)
Unique Ligands	1N3

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3WBL \| pdb_00003wbl	Download File View File

Crystal structure of CDK2 in complex with pyrazolopyrimidine inhibitor

Fujino, A., Fukushima, K., Kubota, T., Kosugi, T., Takimoto-Kamimura, M.

(2013) J Synchrotron Radiat 20: 905-909

Released	2013-10-30
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	Cyclin-dependent kinase 2 (protein)
Unique Ligands	ACT, PDY

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4EK3 \| pdb_00004ek3	Download File View File

Crystal structure of apo CDK2

Kang, Y.N., Stuckey, J.A.

To be published

Released	2013-05-01
Method	X-RAY DIFFRACTION 1.34 Å
Organisms	Homo sapiens
Macromolecule	Cyclin-dependent kinase 2 (protein)

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4EK4 \| pdb_00004ek4	Download File View File

Crystal structure of the cdk2 in complex with aminopyrazole inhibitor

Kang, Y.N., Stuckey, J.A.

To be published

Released	2013-05-01
Method	X-RAY DIFFRACTION 1.26 Å
Organisms	Homo sapiens
Macromolecule	Cyclin-dependent kinase 2 (protein)
Unique Ligands	1CK, NA

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4EK5 \| pdb_00004ek5	Download File View File

Crystal structure of the cdk2 in complex with aminopyrazole inhibitor

Kang, Y.N., Stuckey, J.A.

To be published

Released	2013-05-01
Method	X-RAY DIFFRACTION 1.6 Å
Organisms	Homo sapiens
Macromolecule	Cyclin-dependent kinase 2 (protein)
Unique Ligands	03K

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4EK6 \| pdb_00004ek6	Download File View File

Crystal structure of the cdk2 in complex with aminopyrazole inhibitor

Kang, Y.N., Stuckey, J.A.

To be published

Released	2013-05-01
Method	X-RAY DIFFRACTION 1.52 Å
Organisms	Homo sapiens
Macromolecule	Cyclin-dependent kinase 2 (protein)
Unique Ligands	10K

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4EK8 \| pdb_00004ek8	Download File View File

Crystal structure of the cdk2 in complex with thiazolylpyrimidine inhibitor

Kang, Y.N., Stuckey, J.A.

To be published

Released	2013-05-01
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Homo sapiens
Macromolecule	Cyclin-dependent kinase 2 (protein)
Unique Ligands	16K

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4EOI \| pdb_00004eoi	Download File View File

Thr 160 phosphorylated CDK2 K89D, Q131E - human cyclin A3 complex with the inhibitor RO3306

Echalier, A., Cot, E., Camasses, A., Hodimont, E., Hoh, F., Sheinerman, F., Krasinska, L., Fisher, D.

(2012) Chem Biol 19: 1028-1040

Released	2013-02-06
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	Cyclin-A2 (protein) Cyclin-dependent kinase 2 (protein)
Unique Ligands	1RO, DMS, SGM

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4EOJ \| pdb_00004eoj	Download File View File

Thr 160 phosphorylated CDK2 H84S, Q85M, K89D - human cyclin A3 complex with ATP

Echalier, A., Cot, E., Camasses, A., Hodimont, E., Hoh, F., Sheinerman, F., Krasinska, L., Fisher, D.

(2012) Chem Biol 19: 1028-1040

Released	2013-02-06
Method	X-RAY DIFFRACTION 1.65 Å
Organisms	Homo sapiens
Macromolecule	Cyclin-A2 (protein) Cyclin-dependent kinase 2 (protein)
Unique Ligands	ATP, MG, SGM

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4EOK \| pdb_00004eok	Download File View File

Thr 160 phosphorylated CDK2 H84S, Q85M, K89D - human cyclin A3 complex with the inhibitor NU6102

Echalier, A., Cot, E., Camasses, A., Hodimont, E., Hoh, F., Sheinerman, F., Krasinska, L., Fisher, D.

(2012) Chem Biol 19: 1028-1040

Released	2013-02-06
Method	X-RAY DIFFRACTION 2.57 Å
Organisms	Homo sapiens
Macromolecule	Cyclin-A2 (protein) Cyclin-dependent kinase 2 (protein)
Unique Ligands	4SP, SGM

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4EOL \| pdb_00004eol	Download File View File

Thr 160 phosphorylated CDK2 H84S, Q85M, K89D - human cyclin A3 complex with the inhibitor RO3306

Echalier, A., Cot, E., Camasses, A., Hodimont, E., Hoh, F., Sheinerman, F., Krasinska, L., Fisher, D.

(2012) Chem Biol 19: 1028-1040

Released	2013-02-06
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	Cyclin-A2 (protein) Cyclin-dependent kinase 2 (protein)
Unique Ligands	1RO, MG, SGM

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4EOM \| pdb_00004eom	Download File View File

Thr 160 phosphorylated CDK2 H84S, Q85M, Q131E - human cyclin A3 complex with ATP

Echalier, A., Cot, E., Camasses, A., Hodimont, E., Hoh, F., Sheinerman, F., Krasinska, L., Fisher, D.

(2012) Chem Biol 19: 1028-1040

Released	2013-02-06
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens
Macromolecule	Cyclin-A2 (protein) Cyclin-dependent kinase 2 (protein)
Unique Ligands	ATP, MG

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4EON \| pdb_00004eon	Download File View File

Thr 160 phosphorylated CDK2 H84S, Q85M, Q131E - human cyclin A3 complex with the inhibitor RO3306

Echalier, A., Cot, E., Camasses, A., Hodimont, E., Hoh, F., Sheinerman, F., Krasinska, L., Fisher, D.

(2012) Chem Biol 19: 1028-1040

Released	2013-02-06
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	Cyclin-A2 (protein) Cyclin-dependent kinase 2 (protein)
Unique Ligands	1RO, MG

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4EOO \| pdb_00004eoo	Download File View File

Thr 160 phosphorylated CDK2 Q131E - human cyclin A3 complex with ATP

Echalier, A., Cot, E., Camasses, A., Hodimont, E., Hoh, F., Sheinerman, F., Krasinska, L., Fisher, D.

(2012) Chem Biol 19: 1028-1040

Released	2013-02-06
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens
Macromolecule	Cyclin-A2 (protein) Cyclin-dependent kinase 2 (protein)
Unique Ligands	ATP, MG, SGM

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4EOP \| pdb_00004eop	Download File View File

Thr 160 phosphorylated CDK2 Q131E - human cyclin A3 complex with the inhibitor RO3306

Echalier, A., Cot, E., Camasses, A., Hodimont, E., Hoh, F., Sheinerman, F., Krasinska, L., Fisher, D.

(2012) Chem Biol 19: 1028-1040

Released	2013-02-06
Method	X-RAY DIFFRACTION 1.99 Å
Organisms	Homo sapiens
Macromolecule	Cyclin-A2 (protein) Cyclin-dependent kinase 2 (protein)
Unique Ligands	1RO, MG, SGM

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4EOQ \| pdb_00004eoq	Download File View File

Thr 160 phosphorylated CDK2 WT - human cyclin A3 complex with ATP

Echalier, A., Cot, E., Camasses, A., Hodimont, E., Hoh, F., Sheinerman, F., Krasinska, L., Fisher, D.

(2012) Chem Biol 19: 1028-1040

Released	2013-02-06
Method	X-RAY DIFFRACTION 2.15 Å
Organisms	Homo sapiens
Macromolecule	Cyclin-A2 (protein) Cyclin-dependent kinase 2 (protein)
Unique Ligands	ATP, MG, SGM

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4EOR \| pdb_00004eor	Download File View File

Thr 160 phosphorylated CDK2 WT - human cyclin A3 complex with the inhibitor NU6102

Echalier, A., Cot, E., Camasses, A., Hodimont, E., Hoh, F., Sheinerman, F., Krasinska, L., Fisher, D.

(2012) Chem Biol 19: 1028-1040

Released	2013-02-06
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens
Macromolecule	Cyclin-A2 (protein) Cyclin-dependent kinase 2 (protein)
Unique Ligands	4SP

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4EOS \| pdb_00004eos	Download File View File

Thr 160 phosphorylated CDK2 WT - human cyclin A3 complex with the inhibitor RO3306

Echalier, A., Cot, E., Camasses, A., Hodimont, E., Hoh, F., Sheinerman, F., Krasinska, L., Fisher, D.

(2012) Chem Biol 19: 1028-1040

Released	2013-02-06
Method	X-RAY DIFFRACTION 2.57 Å
Organisms	Homo sapiens
Macromolecule	Cyclin-A2 (protein) Cyclin-dependent kinase 2 (protein)
Unique Ligands	1RO