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233,605 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Gene Name = "EP300"

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Search Summary

This query matches 33 Structures.

Refinements

Structure Determination Methodology

experimental (33)

Scientific Name of Source Organism

	Homo sapiens (33)
	Xenopus laevis (11)
	synthetic construct (11)
	Gallus gallus (1)

Taxonomy

	Eukaryota (33)
	other sequences (11)

Experimental Method

	X-RAY DIFFRACTION (13)
	ELECTRON MICROSCOPY (11)
	SOLUTION NMR (9)

Polymer Entity Type

	Protein (33)
	DNA (13)

Refinement Resolution (Å)

	1.5 - 2.0 (3)
	2.0 - 2.5 (4)
	2.5 - 3.0 (4)
	3.0 - 3.5 (3)
	4.0 - 4.5 (4)
	> 4.5 (6)

Release Date

	2005 - 2009 (1)
	2010 - 2014 (9)
	2015 - 2019 (10)
	2020 - 2024 (13)

Enzyme Classification Name

	Transferases (33)
	Isomerases (2)

Symmetry Type

	Asymmetric (33)
	Cyclic (2)
	Dihedral (1)

SCOP Classification

	All alpha proteins (6)
	Alpha and beta proteins (a+b) (2)
	Artifacts (2)
	Peptides (1)
	Small proteins (1)

AllSelected

1 to 25 of 33 Structures

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2KKF \| pdb_00002kkf	Download File View File

Solution structure of MLL CXXC domain in complex with palindromic CPG DNA

Cierpicki, T., Riesbeck, J.E., Grembecka, J.E., Lukasik, S.M., Popovic, R., Omonkowska, M., Shultis, D.S., Zeleznik-Le, N.J., Bushweller, J.H.

(2010) Nat Struct Mol Biol 17: 62-68

Released	2009-12-08
Method	SOLUTION NMR
Organisms	Homo sapiens
Macromolecule	Histone-lysine N-methyltransferase HRX (protein) 5'-D(CPCPCPTPGPCPGPCPAPGPGPG)-3' (nucleic acid)
Unique Ligands	ZN

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2KYU \| pdb_00002kyu	Download File View File

The solution structure of the PHD3 finger of MLL

Park, S., Bushweller, J.H.

(2010) Biochemistry 49: 6576-6586

Released	2010-08-25
Method	SOLUTION NMR
Organisms	Homo sapiens
Macromolecule	Histone-lysine N-methyltransferase MLL (protein)
Unique Ligands	ZN

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2LXS \| pdb_00002lxs	Download File View File

Allosteric communication in the KIX domain proceeds through dynamic re-packing of the hydrophobic core

Bruschweiler, S., Schanda, P., Konrat, R., Tollinger, M.

(2013) ACS Chem Biol 8: 1600-1610

Released	2013-06-12
Method	SOLUTION NMR
Organisms	Homo sapiens
Macromolecule	CREB-binding protein (protein) Histone-lysine N-methyltransferase MLL (protein)

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2LXT \| pdb_00002lxt	Download File View File

Allosteric communication in the KIX domain proceeds through dynamic re-packing of the hydrophobic core

Bruschweiler, S., Schanda, P., Konrat, R., Tollinger, M.

(2013) ACS Chem Biol 8: 1600-1610

Released	2013-06-12
Method	SOLUTION NMR
Organisms	Homo sapiens
Macromolecule	CREB-binding protein (protein) Cyclic AMP-responsive element-binding protein 1 (protein) Histone-lysine N-methyltransferase MLL (protein)

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2MSR \| pdb_00002msr	Download File View File

Solution structure of LEDGF/p75 IBD in complex with MLL1 peptide (140-160)

Cermakova, K., Tesina, P., Demeulemeester, J., El Ashkar, S., Mereau, H., Schwaller, J., Rezacova, P., Veverka, V., De Rijck, J.

(2014) Cancer Res 74: 5139-5151

Released	2014-08-20
Method	SOLUTION NMR
Organisms	Homo sapiens
Macromolecule	Histone-lysine N-methyltransferase 2A (protein) PC4 and SFRS1-interacting protein (protein)

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2MTN \| pdb_00002mtn	Download File View File

Solution structure of MLL-IBD complex

Cierpicki, T., Pollock, J., Murai, M.

(2014) Blood 124: 3730-3737

Released	2014-12-03
Method	SOLUTION NMR
Organisms	Homo sapiens
Macromolecule	Histone-lysine N-methyltransferase 2A, PC4 and SFRS1-interacting protein fusion (protein)

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3LQH \| pdb_00003lqh	Download File View File

Crystal structure of MLL1 PHD3-Bromo in the free form

Wang, Z., Patel, D.J.

(2010) Cell 141: 1183-1194

Released	2010-07-07
Method	X-RAY DIFFRACTION 1.72 Å
Organisms	Homo sapiens
Macromolecule	Histone-lysine N-methyltransferase MLL (protein)
Unique Ligands	ZN

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3U85 \| pdb_00003u85	Download File View File

Crystal structure of human menin in complex with MLL1

Huang, J., Wan, B., Lei, M.

(2012) Nature 482: 542-546

Released	2012-02-15
Method	X-RAY DIFFRACTION 3 Å
Organisms	Homo sapiens
Macromolecule	Histone-lysine N-methyltransferase 2A (protein) Menin (protein)

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3U88 \| pdb_00003u88	Download File View File

Crystal structure of human menin in complex with MLL1 and LEDGF

Huang, J., Wan, B., Lei, M.

(2012) Nature 482: 542-546

Released	2012-02-15
Method	X-RAY DIFFRACTION 3 Å
Organisms	Homo sapiens
Macromolecule	Histone-lysine N-methyltransferase 2A (protein) Lens epithelium-derived growth factor (protein) Menin (protein)
Unique Ligands	0BR, CHD, GGB, GLV, SO4

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4NW3 \| pdb_00004nw3	Download File View File

Crystal structure of MLL CXXC domain in complex with a CpG DNA

Bian, C., Tempel, W., Chao, X., Walker, J.R., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)

(2018) Structure 26: 85-95.e3

Released	2014-04-23
Method	X-RAY DIFFRACTION 2.82 Å
Organisms	Homo sapiens
Macromolecule	Histone-lysine N-methyltransferase 2A (protein) 5'-D(GPCPCPAPTPCPGPAPTPGPGPC)-3' (nucleic acid)
Unique Ligands	ZN

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5F5E \| pdb_00005f5e	Download File View File

The Crystal Structure of MLL1 SET domain with N3816I/Q3867L mutation

Li, Y., Lei, M., Chen, Y.

(2016) Nature 530: 447-452

Released	2016-02-24
Method	X-RAY DIFFRACTION 1.802 Å
Organisms	Homo sapiens
Macromolecule	Histone-lysine N-methyltransferase 2A (protein)
Unique Ligands	SAH, ZN

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5F6L \| pdb_00005f6l	Download File View File

The crystal structure of MLL1 (N3861I/Q3867L) in complex with RbBP5 and Ash2L

Li, Y., Lei, M., Chen, Y.

(2016) Nature 530: 447-452

Released	2016-02-24
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Homo sapiens
Macromolecule	Histone-lysine N-methyltransferase 2A (protein) Retinoblastoma-binding protein 5 (protein) Set1/Ash2 histone methyltransferase complex subunit ASH2 (protein)
Unique Ligands	SAH, ZN

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5SVH \| pdb_00005svh	Download File View File

Crystal structure of the KIX domain of CBP in complex with a MLL/c-Myb chimera

Langelaan, D.N., Smith, S.P., Allingham, J.A.

To be published

Released	2018-05-09
Method	X-RAY DIFFRACTION 2.05 Å
Organisms	Gallus gallus Homo sapiens
Macromolecule	CREB-binding protein (protein) MLL/c-Myb chimera (protein)
Unique Ligands	CL, GOL

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6EMQ \| pdb_00006emq	Download File View File

Solution structure of the LEDGF/p75 IBD - MLL1 (aa 111-160) complex

Veverka, V.

(2018) Proc Natl Acad Sci U S A 115: E7053-E7062

Released	2018-08-01
Method	SOLUTION NMR
Organisms	Homo sapiens
Macromolecule	PC4 and SFRS1-interacting protein,Histone-lysine N-methyltransferase 2A (protein)

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6KIU \| pdb_00006kiu	Download File View File

Cryo-EM structure of human MLL1-ubNCP complex (3.2 angstrom)

Huang, J., Xue, H., Yao, T.

(2019) Nature 573: 445-449

Released	2019-09-11
Method	ELECTRON MICROSCOPY 3.2 Å
Organisms	Homo sapiens Xenopus laevis synthetic construct
Macromolecule	Unique protein chains: 9 Unique nucleic acid chains: 2
Unique Ligands	GLN, LYS, SAH, ZN

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6KIV \| pdb_00006kiv	Download File View File

Cryo-EM structure of human MLL1-ubNCP complex (4.0 angstrom)

Huang, J., Xue, H., Yao, T.

(2019) Nature 573: 445-449

Released	2019-09-11
Method	ELECTRON MICROSCOPY 4 Å
Organisms	Homo sapiens Xenopus laevis synthetic construct
Macromolecule	Unique protein chains: 9 Unique nucleic acid chains: 2
Unique Ligands	SAH, ZN

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6KIX \| pdb_00006kix	Download File View File

Cryo-EM structure of human MLL1-NCP complex, binding mode1

Huang, J., Xue, H., Yao, T.

(2019) Nature 573: 445-449

Released	2019-09-11
Method	ELECTRON MICROSCOPY 4.1 Å
Organisms	Homo sapiens Xenopus laevis synthetic construct
Macromolecule	Unique protein chains: 8 Unique nucleic acid chains: 2
Unique Ligands	GLN, LYS, SAH, ZN

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6KIZ \| pdb_00006kiz	Download File View File

Cryo-EM structure of human MLL1-NCP complex, binding mode2

Huang, J., Xue, H., Yao, T.

(2019) Nature 573: 445-449

Released	2019-09-11
Method	ELECTRON MICROSCOPY 4.5 Å
Organisms	Homo sapiens Xenopus laevis synthetic construct
Macromolecule	Unique protein chains: 8 Unique nucleic acid chains: 2
Unique Ligands	SAH, ZN

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6PWV \| pdb_00006pwv	Download File View File

Cryo-EM structure of MLL1 core complex bound to the nucleosome

Park, S.H., Ayoub, A., Lee, Y.T., Xu, J., Zhang, W., Zhang, B., Zhang, Y., Cianfrocco, M.A., Su, M., Dou, Y., Cho, U.

(2019) Nat Commun 10: 5540-5540

Released	2019-12-18
Method	ELECTRON MICROSCOPY 6.2 Å
Organisms	Homo sapiens Xenopus laevis synthetic construct
Macromolecule	Unique protein chains: 9 Unique nucleic acid chains: 2
Unique Ligands	SAH, ZN

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6PWW \| pdb_00006pww	Download File View File

Cryo-EM structure of MLL1 in complex with RbBP5 and WDR5 bound to the nucleosome

Park, S.H., Ayoub, A., Lee, Y.T., Xu, J., Zhang, W., Zhang, B., Zhang, Y., Cianfrocco, M.A., Su, M., Dou, Y., Cho, U.

(2019) Nat Commun 10: 5540-5540

Released	2019-12-18
Method	ELECTRON MICROSCOPY 4.4 Å
Organisms	Homo sapiens Xenopus laevis synthetic construct
Macromolecule	Unique protein chains: 7 Unique nucleic acid chains: 2
Unique Ligands	SAH, ZN

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6W5I \| pdb_00006w5i	Download File View File

Cryo-EM structure of MLL1 in complex with RbBP5, WDR5, SET1, and ASH2L bound to the nucleosome (Class01)

Park, S.H., Lee, Y.T., Ayoub, A., Dou, Y., Cho, U.

(2021) Nat Commun 12: 2953-2953

Released	2021-03-31
Method	ELECTRON MICROSCOPY 6.9 Å
Organisms	Homo sapiens Xenopus laevis synthetic construct
Macromolecule	Unique protein chains: 8 Unique nucleic acid chains: 2

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6W5M \| pdb_00006w5m	Download File View File

Cryo-EM structure of MLL1 in complex with RbBP5, WDR5, SET1, and ASH2L bound to the nucleosome (Class02)

Park, S.H., Lee, Y.T., Ayoub, A., Dou, Y., Cho, U.

(2021) Nat Commun 12: 2953-2953

Released	2021-03-31
Method	ELECTRON MICROSCOPY 4.6 Å
Organisms	Homo sapiens Xenopus laevis synthetic construct
Macromolecule	Unique protein chains: 8 Unique nucleic acid chains: 2

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6W5N \| pdb_00006w5n	Download File View File

Cryo-EM structure of MLL1 in complex with RbBP5, WDR5, SET1, and ASH2L bound to the nucleosome (Class05)

Park, S.H., Lee, Y.T., Ayoub, A., Dou, Y., Cho, U.

(2021) Nat Commun 12: 2953-2953

Released	2021-03-31
Method	ELECTRON MICROSCOPY 6 Å
Organisms	Homo sapiens Xenopus laevis synthetic construct
Macromolecule	Unique protein chains: 8 Unique nucleic acid chains: 2

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7MBM \| pdb_00007mbm	Download File View File

Cryo-EM structure of MLL1-NCP (H3K4M) complex, mode01

Park, S.H., Ayoub, A., Lee, Y.T., Dou, Y., Cho, U.

(2022) Biochemistry 61: 1-9

Released	2021-12-29
Method	ELECTRON MICROSCOPY 4.76 Å
Organisms	Homo sapiens Xenopus laevis synthetic construct
Macromolecule	Unique protein chains: 8 Unique nucleic acid chains: 2

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7MBN \| pdb_00007mbn	Download File View File

Cryo-EM structure of MLL1-NCP (H3K4M) complex, mode02

Park, S.H., Ayoub, A., Lee, Y.T., Dou, Y., Cho, U.

(2022) Biochemistry 61: 1-9

Released	2021-12-29
Method	ELECTRON MICROSCOPY 4.02 Å
Organisms	Homo sapiens Xenopus laevis synthetic construct
Macromolecule	Unique protein chains: 8 Unique nucleic acid chains: 2

1 to 25 of 33 Structures

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

2KKF | pdb_00002kkf

2KYU | pdb_00002kyu

2LXS | pdb_00002lxs

2LXT | pdb_00002lxt

2MSR | pdb_00002msr

2MTN | pdb_00002mtn

3LQH | pdb_00003lqh

3U85 | pdb_00003u85

3U88 | pdb_00003u88

4NW3 | pdb_00004nw3

5F5E | pdb_00005f5e

5F6L | pdb_00005f6l

5SVH | pdb_00005svh

6EMQ | pdb_00006emq

6KIU | pdb_00006kiu

6KIV | pdb_00006kiv

6KIX | pdb_00006kix

6KIZ | pdb_00006kiz

6PWV | pdb_00006pwv

6PWW | pdb_00006pww

6W5I | pdb_00006w5i

6W5M | pdb_00006w5m

6W5N | pdb_00006w5n

7MBM | pdb_00007mbm

7MBN | pdb_00007mbn