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233,605 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Gene Name = "SNF2L4"

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Search Summary

This query matches 10 Structures.

Refinements

Structure Determination Methodology

experimental (10)

Scientific Name of Source Organism

	Homo sapiens (10)
	Xenopus laevis (1)
	synthetic construct (1)

Taxonomy

	Eukaryota (10)
	other sequences (1)

Experimental Method

	X-RAY DIFFRACTION (9)
	ELECTRON MICROSCOPY (1)

Polymer Entity Type

	Protein (10)
	DNA (1)

Refinement Resolution (Å)

	1.0 - 1.5 (1)
	1.5 - 2.0 (4)
	2.0 - 2.5 (2)
	2.5 - 3.0 (1)
	3.0 - 3.5 (1)
	3.5 - 4.0 (1)

Release Date

	2005 - 2009 (1)
	2015 - 2019 (3)
	2020 - 2024 (6)

Enzyme Classification Name

Hydrolases (10)

Symmetry Type

Asymmetric (10)

SCOP Classification

	All alpha proteins (5)
	Alpha and beta proteins (a+b) (1)
	Artifacts (2)
	All beta proteins (1)

AllSelected

1 to 10 of 10 Structures

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2GRC \| pdb_00002grc	Download File View File

1.5 A structure of bromodomain from human BRG1 protein, a central ATPase of SWI/SNF remodeling complex

Singh, M., Popowicz, G.M., Krajewski, M., Holak, T.A.

(2007) Chembiochem 8: 1308-1316

Released	2007-05-08
Method	X-RAY DIFFRACTION 1.5 Å
Organisms	Homo sapiens
Macromolecule	Probable global transcription activator SNF2L4 (protein)

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5DKD \| pdb_00005dkd	Download File View File

Crystal structure of the bromodomain of human BRG1 (SMARCA4) in complex with PFI-3 chemical probe

Tallant, C., Owen, D.R., Gerstenberger, B.S., Fedorov, O., Savitsky, P., Nunez-Alonso, G., Newman, J.A., Filippakopoulos, P., Burgess-Brown, N., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Muller, S., Knapp, S.

To be published

Released	2015-10-14
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	Transcription activator BRG1 (protein)
Unique Ligands	5BW, EDO, ZN

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5EA1 \| pdb_00005ea1	Download File View File

Crystal Structure of SMARCA4 bromodomain in complex with MPD

Lolli, G., Caflisch, A.

(2016) ACS Chem Biol 11: 800-807

Released	2016-03-16
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	Transcription activator BRG1 (protein)
Unique Ligands	MPD, MRD

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6HR2 \| pdb_00006hr2	Download File View File

Crystal structure of PROTAC 2 in complex with the bromodomain of human SMARCA4 and pVHL:ElonginC:ElonginB

Roy, M., Bader, G., Diers, E., Trainor, N., Farnaby, W., Ciulli, A.

(2019) Nat Chem Biol 15: 672-680

Released	2019-06-12
Method	X-RAY DIFFRACTION 1.76 Å
Organisms	Homo sapiens
Macromolecule	Elongin-B (protein) Elongin-C (protein) Transcription activator BRG1 (protein) von Hippel-Lindau disease tumor suppressor (protein)
Unique Ligands	DMS, EDO, FWZ

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6ZS2 \| pdb_00006zs2	Download File View File

Crystal Structure of the bromodomain of human transcription activator BRG1 (SMARCA4) in complex with 2-(6-amino-5-(piperazin-1-yl)pyridazin-3-yl)phenol

Preuss, F., Joerger, A.C., Kraemer, A., Wanior, M., Knapp, S., Structural Genomics Consortium (SGC)

(2020) J Med Chem 63: 14680-14699

Released	2020-10-07
Method	X-RAY DIFFRACTION 1.57 Å
Organisms	Homo sapiens
Macromolecule	Transcription activator BRG1 (protein)
Unique Ligands	EDO, FX5

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7TAB \| pdb_00007tab	Download File View File

G-925 bound to the SMARCA4 (BRG1) Bromodomain

Tang, Y., Poy, F., Taylor, A.M., Cochran, A.G., Bellon, S.F.

(2022) J Med Chem 65: 11177-11186

Released	2022-08-17
Method	X-RAY DIFFRACTION 1.16 Å
Organisms	Homo sapiens
Macromolecule	Isoform 4 of Transcription activator BRG1 (protein)
Unique Ligands	GGU

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7TD9 \| pdb_00007td9	Download File View File

G-059 bound to the SMARCA4 (BRG1) Bromodomain

Tang, Y., Poy, F., Taylor, A.M., Cochran, A.G., Bellon, S.F.

(2022) J Med Chem 65: 11177-11186

Released	2022-08-17
Method	X-RAY DIFFRACTION 1.61 Å
Organisms	Homo sapiens
Macromolecule	Isoform 4 of Transcription activator BRG1 (protein)
Unique Ligands	GJN

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7VDT \| pdb_00007vdt	Download File View File

The motor-nucleosome module of human chromatin remodeling PBAF-nucleosome complex

Chen, Z.C., Chen, K.J., Yuan, J.J.

(2022) Nature 605: 166-171

Released	2022-05-18
Method	ELECTRON MICROSCOPY 2.8 Å
Organisms	Homo sapiens Xenopus laevis synthetic construct
Macromolecule	Unique protein chains: 5 Unique nucleic acid chains: 2
Unique Ligands	ADP, BEF, MG

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8G1Q \| pdb_00008g1q	Download File View File

Co-crystal structure of Compound 1 in complex with the bromodomain of human SMARCA4 and pVHL:ElonginC:ElonginB

Ghimire Rijal, S., Wurz, R.P., Vaish, A.

(2023) Nat Commun 14: 4177-4177

Released	2023-07-26
Method	X-RAY DIFFRACTION 3.73 Å
Organisms	Homo sapiens
Macromolecule	Elongin-B (protein) Elongin-C (protein) Transcription activator BRG1 (protein) von Hippel-Lindau disease tumor suppressor (protein)
Unique Ligands	NA, PEG, YHB

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8QJR \| pdb_00008qjr	Download File View File

BRG1 bromodomain in complex with VBC via compound 17

Kerry, P.S., Hole, A.J., Perez-Dorado, J.I.

(2024) J Med Chem 67: 1262-1313

Released	2024-01-17
Method	X-RAY DIFFRACTION 3.17 Å
Organisms	Homo sapiens
Macromolecule	Elongin-B (protein) Elongin-C (protein) Transcription activator BRG1 (protein) von Hippel-Lindau disease tumor suppressor (protein)
Unique Ligands	CL, GOL, PO4, VLH

1 to 10 of 10 Structures

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RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.

2GRC | pdb_00002grc

1.5 A structure of bromodomain from human BRG1 protein, a central ATPase of SWI/SNF remodeling complex

5DKD | pdb_00005dkd

Crystal structure of the bromodomain of human BRG1 (SMARCA4) in complex with PFI-3 chemical probe

5EA1 | pdb_00005ea1

Crystal Structure of SMARCA4 bromodomain in complex with MPD

6HR2 | pdb_00006hr2

Crystal structure of PROTAC 2 in complex with the bromodomain of human SMARCA4 and pVHL:ElonginC:ElonginB

6ZS2 | pdb_00006zs2

Crystal Structure of the bromodomain of human transcription activator BRG1 (SMARCA4) in complex with 2-(6-amino-5-(piperazin-1-yl)pyridazin-3-yl)phenol

7TAB | pdb_00007tab

G-925 bound to the SMARCA4 (BRG1) Bromodomain

7TD9 | pdb_00007td9

G-059 bound to the SMARCA4 (BRG1) Bromodomain

7VDT | pdb_00007vdt

The motor-nucleosome module of human chromatin remodeling PBAF-nucleosome complex

8G1Q | pdb_00008g1q

Co-crystal structure of Compound 1 in complex with the bromodomain of human SMARCA4 and pVHL:ElonginC:ElonginB

8QJR | pdb_00008qjr

BRG1 bromodomain in complex with VBC via compound 17

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

2GRC | pdb_00002grc

5DKD | pdb_00005dkd

5EA1 | pdb_00005ea1

6HR2 | pdb_00006hr2

6ZS2 | pdb_00006zs2

7TAB | pdb_00007tab

7TD9 | pdb_00007td9

7VDT | pdb_00007vdt

8G1Q | pdb_00008g1q

8QJR | pdb_00008qjr