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233,605 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Gene Name = "UNQ3040/PRO9856"

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Search Summary

This query matches 38 Structures.

Refinements

Structure Determination Methodology

experimental (38)

Scientific Name of Source Organism

Homo sapiens (38)

Taxonomy

Eukaryota (38)

Experimental Method

X-RAY DIFFRACTION (38)

Polymer Entity Type

Protein (38)

Refinement Resolution (Å)

	1.0 - 1.5 (9)
	1.5 - 2.0 (24)
	2.0 - 2.5 (4)
	2.5 - 3.0 (1)

Release Date

	2005 - 2009 (1)
	2015 - 2019 (22)
	2020 - 2024 (15)

Symmetry Type

	Asymmetric (34)
	Cyclic (6)

SCOP Classification

All alpha proteins (27)

AllSelected

1 to 25 of 38 Structures

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3HME \| pdb_00003hme	Download File View File

Crystal structure of human bromodomain containing 9 isoform 1 (BRD9)

Filippakopoulos, P., Eswaran, J., Keates, T., Picaud, S., Roos, A., Chaikuad, A., von Delft, F., Arrowsmith, C.H., Edwards, A., Weigelt, J., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)

(2012) Cell 149: 214-231

Released	2009-06-23
Method	X-RAY DIFFRACTION 2.23 Å
Organisms	Homo sapiens
Macromolecule	Bromodomain-containing protein 9 (protein)

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4XY8 \| pdb_00004xy8	Download File View File

Crystal Structure of the bromodomain of BRD9 in complex with a 2-amine-9H-purine ligand

Picaud, S., von Delft, F., Edwards, A.M., Arrowsmith, C.H., Bountra, C., Filippakopoulos, P., Structural Genomics Consortium (SGC)

(2015) J Med Chem 58: 2718-2736

Released	2015-03-11
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Homo sapiens
Macromolecule	Bromodomain-containing protein 9 (protein)
Unique Ligands	43U, BR

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4YY4 \| pdb_00004yy4	Download File View File

Crystal structure of BRD9 Bromodomain bound to DMSO

Tang, Y., Bellon, S., Cochran, A.G., Poy, F.

(2015) Structure 23: 1801-1814

Released	2015-09-16
Method	X-RAY DIFFRACTION 1.47 Å
Organisms	Homo sapiens
Macromolecule	Bromodomain-containing protein 9 (protein)
Unique Ligands	DMS

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4YY6 \| pdb_00004yy6	Download File View File

Crystal structure of BRD9 Bromodomain bound to a butyryllysine peptide

Tang, Y., Bellon, S., Cochran, A.G., Poy, F.

(2015) Structure 23: 1801-1814

Released	2015-09-16
Method	X-RAY DIFFRACTION 1.45 Å
Organisms	Homo sapiens
Macromolecule	Bromodomain-containing protein 9 (protein) Histone H4 (protein)

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4YYD \| pdb_00004yyd	Download File View File

Crystal structure of BRD9 Bromodomain bound to a crotonyllysine peptide

Tang, Y., Bellon, S., Cochran, A.G., Poy, F.

(2015) Structure 23: 1801-1814

Released	2015-09-16
Method	X-RAY DIFFRACTION 1.52 Å
Organisms	Homo sapiens
Macromolecule	Bromodomain-containing protein 9 (protein) Histone H4 (protein)

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4YYG \| pdb_00004yyg	Download File View File

Crystal structure of BRD9 Bromodomain bound to a butyryllysine peptide

Tang, Y., Bellon, S., Cochran, A.G., Poy, F.

(2015) Structure 23: 1801-1814

Released	2015-09-16
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens
Macromolecule	Bromodomain-containing protein 9 (protein) Histone H4 (protein)

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4YYH \| pdb_00004yyh	Download File View File

Crystal structure of BRD9 Bromodomain bound to a crotonyllysine peptide

Tang, Y., Bellon, S., Cochran, A.G., Poy, F.

(2015) Structure 23: 1801-1814

Released	2015-09-16
Method	X-RAY DIFFRACTION 1.74 Å
Organisms	Homo sapiens
Macromolecule	Bromodomain-containing protein 9 (protein) Histone H4 (protein)

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4YYI \| pdb_00004yyi	Download File View File

Crystal structure of BRD9 Bromodomain bound to an acetylated peptide

Tang, Y., Bellon, S., Cochran, A.G., Poy, F.

(2015) Structure 23: 1801-1814

Released	2015-09-16
Method	X-RAY DIFFRACTION 1.5 Å
Organisms	Homo sapiens
Macromolecule	Bromodomain-containing protein 9 (protein) Histone H4 (protein)

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4YYJ \| pdb_00004yyj	Download File View File

Crystal structure of BRD9 Bromodomain bound to a butyryllysine peptide

Tang, Y., Bellon, S., Cochran, A.G., Poy, F.

(2015) Structure 23: 1801-1814

Released	2015-09-16
Method	X-RAY DIFFRACTION 1.85 Å
Organisms	Homo sapiens
Macromolecule	Bromodomain-containing protein 9 (protein) Histone H4 (protein)

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4YYK \| pdb_00004yyk	Download File View File

Crystal structure of BRD9 Bromodomain bound to a crotonyllysine peptide

Tang, Y., Bellon, S., Cochran, A.G., Poy, F.

(2015) Structure 23: 1801-1814

Released	2015-09-16
Method	X-RAY DIFFRACTION 1.79 Å
Organisms	Homo sapiens
Macromolecule	Bromodomain-containing protein 9 (protein) Histone H4 (protein)

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4Z6H \| pdb_00004z6h	Download File View File

Crystal structure of BRD9 bromodomain in complex with a valerolactam quinolone ligand

Tallant, C., Structural Genomics Consortium (SGC), Clark, P.G.K., Vieira, L.C.C., Krojer, T., Nunez-Alonso, G., Picaud, S., Fedorov, O., Dixon, D.J., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Brennan, P.E., Knapp, S.

(2015) Angew Chem Int Ed Engl 54: 6217-6221

Released	2015-05-20
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Homo sapiens
Macromolecule	Bromodomain-containing protein 9 (protein)
Unique Ligands	4L2

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4Z6I \| pdb_00004z6i	Download File View File

Crystal structure of BRD9 bromodomain in complex with a substituted valerolactam quinolone ligand

Tallant, C., Structural Genomics Consortium (SGC), Clark, P.G.K., Vieira, L.C.C., Newman, J.A., Krojer, T., Nunez-Alonso, G., Picaud, S., Fedorov, O., Dixon, D.J., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Brennan, P.E., Knapp, S.

(2015) Angew Chem Int Ed Engl 54: 6217-6221

Released	2015-05-20
Method	X-RAY DIFFRACTION 1.95 Å
Organisms	Homo sapiens
Macromolecule	Bromodomain-containing protein 9 (protein)
Unique Ligands	4L3

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5E9V \| pdb_00005e9v	Download File View File

Crystal structure of BRD9 bromodomain in complex with an indolizine ligand

Tallant, C., Hay, D.A., Krojer, T., Nunez-Alonso, G., Picaud, S., Fedorov, O., Schofield, C.J., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Brennan, P.E., Knapp, S.

To be published

Released	2015-10-28
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Homo sapiens
Macromolecule	Bromodomain-containing protein 9 (protein)
Unique Ligands	5L0, EDO

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5I40 \| pdb_00005i40	Download File View File

BRD9 in complex with Cpd1 (6-methyl-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one)

Murray, J.M.

(2016) J Med Chem 59: 5391-5402

Released	2016-10-12
Method	X-RAY DIFFRACTION 1.0402 Å
Organisms	Homo sapiens
Macromolecule	Bromodomain-containing protein 9 (protein)
Unique Ligands	67N, EDO, PEG

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5I7X \| pdb_00005i7x	Download File View File

BRD9 in complex with Cpd2 (N,N-dimethyl-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)benzamide)

Murray, J.M.

(2016) J Med Chem 59: 5391-5402

Released	2016-10-12
Method	X-RAY DIFFRACTION 1.1752 Å
Organisms	Homo sapiens
Macromolecule	Bromodomain-containing protein 9 (protein)
Unique Ligands	67B

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5I7Y \| pdb_00005i7y	Download File View File

BRD9 in complex with Cpd4 ((E)-3-(6-(but-2-en-1-yl)-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)-N,N-dimethylbenzamide)

Murray, J.M.

(2016) J Med Chem 59: 5391-5402

Released	2016-10-12
Method	X-RAY DIFFRACTION 1.4514 Å
Organisms	Homo sapiens
Macromolecule	Bromodomain-containing protein 9 (protein)
Unique Ligands	69G

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5IGM \| pdb_00005igm	Download File View File

Crystal structure of the bromodomain of human BRD9 in complex with bromosporine (BSP)

Tallant, C., Filippakopoulos, P., Picaud, S., Nunez-Alonso, G., von Delft, F., Edwards, A.M., Arrowsmith, C.H., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)

(2016) Sci Adv 2: e1600760-e1600760

Released	2016-10-19
Method	X-RAY DIFFRACTION 1.6 Å
Organisms	Homo sapiens
Macromolecule	Bromodomain-containing protein 9 (protein)
Unique Ligands	BMF

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5IGN \| pdb_00005ign	Download File View File

Crystal structure of human BRD9 bromodomain in complex with LP99 chemical probe

Tallant, C., Clark, P.G.K., Vieira, L.C.C., Newman, J.A., Krojer, T., Nunez-Alonso, G., Picaud, S., Fedorov, O., Dixon, D.J., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Brennan, P.E., Knapp, S., Structural Genomics Consortium (SGC)

To be published

Released	2016-03-30
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Homo sapiens
Macromolecule	Bromodomain-containing protein 9 (protein)
Unique Ligands	6B2

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5JI8 \| pdb_00005ji8	Download File View File

Crystal structure of the BRD9 bromodomain and hit 1

Wang, N., Li, F., Bao, H., Li, J., Wu, J., Ruan, K.

(2016) Chembiochem 17: 1456-1463

Released	2016-06-22
Method	X-RAY DIFFRACTION 1.42 Å
Organisms	Homo sapiens
Macromolecule	Bromodomain-containing protein 9 (protein)
Unique Ligands	6KT

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5MKY \| pdb_00005mky	Download File View File

BROMODOMAIN OF HUMAN BRD9 WITH 4-chloro-2-methyl-5-((2-methyl-1,2,3,4-tetrahydroisoquinolin-5-yl)amino)pyridazin-3(2H)-one

Chung, C.-W.

(2017) J Med Chem 60: 695-709

Released	2017-12-20
Method	X-RAY DIFFRACTION 1.67 Å
Organisms	Homo sapiens
Macromolecule	Bromodomain-containing protein 9 (protein)
Unique Ligands	I0D

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5TWX \| pdb_00005twx	Download File View File

Crystal Structure of BRD9 bromodomain

Seo, H.-S., Dhe-Paganon, S.

(2017) Angew Chem Int Ed Engl 56: 5738-5743

Released	2017-09-27
Method	X-RAY DIFFRACTION 2.55 Å
Organisms	Homo sapiens
Macromolecule	Bromodomain-containing protein 9 (protein)
Unique Ligands	7P7

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6BQA \| pdb_00006bqa	Download File View File

BRD9 bromodomain in complex with 3-(6-(but-3-en-1-yl)-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)-N,N-dimethylbenzamide

Murray, J.M., Tang, Y.

(2019) J Comput Aided Mol Des 33: 307-330

Released	2018-11-14
Method	X-RAY DIFFRACTION 1.031 Å
Organisms	Homo sapiens
Macromolecule	Bromodomain-containing protein 9 (protein)
Unique Ligands	67C

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6HM0 \| pdb_00006hm0	Download File View File

Crystal structure of human BRD9 bromodomain in complex with a PROTAC

Hughes, S.J., Zoppi, V., Ciulli, A.

(2019) J Med Chem 62: 699-726

Released	2019-01-16
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	Bromodomain-containing protein 9 (protein)
Unique Ligands	GBW

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6UZF \| pdb_00006uzf	Download File View File

Crystal structure of the unliganded bromodomain of human BRD9

Karim, M.R., Chan, A., Schonbrunn, E.

(2020) J Med Chem 63: 3227-3237

Released	2020-03-11
Method	X-RAY DIFFRACTION 1.75 Å
Organisms	Homo sapiens
Macromolecule	Bromodomain-containing protein 9 (protein)
Unique Ligands	DMS, EDO, SO4