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233,605 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Source Organism Taxonomy Name (Full Lineage) = "Hepacivirus hominis"

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Search Summary

This query matches 554 Structures.

Refinements

Structure Determination Methodology

experimental (554)

Scientific Name of Source Organism

	Hepacivirus hominis (238)
	Homo sapiens (72)
	Hepatitis C virus (isolate BK) (51)
	Hepatitis C virus isolate HC-J4 (47)
	hepatitis C virus genotype 1a (45)
	Hepatitis C virus subtype 1b (39)
	Hepatitis C virus (isolate 1) (27)
	Hepatitis C virus JFH-1 (23)
	Mus musculus (22)
	Oryctolagus cuniculus (21)

More...

Taxonomy

	Riboviria (537)
	Eukaryota (115)
	Riboviria (RNA viruses and viroids) (39)
	other sequences (19)
	Bacteria (5)

Experimental Method

	X-RAY DIFFRACTION (491)
	ELECTRON MICROSCOPY (32)
	SOLUTION NMR (31)

Polymer Entity Type

	Protein (550)
	RNA (46)
	DNA (7)
	NA-hybrid (1)

Refinement Resolution (Å)

	1.0 - 1.5 (13)
	1.5 - 2.0 (145)
	2.0 - 2.5 (185)
	2.5 - 3.0 (122)
	3.0 - 3.5 (24)
	3.5 - 4.0 (19)
	4.0 - 4.5 (6)
	> 4.5 (9)

Release Date

	1995 - 1999 (11)
	2000 - 2004 (27)
	2005 - 2009 (99)
	2010 - 2014 (210)
	2015 - 2019 (107)
	2020 - 2024 (100)

Enzyme Classification Name

	Hydrolases (102)
	Transferases (208)
	Lyases (21)

Membrane Protein Annotation

	OPM (20)
	MemProtMD (6)
	PDBTM (3)
	mpstruc (1)

Symmetry Type

	Asymmetric (510)
	Cyclic (44)
	Dihedral (2)
	Helical (1)

SCOP Classification

	Multi-domain proteins (alpha and beta) (196)
	All beta proteins (112)
	Artifacts (115)
	Alpha and beta proteins (a/b) (21)
	Peptides (7)
	Alpha and beta proteins (a+b) (2)

AllSelected

1 to 25 of 554 Structures

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1A1Q \| pdb_00001a1q	Download File View File

HEPATITIS C VIRUS NS3 PROTEINASE

Love, R.A., Parge, H.E., Wickersham, J.A., Hostomsky, Z., Habuka, N., Moomaw, E.W., Adachi, T., Hostomska, Z.

(1996) Cell 87: 331-342

Released	1998-03-25
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Hepacivirus hominis
Macromolecule	NS3 PROTEINASE (protein)
Unique Ligands	ZN

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1A1R \| pdb_00001a1r	Download File View File

HCV NS3 PROTEASE DOMAIN:NS4A PEPTIDE COMPLEX

Kim, J.L., Morgenstern, K.A., Lin, C., Fox, T., Dwyer, M.D., Landro, J.A., Chambers, S.P., Markland, W., Lepre, C.A., O'Malley, E.T., Harbeson, S.L., Rice, C.M., Murcko, M.A., Caron, P.R., Thomson, J.A.

(1996) Cell 87: 343-355

Released	1998-06-17
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Hepacivirus hominis
Macromolecule	NS3 PROTEIN (protein) NS4A PROTEIN (protein)
Unique Ligands	ZN

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1A1V \| pdb_00001a1v	Download File View File

HEPATITIS C VIRUS NS3 HELICASE DOMAIN COMPLEXED WITH SINGLE STRANDED SDNA

Kim, J.L., Morgenstern, K.A., Griffith, J.P., Dwyer, M.D., Thomson, J.A., Murcko, M.A., Lin, C., Caron, P.R.

(1998) Structure 6: 89-100

Released	1999-01-13
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Hepatitis C virus (isolate H)
Macromolecule	PROTEIN (NS3 PROTEIN) (protein) DNA (5'-D(UPUPUPUPUPUPUPU)-3') (nucleic acid)
Unique Ligands	SO4

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1BT7 \| pdb_00001bt7	Download File View File

THE SOLUTION NMR STRUCTURE OF THE N-TERMINAL PROTEASE DOMAIN OF THE HEPATITIS C VIRUS (HCV) NS3-PROTEIN, FROM BK STRAIN, 20 STRUCTURES

Barbato, G., Cicero, D.O., Nardi, M.C., Steinkuhler, C., Cortese, R., De Francesco, R., Bazzo, R.

(1999) J Mol Biology 289: 371-384

Released	1999-06-22
Method	SOLUTION NMR
Organisms	Hepacivirus hominis
Macromolecule	NS3 SERINE PROTEASE (protein)
Unique Ligands	ZN

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1C2P \| pdb_00001c2p	Download File View File

HEPATITIS C VIRUS NS5B RNA-DEPENDENT RNA POLYMERASE

Lesburg, C.A., Cable, M.B., Ferrari, E., Hong, Z., Mannarino, A.F., Weber, P.C.

(1999) Nat Struct Biol 6: 937-943

Released	2000-04-05
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Hepacivirus hominis
Macromolecule	RNA-DEPENDENT RNA POLYMERASE (protein)

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1CSJ \| pdb_00001csj	Download File View File

CRYSTAL STRUCTURE OF THE RNA-DEPENDENT RNA POLYMERASE OF HEPATITIS C VIRUS

Bressanelli, S., Tomei, L., Roussel, A., Incitti, I., Vitale, R.L., Mathieu, M., De Francesco, R., Rey, F.A.

(1999) Proc Natl Acad Sci U S A 96: 13034-13039

Released	1999-11-08
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Hepacivirus hominis
Macromolecule	HEPATITIS C VIRUS RNA POLYMERASE (NS5B) (protein)

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1CU1 \| pdb_00001cu1	Download File View File

CRYSTAL STRUCTURE OF AN ENZYME COMPLEX FROM HEPATITIS C VIRUS

Yao, N., Weber, P.C.

(1999) Structure 7: 1353-1363

Released	2000-08-23
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Hepacivirus hominis
Macromolecule	PROTEIN (PROTEASE/HELICASE NS3) (protein)
Unique Ligands	PO4, ZN

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1CWX \| pdb_00001cwx	Download File View File

SOLUTION STRUCTURE OF THE HEPATITIS C VIRUS N-TERMINAL CAPSID PROTEIN 2-45 [C-HCV(2-45)]

Ladaviere, L., Deleage, G., Montserret, R., Dalbon, P., Jolivet, M., Penin, F.

To be published

Released	1999-08-30
Method	SOLUTION NMR
Organisms	Hepatitis C virus genotype 1a (isolate H77)
Macromolecule	HEPATITIS C VIRUS CAPSID PROTEIN (protein)

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1DXP \| pdb_00001dxp	Download File View File

Inhibition of the Hepatitis C Virus NS3/4A Protease. The Crystal Structures of Two Protease-Inhibitor Complexes (apo structure)

Di Marco, S., Rizzi, M., Volpari, C., Walsh, M., Narjes, F., Colarusso, S., De Francesco, R., Matassa, V.G., Sollazzo, M.

(2000) J Biological Chem 275: 7152

Released	2001-01-12
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Hepatitis C virus (isolate Taiwan)
Macromolecule	NONSTRUCTURAL PROTEIN NS4A (P4) (protein) PROTEASE/HELICASE NS3 (P70) (protein)
Unique Ligands	GOL, ZN

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1DXW \| pdb_00001dxw	Download File View File

structure of hetero complex of non structural protein (NS) of hepatitis C virus (HCV) and synthetic peptidic compound

Barbato, G., Cicero, D.O., Cordier, F., Narjes, F., Gerlach, B., Sambucini, S., Grzesiek, S., Matassa, V.G., Defrancesco, R., Bazzo, R.

(2000) EMBO J 19: 1195

Released	2001-01-12
Method	SOLUTION NMR
Organisms	Hepacivirus hominis
Macromolecule	SERINE PROTEASE (protein)
Unique Ligands	2ZF, ZN

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1DY8 \| pdb_00001dy8	Download File View File

Inhibition of the Hepatitis C Virus NS3/4A Protease. The Crystal Structures of Two Protease-Inhibitor Complexes (inhibitor II)

Di Marco, S., Rizzi, M., Volpari, C., Walsh, M., Narjes, F., Colarusso, S., De Francesco, R., Matassa, V.G., Sollazzo, M.

(2000) J Biological Chem 275: 7152

Released	2001-01-28
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Hepatitis C virus (isolate Taiwan)
Macromolecule	NONSTRUCTURAL PROTEIN NS4A (P4) (protein) PROTEASE/HELICASE NS3 (P70) (protein)
Unique Ligands	0F7

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1DY9 \| pdb_00001dy9	Download File View File

Inhibition of the Hepatitis C Virus NS3/4A Protease. The Crystal Structures of Two Protease-Inhibitor Complexes (inhibitor I)

Di Marco, S., Rizzi, M., Volpari, C., Walsh, M., Narjes, F., Colarusso, S., De Francesco, R., Matassa, V.G., Sollazzo, M.

(2000) J Biological Chem 275: 7152

Released	2001-01-28
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Hepatitis C virus (isolate Taiwan)
Macromolecule	NONSTRUCTURAL PROTEIN NS4A (P4) (protein) PROTEASE/HELICASE NS3 (P70) (protein)
Unique Ligands	2ZF, ZN

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1EMZ \| pdb_00001emz	Download File View File

SOLUTION STRUCTURE OF FRAGMENT (350-370) OF THE TRANSMEMBRANE DOMAIN OF HEPATITIS C ENVELOPE GLYCOPROTEIN E1

Op De Beeck, A., Montserret, R., Duvet, S., Cocquerel, L., Cacan, R., Barberot, B., Le Maire, M., Penin, F., Dubuisson, J.

(2000) J Biological Chem 275: 31428-31437

Released	2000-04-05
Method	SOLUTION NMR
Organisms	Hepacivirus hominis
Macromolecule	ENVELOPE GLYCOPROTEIN E1 (protein)

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1GX5 \| pdb_00001gx5	Download File View File

Hepatitis C Virus RNA Polymerase in Complex with GTP and Manganese

Bressanelli, S., Rey, F.A.

(2002) J Virol 76: 3482

Released	2002-04-09
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Hepatitis C virus (isolate BK)
Macromolecule	RNA-DIRECTED RNA POLYMERASE (protein)
Unique Ligands	GTP, MN

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1GX6 \| pdb_00001gx6	Download File View File

Hepatitis C Virus RNA polymerase in complex with UTP and manganese

Bressanelli, S., Rey, F.A.

(2002) J Virol 76: 3482

Released	2002-04-10
Method	X-RAY DIFFRACTION 1.85 Å
Organisms	Hepatitis C virus (isolate BK)
Macromolecule	RNA-DIRECTED RNA POLYMERASE (protein)
Unique Ligands	MN, UTP

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1HEI \| pdb_00001hei	Download File View File

STRUCTURE OF THE HEPATITIS C VIRUS RNA HELICASE DOMAIN

Yao, N., Weber, P.

(1997) Nat Struct Biol 4: 463-467

Released	1998-10-07
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Hepatitis C virus (isolate 1)
Macromolecule	HCV HELICASE (protein)
Unique Ligands	CA

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1JR6 \| pdb_00001jr6	Download File View File

Solution Structure of an Engineered Arginine-rich Subdomain 2 of the Hepatitis C Virus NS3 RNA Helicase

Liu, D., Wyss, D.F., Wang, Y.S., Gesell, J.J.

(2001) J Mol Biology 314: 543-561

Released	2002-08-10
Method	SOLUTION NMR
Organisms	Hepacivirus hominis
Macromolecule	Helicase NS3 (protein)

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1JXP \| pdb_00001jxp	Download File View File

BK STRAIN HEPATITIS C VIRUS (HCV) NS3-NS4A

Yan, Y., Munshi, S., Chen, Z.

(1998) Protein Sci 7: 837-847

Released	1998-01-14
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Hepatitis C virus (isolate BK)
Macromolecule	NS3 SERINE PROTEASE (protein) NS4A (protein)
Unique Ligands	ZN

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1N1L \| pdb_00001n1l	Download File View File

CRYSTAL STRUCTURE OF HCV NS3 PROTEASE DOMAIN:NS4A PEPTIDE COMPLEX WITH COVALENTLY BOUND INHIBITOR (GW472467X)

Andrews, D.M., Chaignot, H., Coomber, B.A., Good, A.C., Hind, S.L., Jones, P.S., Mill, G., Robinson, J.E., Skarzynski, T., Slater, M.J., Somers, D.O.N.

(2002) Org Lett 4: 4479-4482

Released	2003-10-21
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Hepacivirus hominis
Macromolecule	HCV NS3 SERINE PROTEASE (protein) NS4A COFACTOR (protein)
Unique Ligands	TRL, ZN

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1N64 \| pdb_00001n64	Download File View File

Crystal structure analysis of the immunodominant antigenic site on Hepatitis C virus protein bound to mAb 19D9D6

Menez, R., Bossus, M., Muller, B., Sibai, G., Dalbon, P., Ducancel, F., Jolivet-Reynaud, C., Stura, E.

(2003) J Immunol 170: 1917-1924

Released	2003-02-25
Method	X-RAY DIFFRACTION 2.34 Å
Organisms	Hepatitis C virus genotype 1b (isolate Taiwan) Mus musculus
Macromolecule	Fab 19D9D6 heavy chain (protein) Fab 19D9D6 light chain (protein) Genome polyprotein Capsid protein C (protein)

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1NB4 \| pdb_00001nb4	Download File View File

HC-J4 RNA polymerase apo-form

Jaeger, J., O'Farrell, D.J., Trowbridge, R., Rowlands, D.J.

(2003) J Mol Biology 326: 1025-1035

Released	2003-03-25
Method	X-RAY DIFFRACTION 2 Å
Organisms	Hepacivirus hominis
Macromolecule	polyprotein (protein)

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1NB6 \| pdb_00001nb6	Download File View File

HC-J4 RNA polymerase complexed with UTP

O'Farrell, D.J., Trowbridge, R., Rowlands, D.J., Jaeger, J.

(2003) J Mol Biology 326: 1025-1035

Released	2003-03-25
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Hepacivirus hominis
Macromolecule	polyprotein (protein)
Unique Ligands	MN, UTP

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1NB7 \| pdb_00001nb7	Download File View File

HC-J4 RNA polymerase complexed with short RNA template strand

O'Farrell, D.J., Trowbridge, R., Rowlands, D.J., Jaeger, J.

(2003) J Mol Biology 326: 1025-1035

Released	2003-03-25
Method	X-RAY DIFFRACTION 2.9 Å
Organisms	Hepacivirus hominis
Macromolecule	polyprotein (protein) 5'-R(UPUPUPU)-3' (nucleic acid)
Unique Ligands	MN

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1NHU \| pdb_00001nhu	Download File View File

Hepatitis C virus RNA polymerase in complex with non-nucleoside analogue inhibitor

Wang, M., Ng, K.K.S., Cherney, M.M., Chan, L., Yannopoulos, C.G., Bedard, J., Morin, N., Nguyen-Ba, N., Alaoui-Ismaili, M.H., Bethell, R.C., James, M.N.G.

(2003) J Biological Chem 278: 9489-9495

Released	2003-03-18
Method	X-RAY DIFFRACTION 2 Å
Organisms	Hepatitis C virus subtype 1b
Macromolecule	HEPATITIS C VIRUS NS5B RNA-DEPENDENT RNA POLYMERASE (protein)
Unique Ligands	153

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1NHV \| pdb_00001nhv	Download File View File

Hepatitis C virus RNA polymerase in complex with non-nucleoside analogue inhibitor

Wang, M., Ng, K.K.S., Cherney, M.M., Chan, L., Yannopoulos, C.G., Bedard, J., Morin, N., Nguyen-Ba, N., Alaoui-Ismaili, M.H., Bethell, R.C., James, M.N.G.

(2003) J Biological Chem 278: 9489-9495

Released	2003-03-18
Method	X-RAY DIFFRACTION 2.9 Å
Organisms	Hepatitis C virus subtype 1b
Macromolecule	HEPATITIS C VIRUS NS5B RNA-DEPENDENT RNA POLYMERASE (protein)
Unique Ligands	154

1 to 25 of 554 Structures

Page 1 of 23

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Membrane Protein Annotation

Symmetry Type

SCOP Classification

1A1Q | pdb_00001a1q

1A1R | pdb_00001a1r

1A1V | pdb_00001a1v

1BT7 | pdb_00001bt7

1C2P | pdb_00001c2p

1CSJ | pdb_00001csj

1CU1 | pdb_00001cu1

1CWX | pdb_00001cwx

1DXP | pdb_00001dxp

1DXW | pdb_00001dxw

1DY8 | pdb_00001dy8

1DY9 | pdb_00001dy9

1EMZ | pdb_00001emz

1GX5 | pdb_00001gx5

1GX6 | pdb_00001gx6

1HEI | pdb_00001hei

1JR6 | pdb_00001jr6

1JXP | pdb_00001jxp

1N1L | pdb_00001n1l

1N64 | pdb_00001n64

1NB4 | pdb_00001nb4

1NB6 | pdb_00001nb6

1NB7 | pdb_00001nb7

1NHU | pdb_00001nhu

1NHV | pdb_00001nhv