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233,605 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Enzyme Classification Number = 3.2.1.52

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Search Summary

This query matches 193 Structures.

Refinements

Structure Determination Methodology

experimental (193)

Scientific Name of Source Organism

	Bacteroides thetaiotaomicron VPI-5482 (24)
	Streptococcus pneumoniae TIGR4 (19)
	Clostridium perfringens (10)
	Homo sapiens (10)
	Ostrinia furnacalis (10)
	Akkermansia muciniphila ATCC BAA-835 (9)
	Streptomyces plicatus (8)
	Pseudomonas aeruginosa PAO1 (7)
	Bacteroides thetaiotaomicron (6)
	Paenibacillus sp. TS12 (6)

More...

Taxonomy

	Bacteria (166)
	Eukaryota (28)
	unclassified sequences (2)

Experimental Method

	X-RAY DIFFRACTION (191)
	SOLUTION NMR (2)

Polymer Entity Type

Protein (193)

Refinement Resolution (Å)

	1.0 - 1.5 (12)
	1.5 - 2.0 (68)
	2.0 - 2.5 (81)
	2.5 - 3.0 (25)
	3.0 - 3.5 (5)

Release Date

	1995 - 1999 (2)
	2000 - 2004 (15)
	2005 - 2009 (32)
	2010 - 2014 (65)
	2015 - 2019 (48)
	2020 - 2024 (31)

Enzyme Classification Name

	Hydrolases (193)
	Transferases (1)

Symmetry Type

	Asymmetric (148)
	Cyclic (61)
	Dihedral (1)

SCOP Classification

	Alpha and beta proteins (a/b) (60)
	Alpha and beta proteins (a+b) (42)
	All alpha proteins (17)
	Artifacts (11)
	All beta proteins (5)

AllSelected

1 to 25 of 193 Structures

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1C7S \| pdb_00001c7s	Download File View File

BETA-N-ACETYLHEXOSAMINIDASE MUTANT D539A COMPLEXED WITH DI-N-ACETYL-BETA-D-GLUCOSAMINE (CHITOBIASE)

Prag, G., Papanikolau, Y., Tavlas, G., Vorgias, C.E., Petratos, K., Oppenheim, A.B.

(2000) J Mol Biology 300: 611-617

Released	2000-09-20
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Serratia marcescens
Macromolecule	BETA-N-ACETYLHEXOSAMINIDASE (protein)
Unique Ligands	SO4
Unique branched monosaccharides	NAG

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1C7T \| pdb_00001c7t	Download File View File

BETA-N-ACETYLHEXOSAMINIDASE MUTANT E540D COMPLEXED WITH DI-N ACETYL-D-GLUCOSAMINE (CHITOBIASE)

Prag, G., Papanikolau, Y., Tavlas, G., Vorgias, C.E., Petratos, K., Oppenheim, A.B.

(2000) J Mol Biology 300: 611-617

Released	2000-09-20
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Serratia marcescens
Macromolecule	BETA-N-ACETYLHEXOSAMINIDASE (protein)
Unique Ligands	SO4
Unique branched monosaccharides	NAG

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1E9L \| pdb_00001e9l	Download File View File

The crystal structure of novel mammalian lectin Ym1 suggests a saccharide binding site

Hsiao, C.D., Sun, Y.J.

(2001) J Biological Chem 276: 17507

Released	2001-03-01
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Mus musculus
Macromolecule	YM1 SECRETORY PROTEIN (protein)
Unique Ligands	GCS

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1HP4 \| pdb_00001hp4	Download File View File

CRYSTAL STRUCTURE OF STREPTOMYCES PLICATUS BETA-N-ACETYLHEXOSAMINIDASE

Mark, B.L.

(2001) J Biological Chem 276: 10330-10337

Released	2001-04-04
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Streptomyces plicatus
Macromolecule	BETA-N-ACETYLHEXOSAMINIDASE (protein)
Unique Ligands	CL, GOL, SO4

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1HP5 \| pdb_00001hp5	Download File View File

STREPTOMYCES PLICATUS BETA-N-ACETYLHEXOSAMINIDASE COMPLEXED WITH INTERMEDIATE ANALOUGE NAG-THIAZOLINE

Mark, B.L.

(2001) J Biological Chem 276: 10330-10337

Released	2001-04-04
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Streptomyces plicatus
Macromolecule	BETA-N-ACETYLHEXOSAMINIDASE (protein)
Unique Ligands	CL, GOL, NGT, SO4

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1JAK \| pdb_00001jak	Download File View File

Streptomyces plicatus beta-N-acetylhexosaminidase in Complex with (2R,3R,4S,5R)-2-acetamido-3,4-dihydroxy-5-hydroxymethyl-piperidinium chloride (IFG)

Mark, B.L., Vocadlo, D.J., Zhao, D., Knapp, S., Withers, S.G., James, M.N.

(2001) J Biological Chem 276: 42131-42137

Released	2001-11-21
Method	X-RAY DIFFRACTION 1.75 Å
Organisms	Streptomyces plicatus
Macromolecule	Beta-N-acetylhexosaminidase (protein)
Unique Ligands	CL, GOL, IFG, SO4

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1M01 \| pdb_00001m01	Download File View File

Wildtype Streptomyces plicatus beta-hexosaminidase in complex with product (GlcNAc)

J Williams, S., Mark, B.L., Vocadlo, D.J., James, M.N.G., Withers, S.G.

(2002) J Biological Chem 277: 40055-40065

Released	2003-01-21
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Streptomyces plicatus
Macromolecule	Beta-N-acetylhexosaminidase (protein)
Unique Ligands	CL, GOL, NAG, SO4

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1M03 \| pdb_00001m03	Download File View File

Mutant Streptomyces plicatus beta-hexosaminidase (D313A) in complex with product (GlcNAc)

Williams, S.J., Mark, B.L., Vocadlo, D.J., James, M.N.G., Withers, S.G.

(2002) J Biological Chem 277: 40055-40065

Released	2002-12-11
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Streptomyces plicatus
Macromolecule	Beta-N-acetylhexosaminidase (protein)
Unique Ligands	CL, GOL, NAG, SO4

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1M04 \| pdb_00001m04	Download File View File

Mutant Streptomyces plicatus beta-hexosaminidase (D313N) in complex with product (GlcNAc)

Williams, S.J., Mark, B.L., Vocadlo, D.J., James, M.N.G., Withers, S.G.

(2002) J Biological Chem 277: 40055-40065

Released	2002-12-11
Method	X-RAY DIFFRACTION 1.95 Å
Organisms	Streptomyces plicatus
Macromolecule	Beta-N-acetylhexosaminidase (protein)
Unique Ligands	CL, GOL, NAG, SO4

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1NOU \| pdb_00001nou	Download File View File

Native human lysosomal beta-hexosaminidase isoform B

Mark, B.L., Mahuran, D.J., Cherney, M.M., Zhao, D., Knapp, S., James, M.N.G.

(2003) J Mol Biology 327: 1093-1109

Released	2003-04-08
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	beta-hexosaminidase beta chain (protein)
Unique Ligands	GOL, SO4
Unique branched monosaccharides	NAG

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1NOW \| pdb_00001now	Download File View File

Human lysosomal beta-hexosaminidase isoform B in complex with (2R,3R,4S,5R)-2-Acetamido-3,4-Dihydroxy-5-Hydroxymethyl-Piperidinium Chloride (GalNAc-isofagomine)

Mark, B.L., Mahuran, D.J., Cherney, M.M., Zhao, D., Knapp, S., James, M.N.G.

(2003) J Mol Biology 327: 1093-1109

Released	2003-04-29
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens
Macromolecule	beta-hexosaminidase beta chain (protein)
Unique Ligands	GOL, IFG, SO4
Unique branched monosaccharides	NAG

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1NP0 \| pdb_00001np0	Download File View File

Human lysosomal beta-hexosaminidase isoform B in complex with intermediate analogue NAG-thiazoline

Mark, B.L., Mahuran, D.J., Cherney, M.M., Zhao, D., Knapp, S., James, M.N.G.

(2003) J Mol Biology 327: 1093-1109

Released	2003-04-29
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Homo sapiens
Macromolecule	Beta-hexosaminidase subunit beta (protein) Beta-hexosaminidase subunit beta chain A (protein) Beta-hexosaminidase subunit beta chain B (protein)
Unique Ligands	GOL, NGT, SO4
Unique branched monosaccharides	NAG

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1O7A \| pdb_00001o7a	Download File View File

Human beta-Hexosaminidase B

Maier, T., Strater, N., Schuette, C., Klingenstein, R., Sandhoff, K., Saenger, W.

(2003) J Mol Biology 328: 669

Released	2003-10-23
Method	X-RAY DIFFRACTION 2.25 Å
Organisms	Homo sapiens
Macromolecule	BETA-HEXOSAMINIDASE BETA CHAIN (protein)
Unique Ligands	EDO, GDL, NAG
Unique branched monosaccharides	NAG

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1QBA \| pdb_00001qba	Download File View File

BACTERIAL CHITOBIASE, GLYCOSYL HYDROLASE FAMILY 20

Tews, I., Perrakis, A., Oppenheim, A., Dauter, Z., Wilson, K.S., Vorgias, C.E.

(1996) Nat Struct Biol 3: 638-648

Released	1997-01-11
Method	X-RAY DIFFRACTION 1.85 Å
Organisms	Serratia marcescens
Macromolecule	CHITOBIASE (protein)
Unique Ligands	SO4

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1QBB \| pdb_00001qbb	Download File View File

BACTERIAL CHITOBIASE COMPLEXED WITH CHITOBIOSE (DINAG)

Tews, I., Perrakis, A., Oppenheim, A., Dauter, Z., Wilson, K.S., Vorgias, C.E.

(1996) Nat Struct Biol 3: 638-648

Released	1997-02-12
Method	X-RAY DIFFRACTION 2 Å
Organisms	Serratia marcescens
Macromolecule	CHITOBIASE (protein)
Unique Ligands	SO4
Unique branched monosaccharides	NAG

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1TR9 \| pdb_00001tr9	Download File View File

Structure of beta-hexosaminidase from Vibrio cholerae

Gorman, J., Shapiro, L., Burley, S.K., New York SGX Research Center for Structural Genomics (NYSGXRC)

To be published

Released	2004-12-14
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Vibrio cholerae
Macromolecule	Beta-hexosaminidase (protein)

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1VF8 \| pdb_00001vf8	Download File View File

The Crystal Structure of Ym1 at 1.31 A Resolution

Liaw, S.H., Tsai, M.L., Chang, N.C.

(2004) J Struct Biol 148: 290-296

Released	2005-03-15
Method	X-RAY DIFFRACTION 1.31 Å
Organisms	Mus musculus
Macromolecule	secretory protein (protein)

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1Y65 \| pdb_00001y65	Download File View File

Crystal structure of beta-hexosaminidase from Vibrio cholerae in complex with N-acetyl-D-glucosamine to a resolution of 1.85

Gorman, J., Shapiro, L., Burley, S.K., New York SGX Research Center for Structural Genomics (NYSGXRC)

To be published

Released	2004-12-14
Method	X-RAY DIFFRACTION 1.85 Å
Organisms	Vibrio cholerae
Macromolecule	Beta-hexosaminidase (protein)
Unique Ligands	NAG

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1YHT \| pdb_00001yht	Download File View File

Crystal structure analysis of Dispersin B

Ramasubbu, N., Thomas, L.M., Ragunath, C., Kaplan, J.B.

(2005) J Mol Biology 349: 475-486

Released	2006-01-10
Method	X-RAY DIFFRACTION 2 Å
Organisms	Aggregatibacter actinomycetemcomitans
Macromolecule	DspB (protein)
Unique Ligands	ACY, GOL

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2CHN \| pdb_00002chn	Download File View File

Bacteroides thetaiotaomicron hexosaminidase with O-GlcNAcase activity- NAG-thiazoline complex

Dennis, R.J., Taylor, E.J., Macauley, M.S., Stubbs, K.A., Turkenburg, J.P., Hart, S.J., Black, G.N., Vocadlo, D.J., Davies, G.J.

(2006) Nat Struct Mol Biol 13: 365

Released	2006-05-08
Method	X-RAY DIFFRACTION 1.95 Å
Organisms	Bacteroides thetaiotaomicron VPI-5482
Macromolecule	GLUCOSAMINIDASE (protein)
Unique Ligands	CA, GOL, NGT

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2CHO \| pdb_00002cho	Download File View File

Bacteroides thetaiotaomicron hexosaminidase with O-GlcNAcase activity

Dennis, R.J., Taylor, E.J., Macauley, M.S., Stubbs, K.A., Turkenburg, J.P., Hart, S.J., Black, G.N., Vocadlo, D.J., Davies, G.J.

(2006) Nat Struct Mol Biol 13: 365

Released	2006-06-19
Method	X-RAY DIFFRACTION 1.85 Å
Organisms	Bacteroides thetaiotaomicron VPI-5482
Macromolecule	GLUCOSAMINIDASE (protein)
Unique Ligands	ACT, CA, GOL

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2EPK \| pdb_00002epk	Download File View File

N-acetyl-B-D-glucosaminidase (GCNA) from Streptococcus gordonii

Langley, D.B.

(2008) J Mol Biology 377: 104-116

Released	2008-03-11
Method	X-RAY DIFFRACTION 1.85 Å
Organisms	Streptococcus gordonii
Macromolecule	N-acetyl-beta-D-glucosaminidase (protein)
Unique Ligands	SO4

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2EPL \| pdb_00002epl	Download File View File

N-acetyl-B-D-glucosaminidase (GCNA) from Streptococcus gordonii

Langley, D.B., Harty, D.W.S., Guss, J.M., Collyer, C.A.

(2008) J Mol Biology 377: 104-116

Released	2008-03-11
Method	X-RAY DIFFRACTION 1.4 Å
Organisms	Streptococcus gordonii
Macromolecule	N-acetyl-beta-D-glucosaminidase (protein)
Unique Ligands	GOL, SO4

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2EPM \| pdb_00002epm	Download File View File

N-acetyl-B-D-glucoasminidase (GCNA) from Stretococcus gordonii

Langley, D.B., Harty, D.W.S., Guss, J.M., Collyer, C.A.

(2008) J Mol Biology 377: 104-116

Released	2008-03-11
Method	X-RAY DIFFRACTION 2.04 Å
Organisms	Streptococcus gordonii
Macromolecule	N-acetyl-beta-D-glucosaminidase (protein)
Unique Ligands	GOL, HG, SO4

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2EPN \| pdb_00002epn	Download File View File

N-acetyl-B-D-glucosaminidase (GCNA) from Streptococcus gordonii

Langley, D.B.

(2008) J Mol Biology 377: 104-116

Released	2008-03-11
Method	X-RAY DIFFRACTION 1.61 Å
Organisms	Streptococcus gordonii
Macromolecule	N-acetyl-beta-D-glucosaminidase (protein)
Unique Ligands	NGT

1 to 25 of 193 Structures

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

1C7S | pdb_00001c7s

1C7T | pdb_00001c7t

1E9L | pdb_00001e9l

1HP4 | pdb_00001hp4

1HP5 | pdb_00001hp5

1JAK | pdb_00001jak

1M01 | pdb_00001m01

1M03 | pdb_00001m03

1M04 | pdb_00001m04

1NOU | pdb_00001nou

1NOW | pdb_00001now

1NP0 | pdb_00001np0

1O7A | pdb_00001o7a

1QBA | pdb_00001qba

1QBB | pdb_00001qbb

1TR9 | pdb_00001tr9

1VF8 | pdb_00001vf8

1Y65 | pdb_00001y65

1YHT | pdb_00001yht

2CHN | pdb_00002chn

2CHO | pdb_00002cho

2EPK | pdb_00002epk

2EPL | pdb_00002epl

2EPM | pdb_00002epm

2EPN | pdb_00002epn