Structural comparison of human and malarial purine nucleoside phosphorylases
Shi, W., Lewandowicz, A., Tyler, P.C., Furneaux, R.H., Almo, S.C., Schramm, V.L.To be published.
Experimental Data Snapshot
Starting Model: experimental
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Entity ID: 1 | |||||
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Molecule | Chains | Sequence Length | Organism | Details | Image |
Purine nucleoside phosphorylase | 289 | Homo sapiens | Mutation(s): 0 Gene Names: NP, PNP EC: 2.4.2.1 | ||
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P00491 (Homo sapiens) Explore P00491 Go to UniProtKB: P00491 | |||||
PHAROS: P00491 GTEx: ENSG00000198805 | |||||
Entity Groups | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Group | P00491 | ||||
Sequence AnnotationsExpand | |||||
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Ligands 2 Unique | |||||
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ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
DIH Query on DIH | E [auth A] | 7-[[(3R,4R)-3-(hydroxymethyl)-4-oxidanyl-pyrrolidin-1-ium-1-yl]methyl]-3,5-dihydropyrrolo[3,2-d]pyrimidin-4-one C12 H17 N4 O3 AFNHHLILYQEHKK-BDAKNGLRSA-O | |||
SO4 Query on SO4 | B [auth A], C [auth A], D [auth A] | SULFATE ION O4 S QAOWNCQODCNURD-UHFFFAOYSA-L |
Length ( Å ) | Angle ( ˚ ) |
---|---|
a = 142.162 | α = 90 |
b = 142.162 | β = 90 |
c = 166.387 | γ = 120 |
Software Name | Purpose |
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DENZO | data reduction |
SCALEPACK | data scaling |
AMoRE | phasing |
CNS | refinement |