1WO9 | pdb_00001wo9

Selective inhibition of trypsins by insect peptides: role of P6-P10 loop

(2003) Biochemistry 42: 13605-13612

• PubMed: 14622007 Search on PubMed
• DOI: https://doi.org/10.1021/bi035318t
• Primary Citation of Related Structures:  
  1WO9


• PubMed Abstract: 
  

  PMP-D2 and HI, two peptides from Locusta migratoria, were shown to belong to the family of tight-binding protease inhibitors. However, they interact weakly with bovine trypsin (K(i) around 100 nM) despite a trypsin-specific Arg at the primary specificity site P1. Here we demonstrate that they are potent inhibitors of midgut trypsins isolated from the same insect and of a fungal trypsin from Fusarium oxysporum (K(i)

   View More

---

Organizational Affiliation: 

Centre d'Immunologie de Marseille-Luminy, UMR 145, Parc Scientifique et Technologique de Luminy, Case 906, 13009 Marseille, France. kellenberger@ciml.univ-mrs.fr