Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors
Martin, D.P., Cohen, S.M.(2012) Chem Commun (Camb) 48: 5259-5261
- PubMed: 22531842
- DOI: https://doi.org/10.1039/c2cc32013d
- Primary Citation of Related Structures:
4E3D, 4E3F, 4E3G, 4E3H, 4E49, 4E4A - PubMed Abstract:
A series of hydroxybenzoic acid derivatives have shown inhibitory activity against carbonic anhydrase (CA). X-ray crystallography shows that these molecules inhibit not by binding the active site metal ion but by strong hydrogen bonding to the metal-bound water nucleophile. The binding mode observed for these molecules is distinct when compared to other non-metal-binding CA inhibitors.
Organizational Affiliation:
Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0358, USA.