4FZ5 | pdb_00004fz5

Crystal Structure of Human TIRAP TIR-domain

PDB DOI: https://doi.org/10.2210/pdb4FZ5/pdb

Classification: IMMUNE SYSTEM
Organism(s): Homo sapiens
Expression System: Escherichia coli
Mutation(s): No

Deposited: 2012-07-06 Released: 2013-05-29
Deposition Author(s): Woo, J.R., Kim, S., Shoelson, S.E., Park, S.

Experimental Data Snapshot

Method: X-RAY DIFFRACTION
Resolution: 3.60 Å
R-Value Free:
0.346 (Depositor), 0.370 (DCC)
R-Value Work:
0.324 (Depositor), 0.350 (DCC)

Starting Model: experimental
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wwPDB Validation 3D Report Full Report

This is version 1.2 of the entry. See complete history.

Literature

X-ray Crystallographic Structure of TIR-Domain from the Human TIR-Domain Containing Adaptor Protein/MyD88 Adaptor-Like Protein (TIRAP/MAL)

Woo, J.R., Kim, S., Shoelson, S.E., Park, S.

(2013) Bull Korean Chem Soc 33: 3091-3094

DOI: https://doi.org/10.5012/bkcs.2012.33.9.3091

Macromolecule Content

Total Structure Weight: 33.66 kDa
Atom Count: 1,798
Modelled Residue Count: 230
Deposited Residue Count: 308
Unique protein chains: 1

Macromolecules

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(by identity cutoff) | 3D Structure

Entity ID: 1
Molecule	Chains	Sequence Length	Organism	Details	Image
Toll/interleukin-1 receptor domain-containing adapter protein	A, B	154	Homo sapiens	Mutation(s): 0 Gene Names: TIRAP, MAL
UniProt & NIH Common Fund Data Resources
Find proteins for P58753 (Homo sapiens) Explore P58753 Go to UniProtKB: P58753
PHAROS: P58753 GTEx: ENSG00000150455
Entity Groups
Sequence Clusters	30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity
UniProt Group	P58753
Sequence Annotations Expand
Reference Sequence LOADING

Experimental Data & Validation

Experimental Data

Method: X-RAY DIFFRACTION
Resolution: 3.60 Å
R-Value Free: 0.346 (Depositor), 0.370 (DCC)
R-Value Work: 0.324 (Depositor), 0.350 (DCC)

Space Group: P 4₃ 2 2

Unit Cell:

Length ( Å )	Angle ( ˚ )
a = 100.253	α = 90
b = 100.253	β = 90
c = 78.939	γ = 90

Software Package:

Software Name	Purpose
CBASS	data collection
PHASES	phasing
CNS	refinement
HKL-2000	data reduction
HKL-2000	data scaling

Structure Validation

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Entry History

Deposition Data

Released Date: 2013-05-29

Deposition Author(s):

Revision History (Full details and data files)

Version 1.0: 2013-05-29
Type: Initial release
Version 1.1: 2023-11-08
Changes: Data collection, Database references, Refinement description
Version 1.2: 2024-10-16
Changes: Structure summary

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.