Download MendeleyCrystal Structure of Porcine C2 Domain of Blood Coagulation Factor VIII (FoldIt Target)
Spiegel, P.C., Brison, C.To be published.
4MO3 | pdb_00004mo3
Crystal Structure of Porcine C2 Domain of Blood Coagulation Factor VIII
- PDB DOI: https://doi.org/10.2210/pdb4MO3/pdb
- Classification: BLOOD CLOTTING
- Organism(s): Sus scrofa
- Expression System: Escherichia coli
- Mutation(s): No
- Membrane Protein: Yes OPM
- Deposited: 2013-09-11 Released: 2013-11-06
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 1.70 Å
- R-Value Free: 0.209 (Depositor), 0.210 (DCC)
- R-Value Work: 0.175 (Depositor), 0.180 (DCC)
- R-Value Observed: 0.179 (Depositor)
Starting Model: experimental
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wwPDB Validation 3D Report Full Report
This is version 1.3 of the entry. See complete history.
Literature
To be published.
Macromolecules
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(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Coagulation factor VIII | A [auth M] | 177 | Sus scrofa | Mutation(s): 0 Gene Names: F8, CF8 Membrane Entity: Yes |  |
UniProt | |||||
Find proteins for P12263 (Sus scrofa) Explore P12263 Go to UniProtKB: P12263 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P12263 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 1 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| GOL Query on GOL | B [auth M] | GLYCEROL C3 H8 O3 PEDCQBHIVMGVHV-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 1.70 Å
- R-Value Free: 0.209 (Depositor), 0.210 (DCC)
- R-Value Work: 0.175 (Depositor), 0.180 (DCC)
- R-Value Observed: 0.179 (Depositor)
Space Group: I 2 2 2
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 49.07 | α = 90 |
| b = 68.94 | β = 90 |
| c = 105.96 | γ = 90 |
| Software Name | Purpose |
|---|---|
| CrystalClear | data collection |
| Coot | model building |
| PHENIX | refinement |
| MOSFLM | data reduction |
| SCALA | data scaling |
Entry History
Deposition Data
- Released Date: 2013-11-06 Deposition Author(s): Spiegel, P.C., Brison, C.
Revision History (Full details and data files)
- Version 1.0: 2013-11-06
Type: Initial release - Version 1.1: 2017-11-15
Changes: Refinement description - Version 1.2: 2023-09-20
Changes: Data collection, Database references, Derived calculations, Refinement description - Version 1.3: 2024-10-30
Changes: Structure summary
