7P09 | pdb_00007p09

Human mitochondrial Lon protease with substrate in the ATPase domain

PDB DOI: https://doi.org/10.2210/pdb7P09/pdb
EM Map EMD-13146: EMDB EMDataResource

Classification: HYDROLASE
Organism(s): Homo sapiens
Expression System: Escherichia coli
Mutation(s): No

Deposited: 2021-06-29 Released: 2021-08-11
Deposition Author(s): Valentin Gese, G., Shahzad, S., Hallberg, B.M.

Experimental Data Snapshot

Method: ELECTRON MICROSCOPY
Resolution: 2.70 Å
Aggregation State: PARTICLE
Reconstruction Method: SINGLE PARTICLE

Starting Model: experimental
View more details

wwPDB Validation 3D Report Full Report

This is version 1.1 of the entry. See complete history.

Literature

A dual allosteric pathway drives human mitochondrial Lon

Valentin Gese, G., Shahzad, S., Pardo-Hernandez, C., Wramstedt, A., Falkenberg, M., Hallberg, M.

To be published.

Macromolecule Content

Total Structure Weight: 595.97 kDa
Atom Count: 25,091
Modelled Residue Count: 3,196
Deposited Residue Count: 5,321
Unique protein chains: 2

Macromolecules

Find similar proteins by:

(by identity cutoff) | 3D Structure

Entity ID: 1
Molecule	Chains	Sequence Length	Organism	Details	Image
Lon protease homolog, mitochondrial	A, B, C, D, E A, B, C, D, E, F	885	Homo sapiens	Mutation(s): 0 Gene Names: LONP1, PRSS15 EC: 3.4.21.53
UniProt & NIH Common Fund Data Resources
Find proteins for P36776 (Homo sapiens) Explore P36776 Go to UniProtKB: P36776
PHAROS: P36776 GTEx: ENSG00000196365
Entity Groups
Sequence Clusters	30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity
UniProt Group	P36776
Sequence Annotations Expand
Reference Sequence LOADING

Find similar proteins by: Sequence | 3D Structure

Entity ID: 2
Molecule	Chains	Sequence Length	Organism	Details	Image
Unknown peptide from human mitochondrial transcription factor A (TFAM)	G	11	Homo sapiens	Mutation(s): 0
Sequence Annotations Expand
Reference Sequence LOADING

Small Molecules

Ligands 3 Unique
ID	Chains	Name / Formula / InChI Key	2D Diagram	3D Interactions
ATP Query on ATP Download Ideal Coordinates CCD File SDF format, chain H [auth A] SDF format, chain J [auth B] SDF format, chain L [auth C] SDF format, chain P [auth F] MOL2 format, chain H [auth A] MOL2 format, chain J [auth B] MOL2 format, chain L [auth C] MOL2 format, chain P [auth F] mmCIF format, chain H [auth A] mmCIF format, chain J [auth B] mmCIF format, chain L [auth C] mmCIF format, chain P [auth F]	H [auth A], J [auth B], L [auth C], P [auth F]	ADENOSINE-5'-TRIPHOSPHATE C₁₀ H₁₆ N₅ O₁₃ P₃ ZKHQWZAMYRWXGA-KQYNXXCUSA-N		Interactions Focus chain H [auth A] Focus chain J [auth B] Focus chain L [auth C] Focus chain P [auth F] Interactions & Density Focus chain H [auth A] Focus chain J [auth B] Focus chain L [auth C] Focus chain P [auth F]
ADP Query on ADP Download Ideal Coordinates CCD File SDF format, chain N [auth D] SDF format, chain O [auth E] MOL2 format, chain N [auth D] MOL2 format, chain O [auth E] mmCIF format, chain N [auth D] mmCIF format, chain O [auth E]	N [auth D], O [auth E]	ADENOSINE-5'-DIPHOSPHATE C₁₀ H₁₅ N₅ O₁₀ P₂ XTWYTFMLZFPYCI-KQYNXXCUSA-N		Interactions Focus chain N [auth D] Focus chain O [auth E] Interactions & Density Focus chain N [auth D] Focus chain O [auth E]
MG Query on MG Download Ideal Coordinates CCD File SDF format, chain I [auth A] SDF format, chain K [auth B] SDF format, chain M [auth C] SDF format, chain Q [auth F] MOL2 format, chain I [auth A] MOL2 format, chain K [auth B] MOL2 format, chain M [auth C] MOL2 format, chain Q [auth F] mmCIF format, chain I [auth A] mmCIF format, chain K [auth B] mmCIF format, chain M [auth C] mmCIF format, chain Q [auth F]	I [auth A], K [auth B], M [auth C], Q [auth F]	MAGNESIUM ION Mg JLVVSXFLKOJNIY-UHFFFAOYSA-N		Interactions Focus chain I [auth A] Focus chain K [auth B] Focus chain M [auth C] Focus chain Q [auth F] Interactions & Density Focus chain I [auth A] Focus chain K [auth B] Focus chain M [auth C] Focus chain Q [auth F]